{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:13:53Z","timestamp":1760109233599,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>(1) Background: Although the association between psoriasis and atopic dermatitis (AD) is reported in the literature, scarce data are known about the efficacy of biologic therapy (including TNF and IL-17 inhibitors) in patients with psoriatic arthritis (PsA) and concomitant AD. (2) Objective: We aimed to explore AD in patients with PsA undergoing biologics for their active disease, focusing on prevalence and clinical and potential therapeutic implications. (3) Material and methods: We performed a retrospective analysis of 64 patients with PsA receiving various biological agents, followed-up in an academic outpatient rheumatology department up to 10 years. (4) Results: Atopic diseases were reported in about one third of cases, with a higher incidence of AD (10 cases; 52.6%) vs. atopic rhinitis (6 cases; 31.6%) and allergic asthma (3 cases; 15.8%). Three morphological patterns of AD were recognized including chronic prurigo (3 cases), a chronic lichen simplex (1 case), and eczemas (6 cases). All PsA with concomitant AD displayed a late onset of skin atopy (in their adult life) and demonstrated a specific profile (younger), from urban settings, equally distributed among genders, and requiring switching to a higher number of biologics to achieve disease control. (5) Conclusion: PsA and AD may coexist, requiring special attention when selecting the optimal biologic agent.<\/jats:p>","DOI":"10.3390\/jpm14040427","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T10:52:37Z","timestamp":1713351157000},"page":"427","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Outcomes of Patients with Biologically Treated Psoriatic Arthritis and Atopic Dermatitis\u2014A Single-Center Experience"],"prefix":"10.3390","volume":"14","author":[{"given":"Georgiana","family":"Strugariu","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Rheumatoloy 2 Department, Clinical Rehabilitation Hospital, 14 Pantelimon Halipa Street, 700661 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Pom\u00eerleanu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Rheumatoloy 2 Department, Clinical Rehabilitation Hospital, 14 Pantelimon Halipa Street, 700661 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"Russu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Rheumatoloy 2 Department, Clinical Rehabilitation Hospital, 14 Pantelimon Halipa Street, 700661 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza","family":"Petrariu","sequence":"additional","affiliation":[{"name":"Rheumatoloy 2 Department, Clinical Rehabilitation Hospital, 14 Pantelimon Halipa Street, 700661 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugen","family":"Ancuta","sequence":"additional","affiliation":[{"name":"Research Department, Elena Doamna Clinical Hospital, 700398 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodica","family":"Chirieac","sequence":"additional","affiliation":[{"name":"Sanocare Medical and Research Center, 700503 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doini\u021ba","family":"Temelie-Olinici","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences II, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-8121","authenticated-orcid":false,"given":"Codrina","family":"Ancu\u021ba","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Rheumatoloy 2 Department, Clinical Rehabilitation Hospital, 14 Pantelimon Halipa Street, 700661 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/annrheumdis-2020-218304","article-title":"Immune response profiling of patients with spon-dyloarthritis reveals signalling networks mediating TNF-blocker function in vivo","volume":"80","author":"Menegatti","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.rdc.2012.09.003","article-title":"Epidemiology of spondyloarthritis","volume":"38","author":"Stolwijk","year":"2012","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3899\/jrheum.110845","article-title":"The ClASsification for Psoriatic ARthritis (CASPAR) Criteria\u2014A Retrospective Feasibility, Sensitivity, and Specificity Study","volume":"39","author":"Tillett","year":"2012","journal-title":"J. Rheumatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s40744-021-00378-w","article-title":"Predictors, Risk Factors, and Incidence Rates of Psoriatic Arthritis Development in Psoriasis Patients: A Systematic Literature Review and Meta-Analysis","volume":"8","author":"Zabotti","year":"2021","journal-title":"Rheumatol. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/BOR.0000000000000187","article-title":"The intestinal microbiome in spondyloarthritis","volume":"27","author":"Gill","year":"2015","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sharip, A., and Kunz, J. (2020). Understanding the Pathogenesis of Spondyloarthritis. Biomolecules, 10.","DOI":"10.3390\/biom10101461"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10787-022-01092-x","article-title":"Psoriatic arthritis: Review of potential biomarkers predicting response to TNF inhibitors","volume":"31","author":"Makos","year":"2023","journal-title":"Inflammopharmacology"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chen, W.-Y., Chen, S.-C., Hsu, S.-Y., Lin, Y.-A., Shih, C.-M., Huang, C.-Y., Wang, K.-H., and Lee, A.-W. (2022). Annoying psoriasis, and atopic dermatitis: A narrative review. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094898"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1136\/ard.61.11.968","article-title":"Atopic disorders in ankylosing spondylitis and rheumatoid arthritis","volume":"61","author":"Rudwaleit","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e5172","DOI":"10.1097\/MD.0000000000005172","article-title":"Increased risk of allergic diseases in patients with ankylosing spondylitis: A 10-year follow-up population-based study in Taiwan","volume":"95","author":"Chang","year":"2016","journal-title":"Medicine"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Shen, T.-C., Lin, C.-L., Wei, C.-C., Chen, C.-H., Tu, C.-Y., Hsia, T.-C., Shih, C.-M., Hsu, W.-H., and Sung, F.-C. (2015). The Risk of Asthma in Patients with Ankylosing Spondylitis: A Population-Based Cohort Study. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0116608"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Strugariu, G., Pom\u00eerleanu, C., Bran, C., Costea, A., Vicovan, A., Tatarciuc, D., E\u0219anu, I., Ancu\u021ba, E., Chirieac, R., and Ancu\u021ba, C. (2022). The Prevalence of Atopy in Biologically Treated Spondyloarthropathies: A Retrospective Study of 200 Patients. J. Clin. Med., 11.","DOI":"10.3390\/jcm11010055"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13223-018-0278-1","article-title":"An introduction to immunology and immunopathology","volume":"14","author":"Marshall","year":"2018","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1080\/09546634.2019.1702147","article-title":"Concomitant atopic dermatitis and psoriasis\u2014A retrospective review","volume":"32","author":"Barry","year":"2021","journal-title":"J. Dermatol. Treat."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1002\/ski2.29","article-title":"Can atopic eczema and psoriasis coexist? A systematic review and meta-analysis","volume":"1","author":"Cunliffe","year":"2021","journal-title":"Skin Health Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1056\/NEJMoa1104200","article-title":"Mutual antagonism of T cells causing psoriasis and atopic eczema","volume":"365","author":"Eyerich","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.jid.2018.12.018","article-title":"Atopic dermatitis is an IL-13edominant disease with greater molecular heterogeneity compared to psoriasis","volume":"139","author":"Tsoi","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/exd.13336","article-title":"Systemic immune mechanisms in atopic dermatitis and psoriasis with implications for treatment","volume":"27","author":"Krueger","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/jamadermatol.2015.2","article-title":"Immunologic overlap of helper T-cell subtypes 17 and 22 in erytrodermic psoriasis and atopic dermatitis","volume":"151","author":"Moy","year":"2015","journal-title":"JAMA Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/ard.2010.133645","article-title":"The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general","volume":"70","author":"Rudwaleit","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1136\/annrheumdis-2020-217159","article-title":"EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2019 update","volume":"79","author":"Gossec","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.coi.2017.08.008","article-title":"Atopic dermatitis, and psoriasis: Two different immune diseases or one spectrum?","volume":"48","author":"Krueger","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"ref_23","first-page":"52","article-title":"GRAPPA Treatment Recommendations: 2021 Update","volume":"49","author":"Coates","year":"2022","journal-title":"J. Rheumatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.2147\/CCID.S433367","article-title":"JAK Inhibitors in Psoriatic Disease","volume":"16","author":"Megna","year":"2023","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_25","first-page":"44","article-title":"Janus Kinase Inhibitors: Safety in Patients with Psoriatic Arthritis","volume":"49","author":"Nash","year":"2022","journal-title":"J. Rheumatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"100195","DOI":"10.1016\/j.xjidi.2023.100195","article-title":"Optimal Use of Jak Inhibitors and Biologics for Atopic Dermatitis on the Basis of the Current Evidence","volume":"3","author":"Kamata","year":"2023","journal-title":"JID Innov."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.anai.2023.01.020","article-title":"Oral Janus kinase inhibitors for atopic dermatitis","volume":"130","author":"Mikhaylov","year":"2023","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.jaci.2021.08.013","article-title":"JAK inhibitors for asthma","volume":"148","author":"Georas","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1038\/s41598-020-64732-8","article-title":"Prevalence and pattern of comorbidities in chronic rheumatic and musculoskeletal diseases: The COMORD study","volume":"10","author":"Ziade","year":"2020","journal-title":"Nat. Res. Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s13075-020-02294-w","article-title":"Psoriatic arthritis: Exploring the occurrence of sleep disturbances, fatigue, and depression and their correlates","volume":"22","author":"Haugeberg","year":"2020","journal-title":"Arthritis Res. Ther."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/4\/427\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:29:35Z","timestamp":1760106575000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/4\/427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,17]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["jpm14040427"],"URL":"https:\/\/doi.org\/10.3390\/jpm14040427","relation":{},"ISSN":["2075-4426"],"issn-type":[{"type":"electronic","value":"2075-4426"}],"subject":[],"published":{"date-parts":[[2024,4,17]]}}}