{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:56:41Z","timestamp":1760144201535,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Dental agenesis is one of the most common developmental anomalies in humans and it is frequently associated with several other oral abnormalities. The present case describes non-familial agenesis of permanent teeth in a twenty-one-year-old boy with no apparent systemic abnormalities. The treatment included a personalized and interdisciplinary approach involving endodontics, orthodontics, implant-supported restorations and prosthetic treatments. The treatment plan was thoroughly elaborated using photographic analysis, study models, orthopantomogram, CBCT and cephalograms. Virtual smile design, diagnostic waxing and mock-ups previsualized the treatment objectives. The edentulous spaces were reconstructed by inserting dental implants and monolithic zirconia implant-supported restorations. The final results showed a highly esthetic and functional rehabilitation. Periodic check-ups have shown that the stability of the result is well maintained and that the implant-supported restorations are an optimal solution for patients with multiple anodontia.<\/jats:p>","DOI":"10.3390\/jpm14040350","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T13:39:56Z","timestamp":1711546796000},"page":"350","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Personalized and Complex Esthetic Oral Rehabilitation in a Case of Non-Syndromic Oligodontia"],"prefix":"10.3390","volume":"14","author":[{"given":"Silvia Izabella","family":"Pop","sequence":"first","affiliation":[{"name":"Orthodontic Department, Faculty of Dental Medicine, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gh. Marinescu Str., 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Procopciuc","sequence":"additional","affiliation":[{"name":"Department of Dental Surgery, Faculty of Dental Medicine, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gh. Marinescu Str., 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Mi\u021bariu","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine and Nursing, Faculty of Dental Medicine, Lucian Balga University, Bd-ul. Victoriei, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana","family":"Mi\u021bariu","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine and Nursing, Faculty of Dental Medicine, Lucian Balga University, Bd-ul. Victoriei, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu Vasile","family":"Pop","sequence":"additional","affiliation":[{"name":"Orthodontic Department, Faculty of Dental Medicine, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gh. Marinescu Str., 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"ref_1","first-page":"48","article-title":"Non-syndromic oligodontia: Report of two cases and literature review","volume":"3","author":"Biradar","year":"2012","journal-title":"Int. J. Oral Maxillofac. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Thomas, C., and Vaysse, F. (2021). From child to adulthood, a multidisciplinary approach of multiple microdontia associated with hypodontia: Case report relating a 15 Year-long management and follow-up. Healthcare, 9.","DOI":"10.3390\/healthcare9091180"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4317\/medoral.19158","article-title":"Genetic basis of dental agenesis-molecular genetics patterning clinical dentistry","volume":"19","author":"Chhabra","year":"2014","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_4","first-page":"239","article-title":"The prevalence and pattern of hypodontia of the permanent teeth and crown size and shape deformity affecting upper lateral incisors in a sample of Jordanian dental patients","volume":"23","author":"Albashaireh","year":"2006","journal-title":"Community Dent. Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1365-263X.2007.00876.x","article-title":"Assessing the proposed association between tooth agenesis and taurodontism in 975 paediatric subjects","volume":"18","author":"Calvano","year":"2008","journal-title":"Int. J. Paediatr. Dent."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"996","DOI":"10.2319\/082905-303","article-title":"Hypodontia patterns and variations in craniofacial morphology in Japanese orthodontic patients","volume":"76","author":"Endo","year":"2006","journal-title":"Angle Orthod."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Carter, N., and Gillgrass, T. (2003). The interdisciplinary management of hypodontia: Orthodontics. Br. Dent. J., 361\u2013366.","DOI":"10.1038\/sj.bdj.4809995"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1590\/S1678-77572011000500018","article-title":"A multidisciplinary approach for the management of hypodontia: Case report","volume":"19","author":"Valle","year":"2011","journal-title":"J. Appl. Oral Sci."},{"key":"ref_9","first-page":"476","article-title":"A patient-calibrated individual wax-up as an essential tool for planning and creating a patient-oriented treatment concept for pathological tooth wear","volume":"13","author":"Pour","year":"2018","journal-title":"Int. J. Esthet. Dent."},{"key":"ref_10","first-page":"e27402","article-title":"Additive wax-up and diagnostic mockup as driving tools for minimally invasive veneer preparations","volume":"14","author":"Jurado","year":"2022","journal-title":"Cureus"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/joor.12384","article-title":"Prosthetic treatment outcome in patients with severe hypodontia: A systematic review","volume":"43","author":"Filius","year":"2016","journal-title":"J. Oral Rehabil."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40729-017-0090-6","article-title":"Three-dimensional computer-guided implant placement in oligodontia","volume":"3","author":"Filus","year":"2017","journal-title":"Int. J. Implant Dent."},{"key":"ref_13","first-page":"121","article-title":"Current state of the art of computer-guided implant surgery","volume":"73","author":"Ackhurst","year":"2000","journal-title":"Periodontology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1016\/j.jcms.2015.10.022","article-title":"Accuracy evaluation of computer-designed surgical guide template in oral implantology","volume":"43","author":"Shen","year":"2015","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_15","first-page":"521","article-title":"Advantages of the root submergence technique for pontic site development in esthetic implant therapy","volume":"27","author":"Salama","year":"2007","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1600-051X.2010.01595.x","article-title":"The socket-shield technique: A proof-of-principle report","volume":"37","author":"Zuhr","year":"2010","journal-title":"J. Clin. Periodontol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Attia, S., and Schaaf, H. (2019). Oral rehabilitation of hypodontia patients using an endosseous dental implant: Functional and aesthetic results. J. Clin. Med., 8.","DOI":"10.3390\/jcm8101687"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kerekes-M\u00e1th\u00e9, B., and M\u00e1rtha, K. (2023). Genetic and Morphological Variation in Hypodontia of Maxillary Lateral Incisors. Genes, 14.","DOI":"10.3390\/genes14010231"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Schonberger, S., and Shapira, Y. (2022). Prevalence and Patterns of Permanent Tooth Agenesis among Orthodontic Patients\u2014Treatment Options and Outcome. Appl. Sci., 12.","DOI":"10.3390\/app122312252"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Fekonja, A. (2022). Morphological Diversity of Permanent Maxillary Lateral Incisors and Their Impact on Aesthetics and Function in Orthodontically Treated Patients. Diagnostics, 12.","DOI":"10.3390\/diagnostics12112759"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3390\/prosthesis4040044","article-title":"Computer-Guided Surgery for Dental Implant Placement: A Systematic Review","volume":"4","year":"2022","journal-title":"Prosthesis"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Dioguardi, M., and Spirito, F. (2023). Guided dental implant surgery: Systematic review. J. Clin. Med., 12.","DOI":"10.3390\/jcm12041490"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Velasco-Ortega, E., and Jim\u00e9nez-Guerra, A. (2021). Immediate loading of implants placed by guided surgery in geriatric edentulous mandible patients. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18084125"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/ID.0b013e31829f1f7f","article-title":"Full-mouth rehabilitation with immediate loading of implants inserted with computer-guided flapless surgery: A 3-year multicenter clinical evaluation with oral health impact profile","volume":"22","author":"Marra","year":"2013","journal-title":"Implant Dent."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kim, S.M., and Son, K. (2019). Digital evaluation of the accuracy of computer-guided dental implant placement: An in vitro study. Appl. Sci., 9.","DOI":"10.3390\/app9163373"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Kivovics, M., and P\u00e9nzes, D. (2020). The Influence of Surgical Experience and Bone Density on the Accuracy of Static Computer-Assisted Implant Surgery in Edentulous Jaws Using a Mucosa-Supported Surgical Template with a Half-Guided Implant Placement Protocol\u2014A Randomized Clinical Study. Materials, 13.","DOI":"10.3390\/ma13245759"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/rcs.188","article-title":"Computer-assisted implantology: Historical background and potential outcomes\u2014A review","volume":"4","author":"Azari","year":"2008","journal-title":"Int. J. Med. Robot."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Caggiano, M., and Amato, A. (2022). Evaluation of Deviations between Computer-Planned Implant Position and In Vivo Placement through 3D-Printed Guide: A CBCT Scan Analysis on Implant Inserted in Esthetic Area. Appl. Sci., 12.","DOI":"10.3390\/app12115461"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.prosdent.2013.06.009","article-title":"Pontic site development with a root submergence technique for a screw-retained prosthesis in the anterior maxilla","volume":"110","author":"Comut","year":"2013","journal-title":"J. Prosthet. Dent."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"377","DOI":"10.11607\/prd.3111","article-title":"Partial Extraction Therapies (PET) Part 2: Procedures and Technical Aspects","volume":"37","author":"Gluckman","year":"2017","journal-title":"Int. J. Periodontics Restor. 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