{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T23:08:05Z","timestamp":1781910485997,"version":"3.54.5"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Eales disease manifests as an obliterative periphlebitis affecting the retina; it originates from the periphery and progresses posteriorly. It is characterized by retinal vessel wall inflammation, ischemia, and retinal neovascularization. In this report, we present the case of a 34-year-old male who attended our clinic with a sudden blurring of vision in his right eye. A diagnosis of bilateral retinal vasculitis with vitreal hemorrhage was ascertained in his RE. A dilated ocular fundus examination revealed perivenous sheathing of the peripheral vessels in both eyes. Fluorescein angiography indicated dye staining, vessel obliteration, capillary drop-out, areas of non-perfusion and the formation of new vessels. Laboratory tests revealed positive results for Borrelia; a PPD skin test and QuantiFERON TB assay were also positive. The patient underwent bilateral retinal laser pan-photocoagulation, followed by systemic treatment with oral steroids, cephazoline, isoniazid, azathioprine, and entecavir. The steroid dose was progressively reduced over 10 months; the treatment with azathioprine continues, as we are monitoring the patient over the long term. After 3 months, the vasculitis had regressed without any vitreal hemorrhage recurrence. Vision acuity improved from 0.4 to 1 in the patient\u2019s right eye. A multidisciplinary approach, which included collaborative management with gastroenterology, infectious disease, pulmonology, and rheumatology specialists, was essential for the diagnosis, treatment, and long-term follow up of the patient.<\/jats:p>","DOI":"10.3390\/jpm14030235","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T08:34:35Z","timestamp":1708590875000},"page":"235","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Multidisciplinary Approach to the Management of Eales Disease: A Case Report and Review of the Literature"],"prefix":"10.3390","volume":"14","author":[{"given":"Maria Filoftea","family":"Mercu\u021b","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana Maria","family":"Ic\u0103","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia Andreea","family":"T\u0103nasie","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0103zvan","family":"Mercu\u021b","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Lumini\u021ba","family":"Mocanu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea Mihaela","family":"Nicolcescu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Clinical County Emergency Hospital, 200642 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian","family":"Danielescu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Medicine and Pharmacy Grigorie T. Popa Iasi, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"ref_1","unstructured":"Raizada, K., and Tripathy, K. (2023). StatPearls Internet, StatPearls Publishing."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Nebbioso, M., Franzone, F., Lambiase, A., Bonfiglio, V., Limoli, P., Artico, M., Taurone, S., Vingolo, E., Greco, A., and Polimeni, A. (2022). Oxidative Stress Implication in Retinal Diseases\u2014A Review. Antioxidants, 11.","DOI":"10.3390\/antiox11091790"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Murugeswari, P., Kim, S.D.R., Stitt, N.P.A., and Muthukkaruppan, V. (2014). Angiogenic potential of vitreous from Proliferative Diabetic Retinopathy and Eales\u2019 Disease patients. 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