{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:05:09Z","timestamp":1783393509946,"version":"3.54.6"},"reference-count":83,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Although substantial progress has been made to prevent sudden cardiac death in repaired tetralogy of Fallot patients, ventricular arrhythmia and sudden death continue to be major causes of morbidity and mortality in these patients. Greater survival in contemporary cohorts has been attributed to enhanced surgical techniques, more effective management of heart failure, and increased efforts in risk stratification and management of ventricular arrhythmias. More recently, our understanding of predictive risk factors has evolved into personalized risk prediction tools that rely on comprehensive demographic, imaging, functional, and electrophysiological data. However, the universal applicability of these different scoring systems is limited due to differences between study cohorts, types of anatomic repair, imaging modalities, and disease complexity. Noninvasive risk stratification is critical to identify those who may derive benefit from catheter ablation or cardioverter defibrillator implantation for primary prevention. Ultimately, assessment and risk stratification by a multidisciplinary team is crucial to analyze the various complex factors for every individual patient and discuss further options with patients and their families.<\/jats:p>","DOI":"10.3390\/jpm13121715","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T03:16:33Z","timestamp":1702610193000},"page":"1715","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation and Management of Sudden Death Risk in Repaired Tetralogy of Fallot"],"prefix":"10.3390","volume":"13","author":[{"given":"Eiad","family":"Habib","sequence":"first","affiliation":[{"name":"Division of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komandoor","family":"Srivasthan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mayo Clinic, Scottsdale, AZ 85259, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2470-2862","authenticated-orcid":false,"given":"Hicham","family":"El Masry","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mayo Clinic, Scottsdale, AZ 85259, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1017\/S1047951121000238","article-title":"Outcomes of adults with repaired tetralogy of Fallot from the national Scottish Cohort","volume":"31","author":"Dobson","year":"2021","journal-title":"Cardiol. Young"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1161\/01.CIR.52.4.691","article-title":"Unexpected cardiac arrest in patients after surgical correction of tetralogy of Fallot","volume":"52","author":"James","year":"1975","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/01.CIR.54.2.289","article-title":"Sudden death among postoperative patients with tetralogy of Fallot: A follow-up study of 243 patients for an average of twelve years","volume":"54","author":"Quattlebaum","year":"1976","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e000564","DOI":"10.1136\/openhrt-2016-000564","article-title":"Adults with repaired tetralogy: Low mortality but high morbidity up to middle age","volume":"4","author":"Dennis","year":"2017","journal-title":"Open Heart"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0140-6736(00)02714-8","article-title":"Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: A multicentre study","volume":"356","author":"Gatzoulis","year":"2000","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1093\/eurheartj\/ehac104","article-title":"Sudden cardiac death in congenital heart disease","volume":"43","author":"Khairy","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/heartjnl-2020-316791","article-title":"Predicting sudden cardiac death in adults with congenital heart disease","volume":"107","author":"Oliver","year":"2021","journal-title":"Heart"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.hrthm.2021.01.009","article-title":"Identification of patients at risk of sudden cardiac death in congenital heart disease: The PRospEctiVE study on implaNTable cardIOverter defibrillator therapy and suddeN cardiac death in Adults with Congenital Heart Disease (PREVENTION-ACHD)","volume":"18","author":"Vehmeijer","year":"2021","journal-title":"Heart Rhythm."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jcmg.2021.07.026","article-title":"Predicting Survival in Repaired Tetralogy of Fallot: A Lesion-Specific and Personalized Approach","volume":"15","author":"Ghonim","year":"2022","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/HAE.0000000000000084","article-title":"Arrhythmias in Repaired Tetralogy of Fallot: A Scientific Statement From the American Heart Association","volume":"15","author":"Krieger","year":"2022","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/CIRCULATIONAHA.107.726372","article-title":"Implantable cardioverter-defibrillators in tetralogy of fallot","volume":"117","author":"Khairy","year":"2008","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1161\/CIRCEP.114.001929","article-title":"Re-Entry using anatomically determined isthmuses: A curable ventricular tachycardia in repaired congenital heart disease","volume":"8","author":"Kapel","year":"2015","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_13","first-page":"268","article-title":"Arrhythmogenic anatomical isthmuses identified by electroanatomical mapping are the substrate for ventricular tachycardia in repaired tetralogy of Fallot","volume":"38","author":"Kapel","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1253\/circj.68.126","article-title":"Arrhythmias late after repair of tetralogy of fallot\u2014A Japanese Multicenter Study","volume":"68","author":"Nakazawa","year":"2004","journal-title":"Circ. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/hrt.44.3.248","article-title":"Detection of late arrhythmia and conduction disturbance after correction of tetralogy of Fallot","volume":"44","author":"Deanfield","year":"1980","journal-title":"Heart"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.hrthm.2014.11.026","article-title":"Arrhythmic burdens in patients with tetralogy of Fallot: A national database study","volume":"12","author":"Wu","year":"2015","journal-title":"Heart Rhythm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"ytac428","DOI":"10.1093\/ehjcr\/ytac428","article-title":"A case report of paroxysmal complete atrioventricular block in a patient with dextrocardia and repaired tetralogy of Fallot","volume":"6","author":"Fujita","year":"2022","journal-title":"Eur. Heart J. Case Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0002-9149(01)01518-1","article-title":"Significance of early transient complete heart block as a predictor of sudden death late after operative correction of tetralogy of fallot","volume":"87","author":"Hokanson","year":"2001","journal-title":"Am. J. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0735-1097(88)90183-0","article-title":"Conduction disturbances after correction of tetralogy of Fallot: Are electrophysiologic studies of prognostic value?","volume":"11","author":"Friedli","year":"1988","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1161\/CIRCULATIONAHA.115.017202","article-title":"Survival Prospects and Circumstances of Death in Contemporary Adult Congenital Heart Disease Patients Under Follow-Up at a Large Tertiary Centre","volume":"132","author":"Diller","year":"2015","journal-title":"Circulation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.cjca.2020.01.023","article-title":"Risk Factors for Mortality and Ventricular Tachycardia in Patients With Repaired Tetralogy of Fallot: A Systematic Review and Meta-analysis","volume":"36","author":"Possner","year":"2020","journal-title":"Can. J. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1161\/CIRCULATIONAHA.118.034740","article-title":"Preoperative Predictors of Death and Sustained Ventricular Tachycardia after Pulmonary Valve Replacement in Patients With Repaired Tetralogy of Fallot Enrolled in the INDICATOR Cohort","volume":"138","author":"Geva","year":"2018","journal-title":"Circulation"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.amjcard.2020.07.012","article-title":"Ventricular Arrhythmia and Life-Threatening Events in Patients With Repaired Tetralogy of Fallot","volume":"132","author":"Atallah","year":"2020","journal-title":"Am. J. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/S0735-1097(02)02344-6","article-title":"Left ventricular dysfunction is a risk factor for sudden cardiac death in adults late after repair of tetralogy of fallot","volume":"40","author":"Ghai","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1161\/01.CIR.0000126495.11040.BD","article-title":"Value of programmed ventricular stimulation after tetralogy of fallot repair: A multicenter study","volume":"109","author":"Khairy","year":"2004","journal-title":"Circulation"},{"key":"ref_26","first-page":"f122","article-title":"Sudden cardiac death in adults with congenital heart disease: Does QRS-complex fragmentation discriminate in structurally abnormal hearts?","volume":"20","author":"Vehmeijer","year":"2018","journal-title":"EP Eur."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijcard.2015.05.174","article-title":"Peak oxygen uptake, ventilatory efficiency and QRS-duration predict event free survival in patients late after surgical repair of tetralogy of Fallot","volume":"196","author":"Hager","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"ref_28","first-page":"II7-12","article-title":"Life-threatening arrhythmias and RV dysfunction after surgical repair of tetralogy of Fallot. Comparison between transventricular and transatrial approaches","volume":"90","author":"Dietl","year":"1994","journal-title":"Circulation"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1136\/heartjnl-2013-304958","article-title":"Contemporary predictors of death and sustained ventricular tachycardia in patients with repaired tetralogy of Fallot enrolled in the INDICATOR cohort","volume":"100","author":"Valente","year":"2014","journal-title":"Heart"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jacep.2018.02.002","article-title":"Slow Conducting Electroanatomic Isthmuses: An Important Link Between QRS Duration and Ventricular Tachycardia in Tetralogy of Fallot","volume":"4","author":"Kapel","year":"2018","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/CIRCULATIONAHA.109.928481","article-title":"Arrhythmia burden in adults with surgically repaired tetralogy of fallot: A multi-institutional study","volume":"122","author":"Khairy","year":"2010","journal-title":"Circulation"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/HCO.0b013e328333d35d","article-title":"Fragmented QRS and other depolarization abnormalities as a predictor of mortality and sudden cardiac death","volume":"25","author":"Das","year":"2010","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4330\/wjc.v14.i9.483","article-title":"Association of electrocardiographic markers with myocardial fibrosis as assessed by cardiac magnetic resonance in different clinical settings","volume":"14","author":"Bazoukis","year":"2022","journal-title":"World J. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/heartjnl-2016-310068","article-title":"QRS fragmentation is superior to QRS duration in predicting mortality in adults with tetralogy of Fallot","volume":"103","author":"Bokma","year":"2017","journal-title":"Heart"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e010274","DOI":"10.1161\/JAHA.118.010274","article-title":"Role of QRS Fragmentation for Risk Stratification in Adults With Tetralogy of Fallot","volume":"7","author":"Egbe","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.amjcard.2011.07.070","article-title":"Relation of fragmented QRS complex to right ventricular fibrosis detected by late gadolinium enhancement cardiac magnetic resonance in adults with repaired tetralogy of fallot","volume":"109","author":"On","year":"2012","journal-title":"Am. J. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1161\/CIRCULATIONAHA.120.046745","article-title":"Long-Term Follow-Up of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator: The DAI-T4F Nationwide Registry","volume":"142","author":"Waldmann","year":"2020","journal-title":"Circulation"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1161\/CIRCULATIONAHA.111.086983","article-title":"Left ventricular longitudinal function predicts life-threatening ventricular arrhythmia and death in adults with repaired tetralogy of fallot","volume":"125","author":"Diller","year":"2012","journal-title":"Circulation"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/ehjci\/jex248","article-title":"The relationship between cardiovascular magnetic resonance imaging measurement of extracellular volume fraction and clinical outcomes in adults with repaired tetralogy of Fallot","volume":"19","author":"Hanneman","year":"2018","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.amjcard.2014.12.024","article-title":"Relation of biventricular strain and dyssynchrony in repaired tetralogy of fallot measured by cardiac magnetic resonance to death and sustained ventricular tachycardia","volume":"115","author":"Moon","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.amjcard.2011.01.032","article-title":"Relation of left ventricular dyssynchrony measured by cardiac magnetic resonance tissue tracking in repaired tetralogy of fallot to ventricular tachycardia and death","volume":"107","author":"Ortega","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/heartjnl-2015-308569","article-title":"Myocardial deformation parameters predict outcome in patients with repaired tetralogy of Fallot","volume":"102","author":"Orwat","year":"2016","journal-title":"Heart"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e008321","DOI":"10.1161\/CIRCEP.119.008321","article-title":"Three-Dimensional Late Gadolinium Enhancement Cardiovascular Magnetic Resonance Predicts Inducibility of Ventricular Tachycardia in Adults With Repaired Tetralogy of Fallot","volume":"13","author":"Ghonim","year":"2020","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.cjca.2020.04.019","article-title":"Impact of a 22q11.2 Microdeletion on Adult All-Cause Mortality in Tetralogy of Fallot Patients","volume":"36","author":"Heung","year":"2020","journal-title":"Can. J. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Calcagni, G., Calvieri, C., Baban, A., Bianco, F., Barracano, R., Caputo, M., Madrigali, A., Kikina, S.S., Perrone, M.A., and Digilio, M.C. (2022). Syndromic and Non-Syndromic Patients with Repaired Tetralogy of Fallot: Does It Affect the Long-Term Outcome?. J. Clin. Med., 11.","DOI":"10.3390\/jcm11030850"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1161\/CIRCULATIONAHA.105.557678","article-title":"Projected valve area at normal flow rate improves the assessment of stenosis severity in patients with low-flow, low-gradient aortic stenosis: The multicenter TOPAS (Truly or Pseudo-Severe Aortic Stenosis) study","volume":"113","author":"Blais","year":"2006","journal-title":"Circulation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijcard.2020.02.064","article-title":"22q11.2 deletion syndrome is associated with increased mortality in adults with tetralogy of Fallot and pulmonary atresia with ventricular septal defect","volume":"306","author":"Kauw","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.ijcard.2012.04.103","article-title":"Symptomatic but not asymptomatic non-sustained ventricular tachycardia is associated with appropriate implantable cardioverter therapy in tetralogy of Fallot","volume":"167","author":"Koyak","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.jacc.2023.02.052","article-title":"Improved Outcomes after Pulmonary Valve Replacement in Repaired Tetralogy of Fallot","volume":"81","author":"Bokma","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e005093","DOI":"10.1161\/CIRCEP.116.005093","article-title":"Prevention of Sudden Cardiac Death in Adults with Congenital Heart Disease: Do the Guidelines Fall Short?","volume":"10","author":"Vehmeijer","year":"2017","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1001\/jamacardio.2016.5818","article-title":"Value of Cardiovascular Magnetic Resonance Imaging in Noninvasive Risk Stratification in Tetralogy of Fallot","volume":"2","author":"Bokma","year":"2017","journal-title":"JAMA Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cjcpc.2023.07.002","article-title":"Risk Stratification for Sudden Cardiac Death in Repaired Tetralogy of Fallot","volume":"2","author":"Kakarla","year":"2023","journal-title":"CJC Pediatr. Congenit. Heart Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e015205","DOI":"10.1161\/CIRCIMAGING.122.015205","article-title":"Machine Learning for Prediction of Adverse Cardiovascular Events in Adults With Repaired Tetralogy of Fallot Using Clinical and Cardiovascular Magnetic Resonance Imaging Variables","volume":"16","author":"Ishikita","year":"2023","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"100267","DOI":"10.1016\/j.jacadv.2023.100267","article-title":"Wearable Biosensors in Congenital Heart Disease: Needs to Advance the Field","volume":"2","author":"Tandon","year":"2023","journal-title":"JACC Adv."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.hrthm.2018.01.020","article-title":"Perioperative electrophysiology study in patients with tetralogy of Fallot undergoing pulmonary valve replacement will identify those at high risk of subsequent ventricular tachycardia","volume":"15","author":"Sandhu","year":"2018","journal-title":"Heart Rhythm."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.jacc.2018.08.1028","article-title":"2018 AHA\/ACC Guideline for the Management of Adults With Congenital Heart Disease: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"73","author":"Stout","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tcm.2014.11.011","article-title":"Heart failure in adult congenital heart disease: Emerging concepts with a focus on tetralogy of Fallot","volume":"25","author":"Wald","year":"2015","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ijcard.2010.09.057","article-title":"Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation: The APPROPRIATE study (Ace inhibitors for Potential PRevention of the deleterious effects of Pulmonary Regurgitation in Adults with repaired TEtralogy of Fallot)","volume":"154","author":"Uebing","year":"2012","journal-title":"Int. J. Cardiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1161\/CIRCULATIONAHA.117.031438","article-title":"Effect of Losartan on Right Ventricular Dysfunction: Results From the Double-Blind, Randomized REDEFINE Trial (Right Ventricular Dysfunction in Tetralogy of Fallot: Inhibition of the Renin-Angiotensin-Aldosterone System) in Adults With Repaired Tetralogy","volume":"137","author":"Bokma","year":"2018","journal-title":"Circulation"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1017\/S1047951107000844","article-title":"A prospective, randomized, double-blind, placebo controlled trial of beta-blockade in patients who have undergone surgical correction of tetralogy of Fallot","volume":"17","author":"Norozi","year":"2007","journal-title":"Cardiol. Young"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijcard.2011.06.005","article-title":"Biventricular pacing in patients with Tetralogy of Fallot: Non-invasive epicardial mapping and clinical impact","volume":"163","author":"Thambo","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jelectrocard.2005.08.005","article-title":"Ventricular tachycardia late after repair of congenital heart disease: Efficacy of combination therapy with radiofrequency catheter ablation and class III antiarrhythmic agents and long-term outcome","volume":"39","author":"Furushima","year":"2006","journal-title":"J. Electrocardiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1253\/circj.CJ-16-0932","article-title":"Long-Term Efficacy of Implantable Cardioverter Defibrillator in Repaired Tetralogy of Fallot\u2014Role of Anti-tachycardia Pacing","volume":"81","author":"Henmi","year":"2017","journal-title":"Circ. J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.jacep.2022.06.024","article-title":"Sex Differences in Outcomes of Tetralogy of Fallot Patients With Implantable Cardioverter-Defibrillators","volume":"8","author":"Waldmann","year":"2022","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1136\/heartjnl-2018-314072","article-title":"Cardiac implantable electronic devices in adults with tetralogy of Fallot","volume":"105","author":"Egbe","year":"2019","journal-title":"Heart"},{"key":"ref_66","first-page":"1537","article-title":"The entirely subcutaneous ICDTM system in patients with congenital heart disease: Experience from a large single-centre analysis","volume":"21","author":"Willy","year":"2019","journal-title":"EP Eur."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.jacep.2016.02.008","article-title":"Outcomes in Patients With Congenital Heart Disease Receiving the Subcutaneous Implantable-Cardioverter Defibrillator: Results From a Pooled Analysis From the IDE Study and the EFFORTLESS S-ICD Registry","volume":"2","author":"Epstein","year":"2016","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/pace.13017","article-title":"The Role of Conventional and Right-Sided ECG Screening for Subcutaneous ICD in a Tetralogy of Fallot Population","volume":"40","author":"Alonso","year":"2017","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1161\/CIRCEP.111.966754","article-title":"Implantable cardioverter defibrillator therapy in adults with congenital heart disease: Who is at risk of shocks?","volume":"5","author":"Koyak","year":"2012","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"(2020). L.Goldenthal, I.; Rosenbaum, M.S.; Lewis, M.; Sciacca, R.R.; Garan, H.; Biviano, A.B. Inappropriate implantable cardioverter-defibrillator shocks in repaired tetralogy of fallot patients: Prevalence and electrophysiological mechanisms. IJC Heart Vasc., 28, 100543.","DOI":"10.1016\/j.ijcha.2020.100543"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.cjco.2021.01.005","article-title":"The Role of Ablation in Prevention of Recurrent Implantable Cardioverter Defibrillator Shocks in Patients With Tetralogy of Fallot","volume":"3","author":"Kawada","year":"2021","journal-title":"CJC Open"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.acvd.2017.01.009","article-title":"Ten-year outcomes of monomorphic ventricular tachycardia catheter ablation in repaired tetralogy of Fallot","volume":"110","author":"Laredo","year":"2017","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.hrthm.2016.03.002","article-title":"Mechanism and outcomes of catheter ablation for ventricular tachycardia in adults with repaired congenital heart disease","volume":"13","author":"Kapa","year":"2016","journal-title":"Heart Rhythm."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1161\/CIRCEP.113.000450","article-title":"Characterization of anatomic ventricular tachycardia isthmus pathology after surgical repair of tetralogy of fallot","volume":"6","author":"Moore","year":"2013","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.hrthm.2022.10.016","article-title":"Rapid ventricular tachycardia in patients with tetralogy of Fallot and implantable cardioverter-defibrillator: Insights from the DAI-T4F nationwide registry","volume":"20","author":"Laredo","year":"2023","journal-title":"Heart Rhythm."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/eurheartj\/ehaa554","article-title":"2020 ESC Guidelines for the management of adult congenital heart disease","volume":"42","author":"Baumgartner","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/S0735-1097(00)00930-X","article-title":"Pulmonary valve replacement in adults late after repair of tetralogy of fallot: Are we operating too late?","volume":"36","author":"Therrien","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.jacep.2021.02.022","article-title":"Impact of Pulmonary Valve Replacement on Ventricular Arrhythmias in Patients With Tetralogy of Fallot and Implantable Cardioverter-Defibrillator","volume":"7","author":"Gardey","year":"2021","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1136\/heartjnl-2017-312048","article-title":"A propensity score-adjusted analysis of clinical outcomes after pulmonary valve replacement in tetralogy of Fallot","volume":"104","author":"Bokma","year":"2018","journal-title":"Heart"},{"key":"ref_80","first-page":"i105","article-title":"Exploring the cause of conduction delays in patients with repaired Tetralogy of Fallot","volume":"23","author":"Verzaal","year":"2021","journal-title":"EP Eur."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1161\/01.CIR.103.20.2489","article-title":"Impact of pulmonary valve replacement on arrhythmia propensity late after repair of tetralogy of fallot","volume":"103","author":"Therrien","year":"2001","journal-title":"Circulation"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1111\/jce.15940","article-title":"Electrophysiological study prior to planned pulmonary valve replacement in patients with repaired tetralogy of Fallot","volume":"34","author":"Bouyer","year":"2023","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/CIRCEP.122.011745","article-title":"Systematic Electrophysiological Study Prior to Pulmonary Valve Replacement in Tetralogy of Fallot: A Prospective Multicenter Study","volume":"16","author":"Waldmann","year":"2023","journal-title":"Circ. 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