{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:26:40Z","timestamp":1788348400707,"version":"build-2803163510"},"reference-count":37,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Introduction: Hematopoietic stem cell transplantation (HSCT) recipients are at increased risk of cardiovascular diseases. In our study, we aimed to find subclinical changes in myocardial tissue after HSCT with the help of cardiovascular magnetic resonance (CMR) tissue imaging techniques. Methods: The data of 44 patients undergoing autologous and allogeneic HSCT in the Hospital of Lithuanian University of Health Sciences Kaunas Clinics from October 2021 to February 2023 were analyzed. Bioethics approval for the prospective study was obtained (No BE-2-96). CMR was performed two times: before enrolling for the HSCT procedure (before starting mobilization chemotherapy for autologous HSCT and before starting the conditioning regimen for allogeneic HSCT) and 12 \u00b1 1 months after HSCT. LV end-diastolic volume, LV end-systolic volume, LV mass and values indexed to body surface area (BSA), and LV ejection fraction were calculated. T1 and T2 mapping values were measured. Results: There was a statistically significant change in T1 mapping values. Before HSCT, mean T1 mapping was 1226.13 \u00b1 39.74 ms, and after HSCT, it was 1248.70 \u00b1 41.07 ms (p = 0.01). The other parameters did not differ significantly. Conclusions: Increases in T1 mapping values following HSCT can show the progress of diffuse myocardial fibrosis and may reflect subclinical injury. T2 mapping values remain the same and do not show edema and active inflammation processes at 12 months after HSCT.<\/jats:p>","DOI":"10.3390\/jpm14040412","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T10:24:26Z","timestamp":1713176666000},"page":"412","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["T1 Mapping in Cardiovascular Magnetic Resonance\u2014A Marker of Diffuse Myocardial Fibrosis in Patients Undergoing Hematopoietic Stem Cell Transplantation"],"prefix":"10.3390","volume":"14","author":[{"given":"Audrone","family":"Vaitiekiene","sequence":"first","affiliation":[{"name":"Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Migle","family":"Kulboke","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"},{"name":"Oncology Institute, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Bieseviciene","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antanas","family":"Jankauskas","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"},{"name":"Institute of Cardiology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6317-2032","authenticated-orcid":false,"given":"Agne","family":"Bartnykaite","sequence":"additional","affiliation":[{"name":"Oncology Research Laboratory, Oncology Institute, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Rinkuniene","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Pharmacology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igne","family":"Strazdiene","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilija","family":"Lidziute","sequence":"additional","affiliation":[{"name":"Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darija","family":"Jankauskaite","sequence":"additional","affiliation":[{"name":"Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignas","family":"Gaidamavicius","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"},{"name":"Oncology Institute, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulius","family":"Bucius","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Lapinskas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolandas","family":"Gerbutavicius","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"},{"name":"Oncology Institute, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-7786","authenticated-orcid":false,"given":"Elona","family":"Juozaityte","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"},{"name":"Oncology Institute, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta Justina","family":"Vaskelyte","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"},{"name":"Institute of Cardiology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9583-4475","authenticated-orcid":false,"given":"Domas","family":"Vaitiekus","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"},{"name":"Oncology Institute, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gintare","family":"Sakalyte","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"},{"name":"Institute of Cardiology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/14737159.2017.1283219","article-title":"Using Biomarkers to Predict and to Prevent Cardiotoxicity of Cancer Therapy","volume":"17","author":"Cardinale","year":"2017","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1188\/10.CJON.212-222","article-title":"Mobilization of Hematopoietic Stem Cells for Use in Autologous Transplantation","volume":"14","author":"Devine","year":"2010","journal-title":"Clin. J. Oncol. Nurs."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1093\/jnci\/djn276","article-title":"Trends in 5- and 10-Year Survival after Diagnosis with Childhood Hematologic Malignancies in the United States, 1990\u20132004","volume":"100","author":"Pulte","year":"2008","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11864-021-00850-3","article-title":"Cardiovascular Issues in Hematopoietic Stem Cell Transplantation (HSCT)","volume":"22","author":"Vadillo","year":"2021","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Carreras, E., Dufour, C., Mohty, M., and Kr\u00f6ger, N. (2019). The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies [Internet], Springer.","DOI":"10.1007\/978-3-030-02278-5"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1182\/blood-2007-07-075168","article-title":"Signaling Pathways Governing Stem-Cell Fate","volume":"111","author":"Blank","year":"2008","journal-title":"Blood"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nri1779","article-title":"Bone-Marrow Haematopoietic-Stem-Cell Niches","volume":"6","author":"Wilson","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/cncr.20945","article-title":"Efficacy of Allogeneic Hematopoietic Stem Cell Transplantation Depends on Cytogenetic Risk for Acute Myeloid Leukemia in First Disease Remission: A Metaanalysis","volume":"103","author":"Yanada","year":"2005","journal-title":"Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1182\/blood-2017-05-781799","article-title":"Inherited Bone Marrow Failure Syndromes: Considerations Pre- and Posttransplant","volume":"130","author":"Alter","year":"2017","journal-title":"Blood"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMra1706910","article-title":"Gene Therapy","volume":"381","author":"High","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.transci.2015.05.010","article-title":"Stem Cell Mobilization and Collection from Pediatric Patients and Healthy Children","volume":"53","author":"Karakukcu","year":"2015","journal-title":"Transfus. Apher. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.12968\/hmed.2019.80.1.33","article-title":"Haematopoietic Stem Cell Transplants: Principles and Indications","volume":"80","author":"Balassa","year":"2019","journal-title":"Br. J. Hosp. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/bmt.2008.410","article-title":"Improving Stem Cell Mobilization Strategies: Future Directions","volume":"43","author":"Bensinger","year":"2009","journal-title":"Bone Marrow Transplant."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4067\/S0716-97602012000300012","article-title":"Hematopoietic Stem Cell Transplantation: Clinical Use and Perspectives","volume":"45","author":"Barriga","year":"2012","journal-title":"Biol. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3389\/fimmu.2016.00470","article-title":"Milestones of Hematopoietic Stem Cell Transplantation\u2013From First Human Studies to Current Developments","volume":"7","author":"Juric","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12968-018-0513-4","article-title":"Late Effects of Pediatric Hematopoietic Stem Cell Transplantation on Left Ventricular Function, Aortic Stiffness and Myocardial Tissue Characteristics","volume":"21","author":"Paiman","year":"2019","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11936-016-0447-9","article-title":"Cardiovascular Complications of Hematopoietic Stem Cell Transplantation","volume":"18","author":"Blaes","year":"2016","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1038\/s41409-021-01427-2","article-title":"Cardiac Complications Associated with Hematopoietic Stem-Cell Transplantation","volume":"56","author":"Ohmoto","year":"2021","journal-title":"Bone Marrow Transplant."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"103363","DOI":"10.1016\/j.retram.2022.103363","article-title":"Cardiovascular Diseases in Patients after Hematopoietic Stem Cell Transplantation: Systematic Review and Meta-Analysis","volume":"71","author":"Alizadehasl","year":"2023","journal-title":"Curr. Res. Transl. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hemu, M., Zimmerman, A., Kalra, D., and Okwuosa, T. (2019). Pretransplant Cardiac Evaluation Using Novel Technology. J. Clin. Med., 8.","DOI":"10.3390\/jcm8050690"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11912-019-0774-6","article-title":"Cardiac Complications in the Adult Bone Marrow Transplant Patient","volume":"21","author":"Tuzovic","year":"2019","journal-title":"Curr. Oncol. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","article-title":"2022 ESC Guidelines on Cardio-Oncology Developed in Collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)","volume":"43","author":"Lyon","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1007\/s11239-020-02344-9","article-title":"Cardiovascular Disease and Its Management in Children and Adults Undergoing Hematopoietic Stem Cell Transplantation","volume":"51","author":"Rotz","year":"2021","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Vaitiekiene, A., Kulboke, M., Bieseviciene, M., Bartnykaite, A., Kireilis, B., Rinkuniene, D., Jankauskas, A., Zemaitis, J., Gaidamavicius, I., and Gerbutavicius, R. (2024). Early Impact of Mobilization Process on Cardiac Function and Size in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation. J. Clin. Med., 13.","DOI":"10.3390\/jcm13030773"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/sj.bmt.1705652","article-title":"Impact of Cumulative Anthracycline Dose, Preparative Regimen and Chronic Graft-versus-Host Disease on Pulmonary and Cardiac Function in Children 5 Years after Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective Evaluation on Behalf of the EBMT Pediatric Diseases and Late Effects Working Parties","volume":"39","author":"Uderzo","year":"2007","journal-title":"Bone Marrow Transplant."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1161\/CIRCRESAHA.116.307974","article-title":"T1 Mapping in Characterizing Myocardial Disease: A Comprehensive Review","volume":"119","author":"Puntmann","year":"2016","journal-title":"Circ. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s12012-019-09556-3","article-title":"Impact of Arterial Hypertension on Doxorubicin-Based Chemotherapy-Induced Subclinical Cardiac Damage in Breast Cancer Patients","volume":"20","author":"Vaitiekus","year":"2020","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s12012-020-09595-1","article-title":"HFE Gene Variants\u2019 Impact on Anthracycline-Based Chemotherapy-Induced Subclinical Cardiotoxicity","volume":"21","author":"Vaitiekus","year":"2021","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Wei, X., Lin, L., Zhang, G., and Zhou, X. (2022). Cardiovascular Magnetic Resonance Imaging in the Early Detection of Cardiotoxicity Induced by Cancer Therapies. Diagnostics, 12.","DOI":"10.3390\/diagnostics12081846"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11912-016-0533-x","article-title":"Cardiac MRI: A Translational Imaging Tool for Characterizing Anthracycline-Induced Myocardial Remodeling","volume":"18","author":"Nguyen","year":"2016","journal-title":"Curr. Oncol. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3348\/kjr.2017.18.1.113","article-title":"Myocardial T1 and T2 Mapping: Techniques and Clinical Applications","volume":"18","author":"Kim","year":"2017","journal-title":"Korean J. Radiol."},{"key":"ref_32","first-page":"1956","article-title":"2018 ESC\/ESH Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Cardiology and the European Society of Hypertension","volume":"36","author":"Williams","year":"2018","journal-title":"J. Hypertens."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12968-021-00767-8","article-title":"Ultrahigh-Field Cardiovascular Magnetic Resonance T1 and T2 Mapping for the Assessment of Anthracycline-Induced Cardiotoxicity in Rat Models: Validation against Histopathologic Changes","volume":"23","author":"Park","year":"2021","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/bmt.2017.162","article-title":"Long-Term Systolic Function in Children and Young Adults after Hematopoietic Stem Cell Transplant","volume":"52","author":"Rotz","year":"2017","journal-title":"Bone Marrow Transplant."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e004325","DOI":"10.1161\/CIRCIMAGING.115.004325","article-title":"Anthracycline-Associated T1 Mapping Characteristics Are Elevated Independent of the Presence of Cardiovascular Comorbidities in Cancer Survivors","volume":"9","author":"Jordan","year":"2016","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/CIRCIMAGING.113.000798","article-title":"Occult Cardiotoxicity in Childhood Cancer Survivors Exposed to Anthracycline Therapy","volume":"6","author":"Gillan","year":"2013","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1532-429X-15-48","article-title":"Diffuse Myocardial Fibrosis by T1-Mapping in Children with Subclinical Anthracycline Cardiotoxicity: Relationship to Exercise Capacity, Cumulative Dose and Remodeling","volume":"15","author":"Tham","year":"2013","journal-title":"J. Cardiovasc. Magn. 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