{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:57:30Z","timestamp":1760144250300,"version":"build-2065373602"},"reference-count":51,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taichung Veterans General Hospital (TCVGH), Taichung, Taiwan","award":["TCVGH-1127203C","TCVGH-T1127801","TCVGH-1137203C","TCVGH-T1137801","TYVH-10808","TYVH-10809","TYVH-10902"],"award-info":[{"award-number":["TCVGH-1127203C","TCVGH-T1127801","TCVGH-1137203C","TCVGH-T1137801","TYVH-10808","TYVH-10809","TYVH-10902"]}]},{"name":"Taipei Veterans General Hospital, Taoyuan branch, Taoyuan, Taiwan","award":["TCVGH-1127203C","TCVGH-T1127801","TCVGH-1137203C","TCVGH-T1137801","TYVH-10808","TYVH-10809","TYVH-10902"],"award-info":[{"award-number":["TCVGH-1127203C","TCVGH-T1127801","TCVGH-1137203C","TCVGH-T1137801","TYVH-10808","TYVH-10809","TYVH-10902"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Vibrio is a genus of Gram-negative bacteria found in various aquatic environments, including saltwater and freshwater. Vibrio bacteremia can lead to sepsis, a potentially life-threatening condition in which the immune system enters overdrive in response to the disease, causing widespread inflammation and damage to tissues and organs. V. vulnificus had the highest case fatality rate (39%) of all reported foodborne infections in the United States and a high mortality rate in Asia, including Taiwan. Numerous scoring systems have been created to estimate the mortality risk in the emergency department (ED). However, there are no specific scoring systems to predict the mortality risk of Vibrio bacteremia. Therefore, this study modified the existing scoring systems to better predict the mortality risk of Vibrio bacteremia. Methods: Cases of Vibrio bacteremia were diagnosed based on the results from at least one blood culture in the ED. Patient data were extracted from the electronic clinical database, covering January 2012 to December 2021. The primary outcome was in-hospital mortality.This study used univariate and multivariate analyses to evaluate the mortality risk. Results: This study enrolled 36 patients diagnosed with Vibrio bacteremia, including 23 males (63.9%) and 13 females (36.1%), with a mean age of 65.1 \u00b1 15.7 years. The in-hospital mortality rate amounted to 25% (9\/36), with 31.5% in V. vulnificus (6\/19) and 17.6% in V. non-vulnificus (3\/17). The non-survivors demonstrated higher MEDS (10.3 \u00b1 2.4) than the survivors (6.2 \u00b1 4.1) (p = 0.002). Concerning the qSOFA, the survivors scored 0.3 \u00b1 0.5, and the non-survivors displayed a score of 0.6 \u00b1 0.7 (p = 0.387). The AUC of the ROC for the MEDS and qSOFA was 0.833 and 0.599, respectively. This study modified the scoring systems with other predictive factors, including BUN and pH. The AUC of the ROC for the modified MEDS and qSOFA reached up to 0.852 and 0.802, respectively. Conclusion: The MEDS could serve as reliable indicators for forecasting the mortality rate of patients grappling with Vibrio bacteremia. This study modified the MEDS and qSOFA to strengthen the predictive performance of mortality risk for Vibrio bacteremia. We advocate the prompt initiation of targeted therapeutic interventions and judicious antibiotic treatments to curb fatality rates.<\/jats:p>","DOI":"10.3390\/jpm14040385","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T08:42:34Z","timestamp":1712133754000},"page":"385","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Better Performance of Modified Scoring Systems to Predict the Clinical Outcomes of Vibrio Bacteremia in the Emergency Department: An Observational Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Chia-Ming","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan"},{"name":"Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Yuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan"},{"name":"Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 11217, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Shun","family":"Hsieh","sequence":"additional","affiliation":[{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 11217, Taiwan"},{"name":"Department of Emergency Medicine, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan 330, Taiwan"},{"name":"Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Che","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"},{"name":"Lung Cancer Research Center, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hui","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Chun","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1056\/NEJM198502073120604","article-title":"Cholera and other vibrioses in the United States","volume":"312","author":"Morris","year":"1985","journal-title":"N. 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