{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:51:03Z","timestamp":1791219063013,"version":"4.1.0"},"reference-count":46,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:00:00Z","timestamp":1711756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Scabies is a neglected tropical disease and represents a considerable global burden. Although consensus diagnostic criteria for scabies have been recently published, diagnosing scabies infestation remains challenging in clinical practice. We investigated the diagnostic utility of complete blood cell count (CBC) and CBC-derived ratios obtained at diagnosis in a set of 167 patients who are Vietnamese with confirmed scabies. These parameters were compared with those of patients with dermatophytosis (N = 800) and urticaria (N = 2023), two diseases frequent in Vietnam, which can present with similar skin manifestations to scabies and tend to pose a diagnostic challenge in vulnerable populations. Our analysis revealed that white blood cell, monocyte, and eosinophil counts were significantly higher among patients with scabies than the other two diseases. Similarly, the monocyte-to-lymphocyte ratio (MLR) and eosinophil-to-lymphocyte ratio (ELR) were significantly higher among patients with scabies. The optimal cut-off values to distinguish scabies from dermatophytosis and urticaria were 0.094 for ELR (sensitivity: 74.85%, specificity: 70.7%) and 0.295 for MLR (sensitivity: 52.69%, specificity: 73.54%). CBC, ELR, and MLR are low-cost and easily calculated parameters that may be helpful for the diagnosis of scabies.<\/jats:p>","DOI":"10.3390\/jpm14040373","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T13:42:30Z","timestamp":1711892550000},"page":"373","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring Blood Cell Count-Derived Ratios as Practical Diagnostic Tools for Scabies in Vulnerable Populations"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2188-1073","authenticated-orcid":false,"given":"Hoang Thao Giang","family":"Nguyen","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Kanazawa University, Kanazawa 920-0942, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1668-2902","authenticated-orcid":false,"given":"Ha Long Hai","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hematology and Immunology, National Hospital of Dermatology and Venereology, Hanoi 100000, Vietnam"},{"name":"Faculty of Medical Technology, Hanoi Medical University, Hanoi 116001, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5216-2282","authenticated-orcid":false,"given":"Hoang Viet","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Medical Technology, Hanoi Medical University, Hanoi 116001, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huyen My","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hematology and Immunology, National Hospital of Dermatology and Venereology, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy Luong","family":"Vu","sequence":"additional","affiliation":[{"name":"Department of Laser and Skin Care, National Hospital of Dermatology and Venereology, Hanoi 116001, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7973-0705","authenticated-orcid":false,"given":"Pleiades T.","family":"Inaoka","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Kanazawa University, Kanazawa 920-0942, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ota","family":"Tetsuo","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Kanazawa University, Kanazawa 920-0942, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quoc Trung","family":"Ly","sequence":"additional","affiliation":[{"name":"Soctrang Hospital for Women and Children, Soc Trang 950000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1794-6666","authenticated-orcid":false,"given":"J. Luis","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Kanazawa University, Kanazawa 920-0942, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e405","DOI":"10.1016\/S1473-3099(23)00584-4","article-title":"Scabies: The neglected tropical disease that is everywhere","volume":"23","author":"Burki","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"ref_2","first-page":"5","article-title":"Pattern of common skin diseases in 10 provinces in the epidemiologic investigation (2022) of the National Hospital of Dermatology and Venereology in Vietnam","volume":"40","year":"2023","journal-title":"Vietnam. J. Dermatol. Venereol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Jartarkar, S.R., Patil, A., Goldust, Y., Cockerell, C.J., Schwartz, R.A., Grabbe, S., and Goldust, M. (2021). Pathogenesis, Immunology and Management of Dermatophytosis. J. Fungi, 8.","DOI":"10.3390\/jof8010039"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e50114","DOI":"10.2196\/50114","article-title":"Burden of and Trends in Urticaria Globally, Regionally, and Nationally from 1990 to 2019: Systematic Analysis","volume":"9","author":"Liu","year":"2023","journal-title":"JMIR Public Health Surveill"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/bjd.18943","article-title":"The 2020 international alliance for the control of scabies consensus criteria for the diagnosis of scabies","volume":"183","author":"Engelman","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"822","DOI":"10.5588\/ijtld.22.0598","article-title":"Ratios from full blood count as markers for TB diagnosis, treatment, prognosis: A systematic review","volume":"27","author":"Fritschi","year":"2023","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/01.olq.0000145853.35574.18","article-title":"Sarcoptes scabiei in a sexually transmitted infections unit: A 15-year study","volume":"31","author":"Otero","year":"2004","journal-title":"Sex. Transm. Dis."},{"key":"ref_8","first-page":"164","article-title":"Some clinical and epidemiological characteristics of scabies among scabies patients in clinic of National Hospital of Dermatology and Venereology in 2019\u20132020","volume":"30","year":"2020","journal-title":"Vietnam J. Prev. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Collinson, S., Timothy, J., Zayzay, S.K., Kollie, K.K., Lebas, E., Candy, N., Halliday, K.E., Pullan, R., Fallah, M., and Walker, S.L. (2020). The prevalence of scabies in Monrovia, Liberia: A population-based survey. PLoS Neglected Trop. Dis., 14.","DOI":"10.1101\/2020.06.25.20139808"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1186\/s13071-016-1690-3","article-title":"Prevalence and drivers of human scabies among children and adolescents living and studying in Cameroonian boarding schools","volume":"9","author":"Kouotou","year":"2016","journal-title":"Parasites Vectors"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"13444","DOI":"10.1038\/s41598-022-17744-5","article-title":"Risk factors of dermatophytosis among Korean adults","volume":"12","author":"Son","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_12","first-page":"993","article-title":"Dermatophyte infections in children compared to adults in Germany: A retrospective multicenter study in Germany","volume":"19","author":"Kromer","year":"2021","journal-title":"JDDG J. Dtsch. Dermatol. Ges."},{"key":"ref_13","first-page":"1","article-title":"Superficial mycoses in relation to age and gender","volume":"13","author":"Oninla","year":"2012","journal-title":"Methodology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41572-022-00389-z","article-title":"Urticaria","volume":"8","author":"Kolkhir","year":"2022","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000235300","article-title":"Modulation of rat peritoneal mast cell and human basophil histamine release by estrogens","volume":"93","author":"Cocchiara","year":"1990","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1177\/039463200601900408","article-title":"Progesterone inhibits mast cell secretion","volume":"19","author":"Vasiadi","year":"2006","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jdermsci.2008.04.002","article-title":"Sex hormones and urticaria","volume":"52","author":"Brzoza","year":"2008","journal-title":"J. Dermatol. Sci."},{"key":"ref_18","first-page":"143","article-title":"Characteristics of the cutaneous fungal disease and some dermatophyte species isolated from patients attending examination and treatment at Quyhoa National Leprosydermatology Hospital during 2013\u20132015","volume":"29","year":"2019","journal-title":"Vietnam J. Prev. Med."},{"key":"ref_19","unstructured":"Nguyen Duy, H., Nguyen Tuan, H., and Le Ngoc, D. (2023). Nghien cuu dac \u0111iem lam sang benh nhan may day man tinh tai Benh vien Da lieu Thanh pho Ho Chi Minh. Tap chi Y hoc Cong dong, 64."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.12746\/swrccc.v5i19.391","article-title":"The receiver operating characteristic (ROC) curve","volume":"5","author":"Yang","year":"2017","journal-title":"Southwest Respir. Crit. Care Chron."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1365-4362.1995.tb01564.x","article-title":"The role of mast cells in treatment of scabies","volume":"34","author":"Amer","year":"1995","journal-title":"Int. J. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/j.1398-9995.2011.02570.x","article-title":"Basophil recruitment and activation in inflammatory skin diseases","volume":"66","author":"Ito","year":"2011","journal-title":"Allergy"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000446012","article-title":"Peripheral mechanisms of itch","volume":"50","author":"Azimi","year":"2016","journal-title":"Itch-Manag. Clin. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"628392","DOI":"10.3389\/fmed.2021.628392","article-title":"Itch in scabies\u2014What do we know?","volume":"8","year":"2021","journal-title":"Front. Med."},{"key":"ref_25","unstructured":"Abbas, A.K., Lichtman, A.H., and Pillai, S. (2020). Basic Immunology: Functions and Disorders of the Immune System, Elsevier Health Sciences. [6th ed.]."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s13071-017-2320-4","article-title":"Host immune responses to the itch mite, Sarcoptes scabiei, in humans","volume":"10","author":"Bhat","year":"2017","journal-title":"Parasites Vectors"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Ong, C.Y., and Vasanwala, F.F. (2018). Infected with scabies again? focus in management in long-term care facilities. Diseases, 7.","DOI":"10.3390\/diseases7010003"},{"key":"ref_28","unstructured":"Rezaei, N. (2022). Encyclopedia of Infection and Immunity, Elsevier."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e12900","DOI":"10.1111\/pim.12900","article-title":"Immune mechanisms in human Sarcoptes scabiei (Acari: Sarcoptidae) infestations","volume":"44","author":"Gazi","year":"2022","journal-title":"Parasite Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1111\/j.1365-2133.2008.08541.x","article-title":"New insights into disease pathogenesis in crusted (Norwegian) scabies: The skin immune response in crusted scabies","volume":"158","author":"Walton","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bhat, S.A., Walton, S.F., Ventura, T., Liu, X., McCarthy, J.S., Burgess, S.T., and Mounsey, K.E. (2020). Early immune suppression leads to uncontrolled mite proliferation and potent host inflammatory responses in a porcine model of crusted versus ordinary scabies. PLoS Neglected Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008601"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/cup.12482","article-title":"Superficial fibrin thrombi\u2026 and other findings: A review of the histopathology of human scabietic infections","volume":"42","author":"Elwood","year":"2015","journal-title":"J. Cutan. Pathol."},{"key":"ref_33","first-page":"10240","article-title":"Examination of histopathological findings in scabies cases: A retrospective analysis of five years of experience","volume":"27","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jinf.2004.08.033","article-title":"Crusted scabies: Clinical and immunological findings in seventy-eight patients and a review of the literature","volume":"50","author":"Roberts","year":"2005","journal-title":"J. Infect."},{"key":"ref_35","first-page":"156","article-title":"Hypereosinophilia in erythrodermic psoriasis: Superimposed scabies","volume":"94","author":"Akkurt","year":"2014","journal-title":"Cutis"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1001\/archderm.143.5.670-b","article-title":"Persistent eosinophilia as a presenting sign of scabies in patients with disorders of keratinization","volume":"143","author":"Sluzevich","year":"2007","journal-title":"Arch. Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jaip.2019.08.025","article-title":"Eosinopenia, in chronic spontaneous urticaria, is associated with high disease activity, autoimmunity, and poor response to treatment","volume":"8","author":"Kolkhir","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1014924","DOI":"10.3389\/fimmu.2022.1014924","article-title":"Decreased peripheral basophil counts in urticaria and mouse model of oxazolone-induced hypersensitivity, the latter suggesting basopenia reflecting migration to skin","volume":"13","author":"Kishimoto","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.jaci.2020.03.005","article-title":"The role of eosinophils in chronic spontaneous urticaria","volume":"145","author":"Altrichter","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/myc.13246","article-title":"Host immune responses in dermatophytes infection","volume":"64","author":"Celestrino","year":"2021","journal-title":"Mycoses"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/jobm.201900675","article-title":"Recent advances in the diagnosis of dermatophytosis","volume":"60","author":"Begum","year":"2020","journal-title":"J. Basic Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Khade, A.S., Borah, L., Kulkarni, M., and Gosavi, A. (2023). Presence of peripheral eosinophilia in cutaneous Dermatophytoses in western Maharashtra: An observational study. Int. J. Sci. Res., 12.","DOI":"10.36106\/ijsr\/9102178"},{"key":"ref_43","first-page":"54","article-title":"An overview of the epidemiology, transmission, pathogenesis and treatment of scabies","volume":"5","author":"Hussain","year":"2021","journal-title":"Br. Stud. Dr. J."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Mika, A., Reynolds, S.L., Pickering, D., McMillan, D., Sriprakash, K.S., Kemp, D.J., and Fischer, K. (2012). Complement inhibitors from scabies mites promote streptococcal growth\u2013a novel mechanism in infected epidermis?. PLoS Neglected Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001563"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Albayrak, H. (2023). Neutrophil-to-lymphocyte ratio, neutrophil-to-monocyte ratio, platelet-to-lymphocyte ratio, and systemic Immune-inflammation index in psoriasis patients: Response to treatment with biological drugs. J. Clin. Med., 12.","DOI":"10.20944\/preprints202308.0347.v1"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Mounsey, K.E., Murray, H.C., Bielefeldt-Ohmann, H., Pasay, C., Holt, D.C., Currie, B.J., Walton, S.F., and McCarthy, J.S. (2015). Prospective study in a porcine model of Sarcoptes scabiei indicates the association of Th2 and Th17 pathways with the clinical severity of scabies. PLoS Neglected Trop. Dis., 9.","DOI":"10.1371\/journal.pntd.0003498"}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/4\/373\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:21:24Z","timestamp":1760106084000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/4\/373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,30]]},"references-count":46,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["jpm14040373"],"URL":"https:\/\/doi.org\/10.3390\/jpm14040373","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,30]]}}}