{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:55:12Z","timestamp":1760144112496,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>(1) Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) has a high rate of recurrence in patients, despite therapy with local corticosteroids and functional endoscopic sinus surgery. Dupilumab, a recombinant monoclonal human IgG4 antibody directed against the IL-4 receptor \u03b1 that inhibits both IL-4 and IL-13 signal transduction, is available for symptomatic therapy. Patient preference between repeated surgery and injection therapy with Dupilumab is not known. (2) Methods: Patients who had experienced at least one surgical intervention for nasal polyps and were treated with Dupilumab for at least 3 months completed a retrospective patient questionnaire. (3) Results: In a cohort of 75 previously operated CRSwNP patients, 91.5% preferred therapy with Dupilumab to repeated surgery for nasal polyps. Preference for Dupilumab in the subgroups of patients with concomitant Non-steroidal Anti-inflammatory Drugs Exacerbated Respiratory Disease (N-ERD) (n = 32), patients with concomitant asthma (n = 25), and patients without concomitant disease (n = 18) was 100%, 96%, and 72%, respectively. (4) Conclusions: Patient preference for Dupilumab over repeat surgery is strongest in previously operated CRSwNP patients with concomitant asthma or N-ERD, but remains very high in patients without concomitant disease.<\/jats:p>","DOI":"10.3390\/jpm14040338","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T12:40:11Z","timestamp":1711370411000},"page":"338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real-Life Study of Patient Preference for Dupilumab or Revision Surgery for Recurrent Chronic Rhinosinusitis with Nasal Polyps"],"prefix":"10.3390","volume":"14","author":[{"given":"Katharina","family":"Gangl","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6948-737X","authenticated-orcid":false,"given":"David Tianxiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Bartosik","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas James","family":"Campion","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich","family":"Vyskocil","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Albert","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Knerer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5981-1607","authenticated-orcid":false,"given":"Julia","family":"Eckl-Dorna","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7631-3746","authenticated-orcid":false,"given":"Sven","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1016\/j.jaip.2021.06.037","article-title":"Prevalence and Symptom Burden of Nasal Polyps in a Large Austrian Population","volume":"9","author":"Campion","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1111\/all.13875","article-title":"EUFOREA consensus on biologics for CRSwNP with or without asthma","volume":"74","author":"Fokkens","year":"2019","journal-title":"Allergy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1177\/000348940311200709","article-title":"Prevalence of nasal polyps in adults: The Sk\u00f6vde population-based study","volume":"112","author":"Johansson","year":"2003","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jaip.2016.05.004","article-title":"Phenotypes and emerging endotypes of chronic rhinosinusitis","volume":"4","author":"Bachert","year":"2016","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"ref_6","first-page":"544","article-title":"Endotypes of chronic rhinosinusitis with nasal polyps with and without NSAID intolerance","volume":"58","author":"Steiner","year":"2020","journal-title":"Rhinology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jaci.2014.08.020","article-title":"Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: A meta-analysis of the literature","volume":"135","author":"Rajan","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/lary.25054","article-title":"EQ-5D-derived health utility values in patients undergoing surgery for chronic rhinosinusitis. EQ-5D-derived health utility values in patients undergoing surgery for chronic rhinosinusitis","volume":"125","author":"Remenschneider","year":"2015","journal-title":"Laryngoscope"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0194-59989570152-4","article-title":"The health impact of chronic sinusitis in patients seeking otolaryngologic care","volume":"113","author":"Gliklich","year":"1995","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1001\/jamaoto.2018.4162","article-title":"Does Chronic Rhinosinusitis Lead to Psychiatric Disease?","volume":"145","author":"McCoul","year":"2019","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/lio2.733","article-title":"Chronic rhinosinusitis symptoms differentially impact the likelihood of major depressive disorders","volume":"27","author":"Liu","year":"2022","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1111\/all.14408","article-title":"Real-life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA","volume":"75","author":"Seys","year":"2020","journal-title":"Allergy"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/alr.22487","article-title":"Revision surgery rates in chronic rhinosinusitis with nasal polyps: Meta-analysis of risk factors","volume":"10","author":"Loftus","year":"2020","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1002\/lary.20653","article-title":"Long-term outcomes from the English national comparative audit of surgery for nasal polyposis and chronic rhinosinusitis","volume":"119","author":"Hopkins","year":"2009","journal-title":"Laryngoscope"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/lary.23610","article-title":"Role of frontal sinus surgery in nasal polyp recurrence","volume":"123","author":"Bassiouni","year":"2013","journal-title":"Laryngoscope"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/lary.26391","article-title":"Prevalence of polyp recurrence after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis","volume":"127","author":"DeConde","year":"2017","journal-title":"Laryngoscope"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Bayer, K., Hamidovic, S., Besser, G., Mueller, C.A., and Liu, D.T. (2022). Factors Associated with Revision Sinus Surgery in Patients with Chronic Rhinosinusitis. J. Pers. Med., 12.","DOI":"10.3390\/jpm12020167"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13601-019-0269-4","article-title":"Twelve-year follow-up study after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyposis","volume":"9","author":"Calus","year":"2019","journal-title":"Clin. Transl. Allergy"},{"key":"ref_19","unstructured":"U.S. Food and Drug Administration (FDA) (2024, February 04). FDA Approves First Treatment for Chronic Rhinosinusitis with Nasal Polyps. DUPIXENT FDA Approval, Available online: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-treatment-chronic-rhinosinusitis-nasal-polyps."},{"key":"ref_20","unstructured":"European Medicines Agency (EMA) (2019). Dupixent. Dupilumab. Dupixent IL-17-SMOP, EMA. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/smop\/chmp-post-authorisation-summary-positive-opinion-dupixent-ii-17_en.pdf."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0140-6736(19)31881-1","article-title":"Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): Results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials","volume":"394","author":"Bachert","year":"2019","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/alr.22780","article-title":"Efficacy of dupilumab in patients with a history of prior sinus surgery for chronic rhinosinusitis with nasal polyps","volume":"11","author":"Hopkins","year":"2021","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jaip.2019.08.007","article-title":"Asthma Is the Dominant Factor for Recurrence in Chronic Rhinosinusitis","volume":"8","author":"Sella","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1007\/s00405-023-07856-7","article-title":"Predictive factors of revision endoscopic sinus surgery","volume":"280","author":"Aguiar","year":"2023","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jaci.2022.02.029","article-title":"Prognostic factors for polyp recurrence in chronic rhinosinusitis with nasal polyps","volume":"150","author":"Bai","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/alr.21408","article-title":"SNOT-22 quality of life domains differentially predict treatment modality selection in chronic rhinosinusitis","volume":"4","author":"DeConde","year":"2014","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1002\/lary.24027","article-title":"Patient-Centered Decision Making in the Treatment of Chronic Rhinosinusitis","volume":"123","author":"Soler","year":"2013","journal-title":"Laryngoscope"},{"key":"ref_28","first-page":"552","article-title":"Multi-institutional minimal clinically important difference of the 22-item Sinonasal Outcome Test in medically managed chronic rhinosinusitis","volume":"59","author":"Phillips","year":"2021","journal-title":"Rhinology"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Schneider, S., Campion, N.J., Villazala-Merino, S., Liu, D.T., Bartosik, T., Landegger, L.D., Ahmadi, N., Mueller, C.A., Vyskocil, E., and Stanek, V. (2020). Associations between the quality of life and nasal polyp size in patients suffering from chronic rhinosinusitis without nasal polyps, with nasal polyps or aspirin-exacerbated respiratory disease. J. Clin. Med., 9.","DOI":"10.3390\/jcm9040925"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1111\/all.15772","article-title":"Dupilumab in the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP): A multicentric observational Phase IV real-life study (DUPIREAL)","volume":"78","author":"Pasquini","year":"2023","journal-title":"Allergy"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1111\/all.15796","article-title":"Two-year results of tapered dupilumab for CRSwNP demonstrates enduring efficacy established in the first 6 months","volume":"78","author":"Otten","year":"2023","journal-title":"Allergy"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/alr.22951","article-title":"Outcomes of dupilumab treatment versus endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps","volume":"12","author":"Dharmarajan","year":"2022","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Alicandri-Ciufelli, M., Marchioni, D., Pipolo, C., Garzaro, M., Nitro, L., Dell\u2019Era, V., Ferrella, F., Campagnoli, M., Russo, P., and Galloni, C. (Laryngoscope, 2023). Influence of Prior Endoscopic Sinus Surgery Extent on Dupilumab Effectiveness in CRSwNP Patients, Laryngoscope, online ahead of print.","DOI":"10.1002\/lary.30983"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jaip.2019.06.044","article-title":"Update on Atopic Dermatitis: Diagnosis, Severity Assessment, and Treatment Selection","volume":"8","author":"Fishbein","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/all.14221","article-title":"Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines\u2014Recommendations on the use of biologicals in severe asthma","volume":"75","author":"Agache","year":"2020","journal-title":"Allergy"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s40257-020-00527-x","article-title":"Dupilumab provides favorable safety and sustained efficacy for up to 3 years in an open-label study of adults with moderate-to-severe atopic dermatitis","volume":"21","author":"Beck","year":"2020","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"E26","DOI":"10.1002\/lary.28648","article-title":"Cost Utility Analysis of Dupilumab Versus Endoscopic Sinus Surgery for Chronic Rhinosinusitis with Nasal Polyps","volume":"131","author":"Scangas","year":"2021","journal-title":"Laryngoscope"}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/4\/338\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:17:43Z","timestamp":1760105863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/4\/338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,23]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["jpm14040338"],"URL":"https:\/\/doi.org\/10.3390\/jpm14040338","relation":{},"ISSN":["2075-4426"],"issn-type":[{"type":"electronic","value":"2075-4426"}],"subject":[],"published":{"date-parts":[[2024,3,23]]}}}