{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:36:28Z","timestamp":1760524588386,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Injuries to the articular cartilage of the human knee joint, commonly resulting from trauma, inflammation, or age- and activity-related wear and tear, have significant implications, primarily leading to osteoarthritis (OA). Conservative treatments for such injuries often yield suboptimal clinical outcomes. Surgical interventions using current methods may not consistently provide satisfactory results, largely due to the formation of low-quality scar tissue lacking the biomechanical properties of hyaline cartilage. In this retrospective study, we compared the results of two promising methods for regenerating cartilage defects in the knee joints using scaffolds soaked with stem cells of different origins: bone marrow aspirate concentrate mesenchymal stem cells (BMAC-MSCs) and human umbilical cord-derived mesenchymal stem cells (hUCB-MSCs). We evaluated 39 patients (39 knees, hUCB-MSCs: 20 knees, BMAC: 19 knees) at the 12-month follow-up using VAS, KOOS, Lysholm scales and radiologically with M-MOCART 2.0 score. The analysis demonstrated substantial overall improvement in both groups, notably reflected in enhanced quality of life for the patients. Interestingly, the final scores in the hUCB-MSCs group were comparable to those in the BMAC-MSCs group, with no statistically significant differences observed, despite variations in preoperative age and lesion size. Notably, the hUCB-MSCs group consisted of significantly older individuals with larger lesion sizes. Both procedures were found to be safe, and improvement was observed in both groups, which holds promise for future clinical investigations.<\/jats:p>","DOI":"10.3390\/jpm14030220","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T04:04:14Z","timestamp":1708401854000},"page":"220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of the Efficacy of Human Umbilical Cord-Derived and Bone Marrow Aspirate Concentrate Mesenchymal Stem Cells for Cartilage Repair Defects of the Knee via Arthroscopic Implementation on Scaffolds in a Retrospective Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2559-2896","authenticated-orcid":false,"given":"Karol","family":"Pa\u0142ka","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogus\u0142aw","family":"Sadlik","sequence":"additional","affiliation":[{"name":"College of Physiotherapy in Wroc\u0142aw, ul. Ko\u015bciuszki 4, 50-038 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Kami\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiodiagnostics, Public Clinical Hospital, Medical University of Silesia in Katowice, 3-go Maja 13-15, 41-800 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0405-0596","authenticated-orcid":false,"given":"Rafa\u0142 J.","family":"Bu\u0142dak","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Laboratory Diagnostics, Institute of Medical Sciences, University of Opole, Oleska 48, 45-052 Opole, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8399-7624","authenticated-orcid":false,"given":"Micha\u0142","family":"Dobrakowski","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland"},{"name":"Department of Radiology and Radiodiagnostics, Public Clinical Hospital, Medical University of Silesia in Katowice, 3-go Maja 13-15, 41-800 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(20)32230-3","article-title":"Osteoarthritis in 2020 and beyond: A Lancet Commission","volume":"396","author":"Hunter","year":"2020","journal-title":"Lancet"},{"key":"ref_2","unstructured":"(2023, December 01). Global Burden of Disease Collaborative Network. Available online: https:\/\/ghdx.healthdata.org\/organizations\/global-burden-disease-collaborative-network."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.addr.2018.12.015","article-title":"Articular fibrocartilage\u2014Why does hyaline cartilage fail to repair?","volume":"146","author":"Armiento","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1302\/0301-620X.97B2.33707","article-title":"Financial analysis of revision knee surgery based on NHS tariffs and hospital costs Does it pay to provide a revision service?","volume":"97-B","author":"Kallala","year":"2015","journal-title":"Bone Jt. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100044","DOI":"10.1016\/j.ocarto.2020.100044","article-title":"Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis","volume":"2","author":"Perry","year":"2020","journal-title":"Osteoarthr. Cartil. Open"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1007\/s00167-016-4047-8","article-title":"Chondral and osteochondral operative treatment in early osteoarthritis","volume":"24","author":"Angele","year":"2016","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.arthro.2013.05.027","article-title":"Evidence-Based Status of Microfracture Technique: A Systematic Review of Level I and II Studies","volume":"29","author":"Goyal","year":"2013","journal-title":"Arthrosc. J. Arthrosc. Relat. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.csm.2017.02.006","article-title":"Osteochondral Autologous Transplantation","volume":"36","author":"Sherman","year":"2017","journal-title":"Clin. Sports Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta21060","article-title":"Autologous chondrocyte implantation in the knee: Systematic review and economic evaluation","volume":"21","author":"Mistry","year":"2017","journal-title":"Health Technol. Assess."},{"key":"ref_10","first-page":"3","article-title":"Osteochondral scaffolds for early treatment of cartilage defects in osteoarthritic joints: From bench to clinic","volume":"1","author":"Tamaddon","year":"2020","journal-title":"Biomater. Transl."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1007\/s00167-021-06513-y","article-title":"Matrix-induced chondrogenesis is a valid and safe cartilage repair option for small- to medium-sized cartilage defects of the knee: A systematic review","volume":"29","author":"Karpinski","year":"2021","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1186\/s13018-021-02684-z","article-title":"Surgical management of focal chondral defects of the knee: A Bayesian network meta-analysis","volume":"16","author":"Migliorini","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Lee, D.H., Kim, S.A., Song, J.-S., Shetty, A.A., Kim, B.-H., and Kim, S.J. (2022). Cartilage Regeneration Using Human Umbilical Cord Blood Derived Mesenchymal Stem Cells: A Systematic Review and Meta-Analysis. Medicina, 58.","DOI":"10.3390\/medicina58121801"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1007\/s00264-015-2785-8","article-title":"Efficacy of mesenchymal stem cells injection for the management of knee osteoarthritis: A systematic review and meta-analysis","volume":"39","author":"Xia","year":"2015","journal-title":"Int. Orthop."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Yubo, M., Yanyan, L., Li, L., Tao, S., Bo, L., and Lin, C. (2017). Clinical efficacy and safety of mesenchymal stem cell transplantation for osteoarthritis treatment: A meta-analysis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0175449"},{"key":"ref_16","first-page":"121","article-title":"Mesenchymal stem cells in knee osteoarthritis treatment: A systematic review and meta-analysis","volume":"24","author":"Song","year":"2020","journal-title":"J. Orthop. Transl."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"452","DOI":"10.21037\/atm-20-5116","article-title":"Which is the most effective one in knee osteoarthritis treatment from mesenchymal stem cells obtained from different sources?\u2014A systematic review with conventional and network meta-analyses of randomized controlled trials","volume":"9","author":"Wei","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0963689720943581","article-title":"Comparison of Bone Marrow Aspirate Concentrate and Allogenic Human Umbilical Cord Blood Derived Mesenchymal Stem Cell Implantation on Chondral Defect of Knee: Assessment of Clinical and Magnetic Resonance Imaging Outcomes at 2-Year Follow-Up","volume":"29","author":"Ryu","year":"2020","journal-title":"Cell Transplant."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s00167-021-06450-w","article-title":"Allogenic umbilical cord blood-derived mesenchymal stromal cell implantation was superior to bone marrow aspirate concentrate augmentation for cartilage regeneration despite similar clinical outcomes","volume":"30","author":"Yang","year":"2022","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1016\/j.arthro.2021.02.022","article-title":"Allogenic Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Are More Effective than Bone Marrow Aspiration Concentrate for Cartilage Regeneration after High Tibial Osteotomy in Medial Unicompartmental Osteoarthritis of Knee","volume":"37","author":"Lee","year":"2021","journal-title":"Arthrosc. J. Arthrosc. Relat. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/JSA.0000000000000105","article-title":"Platelet-rich Plasma and Bone Marrow\u2013derived Mesenchymal Stem Cells in Sports Medicine","volume":"24","author":"Gobbi","year":"2016","journal-title":"Sports Med. Arthrosc. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.eats.2017.08.055","article-title":"Cartilage Repair in the Knee Using Umbilical Cord Wharton\u2019s Jelly\u2013Derived Mesenchymal Stem Cells Embedded onto Collagen Scaffolding and Implanted under Dry Arthroscopy","volume":"7","author":"Sadlik","year":"2018","journal-title":"Arthrosc. Tech."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1177\/036354658201000306","article-title":"Evaluation of knee ligament surgery results with special emphasis on use of a scoring scale","volume":"10","author":"Lysholm","year":"1982","journal-title":"Am. J. Sports Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1002\/acr.20632","article-title":"Measures of knee function: International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, Knee Injury and Osteoarthritis Outcome Score (KOOS), Knee Injury and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS), Knee Ou","volume":"63","author":"Collins","year":"2011","journal-title":"Arthritis Care Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"571S","DOI":"10.1177\/1947603519865308","article-title":"The MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) 2.0 Knee Score and Atlas","volume":"13","author":"Schreiner","year":"2021","journal-title":"Cartilage"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.knee.2021.11.003","article-title":"Magnetic resonance observation of cartilage repair tissue (MOCART) 2.0 for the evaluation of retropatellar autologous chondrocyte transplantation and correlation to clinical outcome","volume":"34","author":"Goller","year":"2022","journal-title":"Knee"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5734","DOI":"10.1007\/s00330-021-07688-1","article-title":"Reliability of the MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) 2.0 knee score for different cartilage repair techniques\u2014A retrospective observational study","volume":"31","author":"Schreiner","year":"2021","journal-title":"Eur. Radiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.arthro.2006.06.020","article-title":"Is Microfracture of Chondral Defects in the Knee Associated with Different Results in Patients Aged 40 Years or Younger?","volume":"22","author":"Kreuz","year":"2006","journal-title":"Arthrosc. J. Arthrosc. Relat. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000516668","article-title":"Aging and Mesenchymal Stem Cells: Therapeutic Opportunities and Challenges in the Older Group","volume":"68","author":"Chen","year":"2022","journal-title":"Gerontology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.mad.2007.12.002","article-title":"Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies","volume":"129","author":"Stolzing","year":"2008","journal-title":"Mech. Ageing Dev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.stem.2011.06.008","article-title":"The MSC: An Injury Drugstore","volume":"9","author":"Caplan","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"914","DOI":"10.5435\/JAAOS-D-20-00266","article-title":"Cartilage Injury in the Knee: Assessment and Treatment Options","volume":"28","author":"Krych","year":"2020","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2325967118773041","DOI":"10.1177\/2325967118773041","article-title":"Learning From Failure in Cartilage Repair Surgery: An Analysis of the Mode of Failure of Primary Procedures in Consecutive Cases at a Tertiary Referral Center","volume":"6","author":"Krych","year":"2018","journal-title":"Orthop. J. Sports Med."},{"key":"ref_34","first-page":"456","article-title":"Recent Development of Biomaterials Combined with Mesenchymal Stem Cells as a Strategy in Cartilage Regeneration","volume":"2","author":"Chen","year":"2022","journal-title":"Int. J. Transl. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1007\/s00402-020-03564-7","article-title":"Stable clinical long term results after AMIC in the aligned knee","volume":"141","author":"Kaiser","year":"2021","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1177\/0363546516656179","article-title":"One-Stage Cartilage Repair Using a Hyaluronic Acid\u2013Based Scaffold with Activated Bone Marrow\u2013Derived Mesenchymal Stem Cells Compared with Microfracture","volume":"44","author":"Gobbi","year":"2016","journal-title":"Am. J. Sports Med."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/3\/220\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:02:30Z","timestamp":1760104950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/3\/220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":36,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["jpm14030220"],"URL":"https:\/\/doi.org\/10.3390\/jpm14030220","relation":{},"ISSN":["2075-4426"],"issn-type":[{"type":"electronic","value":"2075-4426"}],"subject":[],"published":{"date-parts":[[2024,2,20]]}}}