{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:51:39Z","timestamp":1784735499516,"version":"3.55.0"},"reference-count":109,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Despite the increased frequency of endometriosis, it remains one of the most enigmatic disorders regarding its effects on pregnancy. Endometriosis adversely affects both natural and assisted conception. Impaired folliculogenesis, which causes follicular dysfunction and low egg quality, as well as luteal phase problems, reduced fertilization, and abnormal embryogenesis, are some of the mechanisms advocated to explain reproductive dysfunction. There is a rising need for a comprehensive study of the potential negative consequences of this condition on pregnancy outcomes, including the postpartum period, as more women with a medical history of endometriosis become pregnant. Obstetrical complications (small for gestational age [SGA], cesarean section [CS], miscarriage, hemorrhage, low placental adhesion, and preterm delivery) are statistically elevated in women with endometriosis. Furthermore, ruptured ovarian endometrioma, appendicitis, intestinal perforation, and hemoperitoneum have been described in pregnancy. Obstetricians are largely unfamiliar with these complications, as they have not been thoroughly investigated. The development and pathogenesis of endometriosis is an important field of study and has not yet been fully elucidated. Finding these mechanisms is crucial for the development of new and more effective strategies to treat this condition. Endometriosis can have an impact on obstetric and neonatal outcomes of pregnancy, in addition to its potential effects on conception. To date, no additional monitoring is recommended for pregnancies with a history of endometriosis. However, more studies are urgently needed to assess the need for the tailored pregnancy monitoring of women with endometriosis.<\/jats:p>","DOI":"10.3390\/jpm14010126","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T12:01:13Z","timestamp":1705924873000},"page":"126","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Impact of Endometriosis on Pregnancy"],"prefix":"10.3390","volume":"14","author":[{"given":"Panagiotis","family":"Tsikouras","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2177-953X","authenticated-orcid":false,"given":"Efthimios","family":"Oikonomou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Bothou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelopi","family":"Chaitidou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Kyriakou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Nikolettos","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Andreou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foteini","family":"Gaitatzi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theopi","family":"Nalbanti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9772-4133","authenticated-orcid":false,"given":"Panagiotis","family":"Peitsidis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon","family":"Michalopoulos","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanos","family":"Zervoudis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8958-1248","authenticated-orcid":false,"given":"George","family":"Iatrakis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Nikolettos","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bpobgyn.2018.06.001","article-title":"Risk for and consequences of endometriosis: A critical epidemiologic review","volume":"51","author":"Shafrir","year":"2018","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/aogs.12373","article-title":"Reproductive prognosis in endometriosis. A national cohort study","volume":"93","author":"Hansen","year":"2014","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ajog.2007.04.030","article-title":"Severe intraabdominal bleeding caused by endometriotic lesions during the third trimester of pregnancy","volume":"197","author":"Katorza","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/aogs.14337","article-title":"Prevalence of endometriosis and adenomyosis at transvaginal ultrasound examination in symptomatic women","volume":"101","author":"Orlov","year":"2022","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.fertnstert.2007.12.066","article-title":"Defining the proliferative phase endometrial defect","volume":"91","author":"Bromer","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_6","first-page":"131","article-title":"Australas Anatomical distribution of endometriosis: A cross-sectional analysis of transvaginal ultrasound in symptomatic patients","volume":"26","author":"Leonardi","year":"2023","journal-title":"J. Ultrasound Med."},{"key":"ref_7","first-page":"e28864","article-title":"Endometriosis: Review of Clinical Diagnosis, Treatment, and Pathogenesis","volume":"14","author":"Chauhan","year":"2022","journal-title":"Cureus"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1177\/1933719116637919","article-title":"Origins and Progression of Adolescent Endometriosis","volume":"23","author":"Brosens","year":"2016","journal-title":"Reprod. Sci."},{"key":"ref_9","first-page":"76","article-title":"Endometrium and ovarian cancer synchronous to endometriosis\u2014A retrospective study of our experience of 7 years","volume":"3","author":"Grammatikakis","year":"2010","journal-title":"J. Med. Life"},{"key":"ref_10","first-page":"e3361","article-title":"The Clinical Anatomy of Endometriosis: A Review","volume":"10","author":"Alimi","year":"2018","journal-title":"Cureus"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-018-0008-5","article-title":"Endometriosis","volume":"4","author":"Zondervan","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.jmig.2021.08.032","article-title":"An International Terminology for Endometriosis","volume":"28","author":"Tomassetti","year":"2021","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/ije\/dyx252","article-title":"Racial\/ethnic differences in the epidemiology of ovarian cancer: A pooled analysis of 12 case-control studies","volume":"47","author":"Peres","year":"2018","journal-title":"Int. J Epidemiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/aje\/kwh275","article-title":"Incidence of Laparoscopically Confirmed Endometriosisby Demographic, Anthropometric, and Lifestyle Factors","volume":"160","author":"Missmer","year":"2004","journal-title":"Am. J. Epidemiol."},{"key":"ref_15","first-page":"83","article-title":"Neonatal uterine bleeding as a precursor to endometriosis in adulthood","volume":"26","author":"Tandashvili","year":"2022","journal-title":"Afr. J. Reprod. Health"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Hisrich, B.V., Young, R.B., Sansone, A.M., Bowens, Z., Green, L.J., Lessey, B.A., and Blenda, A.V. (2020). Role of Human Galectins in Inflammation and Cancers Associated with Endometriosis. Biomolecules, 10.","DOI":"10.3390\/biom10020230"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0015-0282(97)81391-X","article-title":"Revised American Society for Reproductive Medicine classification of endometriosis: 1996","volume":"67","author":"American","year":"1997","journal-title":"Fertil. Steril."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejogrb.2013.02.010","article-title":"Peritoneal fluid concentrations of \u03b2-chemokines in endometriosis","volume":"169","author":"Margari","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/oxfordjournals.humrep.a019023","article-title":"Vascular endothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis","volume":"11","author":"McLaren","year":"1996","journal-title":"Hum. Reprod."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0015-0282(02)04834-3","article-title":"Time series analysis of transmesothelial invasion by endometrial stromal and epithelial cells using three-dimensional confocal microscopy","volume":"79","author":"Witz","year":"2003","journal-title":"Fertil. Steril."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"756704","DOI":"10.3389\/frph.2021.756704","article-title":"Menstruation Dysregulation and Endometriosis Development","volume":"3","author":"Kuan","year":"2021","journal-title":"Front. Reprod. Health"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1177\/1933719114529374","article-title":"The endometriotic tissue lining the internal surface of endometrioma: Hormonal, genetic, epigenetic status, and gene expression profile","volume":"22","author":"Sanchez","year":"2014","journal-title":"Reprod. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"879015","DOI":"10.3389\/fmed.2022.879015","article-title":"New Insights in Pathogenesis of Endometriosis","volume":"9","author":"Signorile","year":"2022","journal-title":"Front. Med."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Lamceva, J., Uljanovs, R., and Strumfa, I. (2023). The Main Theories on the Pathogenesis of Endometriosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054254"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/humrep\/dep401","article-title":"Altered glycosylation in peri-implantation phase endometrium in women with stages III and IV endometriosis","volume":"25","author":"Miller","year":"2009","journal-title":"Hum. Reprod."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bpobgyn.2004.01.007","article-title":"Endometriosis: Epidemiology and aetiological factors","volume":"18","author":"Parazzini","year":"2004","journal-title":"Best Pr. Res. Clin. Obstet. Gynaecol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.21873\/invivo.13288","article-title":"Pathogenesis of Endometriosis: Focus on Adenogenesis-related Factors","volume":"37","author":"Signorile","year":"2023","journal-title":"In Vivo"},{"key":"ref_29","first-page":"2083121","article-title":"Endometriosis in a Man as a Rare Source of Abdominal Pain: A Case Report and Review of the Literature","volume":"2018","author":"Rei","year":"2018","journal-title":"Case Rep. Obstet. Gynecol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"943839","DOI":"10.3389\/fimmu.2022.943839","article-title":"Epigenetic regulation and T-cell responses in endometriosis\u2014Something other than autoimmunity","volume":"13","author":"Szukiewicz","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13148-021-01103-8","article-title":"The role of epigenetic mechanisms in the regulation of gene expression in the cyclical endometrium","volume":"13","year":"2021","journal-title":"Clin. Epigenet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.3892\/mmr.2016.4925","article-title":"DNA methylation in endometriosis (Review)","volume":"13","author":"Koukoura","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1093\/biolre\/ioz014","article-title":"MicroRNAs in endometriosis: Biological function and emerging biomarker candidates","volume":"101","author":"Bjorkman","year":"2019","journal-title":"Biol. Reprod."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1093\/molehr\/5.10.990","article-title":"Absence of a relationship between endometriosis and the N314D polymorphism of galactose-1-phosphate uridyl transferase in a UK population","volume":"5","author":"Hadfield","year":"1999","journal-title":"Mol. Hum. Reprod."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.fertnstert.2018.10.013","article-title":"Pathogenesis of endometriosis: The genetic\/epigenetic theory","volume":"111","author":"Koninckx","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1093\/humrep\/deg393","article-title":"Mutagen sensitivity as a susceptibility marker for endometriosis","volume":"18","author":"Lin","year":"2003","journal-title":"Hum. Reprod."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Chantalat, E., Valera, M.C., Vaysse, C., Noirrit, E., Rusidze, M., Weyl, A., Vergriete, K., Buscail, E., Lluel, P., and Fontaine, C. (2020). Estrogen Receptors and Endometriosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082815"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Zhang, P., and Wang, G. (2023). Progesterone Resistance in Endometriosis: Current Evidence and Putative Mechanisms. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24086992"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/aogs.13156","article-title":"Progesterone resistance in endometriosis: Origins, consequences and interventions","volume":"96","author":"Patel","year":"2017","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1185\/030079906X121084","article-title":"Health-related quality of life burden of women with endometriosis: A literature review","volume":"22","author":"Gao","year":"2006","journal-title":"Curr. Med Res. Opin."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1020827","DOI":"10.3389\/fendo.2022.1020827","article-title":"Endometriosis-associated infertility: From pathophysiology to tailored treatment","volume":"13","author":"Bonavina","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.esxm.2020.01.002","article-title":"Deep Dyspareunia, Superficial Dyspareunia, and Infertility Concerns Among Women With Endometriosis: A Cross-Sectional Study","volume":"8","author":"Wahl","year":"2020","journal-title":"Sex. Med."},{"key":"ref_43","first-page":"151","article-title":"Endometrioma and ovarian reserve: Effects of endometriomata per se and its surgical treatment on the ovarian reserve","volume":"11","author":"Ata","year":"2019","journal-title":"Facts Views Vision ObGyn"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/humrep\/det466","article-title":"Iron availability is increased in individual human ovarian follicles in close proximity to an endometrioma compared with distal ones","volume":"29","author":"Sanchez","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/humupd\/dmt053","article-title":"The distinguishing cellular and molecular features of the endometriotic ovarian cyst: From pathophysiology to the potential endometrioma-mediated damage to the ovary","volume":"20","author":"Sanchez","year":"2013","journal-title":"Hum. Reprod. Update"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"669342","DOI":"10.3389\/fmed.2021.669342","article-title":"The Impact of Endometriosis on Embryo Quality in In-Vitro Fertilization\/Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis","volume":"8","author":"Dongye","year":"2021","journal-title":"Front. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Chen, L.H., Lo, W.C., Huang, H.Y., and Wu, H.M. (2023). A Lifelong Impact on Endometriosis: Pathophysiology and Pharmacological Treatment. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087503"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1177\/1933719118777637","article-title":"The Gametotoxic Effects of the Endometrioma Content: Insights From a Parthenogenetic Human Model","volume":"26","author":"Paffoni","year":"2018","journal-title":"Reprod. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1007\/s10815-020-01989-y","article-title":"Characterizing the endometrial fluid cytokine profile in women with endometriosis","volume":"37","author":"Llarena","year":"2020","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"863173","DOI":"10.3389\/frph.2022.863173","article-title":"Non-Invasive and Mechanism-Based Molecular Assessment of Endometrial Receptivity During the Window of Implantation: Current Concepts and Future Prospective Testing Directions","volume":"4","author":"Sun","year":"2022","journal-title":"Front. Reprod. Health"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Germeyer, A., Savaris, R.F., Jauckus, J., and Lessey, B. (2014). Endometrial beta3 integrin profile reflects endometrial receptivity defects in women with unexplained recurrent pregnancy loss. Reprod. Biol. Endocrinol., 12.","DOI":"10.1186\/1477-7827-12-53"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1007\/s43032-021-00527-0","article-title":"A Detailed Study in Adenomyosis and Endometriosis: Evaluation of the Rate of Coexistence Between Uterine Adenomyosis and DIE According to Imaging and Histopathology Findings","volume":"28","author":"Alborzi","year":"2021","journal-title":"Reprod. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Marquardt, R.M., Kim, T.H., Shin, J.-H., and Jeong, J.-W. (2019). Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153822"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/humupd\/dmz012","article-title":"Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: A systematic review and meta-analysis","volume":"25","author":"Horton","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.fertnstert.2019.06.002","article-title":"Benefits of pregnancy on endometriosis: Can we dispel the myths?","volume":"112","author":"Leeners","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_56","first-page":"70","article-title":"A systematic review on endometriosis during pregnancy: Diagnosis, misdiagnosis, complications and outcomes","volume":"22","author":"Ferrero","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Huang, Y., Zhao, X., Chen, Y., Wang, J., Zheng, W., and Cao, L. (2020). Miscarriage on Endometriosis and Adenomyosis in Women by Assisted Reproductive Technology or with Spontaneous Conception: A Systematic Review and Meta-Analysis. BioMed Res. Int., 2020.","DOI":"10.1155\/2020\/4381346"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Matsuzaki, S., Nagase, Y., Ueda, Y., Kakuda, M., Maeda, M., Matsuzaki, S., and Kamiura, S. (2021). Placenta Previa Complicated with Endometriosis: Contemporary Clinical Management, Molecular Mechanisms, and Future Research Opportunities. Biomedicines, 9.","DOI":"10.3390\/biomedicines9111536"},{"key":"ref_59","first-page":"31","article-title":"Endometriosis and adverse pregnancy outcome","volume":"74","author":"Sorrentino","year":"2021","journal-title":"Minerva Obstet. Gynecol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s43032-019-00118-0","article-title":"A Relationship between Endometriosis and Obstetric Complications","volume":"27","author":"Kobayashi","year":"2020","journal-title":"Reprod. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/AOG.0000000000003410","article-title":"Endometriosis and Risk of Adverse Pregnancy Outcomes","volume":"134","author":"Farland","year":"2019","journal-title":"Obstet. Gynecol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.fertnstert.2017.07.019","article-title":"Endometriosis and obstetrics complications: A systematic review and meta-analysis","volume":"108","author":"Zullo","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"383","DOI":"10.5603\/GP.a2020.0084","article-title":"Should the patients with endometriosis be treated as a risk group of pregnancycomplications? Single center experience and literature review and literature review","volume":"91","author":"Warzecha","year":"2020","journal-title":"Ginekol. Pol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.fertnstert.2018.06.029","article-title":"Endometriosis and pregnancy outcome","volume":"110","author":"Koninckx","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.fertnstert.2017.08.014","article-title":"Pregnancy complications in patients with endometriosis","volume":"108","author":"Nezhat","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.fertnstert.2016.09.020","article-title":"Endometriosis and pregnancy complications: A Danish cohort study","volume":"107","author":"Glavind","year":"2016","journal-title":"Fertil. Steril."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1080\/14767058.2020.1793326","article-title":"Obstetrical complications and outcome in patients with endometriosis","volume":"35","author":"Borisova","year":"2020","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/aogs.13111","article-title":"Endometriosis increases the risk of obstetrical and neonatal complications","volume":"96","author":"Berlac","year":"2017","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1701-2163(16)30527-8","article-title":"Perinatel outcomes of singleton pregnancies achieved by in vitro fertilization: A systematic review and meta-analysis","volume":"27","author":"McDonald","year":"2005","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Marino, J.L., Moore, V.M., Willson, K.J., Rumbold, A., Whitrow, M.J., Giles, L.C., and Davies, M.J. (2014). Perinatal outcomes by mode of assisted conception and sub-fertility in an Australian data linkage cohort. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0080398"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1016\/j.fertnstert.2010.01.014","article-title":"In vitro fertilization and preterm delivery, low birth weight, and admission to the neonatal intensive care unit: A prospective follow-up study","volume":"94","author":"Wisborg","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"283","DOI":"10.5468\/ogs.2017.60.3.283","article-title":"Primiparous singleton women with endometriosis have an increased risk of preterm birth: Meta-analyses","volume":"60","author":"Kim","year":"2017","journal-title":"Obstet. Gynecol. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Miura, M., Ushida, T., Imai, K., Wang, J., Moriyama, Y., Nakano-Kobayashi, T., Osuka, S., Kikkawa, F., and Kotani, T. (2019). Adverse effects of endometriosis on pregnancy: A case-control study. BMC Pregnancy Childbirth, 19.","DOI":"10.1186\/s12884-019-2514-1"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"102274","DOI":"10.1016\/j.jogoh.2021.102274","article-title":"Pregnancy outcomes after in vitro fertilization for moderate and severe endometriosis. A case-control study","volume":"51","author":"Ribot","year":"2021","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejogrb.2013.10.024","article-title":"Endometriosis and pregnancy outcome: Are pregnancies complicated by endometriosis a high-risk group?","volume":"172","author":"Mekaru","year":"2014","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Harada, T., Taniguchi, F., Amano, H., Kurozawa, Y., Ideno, Y., Hayashi, K., Harada, T., and Japan Environment and Children\u2019s Study Group (2019). Adverse obstetrical outcomes for women with endometriosis and adenomyosis: A large cohort of the Japan Environment and Children\u2019s Study. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0220256"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/humupd\/4.4.312","article-title":"Pathophysiology of adenomyosis","volume":"4","author":"Ferenczy","year":"1998","journal-title":"Hum. Reprod. Update"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.3109\/14767058.2014.968843","article-title":"Women with endometriosis at first pregnancy have an increased risk of adverse obstetric outcome","volume":"28","author":"Conti","year":"2014","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1055\/s-0039-1692130","article-title":"Pregnancy after Endometriosis: Maternal and Neonatal Outcomes according to the Location of the Disease","volume":"36","author":"Uccella","year":"2019","journal-title":"Am. J. Perinatol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.fertnstert.2018.04.036","article-title":"Obstetric complications after laparoscopic excision of posterior deep infiltrating endometriosis: A case\u2013control study","volume":"110","author":"Nirgianakis","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e234","DOI":"10.3346\/jkms.2018.33.e234","article-title":"Women with Endometriosis, Especially Those Who Conceived with Assisted Reproductive Technology, Have Increased Risk of Placenta Previa: Meta-analyses","volume":"33","author":"Jeon","year":"2018","journal-title":"J. Korean Med. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Practice Committee of the American Society for Reproductive Medicine (2012). Endometriosis and infertility: A committee opinion. Fertil. Steril., 98, 591\u2013598.","DOI":"10.1016\/j.fertnstert.2012.05.031"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1055\/s-2008-1068759","article-title":"Integrins and Other Cell Adhesion Molecules in Endometrium and Endometriosis","volume":"15","author":"Lessey","year":"1997","journal-title":"Semin. Reprod. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4103\/0366-6999.199840","article-title":"Effects of Previous Laparoscopic Surgical Diagnosis of Endometriosis on Pregnancy Outcomes","volume":"130","author":"Li","year":"2017","journal-title":"Chin. Med. J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bpobgyn.2018.01.019","article-title":"Endometriosis, endometrioma, and ART results: Current understanding and recommended practices","volume":"51","author":"Prefumo","year":"2018","journal-title":"Best Pr. Res. Clin. Obstet. Gynaecol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1080\/14767058.2017.1393513","article-title":"Obstetrical and neonatal outcomes of pregnancies complicated by endometriosis","volume":"32","author":"Shmueli","year":"2017","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejogrb.2008.12.018","article-title":"Endometriosis and spontaneous rupture of uterine vessels with hemothorax during pregnancy","volume":"144","author":"Bouet","year":"2009","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.fertnstert.2013.11.001","article-title":"Bowel complications of deep endometriosis during pregnancy or in vitro fertilization","volume":"101","author":"Sidiropoulou","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1007\/s00261-019-02307-6","article-title":"Fertility-related considerations in endometriosis","volume":"45","author":"Khan","year":"2020","journal-title":"Abdom. Radiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: Pathogenesis and treatment","volume":"10","author":"Vercellini","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1177\/1933719118799199","article-title":"Endometrial miR-543 Is Downregulated During the Implantation Window in Women With Endometriosis-Related Infertility","volume":"26","author":"Yang","year":"2019","journal-title":"Reprod. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1136\/bmj.37957.560278.EE","article-title":"Perinatal outcome of singletons and twins after assisted conception: A systematic review of controlled studies","volume":"328","author":"Helmerhorst","year":"2004","journal-title":"BMJ"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00404-018-4765-x","article-title":"Placenta previa and placental abruption after assisted reproductive technology in patients with endometriosis: A systematic review and meta-analysis","volume":"298","author":"Gasparri","year":"2018","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/01.AOG.0000114989.84822.51","article-title":"Perinatal Outcomes in Singletons Following In Vitro Fertilization: A Meta-Analysis","volume":"103","author":"Jackson","year":"2004","journal-title":"Obstet. Gynecol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Menzhinskaya, I.V., Pavlovich, S.V., Melkumyan, A.G., Chuprynin, V.D., Yarotskaya, E.L., and Sukhikh, G.T. (2023). Potential Significance of Serum Autoantibodies to Endometrial Antigens, \u03b1-Enolase and Hormones in Non-Invasive Diagnosis and Pathogenesis of Endometriosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242115578"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s12522-016-0237-9","article-title":"Clinical management of endometriosis-associated infertility","volume":"15","author":"Khine","year":"2016","journal-title":"Reprod. Med. Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.fertnstert.2011.08.038","article-title":"Smaller fetal size in singletons after infertility therapies: The influence of technology and the underlying infertility","volume":"96","author":"Cooper","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_98","first-page":"552","article-title":"Pleural and parenchymal pulmonary endometriosis","volume":"58","author":"Foster","year":"1981","journal-title":"Obstet. Gynecol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.fertnstert.2012.01.112","article-title":"In vitro fertilization is a successful treatment in endometriosis-associated infertility","volume":"97","author":"Fedorcsak","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/humupd\/dmv035","article-title":"The impact of endometrioma on IVF\/ICSI outcomes: A systematic review and meta-analysis","volume":"21","author":"Hamdan","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Coccia, M.E., Nardone, L., and Rizzello, F. (2022). Endometriosis and Infertility: A Long-Life Approach to Preserve Reproductive Integrity. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19106162"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/aogs.13082","article-title":"Endometriosis-associated infertility: Aspects of pathophysiological mechanisms and treatment options","volume":"96","author":"Tanbo","year":"2017","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1055\/s-2001-14945","article-title":"Hyperprolactinemia and Luteal Insufficiency in Infertile Patients with Mild and Minimal Endometriosis1","volume":"33","author":"Gross","year":"2001","journal-title":"Horm. Metab. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5653\/cerm.2019.02971","article-title":"Management of endometriosis-related infertility: Considerations and treatment options","volume":"47","author":"Lee","year":"2020","journal-title":"Clin. Exp. Reprod. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10815-004-8760-8","article-title":"A Meta-Analysis of Controlled Studies Comparing Major Malformation Rates in IVF and ICSI Infants with Naturally Conceived Children","volume":"21","author":"Rimm","year":"2004","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.fertnstert.2012.02.053","article-title":"Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: A meta-analysis","volume":"97","author":"Wen","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s10815-011-9583-z","article-title":"A meta-analysis of the impact of IVF and ICSI on major malformations after adjusting for the effect of subfertility","volume":"28","author":"Rimm","year":"2011","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1056\/NEJMoa1008095","article-title":"Reproductive Technologies and the Risk of Birth Defects","volume":"366","author":"Davies","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/aja.2011.66","article-title":"Chromosomal disorders and male infertility","volume":"14","author":"Harton","year":"2012","journal-title":"Asian J. Androl."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/1\/126\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:47:25Z","timestamp":1760104045000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/1\/126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,22]]},"references-count":109,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["jpm14010126"],"URL":"https:\/\/doi.org\/10.3390\/jpm14010126","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,22]]}}}