{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:50:45Z","timestamp":1760143845921,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Medical Device Development Fund","award":["RS-2020-KD000232"],"award-info":[{"award-number":["RS-2020-KD000232"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Polycystic ovarian syndrome (PCOS) can be diagnosed when the anti-M\u00fcllerian hormone (AMH) levels are high, but in clinic, women who do not meet the diagnosis of PCOS but have elevated AMH levels are often seen. This study aimed to compare the differences in menstrual cycle patterns and hormone levels in women with regular menstrual cycles, but not PCOS, by dividing them into high and low AMH groups. Material and Methods: This multicenter prospective study included 68 healthy women. Participants with regular menstrual cycles were divided into two groups according to their AMH levels. The main outcome measures were menstrual cycle pattern, body mass index, and hormone levels (thyroid stimulating hormone, prolactin, testosterone, sex hormone-binding globulin, and free androgen index), which were compared between the groups according to AMH levels. The ovulation was assessed by performing pelvic ultrasound, and by assessing the hormone levels of the luteinizing hormone and progesterone. Results: The criteria for determining normal and high AMH levels were based on previous literatures. The participants were divided into normal (39 people) and high (29 people) AMH group. No differences were found in age or BMI between the two groups, and no other differences were observed in TSH, prolactin, testosterone, or free androgen index. However, the high AMH group had significantly higher SHBG levels than the normal group (normal group: 65.46 \u00b1 25.78 nmol\/L; high group: 87.08 \u00b1 45.05 nmol\/L) (p = 0.025). Conclusions: This study is the first to analyze the association between SHBG and AMH levels in women with regular menstrual cycles. Elevated AMH levels are associated with increased levels of SHBG levels.<\/jats:p>","DOI":"10.3390\/jpm14030274","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T06:07:53Z","timestamp":1709273273000},"page":"274","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Correlation between Sex Hormone-Binding Globulin and Clinical Characteristics According to Anti-M\u00fcllerian Hormone in Women with Regular Menstrual Cycles: A Prospective Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2032-0971","authenticated-orcid":false,"given":"Jihyun","family":"Keum","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-2126","authenticated-orcid":false,"given":"Yong Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Korea University Medical College, Seoul 02841, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sae Kyung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Moo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-1443","authenticated-orcid":false,"given":"Jaeman","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101634","DOI":"10.1016\/j.beem.2022.101634","article-title":"Genetics of anti-M\u00fcllerian hormone and its signaling pathway","volume":"36","author":"Josso","year":"2022","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/molehr\/gah015","article-title":"Anti-M\u00fcllerian hormone expression pattern in the human ovary: Potential implications for initial and cyclic follicle recruitment","volume":"10","author":"Weenen","year":"2004","journal-title":"Mol. Hum. Reprod."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1210\/clinem\/dgab232","article-title":"Clinical practice guidelines on the diagnosis and management of polycystic ovary syndrome: A systematic review and quality assessment study","volume":"106","author":"Fisher","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"59.e1","DOI":"10.1016\/j.ajog.2014.02.026","article-title":"Characterization of women with elevated antim\u00fcllerian hormone levels (AMH): Correlation of AMH with polycystic ovarian syndrome phenotypes and assisted reproductive technology outcomes","volume":"211","author":"Tal","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1017\/S1462399408000598","article-title":"Polycystic ovarian syndrome: Pathophysiology, molecular aspects and clinical implications","volume":"10","year":"2008","journal-title":"Expert Rev. Mol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1210\/jc.2013-2350","article-title":"Diagnosis and treatment of polycystic ovary syndrome: An Endocrine Society clinical practice guideline","volume":"98","author":"Legro","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1515\/cclm-2019-1059","article-title":"Age-specific reference values improve the diagnostic performance of AMH in polycystic ovary syndrome","volume":"58","author":"Evliyaoglu","year":"2020","journal-title":"Clin. Chem. Lab. Med. (CCLM)"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.rbmo.2020.10.003","article-title":"Association between human SHBG gene polymorphisms and risk of PCOS: A meta-analysis","volume":"42","author":"Li","year":"2021","journal-title":"Reprod. BioMed. Online"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"G43","DOI":"10.1093\/ejendo\/lvad096","article-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"189","author":"Teede","year":"2023","journal-title":"Eur. J. Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1080\/01443615.2019.1587604","article-title":"AMH in combination with SHBG for the diagnosis of polycystic ovary syndrome","volume":"39","author":"Calzada","year":"2019","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1210\/jc.2003-030197","article-title":"Association of the (TAAAA) n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels","volume":"88","author":"Xita","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1210\/jcem-42-3-432","article-title":"Strength-duration characteristics of estrogen effects on gonadotropin response to gonadotropin-releasing hormone in women. II. Effects of varying concentrations of estradiol","volume":"42","author":"Young","year":"1976","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_13","first-page":"299","article-title":"The source of pulsatile secretion of progesterone during the human follicular phase","volume":"74","author":"Judd","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.fertnstert.2019.03.032","article-title":"Association between diminished ovarian reserve and luteal phase deficiency","volume":"112","author":"Pfister","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s10815-014-0300-6","article-title":"Anti-mullerian hormone as a diagnostic and prognostic tool for PCOS patients","volume":"31","author":"Wiweko","year":"2014","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1093\/humrep\/deaa129","article-title":"Age-related natural fertility outcomes in women over 35 years: A systematic review and individual participant data meta-analysis","volume":"35","author":"Chua","year":"2020","journal-title":"Hum. Reprod."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ramezani Tehrani, F., Rahmati, M., Mahboobifard, F., Firouzi, F., Hashemi, N., and Azizi, F. (2021). Age-specific cut-off levels of anti-M\u00fcllerian hormone can be used as diagnostic markers for polycystic ovary syndrome. Reprod. Biol. Endocrinol., 19.","DOI":"10.1186\/s12958-021-00755-8"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s40618-016-0497-6","article-title":"Fertility in women of late reproductive age: The role of serum anti-M\u00fcllerian hormone (AMH) levels in its assessment","volume":"39","author":"Meczekalski","year":"2016","journal-title":"J. Endocrinol. Investig."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jadohealth.2016.10.015","article-title":"Anti-M\u00fcllerian hormone in obese adolescent girls with polycystic ovary syndrome","volume":"60","author":"Kim","year":"2017","journal-title":"J. Adolesc. Health"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Rudnicka, E., Kunicki, M., Calik-Ksepka, A., Suchta, K., Duszewska, A., Smolarczyk, K., and Smolarczyk, R. (2021). Anti-m\u00fcllerian hormone in pathogenesis, diagnostic and treatment of PCOS. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212507"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00404-015-3889-5","article-title":"Comparison of clinical and hormonal characteristics among four phenotypes of polycystic ovary syndrome based on the Rotterdam criteria","volume":"293","author":"Jamil","year":"2016","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1530\/REP-09-0415","article-title":"Anti-M\u00fcllerian hormone and polycystic ovary syndrome: A mountain too high?","volume":"139","author":"Pellatt","year":"2010","journal-title":"Reproduction"},{"key":"ref_23","unstructured":"Seifer, D.B., and Tal, R. (2016). Anti-Mullerian Hormone: Role in Ovarian Function and Clinical Significance, Nova Science."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.fertnstert.2011.04.003","article-title":"Antim\u00fcllerian hormone and polycystic ovary syndrome","volume":"96","author":"Lin","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Yue, C.-Y., Lu, L.-k.-y., Li, M., Zhang, Q.-L., and Ying, C.-M. (2018). Threshold value of anti-Mullerian hormone for the diagnosis of polycystic ovary syndrome in Chinese women. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0203129"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1097\/GME.0000000000001116","article-title":"Is ovarian reserve associated with body mass index and obesity in reproductive aged women? A meta-analysis","volume":"25","author":"Moslehi","year":"2018","journal-title":"Menopause"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The pathogenesis of polycystic ovary syndrome (PCOS): The hypothesis of PCOS as functional ovarian hyperandrogenism revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1055\/s-0041-1735259","article-title":"The need to reassess the diagnosis of polycystic ovary syndrome (PCOS): A review of diagnostic recommendations from the international evidence-based guideline for the assessment and management of PCOS","volume":"Volume 39","author":"Kiconco","year":"2021","journal-title":"Seminars in Reproductive Medicine"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/cen.12984","article-title":"Antim\u00fcllerian hormone, antral follicle count and ovarian volume predict menstrual cycle length in healthy women","volume":"84","author":"Zhu","year":"2016","journal-title":"Clin. Endocrinol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/MED.0b013e328353732f","article-title":"Evolving utility of sex hormone-binding globulin measurements in clinical medicine","volume":"19","author":"Hammond","year":"2012","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"8196","DOI":"10.4081\/ejtm.2019.8196","article-title":"The relationship between components of metabolic syndrome and plasma level of sex hormone-binding globulin","volume":"29","author":"Alinezhad","year":"2019","journal-title":"Eur. J. Transl. Myol."},{"key":"ref_32","first-page":"5527973","article-title":"Classic and novel sex hormone binding globulin effects on the cardiovascular system in men","volume":"2021","author":"Llanos","year":"2021","journal-title":"Int. J. Endocrinol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Qu, X., and Donnelly, R. (2020). Sex hormone-binding globulin (SHBG) as an early biomarker and therapeutic target in polycystic ovary syndrome. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218191"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.3892\/or.2013.2793","article-title":"Activation of estrogen receptors with E2 downregulates peroxisome proliferator-activated receptor \u03b3 in hepatocellular carcinoma","volume":"30","author":"Lin","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1590\/S0100-879X2004001100007","article-title":"Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome","volume":"37","author":"Meenakumari","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0889-8529(18)30233-0","article-title":"Luteal phase defect: Etiology, diagnosis, and management","volume":"21","author":"Ginsburg","year":"1992","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mce.2009.09.020","article-title":"Sex hormone-binding globulin gene expression in the liver: Drugs and the metabolic syndrome","volume":"316","author":"Pugeat","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/13625187.2020.1736546","article-title":"Evaluation of different antiandrogenic progestins on clinical and biochemical variables in polycystic ovary syndrome","volume":"25","author":"Morgante","year":"2020","journal-title":"Eur. J. Contracept. Reprod. Health Care"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e3257","DOI":"10.1210\/clinem\/dgaa355","article-title":"Menstrual pattern, reproductive hormones, and transabdominal 3D ultrasound in 317 adolescent girls","volume":"105","author":"Assens","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5603\/GP.2019.0002","article-title":"Metabolic and hormonal effects of a combined Myo-inositol and d-chiro-inositol therapy on patients with polycystic ovary syndrome (PCOS)","volume":"90","author":"Januszewski","year":"2019","journal-title":"Ginekol. Pol."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/3\/274\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:07:22Z","timestamp":1760105242000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/3\/274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,29]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["jpm14030274"],"URL":"https:\/\/doi.org\/10.3390\/jpm14030274","relation":{},"ISSN":["2075-4426"],"issn-type":[{"type":"electronic","value":"2075-4426"}],"subject":[],"published":{"date-parts":[[2024,2,29]]}}}