{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T13:47:28Z","timestamp":1777124848092,"version":"3.51.4"},"reference-count":56,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Micronutrients are vital for general and oral health, and their potential anti-cancer properties are documented. We explore beneficial vitamins for oral potentially malignant disorders (OPMDs) and oral cancer (OC), assessing the therapeutic impacts of essential vitamin supplementation. Methods: We systematically review evidence on vitamin supplementation\u2019s therapeutic effects for OPMDs and OC. Relevant studies were identified through comprehensive searches of MEDLINE, Evidence-Based Medicine, and Web of Science until 16 May 2023. All studies underwent risk of bias using criteria modified from the Office of Health Assessment and Translation (OHAT) tool. Results: We analysed 80 papers. Vitamin K, studied in vitro, shows promising therapeutic potential. Vitamin C, investigated in vivo (animals and humans), demonstrated mixed animal results and generally positive human trial effects. Vitamin A\u2019s efficacy varied, with positive monotherapy or adjunct effects. Vitamins B and D showed therapeutic benefits. Oral cancer research was extensive, with a focus on oral lichen planus and oral leukoplakia among the 11 OPMDs. All bias levels were reported in \u2018selective reporting\u2019 and \u2018performance\u2019, except for \u201cdefinitely high\u201d in the \u2018selection\u2019, \u2018detection\u2019, and \u2018attrition\/exclusion\u2019 domains. Conclusions: Evidence of vitamin interventions for OPMDs and OC ranges from mixed to promising. Standardizing the study design and outcomes would enhance future research.<\/jats:p>","DOI":"10.3390\/jpm13101520","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:54:35Z","timestamp":1698040475000},"page":"1520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Role of Vitamins in Oral Potentially Malignant Disorders and Oral Cancer: A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4521-0147","authenticated-orcid":false,"given":"Jewel Kai Lin","family":"See","sequence":"first","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-9561","authenticated-orcid":false,"given":"Xinyao","family":"Liu","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4610-6690","authenticated-orcid":false,"given":"Federica","family":"Canfora","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"},{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, 5 Via Pansini, 80138 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Moore","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7829-4684","authenticated-orcid":false,"given":"Michael","family":"McCullough","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8412-1114","authenticated-orcid":false,"given":"Tami","family":"Yap","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-4723","authenticated-orcid":false,"given":"Rita","family":"Paolini","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-2511","authenticated-orcid":false,"given":"Antonio","family":"Celentano","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/01635589709514499","article-title":"Evaluation of multiple micronutrient supplementation in the management of oral submucous fibrosis in Karachi, Pakistan","volume":"27","author":"Maher","year":"1997","journal-title":"Nutr. 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