{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:11:32Z","timestamp":1780405892597,"version":"3.54.1"},"reference-count":72,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Young patients with tongue squamous cell carcinoma (TSCC) mostly lack typical prognostic markers and face a dire prognosis. The aim of this study was to analyze the prognostic relevance of lymphocyte-to-monocyte ratio (LMR) in TSCC patients, with a special emphasis on patients under 45 years. Methods: This retrospective study included all patients primarily treated for TSCC. The prognostic relevance of LMR was investigated in terms of predicting the overallsurvival (OS) and disease-free survival (DFS). Results: A total of 74 patients were included and the young cohort (&lt;45 years) comprised 27 individuals. The mortality and recurrence rates were 39.2% (n = 29) and 37.8% (n = 28), respectively. OS and DFS were significantly shorter in the low LMR group within the whole cohort. Furthermore, low LMR was associated with worse prognosis, particularly inferior OS (median OS 1.7 vs. 14.6 years, p = 0.0156) and worse DFS (median DFS 0.8 years vs. not reached, p = 0.0405) in the young patient cohort. Conclusions: Our results reveal that pretreatment LMR might become a prognostic tool for young TSCC patients, especially due to its availability. However, further studies on larger cohorts are necessary to validate our results.<\/jats:p>","DOI":"10.3390\/jpm14020159","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T11:35:34Z","timestamp":1706614534000},"page":"159","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lymphocyte-to-Monocyte Ratio Might Serve as a Prognostic Marker in Young Patients with Tongue Squamous Cell Carcinoma"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4139-7940","authenticated-orcid":false,"given":"Sam Augustine","family":"Kandathil","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria"},{"name":"Division of Anatomy, Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Peter Truta","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Kadletz-Wanke","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Heiduschka","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-867X","authenticated-orcid":false,"given":"Stefan","family":"Stoiber","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria"},{"name":"Christian Doppler Laboratory for Applied Metabolomics, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2184-1338","authenticated-orcid":false,"given":"Lukas","family":"Kenner","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria"},{"name":"Christian Doppler Laboratory for Applied Metabolomics, 1090 Vienna, Austria"},{"name":"Center for Biomarker Research in Medicine, 8010 Graz, Austria"},{"name":"Unit for Pathology of Laboratory Animals, University of Veterinary Medicine Vienna, 1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harun","family":"Huskic","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0770-6677","authenticated-orcid":false,"given":"Faris F.","family":"Brkic","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hed.24589","article-title":"Changing epidemiology of oral squamous cell carcinoma of the tongue: A global study","volume":"39","author":"Ng","year":"2017","journal-title":"Head Neck"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/ijc.33896","article-title":"Diverging incidence trends of oral tongue cancer compared to other head and neck cancers in young adults in France","volume":"150","author":"Deneuve","year":"2022","journal-title":"Int. J. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1158\/2159-8290.CD-14-1205","article-title":"Therapeutic insights from genomic studies of head and neck squamous cell carcinomas","volume":"5","author":"Hammerman","year":"2015","journal-title":"Cancer Discov."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1200\/JCO.2015.61.1509","article-title":"Immunology and Immunotherapy of Head and Neck Cancer","volume":"33","author":"Ferris","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1056\/NEJMoa1602252","article-title":"Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck","volume":"375","author":"Ferris","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S1470-2045(16)30066-3","article-title":"Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): An open-label, multicentre, phase 1b trial","volume":"17","author":"Seiwert","year":"2016","journal-title":"Lancet Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0140-6736(18)31999-8","article-title":"Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): A randomised, open-label, phase 3 study","volume":"393","author":"Cohen","year":"2019","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0140-6736(19)32591-7","article-title":"Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): A randomised, open-label, phase 3 study","volume":"394","author":"Burtness","year":"2019","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s40425-019-0578-0","article-title":"Comparative analysis of the phase III clinical trials of anti-PD1 monotherapy in head and neck squamous cell carcinoma patients (CheckMate 141 and KEYNOTE 040)","volume":"7","author":"Pai","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1200\/JCO.22.00332","article-title":"Nivolumab Plus Ipilimumab Versus EXTREME Regimen as First-Line Treatment for Recurrent\/Metastatic Squamous Cell Carcinoma of the Head and Neck: The Final Results of CheckMate 651","volume":"41","author":"Haddad","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1007\/s00784-019-02958-1","article-title":"The synergistic effect of tobacco and alcohol consumption on oral squamous cell carcinoma: A systematic review and meta-analysis","volume":"23","author":"Mello","year":"2019","journal-title":"Clin. Oral Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"104112","DOI":"10.1016\/j.critrevonc.2023.104112","article-title":"Oral cavity cancer in young, non-smoking, and non-drinking patients: A contemporary review","volume":"190","author":"Tran","year":"2023","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/ijmr.IJMR_2023_17","article-title":"Relationship between type of smokeless tobacco & risk of cancer: A systematic review","volume":"148","author":"Gupta","year":"2018","journal-title":"Indian J. Med. Res."},{"key":"ref_16","first-page":"2742","article-title":"Mechanisms of resistance in head and neck cancer","volume":"10","author":"Picon","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejca.2017.05.026","article-title":"Global incidence of oral and oropharynx cancer in patients younger than 45 years versus older patients: A systematic review","volume":"82","author":"Hussein","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.14639\/0392-100X-1932","article-title":"Tongue carcinoma in young adults: A review of the literature","volume":"38","author":"Paderno","year":"2018","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/ije\/dyu255","article-title":"Risk factors for head and neck cancer in young adults: A pooled analysis in the INHANCE consortium","volume":"44","author":"Toporcov","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.joms.2016.12.023","article-title":"Low Pretreatment Lymphocyte-Monocyte Ratio and High Platelet-Lymphocyte Ratio Indicate Poor Cancer Outcome in Early Tongue Cancer","volume":"75","author":"Ong","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.21873\/anticanres.13126","article-title":"Prognostic Significance of Pretreatment Lymphocyte-to-Monocyte Ratio in Patients with Tongue Cancer","volume":"39","author":"Furukawa","year":"2019","journal-title":"Anticancer Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.annonc.2020.04.001","article-title":"Durvalumab with or without tremelimumab in patients with recurrent or metastatic head and neck squamous cell carcinoma: EAGLE, a randomized, open-label phase III study","volume":"31","author":"Ferris","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s10654-021-00752-6","article-title":"Systemic inflammation markers and cancer incidence in the UK Biobank","volume":"36","author":"Alcala","year":"2021","journal-title":"Eur. J. Epidemiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"16717","DOI":"10.1038\/s41598-017-16955-5","article-title":"The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: Systematic review and meta-analysis","volume":"7","author":"Dolan","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.oooo.2018.10.009","article-title":"Pretreatment assessment of hematologic and inflammatory markers in adenoid cystic carcinoma: Neutrophil\/lymphocyte ratio is associated with multiple recurrences","volume":"127","author":"Brkic","year":"2019","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jcms.2019.11.010","article-title":"Impact of pretherapeutic neutrophil-to-lymphocyte ratio, serum albumin, body-mass index, and advanced lung cancer inflammation index on clinical outcome in sinonasal squamous cell carcinoma","volume":"48","author":"Brkic","year":"2020","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Brkic, F.F., Stoiber, S., Friedl, M., Maier, T., Heiduschka, G., and Kadletz-Wanke, L. (2021). The Potential Prognostic Value of a Novel Hematologic Marker Fibrinogen-to-Lymphocyte Ratio in Head and Neck Adenoid-Cystic Carcinoma. J. Pers. Med., 11.","DOI":"10.3390\/jpm11111228"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/ijc.28677","article-title":"The lymphocyte\/monocyte ratio predicts poor clinical outcome and improves the predictive accuracy in patients with soft tissue sarcomas","volume":"135","author":"Szkandera","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Hu, P., Shen, H., Wang, G., Zhang, P., Liu, Q., and Du, J. (2014). Prognostic significance of systemic inflammation-based lymphocyte- monocyte ratio in patients with lung cancer: Based on a large cohort study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108062"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.urolonc.2014.04.001","article-title":"Low preoperative lymphocyte-monocyte ratio (LMR) represents a potentially poor prognostic factor in nonmetastatic clear cell renal cell carcinoma","volume":"32","author":"Hutterer","year":"2014","journal-title":"Urol. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/bjc.2013.785","article-title":"The preoperative lymphocyte to monocyte ratio predicts clinical outcome in patients with stage III colon cancer","volume":"110","author":"Stotz","year":"2014","journal-title":"Br. J. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.7314\/APJCP.2015.16.6.2245","article-title":"Prognostic significance of preoperative lymphocyte-monocyte ratio in patients with resectable esophageal squamous cell carcinoma","volume":"16","author":"Han","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8537","DOI":"10.1007\/s13277-015-3613-x","article-title":"Preoperative lymphocyte-monocyte and platelet-lymphocyte ratios as predictors of overall survival in patients with bladder cancer undergoing radical cystectomy","volume":"36","author":"Zhang","year":"2015","journal-title":"Tumour Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"10898","DOI":"10.3748\/wjg.v21.i38.10898","article-title":"Lymphocyte-to-monocyte ratio predicts survival of patients with hepatocellular carcinoma after curative resection","volume":"21","author":"Lin","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.lungcan.2015.07.014","article-title":"Prognostic significance of the lymphocyte-to-monocyte ratio in patients with malignant pleural mesothelioma","volume":"90","author":"Yamagishi","year":"2015","journal-title":"Lung Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jss.2015.06.014","article-title":"Impact of a lymphocyte to monocyte ratio in stage IV colorectal cancer","volume":"199","author":"Ozawa","year":"2015","journal-title":"J. Surg. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/SLA.0000000000001743","article-title":"The Lymphocyte-to-Monocyte Ratio is a Superior Predictor of Overall Survival in Comparison to Established Biomarkers of Resectable Colorectal Cancer","volume":"265","author":"Chan","year":"2017","journal-title":"Ann. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1002\/hed.24898","article-title":"Clinicopathological characteristics and outcomes of squamous cell carcinoma of the tongue in different age groups","volume":"39","author":"Zhang","year":"2017","journal-title":"Head Neck"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1002\/lary.29589","article-title":"Prognostic Role of Tumor-Infiltrating Lymphocytes and Tumor Budding in Early Oral Tongue Carcinoma","volume":"131","author":"Hori","year":"2021","journal-title":"Laryngoscope"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/bjc.2017.425","article-title":"Tumour budding in oral squamous cell carcinoma: A meta-analysis","volume":"118","author":"Almangush","year":"2018","journal-title":"Br. J. Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-3-0348-0837-8_5","article-title":"The role of inflammation in head and neck cancer","volume":"816","author":"Bonomi","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.critrevonc.2013.03.010","article-title":"The systemic inflammation-based neutrophil-lymphocyte ratio: Experience in patients with cancer","volume":"88","author":"Guthrie","year":"2013","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1158\/1055-9965.EPI-14-0146","article-title":"Prognostic role of platelet to lymphocyte ratio in solid tumors: A systematic review and meta-analysis","volume":"23","author":"Templeton","year":"2014","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.ctrv.2015.10.003","article-title":"Prognostic value of lymphocyte-to-monocyte ratio in patients with solid tumors: A systematic review and meta-analysis","volume":"41","author":"Nishijima","year":"2015","journal-title":"Cancer Treat. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41577-020-0306-5","article-title":"A guide to cancer immunotherapy: From T cell basic science to clinical practice","volume":"20","author":"Waldman","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s40265-023-01835-2","article-title":"Treating Head and Neck Cancer in the Age of Immunotherapy: A 2023 Update","volume":"83","author":"Bhatia","year":"2023","journal-title":"Drugs"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.3390\/cancers6031670","article-title":"Tumor-associated macrophages as major players in the tumor microenvironment","volume":"6","author":"Chanmee","year":"2014","journal-title":"Cancers"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s00405-018-4972-x","article-title":"The lymphocyte-to-monocyte ratio as a prognostic indicator in head and neck cancer: A systematic review and meta-analysis","volume":"275","author":"Tham","year":"2018","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"782383","DOI":"10.3389\/fonc.2021.782383","article-title":"Prognostic Evaluation of Metastasis-Related Lymphocyte\/Monocyte Ratio in Stage I\u2013III Breast Cancer Receiving Chemotherapy","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"20011","DOI":"10.18632\/oncotarget.15311","article-title":"The clinical use of the platelet\/lymphocyte ratio and lymphocyte\/monocyte ratio as prognostic predictors in colorectal cancer: A meta-analysis","volume":"8","author":"Guo","year":"2017","journal-title":"Oncotarget"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1245\/s10434-015-4481-8","article-title":"The Preoperative Lymphocyte-to-Monocyte Ratio is Prognostic of Clinical Outcomes for Patients with Liver-Only Colorectal Metastases in the Neoadjuvant Setting","volume":"22","author":"Neofytou","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s12032-014-0070-0","article-title":"Prognostic impact of circulating monocytes and lymphocyte-to-monocyte ratio on previously untreated metastatic non-small cell lung cancer patients receiving platinum-based doublet","volume":"31","author":"Lin","year":"2014","journal-title":"Med. Oncol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"289","DOI":"10.7150\/jca.13432","article-title":"The Lymphocyte-Monocyte Ratio Predicts Patient Survival and Aggressiveness of Ovarian Cancer","volume":"7","author":"Eo","year":"2016","journal-title":"J. Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pan.2014.12.004","article-title":"Clinical implications of systemic inflammatory response markers as independent prognostic factors for advanced pancreatic cancer","volume":"15","author":"Qi","year":"2015","journal-title":"Pancreatology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12935-019-0785-2","article-title":"Prognostic significance of elevated pretreatment systemic inflammatory markers for patients with prostate cancer: A meta-analysis","volume":"19","author":"Peng","year":"2019","journal-title":"Cancer Cell Int."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jss.2019.09.034","article-title":"Lymphocyte-Monocyte Ratio Significantly Predicts Recurrence in Papillary Thyroid Cancer","volume":"246","author":"Yokota","year":"2020","journal-title":"J. Surg. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"7338","DOI":"10.1038\/s41467-021-27619-4","article-title":"Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing","volume":"12","author":"Kulkarni","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Arutyunyan, I., Jumaniyazova, E., Makarov, A., and Fatkhudinov, T. (2023). In Vitro Models of Head and Neck Cancer: From Primitive to Most Advanced. J. Pers. Med., 13.","DOI":"10.3390\/jpm13111575"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41563-021-01057-5","article-title":"Next-generation cancer organoids","volume":"21","author":"LeSavage","year":"2022","journal-title":"Nat. Mater."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41568-018-0104-6","article-title":"Modelling cancer in microfluidic human organs-on-chips","volume":"19","author":"Hassell","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s12079-023-00790-7","article-title":"Use and application of organ-on-a-chip platforms in cancer research","volume":"17","author":"Yu","year":"2023","journal-title":"J. Cell Commun. Signal."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"15334","DOI":"10.1038\/s41598-022-19555-0","article-title":"Patient-derived head and neck tumor slice cultures: A versatile tool to study oncolytic virus action","volume":"12","author":"Runge","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e1155","DOI":"10.1002\/ctm2.1155","article-title":"Multiplex immunofluorescence and single-cell transcriptomic profiling reveal the spatial cell interaction networks in the non-small cell lung cancer microenvironment","volume":"13","author":"Peng","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"K\u00fchn, J.P., Schmid, W., K\u00f6rner, S., Bochen, F., Wemmert, S., Rimbach, H., Smola, S., Radosa, J.C., Wagner, M., and Morris, L.G. (2021). HPV Status as Prognostic Biomarker in Head and Neck Cancer-Which Method Fits the Best for Outcome Prediction?. Cancers, 13.","DOI":"10.3390\/cancers13184730"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.18632\/oncotarget.23248","article-title":"Epithelial-mesenchymal crosstalk induces radioresistance in HNSCC cells","volume":"9","author":"Steinbichler","year":"2018","journal-title":"Oncotarget"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Starska-Kowarska, K. (2023). The Role of Different Immunocompetent Cell Populations in the Pathogenesis of Head and Neck Cancer-Regulatory Mechanisms of Pro- and Anti-Cancer Activity and Their Impact on Immunotherapy. Cancers, 15.","DOI":"10.3390\/cancers15061642"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Borsetto, D., Tomasoni, M., Payne, K., Polesel, J., Deganello, A., Bossi, P., Tysome, J.R., Masterson, L., Tirelli, G., and Tofanelli, M. (2021). Prognostic Significance of CD4+ and CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis. Cancers, 13.","DOI":"10.3390\/cancers13040781"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s12026-012-8306-6","article-title":"Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer","volume":"54","author":"Tong","year":"2012","journal-title":"Immunol. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.oraloncology.2016.08.003","article-title":"Telltale tumor infiltrating lymphocytes (TIL) in oral, head & neck cancer","volume":"61","author":"Lei","year":"2016","journal-title":"Oral Oncol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13005-021-00286-y","article-title":"Biological consequences of cancer radiotherapy in the context of oral squamous cell carcinoma","volume":"17","author":"Feller","year":"2021","journal-title":"Head Face Med."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Okuyama, K., Suzuki, K., and Yanamoto, S. (2023). Relationship between Tumor Budding and Partial Epithelial-Mesenchymal Transition in Head and Neck Cancer. 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