{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:32:20Z","timestamp":1788251540386,"version":"build-2803163510"},"reference-count":58,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Spontaneous orbital cephaloceles are a rare condition. The purpose of this study is to provide a description of a clinical case and to carry out a systematic literature review. Methods: A systematic review of the English literature published on the Pubmed, Scopus, and Web of Science databases was conducted, according to the PRISMA recommendations. Results: A 6-year-old patient was admitted for right otomastoiditis and thrombosis of the sigmoid and transverse sinuses, as well as the proximal portion of the internal jugular vein. Radiological examinations revealed a left orbital mass (22 \u00d7 14 mm) compatible with asymptomatic orbital meningocele (MC) herniated from the superior orbital fissure (SOF). The child underwent a right mastoidectomy. After the development of symptoms and signs of intracranial hypertension (ICH), endovascular thrombectomy and transverse sinus stenting were performed, with improvement of the clinical conditions and reduction of the orbital MC. The systematic literature review encompassed 29 publications on 43 patients with spontaneous orbital MC. In the majority of cases, surgery was the preferred treatment. Conclusions: The present case report and systematic review highlight the importance of ICH investigation and a pathophysiological-oriented treatment approach. The experiences described in the literature are limited, making the collection of additional data paramount.<\/jats:p>","DOI":"10.3390\/jpm14050465","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T09:50:07Z","timestamp":1714470607000},"page":"465","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Pathophysiological Approach to Spontaneous Orbital Meningoceles: Case Report and Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6219-9180","authenticated-orcid":false,"given":"Piergiorgio","family":"Gaudioso","sequence":"first","affiliation":[{"name":"Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, \u201cAzienda Ospedale Universit\u00e0 di Padova\u201d, University of Padua, 35128 Padua, Italy"},{"name":"Unit of Otorhinolaryngology\u2014Head and Neck Surgery, Azienda Ospedale Universit\u00e0 Padova, 35128 Padua, Italy"},{"name":"Oncology and Immunology (PhD Program), Department of Surgery Oncology and Gastroenterology (DiSCOG), University of Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2419-364X","authenticated-orcid":false,"given":"Elia","family":"Biancoli","sequence":"additional","affiliation":[{"name":"Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, \u201cAzienda Ospedale Universit\u00e0 di Padova\u201d, University of Padua, 35128 Padua, Italy"},{"name":"Unit of Otorhinolaryngology\u2014Head and Neck Surgery, Azienda Ospedale Universit\u00e0 Padova, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Battistuzzi","sequence":"additional","affiliation":[{"name":"Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, \u201cAzienda Ospedale Universit\u00e0 di 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