{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:47:50Z","timestamp":1790412470443,"version":"4.1.0"},"reference-count":55,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Sepsis is a time-dependent disease whose prognosis is influenced by early diagnosis and therapeutic measures. Mortality from sepsis remains high, and for this reason, the guidelines of the Surviving Sepsis Campaign recommend establishing specific care programs aimed at patients with sepsis. We present the results of the application of a hospital model to improve performance in sepsis care, called Princess Sepsis Code, with the aim of reducing mortality. A retrospective study was conducted using clinical, epidemiological, and outcome variables in patients diagnosed with sepsis from 2015 to 2022. A total of 2676 patients were included, 32% of whom required admission to the intensive care unit, with the most frequent focus of the sepsis being abdominal. Mortality in 2015, at the beginning of the sepsis code program, was 24%, with a declining rate noted over the study period, with mortality reaching 17% in 2022. In the multivariate analysis, age &gt; 70 years, respiratory rate &gt; 22 rpm, deterioration in the level of consciousness, serum lactate &gt; 2 mmol\/L, creatinine &gt; 1.6 mg\/dL, and the focus of the sepsis were identified as variables independently related to mortality. The implementation of the Princess Sepsis Code care model reduces the mortality of patients exhibiting sepsis and septic shock.<\/jats:p>","DOI":"10.3390\/jpm14020149","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:11:27Z","timestamp":1706515887000},"page":"149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Decrease in Mortality after the Implementation of a Hospital Model to Improve Performance in Sepsis Care: Princess Sepsis Code"],"prefix":"10.3390","volume":"14","author":[{"given":"Rosa","family":"M\u00e9ndez","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Surgical Intensive Care, Hospital Universitario de La Princesa, Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angels","family":"Figuerola","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Hospital Universitario de La Princesa, Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3045-4890","authenticated-orcid":false,"given":"Fernando","family":"Ramasco","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Surgical Intensive Care, Hospital Universitario de La Princesa, Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2983-2356","authenticated-orcid":false,"given":"Marta","family":"Chicot","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Hospital Universitario de La Princesa, Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7564-1668","authenticated-orcid":false,"given":"Natalia F.","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Hospital Universitario de La Princesa, Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cd\u00f1igo","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hospital Universitario de La Princesa, Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"von Wernitz","sequence":"additional","affiliation":[{"name":"Department of Emergency, Hospital Universitario de La Princesa, Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly D.","family":"Zurita","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hospital Universitario de La Princesa, Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auxiliadora","family":"Semiglia","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hospital Universitario de La Princesa, Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Pizarro","sequence":"additional","affiliation":[{"name":"Department of Emergency, Hospital Universitario de La Princesa, Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Saez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario de La Princesa, Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1841-2751","authenticated-orcid":false,"given":"Diego","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Hospital Universitario Pr\u00edncipe de Asturias, Avenida Principal de La Universidad s\/n, 28805 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12963-018-0160-x","article-title":"Epidemiological trends of sepsis in the twenty-first century (2000\u20132013): An analysis of incidence, mortality, and associated costs in Spain","volume":"16","author":"Micheloud","year":"2018","journal-title":"Popul. Health Metr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1007\/s00134-020-06151-x","article-title":"Incidence and mortality of hospital- and ICU-treated sepsis: Results from an updated and expanded systematic review and meta-analysis","volume":"46","author":"Mellhammar","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Vincent, J.L., van der Poll, T., and Marshall, J.C. (2022). The End of \u2018One Size Fits All\u2019 Sepsis Therapies: Toward an Individualized Approach. Biomedicines, 10.","DOI":"10.3390\/biomedicines10092260"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1097\/CCM.0000000000001231","article-title":"Foreword. The Future of Sepsis Performance Improvement","volume":"43","author":"Dellinger","year":"2015","journal-title":"Crit. Care Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: International guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.2967\/jnumed.110.082537","article-title":"Safe Patients, Smart Hospitals: How One Doctor\u2019s Checklist Can Help Us Change Health Care from the Inside Out","volume":"52","author":"Kim","year":"2011","journal-title":"J. Nucl. Med."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"The ProCESS Investigators (2014). A Randomized Trial of Protocol-Based Care for Early Septic Shock. N. Engl. J. Med., 370, 1683\u20131693.","DOI":"10.1056\/NEJMoa1401602"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJMoa1500896","article-title":"Trial of Early, Goal-Directed Resuscitation for Septic Shock","volume":"372","author":"Mouncey","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"ARISE Investigators, ANZICS Clinical Trials Group, Peake, S.L., Delaney, A., Bailey, M., Bellomo, R., Cameron, P.A., Cooper, D.J., Higgins, A.M., and Holdgate, A. (2014). Goal-directed resuscitation for patients with early septic shock. N. Engl. J. Med., 371, 1496\u20131506.","DOI":"10.1056\/NEJMoa1404380"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ccc.2016.12.004","article-title":"Severe Sepsis and Septic Shock Trials (ProCESS, ARISE, ProMISe): What is Optimal Resuscitation?","volume":"33","author":"Osborn","year":"2017","journal-title":"Crit. Care Clin."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1007\/s00134-015-3822-1","article-title":"A systematic review and meta-analysis of early goal-directed therapy for septic shock: The ARISE, ProCESS and ProMISe Investigators","volume":"41","author":"Angus","year":"2015","journal-title":"Intensive Care Med."},{"key":"ref_13","unstructured":"Ramasco Rueda, F., and Gonz\u00e1lez de Castro, R. (2023). Editorial M\u00e9dica Ergon. [2nd ed.]. Available online: https:\/\/ergon.es\/producto\/manual-infecciones-perioperatorias-2ed\/."},{"key":"ref_14","first-page":"238","article-title":"Initial clinical outcomes and prognostic variables in the implementation of a Code Sepsis in a high complexity University Hospital","volume":"32","author":"Ramasco","year":"2019","journal-title":"Rev. Esp. Quimioter."},{"key":"ref_15","first-page":"43","article-title":"C\u00f3digo Sepsis: Esquivando la mortalidad en un hospital terciario","volume":"35","author":"Figuerola","year":"2022","journal-title":"Rev. Esp. Quimioter."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"178","DOI":"10.37201\/req\/132.2021","article-title":"Impact of the implementation of a Sepsis Code Program in medical patient management: A cohort study in an Internal Medicine ward","volume":"35","author":"Ballesteros","year":"2022","journal-title":"Rev. Esp. Quimioter."},{"key":"ref_17","first-page":"400","article-title":"Documento de consenso para la implantaci\u00f3n y desarrollo del C\u00f3digo Sepsis en la Comunidad de Madrid","volume":"32","author":"Rueda","year":"2019","journal-title":"Rev. Esp. Quimioter."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40635-021-00400-z","article-title":"The Surviving Sepsis Campaign: Research priorities for the administration, epidemiology, scoring and identification of sepsis","volume":"9","author":"Nunnally","year":"2021","journal-title":"Intensive Care Med. Exp."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Bouza, C., L\u00f3pez-Cuadrado, T., Saz-Parkinson, Z., and Amate-Blanco, J.M. (2014). Epidemiology and recent trends of severe sepsis in Spain: A nationwide population-based analysis (2006\u20132011). BMC Infect. Dis., 14.","DOI":"10.1186\/s12879-014-0717-7"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1164\/rccm.202010-4023LE","article-title":"What Sepsis Researchers Can Learn from COVID-19","volume":"203","author":"Schinkel","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"European Society of Intensive Care Medicine (ESICM), Global Sepsis Alliance (GSA), and Society of Critical Care Medicine (SCCM) (2021). Reducing the global burden of sepsis: A positive legacy for the COVID-19 pandemic?. Intensive Care Med., 47, 733\u2013736.","DOI":"10.1007\/s00134-021-06409-y"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1037\/amp0000298","article-title":"Teamwork in healthcare: Key discoveries enabling safer, high-quality care","volume":"73","author":"Rosen","year":"2018","journal-title":"Am. Psychol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Damiani, E., Donati, A., Serafini, G., Rinaldi, L., Adrario, E., Pelaia, P., Busani, S., and Girardis, M. (2015). Effect of Performance Improvement Programs on Compliance with Sepsis Bundles and Mortality: A Systematic Review and Meta-Analysis of Observational Studies. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0125827"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e0251","DOI":"10.1097\/CCE.0000000000000251","article-title":"A Multimodal Sepsis Quality-Improvement Initiative Including 24\/7 Screening and a Dedicated Sepsis Response Team-Reduced Readmissions and Mortality","volume":"2","author":"Alnababteh","year":"2020","journal-title":"Crit. Care Explor."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.6018\/eglobal.503441","article-title":"Improving the quality of care for patients with sepsis in the context of an emergency service","volume":"21","author":"Nobre","year":"2022","journal-title":"Enf. Glob."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1001\/jama.2017.13836","article-title":"Incidence and Trends of Sepsis in US Hospitals Using Clinical vs. Claims Data, 2009\u20132014","volume":"318","author":"Rhee","year":"2017","journal-title":"JAMA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1007\/s00134-014-3496-0","article-title":"Surviving Sepsis Campaign: Association between performance metrics and outcomes in a 7.5-year study","volume":"40","author":"Levy","year":"2014","journal-title":"Intensive Care Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1186\/cc9008","article-title":"Reducing mortality in severe sepsis with the implementation of a core 6-h bundle: Results from the Portuguese community-acquired sepsis study (SACiUCI study)","volume":"14","author":"Cardoso","year":"2010","journal-title":"Crit. Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"R143","DOI":"10.1186\/cc8029","article-title":"Effects on management and outcome of severe sepsis and septic shock patients admitted to the intensive care unit after implementation of a sepsis program: A pilot study","volume":"13","author":"Girardis","year":"2009","journal-title":"Crit. Care"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13054-022-03917-1","article-title":"Sepsis Performance Improvement Programs: From Evidence toward Clinical Implementation","volume":"26","author":"Schinkel","year":"2022","journal-title":"Crit. Care"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13054-020-2756-3","article-title":"Effects of very early start of norepinephrine in patients with septic shock: A propensity score-based analysis","volume":"24","author":"Hernandez","year":"2020","journal-title":"Crit. Care"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s13054-023-04593-5","article-title":"Evidence for a personalized early start of norepinephrine in septic shock","volume":"27","author":"Monnet","year":"2023","journal-title":"Crit. Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1097\/01.CCM.0000217961.75225.E9","article-title":"Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock","volume":"34","author":"Kumar","year":"2006","journal-title":"Crit. Care Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"620","DOI":"10.4067\/S0034-98872007000500010","article-title":"Prevalencia de sepsis grave en las Unidades de Cuidado Intensivo: Primer estudio nacional multic\u00e9ntrico","volume":"135","author":"Dougnac","year":"2007","journal-title":"Rev. M\u00e9d. Chile"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"915224","DOI":"10.3389\/fmed.2022.915224","article-title":"In-Hospital Mortality of Sepsis Differs Depending on the Origin of Infection: An Investigation of Predisposing Factors","volume":"9","author":"Pieroni","year":"2022","journal-title":"Front. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s13054-020-02917-3","article-title":"Phenotypic heterogeneity by site of infection in surgical sepsis: A prospective longitudinal study","volume":"24","author":"Stortz","year":"2020","journal-title":"Crit. Care"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1164\/rccm.201310-1875OC","article-title":"Association between Source of Infection and Hospital Mortality in Patients Who Have Septic Shock","volume":"189","author":"Leligdowicz","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Mewes, C., Runzheimer, J., B\u00f6hnke, C., B\u00fcttner, B., Nemeth, M., Hinz, J., Quintel, M., and Mansur, A. (2023). Differences in Mortality and Sepsis-Associated Organ Dysfunction between Surgical and Non-Surgical Sepsis Patients. Biomedicines, 11.","DOI":"10.3390\/biomedicines11082233"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1002\/jhm.2656","article-title":"Implementation of a multicenter performance improvement program for early detection and treatment of severe sepsis in general medical\u2013surgical wards","volume":"11","author":"Schorr","year":"2016","journal-title":"J. Hosp. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e194900","DOI":"10.1001\/jamanetworkopen.2019.4900","article-title":"Risk Factors at Index Hospitalization Associated with Longer-term Mortality in Adult Sepsis Survivors","volume":"2","author":"Harrison","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1007\/s15010-023-02082-z","article-title":"Trends in mortality after a sepsis hospitalization: A nationwide prospective registry study from 2008 to 2021","volume":"51","author":"Skei","year":"2023","journal-title":"Infection"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e16871","DOI":"10.1097\/MD.0000000000016871","article-title":"Factors predicting long-term survival of patients with sepsis on arrival at the emergency department","volume":"98","author":"Roh","year":"2019","journal-title":"Medicine"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"M\u00e9ndez Hern\u00e1ndez, R., and Ramasco Rueda, F. (2023). Biomarkers as Prognostic Predictors and Therapeutic Guide in Critically ill Patients: Clinical Evidence. J. Pers. Med., 13.","DOI":"10.3390\/jpm13020333"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1056\/NEJMoa1312173","article-title":"High versus Low Blood-Pressure Target in Patients with Septic Shock","volume":"370","author":"Asfar","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/s13054-022-04255-y","article-title":"A plea for personalization of the hemodynamic management of septic shock","volume":"26","author":"Cecconi","year":"2022","journal-title":"Crit. Care"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1097\/CCM.0000000000001142","article-title":"The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis","volume":"43","author":"Sterling","year":"2015","journal-title":"Crit. Care Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1086\/504383","article-title":"The antimicrobial therapy puzzle: Could pharmacokinetic-pharmacodynamic relationships be helpful in addressing the issue of appropriate pneumonia treatment in critically ill patients?","volume":"42","author":"Pea","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/MEJ.0000000000000924","article-title":"Prognostic value of serial score measurements of the national early warning score, the quick sequential organ failure assessment and the systemic inflammatory response syndrome to predict clinical outcome in early sepsis","volume":"29","author":"Zonneveld","year":"2022","journal-title":"Eur. J. Emerg. Med."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Brink, A., Alsma, J., Verdonschot, R.J.C.G., Rood, P.P.M., Zietse, R., Lingsma, H.F., and Schuit, S.C.E. (2019). Predicting mortality in patients with suspected sepsis at the Emergency Department; A retrospective cohort study comparing qSOFA, SIRS and National Early Warning Score. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0211133"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"16605","DOI":"10.1038\/s41598-020-73676-y","article-title":"Best diagnostic accuracy of sepsis combining SIRS criteria or qSOFA score with Procalcitonin and Mid-Regional pro-Adrenomedullin outside ICU","volume":"10","author":"Spoto","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"145","DOI":"10.7196\/AJTCCM.2021.v27i4.158","article-title":"Prognostic value of the Quick Sepsis-related Organ Failure Assessment (qSOFA) score among critically ill medical and surgical patients with suspected infection in a resourcelimited setting","volume":"24","author":"Bischop","year":"2021","journal-title":"Afr. J. Thorac. Crit. Care Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"103651","DOI":"10.1016\/j.isci.2021.103651","article-title":"Evaluating machine learning models for sepsis prediction: A systematic review of methodologies","volume":"25","author":"Deng","year":"2021","journal-title":"iScience"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1001\/jama.2019.5791","article-title":"Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis","volume":"321","author":"Seymour","year":"2019","journal-title":"JAMA"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Sinapidis, D., Kosmas, V., Vittoros, V., Koutelidakis, I.M., Pantazi, A., Stefos, A., Katsaros, K.E., Akinosoglou, K., Bristianou, M., and Toutouzas, K. (2018). Progression into sepsis: An individualized process varying by the interaction of comorbidities with the underlying infection. BMC Infect. Dis., 18.","DOI":"10.1186\/s12879-018-3156-z"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e1231","DOI":"10.1097\/PTS.0000000000001062","article-title":"Hospitals That Report Severe Sepsis and Septic Shock Bundle Compliance Have More Structured Sepsis Performance Improvement","volume":"18","author":"Bolte","year":"2022","journal-title":"J. Patient Saf."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/2\/149\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:51:06Z","timestamp":1760104266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/2\/149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,29]]},"references-count":55,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["jpm14020149"],"URL":"https:\/\/doi.org\/10.3390\/jpm14020149","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,29]]}}}