{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:35:08Z","timestamp":1785886508926,"version":"3.56.0"},"reference-count":77,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Research, Innovation and Digitization, CCCDI-UEFISCDI","award":["PN-III-P2-2.1-PED-2021-2243"],"award-info":[{"award-number":["PN-III-P2-2.1-PED-2021-2243"]}]},{"name":"Ministry of Research, Innovation and Digitization, CCCDI-UEFISCDI","award":["PN-III-P4-PCE-2021-0549"],"award-info":[{"award-number":["PN-III-P4-PCE-2021-0549"]}]},{"name":"Ministry of Research, Innovation and Digitization, CCCDI-UEFISCDI","award":["PN 23.16.01.03"],"award-info":[{"award-number":["PN 23.16.01.03"]}]},{"name":"Core Program","award":["PN-III-P2-2.1-PED-2021-2243"],"award-info":[{"award-number":["PN-III-P2-2.1-PED-2021-2243"]}]},{"name":"Core Program","award":["PN-III-P4-PCE-2021-0549"],"award-info":[{"award-number":["PN-III-P4-PCE-2021-0549"]}]},{"name":"Core Program","award":["PN 23.16.01.03"],"award-info":[{"award-number":["PN 23.16.01.03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Despite all the available treatments, psoriasis remains incurable; therefore, finding personalized therapies is a continuous challenge. Psoriasis is linked to a gut microbiota imbalance, highlighting the importance of the gut\u2013skin axis and its inflammatory mediators. Restoring this imbalance can open new perspectives in psoriasis therapy. We investigated the effect of purified IgY raised against pathological human bacteria antibiotic-resistant in induced murine psoriatic dermatitis (PSO). Methods: To evaluate the immune portrayal in an imiquimod experimental model, before and after IgY treatment, xMAP array and flow cytometry were used. Results: There were significant changes in IL-1\u03b1,\u03b2, IL-5, IL-6, IL-9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17a, IFN-\u03b3, TNF-\u03b1, IP-10\/CXCL10, MCP-1\/CCL2, MIP-1\u03b1\/CCL3, MIP-1\u03b2\/CCL4, MIG\/CXCL9, and KC\/CXCL1 serum levels. T (CD3\u03b5+), B (CD19+) and NK (NK1.1+) cells were also quantified. In our model, TNF-\u03b1, IL-6, and IL-1\u03b2 cytokines and CXCL1 chemokine have extremely high circulatory levels in the PSO group. Upon experimental therapy, the cytokine serum values were not different between IgY-treated groups and spontaneously remitted PSO. Conclusions: Using the murine model of psoriatic dermatitis, we show that the orally purified IgY treatment can lead to an improvement in skin lesion healing along with the normalization of cellular and humoral immune parameters.<\/jats:p>","DOI":"10.3390\/jpm13111556","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T12:07:45Z","timestamp":1698667665000},"page":"1556","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Immune Portrayal of a New Therapy Targeting Microbiota in an Animal Model of Psoriasis"],"prefix":"10.3390","volume":"13","author":[{"given":"Mihaela","family":"Surcel","sequence":"first","affiliation":[{"name":"Immunology Department, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Constantin","sequence":"additional","affiliation":[{"name":"Immunology Department, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, 050096 Bucharest, Romania"},{"name":"Department of Pathology, Colentina University Hospital, \u0218os. \u0218tefan cel Mare 19-21, 020125 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Narcisa","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Immunology Department, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, 050096 Bucharest, Romania"},{"name":"Doctoral School of Biology, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Antonia","family":"Costea","sequence":"additional","affiliation":[{"name":"Immunology Department, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, 050096 Bucharest, Romania"},{"name":"Doctoral School of Biology, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gheorghi\u021ba","family":"Isvoranu","sequence":"additional","affiliation":[{"name":"Animal Husbandry, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Codrici","sequence":"additional","affiliation":[{"name":"Biochemistry-Proteomics Department, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionela Daniela","family":"Popescu","sequence":"additional","affiliation":[{"name":"Biochemistry-Proteomics Department, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"T\u0103nase","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Titu Maiorescu University, Calea V\u0103c\u0103re\u015fti 189, 031593 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alef","family":"Ibram","sequence":"additional","affiliation":[{"name":"Research Laboratory, Romvac Company SA, \u015eos. Centurii 7, 077190 Voluntari, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9339-2805","authenticated-orcid":false,"given":"Monica","family":"Neagu","sequence":"additional","affiliation":[{"name":"Immunology Department, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, 050096 Bucharest, Romania"},{"name":"Department of Pathology, Colentina University Hospital, \u0218os. \u0218tefan cel Mare 19-21, 020125 Bucharest, Romania"},{"name":"Doctoral School of Biology, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tashiro, T., and Sawada, Y. (2022). Psoriasis and Systemic Inflammatory Disorders. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084457"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Jansen, J.E., Aschenbrenner, D., Uhlig, H.H., Coles, M.C., and Gaffney, E.A. (2022). A method for the inference of cytokine interaction networks. PLoS Comput. Biol., 18.","DOI":"10.1371\/journal.pcbi.1010112"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1002\/bit.28164","article-title":"Multiorgan-on-a-chip for realization of gut-skin axis","volume":"119","author":"Lee","year":"2022","journal-title":"Biotechnol. Bioeng."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ion, A., Doroban\u021bu, A.M., Popa, L.G., Mihai, M.M., and Orzan, O.A. (2022). Risks of Biologic Therapy and the Importance of Multidisciplinary Approach for an Accurate Management of Patients with Moderate-Severe Psoriasis and Concomitant Diseases. Biology, 11.","DOI":"10.3390\/biology11060808"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.36849\/JDD.6237","article-title":"Probiotics Supplementation Improves Quality of Life, Clinical Symptoms, and Inflammatory Status in Patients with Psoriasis","volume":"21","author":"Moludi","year":"2022","journal-title":"J. Drugs Dermatol."},{"key":"ref_6","first-page":"S25","article-title":"The Role of the Gut Microbiome in Psoriasis: From Pathogens to Pathology","volume":"15","author":"Wilchowski","year":"2022","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Miyagawa, F. (2022). Pathogenesis of Paradoxical Reactions Associated with Targeted Biologic Agents for Inflammatory Skin Diseases. Biomedicines, 10.","DOI":"10.3390\/biomedicines10071485"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1199427","DOI":"10.3389\/fimmu.2023.1199427","article-title":"IgYs: On her majesty\u2019s secret service","volume":"14","author":"Grzywa","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1065353","DOI":"10.3389\/fimmu.2023.1065353","article-title":"IgY antibodies: The promising potential to overcome antibiotic resistance","volume":"14","author":"Abbas","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_10","unstructured":"WHO Pathogens Priority List Working Group (2018). Discovery, research, and development of new antibiotics: The who priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect. Dis., 18, 318\u2013327."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"696003","DOI":"10.3389\/fimmu.2021.696003","article-title":"Immunoglobulin Y for potential diagnostic and therapeutic applications in infectious diseases","volume":"12","author":"Lee","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Han, S., Wen, Y., Yang, F., and He, P. (2021). Chicken Egg Yolk Antibody (IgY) Protects Mice Against Enterotoxigenic Escherichia coli Infection Through Improving Intestinal Health and Immune Response. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.662710"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Zhou, X., and Ma, S. (2018). Anti-lipopolysaccharide egg yolk antibodies enhance the phagocytosis of mammalian phagocytes. Biol. Open, 7.","DOI":"10.1242\/bio.032821"},{"key":"ref_14","first-page":"67","article-title":"Chicken Egg Yolk-IgY: Passive Immunization Promising Targeted Therapy of COVID-19 Pandemic","volume":"6","author":"Ibrahim","year":"2021","journal-title":"J. Appl. Vet. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kany, S., Vollrath, J.T., and Relja, B. (2019). Cytokines in Inflammatory Disease. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20236008"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Lu, R.M., Hwang, Y.C., Liu, I.J., Lee, C.C., Tsai, H.Z., Li, H.J., and Wu, H.C. (2020). Development of therapeutic antibodies for the treatment of diseases. J. Biomed. Sci., 27.","DOI":"10.1186\/s12929-019-0592-z"},{"key":"ref_17","unstructured":"Vieira-Pires, R.S., Ahn, H.C., Bok, M., Caulfield, C.D., Chacana, P., Elahi, F., and Chacana, P. (2021). IgY-Technology: Production and Application of Egg Yolk Antibodies, Springer."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.4161\/hv.23383","article-title":"Oral passive IgY-based immunotherapeutics: A novel solution for prevention and treatment of alimentary tract diseases","volume":"9","author":"Rahman","year":"2013","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Le\u00f3n-N\u00fa\u00f1ez, D., Vizca\u00edno-L\u00f3pez, M.F., Escorcia, M., Correa, D., P\u00e9rez-Hern\u00e1ndez, E., and G\u00f3mez-Ch\u00e1vez, F. (2022). IgY Antibodies as Biotherapeutics in Biomedicine. Antibodies, 11.","DOI":"10.3390\/antib11040062"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.rvsc.2015.09.005","article-title":"Egg yolk IgY antibodies: A therapeutic intervention against group a rotavirus in calves","volume":"103","author":"Vega","year":"2015","journal-title":"Res. Vet. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Yu, M., Zhang, R., Ni, P., Chen, S., and Duan, G. (2019). Helicobacter pylori Infection and Psoriasis: A Systematic Review and Meta-Analysis. Medicina, 55.","DOI":"10.3390\/medicina55100645"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"de Jes\u00fas-Gil, C., Sans-de San Nicol\u00e0s, L., Ruiz-Romeu, E., Ferran, M., Soria-Mart\u00ednez, L., and Garc\u00eda-Jim\u00e9nez, I. (2021). Interplay between Humoral and CLA+ T Cell Response against Candida albicans in Psoriasis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041519"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Visser, M.J.E., Kell, D.B., and Pretorius, E. (2019). Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris. Front. Cell Infect. Microbiol., 9.","DOI":"10.3389\/fcimb.2019.00007"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Surcel, M., Munteanu, A., Isvoranu, G., Ibram, A., Caruntu, C., and Constantin, C. (2021). Unconventional Therapy with IgY in a Psoriatic Mouse Model Targeting Gut Microbiome. J. Pers. Med., 11.","DOI":"10.3390\/jpm11090841"},{"key":"ref_25","unstructured":"P\u0103tra\u015fcu, I.V., Chiurciu, V., Chiurciu, C., and Topilescu, G. (2014). Procedure to Obtain and Use Hen Egg Immunoglobulins (IgY). (RO129645 A0, 2014 00156), OSIM Patent."},{"key":"ref_26","unstructured":"Chiurciu, V., Ibram, A., Neagu, M., Tanase, C., Constantin, C., Surcel, M., and Munteanu, A.N. (2023). Method of Purification of IgY Preparation Obtained from Hyperimmune Eggs (ROMVAC) Using the Automatic High-Performance Liquid Chromatography System and of Testing the Biological Activity of the Resulting Fractions on the Standard Cell Line CAL-27. (RO137295A2), OSIM Patent."},{"key":"ref_27","first-page":"1030","article-title":"Phenotypic changes of lymphocyte populations in psoriasiform dermatitis animal model","volume":"17","author":"Surcel","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_28","first-page":"4956","article-title":"Reinforcing involvement of NK cells in psoriasiform dermatitis animal model","volume":"18","author":"Surcel","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_29","unstructured":"Chiurciu, C., Chiurciu, V., Sima, L., Mihai, I., and Patrascu, I.V. (2016). Production and Use of Personalized (Ovopatch) Hyperimmune Egg in the Treatment of Psoriasis. (RO 130965 A0, 2015 00735), OSIM Patent."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e13096","DOI":"10.1111\/sji.13096","article-title":"Keratinocytes secrete multiple inflammatory and immune biomarkers, which are regulated by LL-37, in a psoriasis mimicking microenvironment","volume":"94","author":"Sigurgrimsdottir","year":"2021","journal-title":"Scand. J. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3389\/fphys.2018.00877","article-title":"Role of Cytokine Combinations on CD4+ T Cell Differentiation, Partial Polarization, and Plasticity: Continuous Network Modeling Approach","volume":"9","author":"Huerta","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1038\/s41598-022-06685-8","article-title":"A meta-analysis of Th1 and Th2 cytokine profiles differentiating tuberculous from malignant pleural effusion","volume":"12","author":"Zeng","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00011-019-01238-8","article-title":"Proinflammatory and anti-inflammatory cytokine profiles in psoriasis: Use as laboratory biomarkers and disease predictors","volume":"68","author":"Cataldi","year":"2019","journal-title":"Inflamm. Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Georgescu, S.R., Tampa, M., Caruntu, C., Sarbu, M.I., Mitran, C.I., and Mitran, M.I. (2019). Advances in Understanding the Immunological Pathways in Psoriasis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030739"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1080\/21645515.2017.1356498","article-title":"Monoclonal antibodies inhibiting IL-12, -23, and -17 for the treatment of psoriasis","volume":"13","author":"Jeon","year":"2017","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cyto.2016.06.020","article-title":"Correlation of IL-12, IL-22, and IL-23 in patients with psoriasis and metabolic syndrome. Preliminary report","volume":"85","year":"2016","journal-title":"Cytokine"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2230.2009.03704.x","article-title":"Serum cytokines and growth factor levels in Japanese patients with psoriasis","volume":"35","author":"Takahashi","year":"2010","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.biopha.2018.09.178","article-title":"Ameliorative effects of a fusion protein dual targeting interleukin 17A and tumor necrosis factor \u03b1 on imiquimod-induced psoriasis in mice","volume":"108","author":"Liu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jid.2016.11.022","article-title":"IL-6 Differs from TNF-\u03b1: Unpredicted Clinical Effects Caused by IL-6 Blockade in Psoriasis","volume":"137","author":"Blauvelt","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.jid.2016.10.021","article-title":"Induction of Alternative Proinflammatory Cytokines Accounts for Sustained Psoriasiform Skin Inflammation in IL-17C+IL-6KO Mice","volume":"137","author":"Fritz","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.18632\/oncotarget.22260","article-title":"Serum levels of adipokines and cytokines in psoriasis patients: A systematic review and meta-analysis","volume":"9","author":"Bai","year":"2017","journal-title":"Oncotarget"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/14397595.2016.1174328","article-title":"Serum interleukin-6 levels in response to biologic treatment in patients with psoriasis","volume":"27","author":"Muramatsu","year":"2017","journal-title":"Mod. Rheumatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41467-017-02466-4","article-title":"TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis","volume":"9","author":"Conrad","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/art.38896","article-title":"Combined inhibition of tumor necrosis factor \u03b1 and interleukin-17 as a therapeutic opportunity in rheumatoid arthritis: Development and characterization of a novel bispecific antibody","volume":"67","author":"Fischer","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10238-017-0475-0","article-title":"Expression of MIF and TNFA in psoriatic arthritis: Relationship with Th1\/Th2\/Th17 cytokine profiles and clinical variables","volume":"18","year":"2018","journal-title":"Clin. Exp. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/sji.12117","article-title":"Association of disease severity with IL-1 levels in methotrexate-treated psoriasis patients","volume":"78","author":"Tamilselvi","year":"2013","journal-title":"Scand. J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Dissanayake, W.C., Oh, J.K., Sorrenson, B., and Shepherd, P.R. (2021). Glucose regulates expression of pro-inflammatory genes, IL-1\u03b2 and IL-12, through a mechanism involving hexosamine biosynthesis pathway-dependent regulation of \u03b1-E catenin. Biosci. Rep., 41.","DOI":"10.1042\/BSR20211066"},{"key":"ref_48","first-page":"4","article-title":"IL-1\u03b2-activated mTORC2 promotes accumulation of IFN-\u03b3+ \u03b3\u03b4 T cells by upregulating CXCR3 to restrict hepatic fibrosis","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Singh, T.P., Sch\u00f6n, M.P., Wallbrecht, K., Gruber-Wackernagel, A., Wang, X.J., and Wolf, P. (2013). Involvement of IL-9 in Th17-Associated Inflammation and Angiogenesis of Psoriasis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0051752"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.humimm.2016.12.010","article-title":"Th9 cells and IL-9 in autoimmune disorders: Pathogenesis and therapeutic potentials","volume":"78","author":"Deng","year":"2017","journal-title":"Hum. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/ced.14335","article-title":"Interleukin-9 serves as a key link between systemic inflammation and angiogenesis in psoriasis","volume":"46","author":"Midde","year":"2021","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1172\/JCI200318986","article-title":"Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model","volume":"112","author":"Villadsen","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3892\/etm.2021.10107","article-title":"Therapeutic potential of interleukin-15 in cancer (Review)","volume":"22","author":"Isvoranu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_54","first-page":"171","article-title":"Chapter Five\u2014Cytokines in psoriasis. In: Makowski GS, editor. Advances in Clinical Chemistry","volume":"100","author":"Reiche","year":"2021","journal-title":"Adv. Clin. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"819149","DOI":"10.1155\/2015\/819149","article-title":"IL-17A, IL-22, IL-6, and IL-21 Serum Levels in Plaque-Type Psoriasis in Brazilian Patients","volume":"2015","author":"Cardoso","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"9212134","DOI":"10.1155\/2017\/9212134","article-title":"Inflammatory Cytokine Pattern Is Sex-Dependent in Mouse Cutaneous Melanoma Experimental Model","volume":"2017","author":"Surcel","year":"2017","journal-title":"J. Immunol. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"600","DOI":"10.2353\/ajpath.2008.071008","article-title":"Sex Differences in Autoimmune Disease from a Pathological Perspective","volume":"173","author":"Fairweather","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.4049\/jimmunol.164.5.2832","article-title":"High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism","volume":"164","author":"Ziolkowska","year":"2000","journal-title":"J. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/09674845.2016.1207869","article-title":"Immunophenotyping of T cells in the peripheral circulation in psoriasis","volume":"73","author":"Priyadarssini","year":"2016","journal-title":"Br. J. Biomed. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Zdanowska, N., Kasprowicz-Furma\u0144czyk, M., Placek, W., and Owczarczyk-Saczonek, A. (2021). The Role of Chemokines in Psoriasis\u2014An Overview. Medicina, 57.","DOI":"10.3390\/medicina57080754"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.cyto.2017.12.010","article-title":"A brief look at the role of monocyte chemoattractant protein-1 (CCL2) in the pathophysiology of psoriasis","volume":"110","author":"Behfar","year":"2018","journal-title":"Cytokine"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/09546634.2013.782091","article-title":"MCP-1 in psoriatic patients: Effect of biological therapy","volume":"25","author":"Lembo","year":"2014","journal-title":"J. Dermatolog. Treat."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/jor.20939","article-title":"Evaluation of local MCP-1 and IL-12 nanocoatings for infection prevention in open fractures","volume":"28","author":"Li","year":"2010","journal-title":"J. Orthop. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.advms.2015.07.011","article-title":"CXCL10 in psoriasis","volume":"60","author":"Ferrari","year":"2015","journal-title":"Adv. Med. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ctrv.2017.11.007","article-title":"CXCL9, CXCL10, CXCL11\/CXCR3 axis for immune activation\u2014A target for novel cancer therapy","volume":"63","author":"Tokunaga","year":"2018","journal-title":"Cancer Treat. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/bph.15983","article-title":"Allicin ameliorates imiquimod-induced psoriasis-likeskin inflammation via disturbing the interaction of keratinocytes with IL-17A","volume":"180","author":"Zhang","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"ref_67","first-page":"628","article-title":"Nutraceutical combination ameliorates imiquimod-induced psoriasis in mice","volume":"180","author":"Vijayapoopathi","year":"2023","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"296","DOI":"10.5483\/BMBRep.2022-0169","article-title":"Alleviation of imiquimod-induced psoriasis-like symptoms in Ror\u03b1-deficient mouse skin","volume":"56","author":"Park","year":"2023","journal-title":"BMB Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.jid.2021.06.019","article-title":"Mouse Models of Psoriasis: A Comprehensive Review","volume":"142","author":"Gangwar","year":"2022","journal-title":"J. Investig. Dermatol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.3390\/ijms22094529","article-title":"Psoriasis and Gut Microbiome-Current State of Art","volume":"22","author":"Polak","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"111191","DOI":"10.1016\/j.celrep.2022.111191","article-title":"Dysbiosis in imiquimod-induced psoriasis alters gut immunity and exacerbates colitis development","volume":"40","author":"Pinget","year":"2022","journal-title":"Cell Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"571319","DOI":"10.3389\/fimmu.2020.571319","article-title":"Psoriasis is Associated with Elevated Gut IL-1\u03b1 and Intestinal Microbiome Alterations","volume":"11","author":"Yegorov","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Zhang, X., Shi, L., Sun, T., Guo, K., and Geng, S. (2021). Dysbiosis of gut microbiota and its correlation with dysregulation of cytokines in psoriasis patients. BMC Microbiol., 21.","DOI":"10.1186\/s12866-021-02125-1"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"768076","DOI":"10.3389\/fimmu.2022.768076","article-title":"Regulation of Peripheral Inflammation by a Non-Viable, Non-Colonizing Strain of Commensal Bacteria","volume":"13","author":"Ramani","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Di, T., Zhao, J., Wang, Y., Han, L., Guo, X., and Han, X. (2021). Tuhuaiyin alleviates imiquimod-induced psoriasis via inhibiting the properties of IL-17-producing cells and remodels the gut microbiota. Biomed. Pharmacother., 141.","DOI":"10.1016\/j.biopha.2021.111884"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Okada, K., Matsushima, Y., Mizutani, K., and Yamanaka, K. (2020). The Role of Gut Microbiome in Psoriasis: Oral Administration of Staphylococcus aureus and Streptococcus danieliae Exacerbates Skin Inflammation of Imiquimod-Induced Psoriasis-Like Dermatitis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21093303"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Lu, W., Deng, Y., Fang, Z., Zhai, Q., Cui, S., and Zhao, J. (2021). Potential Role of Probiotics in Ameliorating Psoriasis by Modulating Gut Microbiota in Imiquimod-Induced Psoriasis-Like Mice. Nutrients, 13.","DOI":"10.3390\/nu13062010"}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/11\/1556\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:14:24Z","timestamp":1760130864000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/11\/1556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,30]]},"references-count":77,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["jpm13111556"],"URL":"https:\/\/doi.org\/10.3390\/jpm13111556","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,30]]}}}