{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:25:46Z","timestamp":1777937146582,"version":"3.51.4"},"reference-count":59,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"New York State Research Foundation","award":["RIAQ0940"],"award-info":[{"award-number":["RIAQ0940"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Exercise promotes health and wellness, including its operation as a protective factor against a variety of psychological, neurological, and chronic diseases. Selenium and its biomarker, selenoprotein P (SEPP1), have been implicated in health, including cancer prevention, neurological function, and dopamine signaling. SEPP1 blood serum levels were compared with a one-way ANOVA between sedentary (SED), moderately exercised (MOD) [10 m\/min starting at 10 min, increasing to 60 min], and high-intensity interval training (HIIT) exercised rats [30 min in intervals of 2-min followed by a 1-min break, speed progressively increased from 10 to 21 m\/min]. HIIT rats showed significantly higher serum SEPP1 concentrations compared to MOD and SED. More specifically, HIIT exercise showed an 84% increase in SEPP1 levels compared to sedentary controls. MOD rats had greater serum SEPP1 concentrations compared to SED, a 33% increase. The results indicated that increased exercise intensity increases SEPP1 levels. Exercise-induced increases in SEPP1 may indicate an adaptive response to the heightened oxidative stress. Previous studies found a significant increase in dopamine D2 receptor (D2R) binding in these same rats, suggesting a potential association between SEPP1 and dopamine signaling during exercise. Modulating antioxidants like SEPP1 through personalized therapies, including exercise, has broad implications for health, disease, and addiction.<\/jats:p>","DOI":"10.3390\/jpm14050489","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T05:52:02Z","timestamp":1714715522000},"page":"489","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Selenoprotein P in a Rodent Model of Exercise; Theorizing Its Interaction with Brain Reward Dysregulation, Addictive Behavior, and Aging"],"prefix":"10.3390","volume":"14","author":[{"given":"Patrick","family":"Mohr","sequence":"first","affiliation":[{"name":"Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacob School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203-1014, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Hanna","sequence":"additional","affiliation":[{"name":"Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacob School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203-1014, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8849-9165","authenticated-orcid":false,"given":"Aidan","family":"Powell","sequence":"additional","affiliation":[{"name":"Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacob School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203-1014, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Penman","sequence":"additional","affiliation":[{"name":"Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacob School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203-1014, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-803X","authenticated-orcid":false,"given":"Kenneth","family":"Blum","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel 40700, Israel"},{"name":"Division of Addiction Research & Education, Center for Sports, Exercise, and Mental Health, Western University of Health Sciences, Pomona, CA 91766, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Sharafshah","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht 8813833435, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7842-2914","authenticated-orcid":false,"given":"Kai-Uwe","family":"Lewandrowski","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Universitaria Sanitas, Fundaci\u00f3n, Bogot\u00e1 P.O. Box 011, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5586-5114","authenticated-orcid":false,"given":"Rajendra D.","family":"Badgaiyan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Mt. 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Brain Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1249\/MSS.0000000000001627","article-title":"Exercise Reduces Dopamine D1R and Increases D2R in Rats: Implications for Addiction","volume":"50","author":"Robison","year":"2018","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1257629","DOI":"10.3389\/fpubh.2023.1257629","article-title":"High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling","volume":"11","author":"Tyler","year":"2023","journal-title":"Front. Public Health"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Hanna, C., Hamilton, J., Arnavut, E., Blum, K., and Thanos, P.K. (2022). Brain Mapping the Effects of Chronic Aerobic Exercise in the Rat Brain Using FDG PET. J. Pers. Med., 12.","DOI":"10.3390\/jpm12060860"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.biopsycho.2018.01.015","article-title":"Exercise reduces depression and inflammation but intensity matters","volume":"133","author":"Paolucci","year":"2018","journal-title":"Biol. Psychol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1001\/jama.2018.14854","article-title":"The Physical Activity Guidelines for Americans","volume":"320","author":"Piercy","year":"2018","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-publhealth-040119-094201","article-title":"Sedentary Behavior and Public Health: Integrating the Evidence and Identifying Potential Solutions","volume":"41","author":"Owen","year":"2020","journal-title":"Annu. Rev. Public Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cmet.2022.01.005","article-title":"Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging","volume":"34","author":"Leiter","year":"2022","journal-title":"Cell Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.stemcr.2019.02.009","article-title":"Exercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation","volume":"12","author":"Leiter","year":"2019","journal-title":"Stem Cell Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1523\/JNEUROSCI.1153-07.2007","article-title":"Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed","volume":"27","author":"Burk","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(00)02490-9","article-title":"The importance of selenium to human health","volume":"356","author":"Rayman","year":"2000","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.freeradbiomed.2022.07.021","article-title":"New insights on selenoproteins and neuronal function","volume":"190","author":"Nicholson","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"631825","DOI":"10.3389\/fnins.2021.631825","article-title":"Selenoprotein P Modulates Methamphetamine Enhancement of Vesicular Dopamine Release in Mouse Nucleus Accumbens Via Dopamine D2 Receptors","volume":"15","author":"Torres","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3233\/JPD-2012-11052","article-title":"Changes in selenoprotein P in substantia nigra and putamen in Parkinson\u2019s disease","volume":"2","author":"Bellinger","year":"2012","journal-title":"J. Parkinsons Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1096\/fj.14-252874","article-title":"Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration","volume":"28","author":"Burk","year":"2014","journal-title":"FASEB J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1037\/bne0000019","article-title":"The effects of lesions to the postsubiculum or the anterior dorsal nucleus of the thalamus on spatial learning in rats","volume":"128","author":"Peckford","year":"2014","journal-title":"Behav. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1037\/a0027163","article-title":"The postsubiculum is necessary for spatial alternation but not for homing by path integration","volume":"126","author":"Bett","year":"2012","journal-title":"Behav. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Hanna, C., Hamilton, J., Blum, K., Badgaiyan, R.D., and Thanos, P.K. (2022). Exercise Modulates Brain Glucose Utilization Response to Acute Cocaine. J. Pers. Med., 12.","DOI":"10.3390\/jpm12121976"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1073\/pnas.1015950108","article-title":"Exercise training increases size of hippocampus and improves memory","volume":"108","author":"Erickson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"102182","DOI":"10.1016\/j.nicl.2020.102182","article-title":"Hippocampal plasticity underpins long-term cognitive gains from resistance exercise in MCI","volume":"25","author":"Broadhouse","year":"2020","journal-title":"Neuroimage Clin."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Schomburg, L., Orho-Melander, M., Struck, J., Bergmann, A., and Melander, O. (2019). Selenoprotein-P Deficiency Predicts Cardiovascular Disease and Death. Nutrients, 11.","DOI":"10.3390\/nu11081852"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10654-023-01091-4","article-title":"Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults","volume":"39","author":"Schottker","year":"2024","journal-title":"Eur. J. Epidemiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1039\/c5mt00075k","article-title":"Selenium, selenoproteins and neurodegenerative diseases","volume":"7","author":"Cardoso","year":"2015","journal-title":"Metallomics"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Schoenmakers, E., and Chatterjee, K. (2021). Human Genetic Disorders Resulting in Systemic Selenoprotein Deficiency. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312927"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/pros.22611","article-title":"Selenoprotein P genetic variants and mrna expression, circulating selenium, and prostate cancer risk and survival","volume":"73","author":"Penney","year":"2013","journal-title":"Prostate"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Rahman, N., Mihalkovic, A., Geary, O., Haffey, R., Hamilton, J., and Thanos, P.K. (2020). Chronic aerobic exercise: Autoradiographic assessment of GABA(a) and mu-opioid receptor binding in adult rats. Pharmacol. Biochem. Behav., 196.","DOI":"10.1016\/j.pbb.2020.172980"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbr.2012.10.035","article-title":"Daily treadmill exercise attenuates cocaine cue-induced reinstatement and cocaine induced locomotor response but increases cocaine-primed reinstatement","volume":"239","author":"Thanos","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Roeder, N.M., Mihalkovic, A., Richardson, B.J., Penman, S.L., Novalen, M., Hammond, N., Eiden, R., Khokhar, J.Y., Tyndale, R.F., and Thanos, P.K. (Nicotine Tob. Res., 2023). Behavioral and pharmacokinetic assessment of nicotine e-cigarette inhalation in female rats, Nicotine Tob. Res., ahead of print.","DOI":"10.1093\/ntr\/ntad240"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ijrobp.2013.06.2063","article-title":"Selenoprotein P Inhibits Radiation-Induced Late Reactive Oxygen Species Accumulation and Normal Cell Injury","volume":"87","author":"Eckers","year":"2013","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1080\/10715760600806248","article-title":"Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity","volume":"40","author":"Steinbrenner","year":"2006","journal-title":"Free Radic. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Kawamura, T., and Muraoka, I. (2018). Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint. Antioxidants, 7.","DOI":"10.3390\/antiox7090119"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s10522-020-09883-x","article-title":"Targeting reactive oxygen species (ROS) to combat the age-related loss of muscle mass and function","volume":"21","author":"Thoma","year":"2020","journal-title":"Biogerontology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e13031","DOI":"10.1111\/acel.13031","article-title":"Oxidative stress in the aging substantia nigra and the etiology of Parkinson\u2019s disease","volume":"18","author":"Trist","year":"2019","journal-title":"Aging Cell"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neurobiolaging.2021.07.014","article-title":"Emerging roles of oxidative stress in brain aging and Alzheimer\u2019s disease","volume":"107","author":"Cotman","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/j.clnu.2018.11.034","article-title":"Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer\u2019s disease: A randomized, double-blind, controlled trial","volume":"38","author":"Tamtaji","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4970","DOI":"10.1021\/acs.jafc.7b01465","article-title":"Long-Term Dietary Supplementation with Selenium-Enriched Yeast Improves Cognitive Impairment, Reverses Synaptic Deficits, and Mitigates Tau Pathology in a Triple Transgenic Mouse Model of Alzheimer\u2019s Disease","volume":"65","author":"Zhang","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e1800107","DOI":"10.1002\/mnfr.201800107","article-title":"Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice","volume":"62","author":"Xie","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2174\/1568026615666150827094936","article-title":"Potential Roles of Selenium and Selenoproteins in the Prevention of Alzheimer\u2019s Disease","volume":"16","author":"Du","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/s11357-022-00534-2","article-title":"Long-term exercise pre-training attenuates Alzheimer\u2019s disease-related pathology in a transgenic rat model of Alzheimer\u2019s disease","volume":"44","author":"Yang","year":"2022","journal-title":"Geroscience"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1158\/1055-9965.EPI-05-0950","article-title":"Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial","volume":"15","author":"Burk","year":"2006","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"8282","DOI":"10.1002\/jcb.26844","article-title":"Effects of selenium supplementation on expression of SEPP1 in mRNA and protein levels in subjects with and without metabolic syndrome suffering from coronary artery disease: Selenegene study a double-blind randomized controlled trial","volume":"119","author":"Gharipour","year":"2018","journal-title":"J. Cell Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/sj.ejcn.1600565","article-title":"Plasma selenoprotein P levels of healthy males in different selenium status after oral supplementation with different forms of selenium","volume":"52","author":"Alfthan","year":"1998","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative Stress: Harms and Benefits for Human Health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"379","DOI":"10.5717\/jenb.2014.18.4.379","article-title":"Effect of exercise on hyperactivity, impulsivity and dopamine D2 receptor expression in the substantia nigra and striatum of spontaneous hypertensive rats","volume":"18","author":"Cho","year":"2014","journal-title":"J. Exerc. Nutr. Biochem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1002\/mds.23407","article-title":"Exercise elevates dopamine D2 receptor in a mouse model of Parkinson\u2019s disease: In vivo imaging with [18F]fallypride","volume":"25","author":"Vuckovic","year":"2010","journal-title":"Mov. Disord."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/jnr.20162","article-title":"Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia","volume":"77","author":"Fisher","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12017-008-8032-3","article-title":"Neuroplasticity of dopamine circuits after exercise: Implications for central fatigue","volume":"10","author":"Foley","year":"2008","journal-title":"Neuromol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/syn.20523","article-title":"D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats","volume":"62","author":"Thanos","year":"2008","journal-title":"Synapse"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.lfs.2004.10.061","article-title":"Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: Effects on ethanol drinking","volume":"77","author":"Thanos","year":"2005","journal-title":"Life Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nn.3369","article-title":"Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use","volume":"16","author":"Bock","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.neuropharm.2013.06.031","article-title":"Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity","volume":"76 Pt B","author":"Trifilieff","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7928","DOI":"10.1007\/s12035-016-0272-x","article-title":"Strength and Aerobic Exercises Improve Spatial Memory in Aging Rats Through Stimulating Distinct Neuroplasticity Mechanisms","volume":"54","author":"Vilela","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/1354750X.2022.2049367","article-title":"Dopaminergic and glutamatergic biomarkers disruption in addiction and regulation by exercise: A mini review","volume":"27","author":"Abdullah","year":"2022","journal-title":"Biomarkers"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3164\/jcbn.19-96","article-title":"Effects of exercise on biological trace element concentrations and selenoprotein P expression in rats with fructose-induced glucose intolerance","volume":"66","author":"Miya","year":"2020","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1038\/s41467-023-39873-9","article-title":"Platelet-derived exerkine CXCL4\/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice","volume":"14","author":"Leiter","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1139\/apnm-2017-0639","article-title":"The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight\/obese men","volume":"43","author":"Sargeant","year":"2018","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"6","DOI":"10.15605\/jafes.037.S4","article-title":"Lower Plasma Selenoprotein P Levels in Regularly Exercising Young Adults","volume":"38","author":"Oo","year":"2023","journal-title":"J. ASEAN Fed. Endocr. Soc."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/5\/489\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:39:09Z","timestamp":1760107149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/5\/489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,3]]},"references-count":59,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["jpm14050489"],"URL":"https:\/\/doi.org\/10.3390\/jpm14050489","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,3]]}}}