{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:02:45Z","timestamp":1760144565252,"version":"build-2065373602"},"reference-count":63,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>This Editorial precedes the Special Issue entitled \u201cNovel Challenges and Therapeutic Options for Liver Diseases\u201d. Following a historical outline of the roots of hepatology, we provide a brief insight into our colleagues\u2019 contributions in this issue on the current developments in this discipline related to the prevention of liver diseases, the metabolic dysfunction-associated steatotic liver disease (or non-alcoholic fatty liver disease, respectively), liver cirrhosis, chronic viral hepatitides, acute-on-chronic liver failure, liver transplantation, the liver\u2013microbiome axis and microbiome transplantation, and telemedicine. We further add some topics not covered by the contributions herein that will likely impact future hepatology. Clinically, these comprise the predictive potential of organokine crosstalk and treatment options for liver fibrosis. With regard to promising developments in basic research, some current findings on the genetic basis of metabolism-associated chronic liver diseases, chronobiology, metabolic zonation of the liver, aspects of the aging liver against the background of demography, and liver regeneration will be presented. We expect machine learning to thrive as an overarching topic throughout hepatology. The largest study to date on the early detection of liver damage\u2014which has been kicked off on 1 March 2024\u2014is highlighted, too.<\/jats:p>","DOI":"10.3390\/jpm14050492","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T15:05:01Z","timestamp":1715007901000},"page":"492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liver Diseases: Science, Fiction and the Foreseeable Future"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3064-8516","authenticated-orcid":false,"given":"Robert K.","family":"Gieseler","sequence":"first","affiliation":[{"name":"Department of Medicine, University Hospital Knappschaftskrankenhaus, Ruhr University Bochum, 44892 Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1862-6461","authenticated-orcid":false,"given":"Theodor","family":"Baars","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital Knappschaftskrankenhaus, Ruhr University Bochum, 44892 Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4360-5005","authenticated-orcid":false,"given":"Mustafa K.","family":"\u00d6z\u00e7\u00fcr\u00fcmez","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital Knappschaftskrankenhaus, Ruhr University Bochum, 44892 Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6069-7899","authenticated-orcid":false,"given":"Ali","family":"Canbay","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital Knappschaftskrankenhaus, Ruhr University Bochum, 44892 Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/00004836-198802000-00006","article-title":"The life and death of Ismar Boas","volume":"10","author":"Hoenig","year":"1988","journal-title":"J. Clin. Gastroenterol."},{"unstructured":"Jenss, H. (2024, March 15). Gegen das Vergessen (We Remember). Deutsche Gesellschaft f\u00fcr Verdauungs- und Stoffwechselkrankheiten (German Society of Gastroenterology). (In English).","key":"ref_2"},{"unstructured":"Frerichs, F.T. (1858). Klinik der Leberkrankheiten (Clinic of Liver Diseases), Friedrich Vieweg und Sohn.","key":"ref_3"},{"unstructured":"Frerichs, F.T. (1861). Klinik der Leberkrankheiten (Clinic of Liver Diseases), Friedrich Vieweg und Sohn.","key":"ref_4"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1055\/a-0853-6287","article-title":"Friedrich Theodor Frerichs\u2014Begr\u00fcnder der modernen Hepatologie\u2014200. Geburtstag (Friedrich Theodor Frerichs\u2014founder of modern hepatology\u2014200th birthday)","volume":"57","author":"Jenss","year":"2019","journal-title":"Z. Gastroenterol."},{"unstructured":"Franken, F.H. (1994). Friedrich Theodor Frerichs (1819\u20131885)\u2014Leben und Hepatologisches Werk, Falk Foundation e.V.","key":"ref_6"},{"unstructured":"Schmid, R. (2024, March 18). Available online: https:\/\/www.nasonline.org\/publications\/biographical-memoirs\/memoir-pdfs\/popper-hans.pdf.","key":"ref_7"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00292-019-0619-y","article-title":"The hepatopathologist Hans Popper (1903-1988): An early victim of National Socialism in Austria","volume":"41","author":"Kaiser","year":"2020","journal-title":"Pathologe"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/alcalc\/37.6.622","article-title":"Dame Sheila Sherlock: MCA Patron and Hepatologist Extraordinaire","volume":"37","author":"Williams","year":"2002","journal-title":"Alcohol. Alcohol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.aohep.2019.11.002","article-title":"50 years of Hepatology: The Royal Free Hospital School of Hepatology","volume":"19","author":"Campollo","year":"2020","journal-title":"Ann. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1055\/a-1955-5297","article-title":"The aging human liver: The weal and woe of evolutionary legacy","volume":"61","author":"Gieseler","year":"2023","journal-title":"Z. Gastroenterol."},{"key":"ref_12","first-page":"509","article-title":"The Influence of Age upon the Incorporation of Thymidine-2-C14 into the DNA of Regenerating Rat Liver","volume":"24","author":"Bucher","year":"1964","journal-title":"Cancer Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e06449","DOI":"10.1016\/j.heliyon.2021.e06449","article-title":"Liver regeneration observed across the different classes of vertebrates from an evolutionary perspective","volume":"7","year":"2021","journal-title":"Heliyon"},{"doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-Restrepo, A.M., Navas, M.C., Daza, J., Girala, M., Ridruejo, E., Gerken, G., and Teufel, A. (2024). Prevention in Hepatology. J. Pers. Med., 14.","key":"ref_14","DOI":"10.3390\/jpm14020132"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"155179","DOI":"10.1016\/j.metabol.2022.155179","article-title":"Towards harnessing the value of organokine crosstalk to predict the risk for cardiovascular disease in non-alcoholic fatty liver disease","volume":"130","author":"Baars","year":"2022","journal-title":"Metabolism"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","article-title":"MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S2468-1253(22)00062-0","article-title":"Global multi-stakeholder endorsement of the MAFLD definition","volume":"7","author":"Bugianesi","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"doi-asserted-by":"crossref","unstructured":"Kreimeyer, H., Vogt, K., G\u00f6tze, T., Best, J., G\u00f6tze, O., Weigt, J., Kahraman, A., \u00d6z\u00e7\u00fcr\u00fcmez, M., K\u00e4lsch, J., and Syn, W.K. (2023). Influence of the Bile Acid Transporter Genes ABCB4, ABCB8, and ABCB11 and the Farnesoid X Receptor on the Response to Ursodeoxycholic Acid in Patients with Nonalcoholic Steatohepatitis. J. Pers. Med., 13.","key":"ref_18","DOI":"10.3390\/jpm13071180"},{"doi-asserted-by":"crossref","unstructured":"Schwertheim, S., Alhardan, M., Manka, P.P., Sowa, J.P., Canbay, A., Schmidt, H.H., Baba, H.A., and K\u00e4lsch, J. (2023). Higher pNRF2, SOCS3, IRF3, and RIG1 Tissue Protein Expression in NASH Patients versus NAFL Patients: pNRF2 Expression Is Concomitantly Associated with Elevated Fasting Glucose Levels. J. Pers. Med., 13.","key":"ref_19","DOI":"10.3390\/jpm13071152"},{"doi-asserted-by":"crossref","unstructured":"Drotarova, M., Zolkova, J., Belakova, K.M., Brunclikova, M., Skornova, I., Stasko, J., and Simurda, T. (2023). Basic Principles of Rotational Thromboelastometry (ROTEM\u00ae) and the Role of ROTEM-Guided Fibrinogen Replacement Therapy in the Management of Coagulopathies. Diagnostics, 13.","key":"ref_20","DOI":"10.3390\/diagnostics13203219"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.3748\/wjg.v26.i37.5561","article-title":"Transjugular intrahepatic portosystemic shunt in cirrhosis: An exhaustive critical update","volume":"26","author":"Rajesh","year":"2020","journal-title":"World J. Gastroenterol."},{"doi-asserted-by":"crossref","unstructured":"Bedreli, S., Manka, P., Buechter, M., Jahn, M., Theysohn, J.M., Canbay, A., and Katsounas, A. (2023). No Differences in Rotational Thromboelastometry Measurements between Portal and Peripheral Circulation in Cirrhotic Patients Undergoing TIPS. J. Pers. Med., 13.","key":"ref_22","DOI":"10.3390\/jpm13030424"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.idc.2019.08.004","article-title":"Viral Hepatitis: Etiology, Epidemiology, Transmission, Diagnostics, Treatment, and Prevention","volume":"33","author":"Lanini","year":"2019","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1001\/jama.2023.23242","article-title":"Hepatitis D: A Review","volume":"330","author":"Negro","year":"2023","journal-title":"JAMA"},{"doi-asserted-by":"crossref","unstructured":"Schlaak, J.F. (2023). Current Therapy of Chronic Viral Hepatitis B, C and D. J. Pers. Med., 13.","key":"ref_25","DOI":"10.3390\/jpm13060964"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1056\/NEJMra1914900","article-title":"Acute-on-Chronic Liver Failure","volume":"382","author":"Arroyo","year":"2020","journal-title":"N. Engl. J. Med."},{"doi-asserted-by":"crossref","unstructured":"Kimmann, M., and Trebicka, J. (2023). Acute-On-Chronic Liver Failure: Current Interventional Treatment Options and Future Challenges. J. Pers. Med., 13.","key":"ref_27","DOI":"10.3390\/jpm13071052"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/hpb.12308","article-title":"Liver transplantation for neuroendocrine tumour liver metastases","volume":"17","author":"Fan","year":"2015","journal-title":"HPB"},{"doi-asserted-by":"crossref","unstructured":"Palaniappan, V., Li, C.H., Frilling, A., and Clift, A.K. (2023). Long-Term Outcomes of Liver Transplantation for the Management of Neuroendocrine Neoplasms: A Systematic Review. J. Pers. Med., 13.","key":"ref_29","DOI":"10.3390\/jpm13101428"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature18846","article-title":"Diet\u2013microbiota interactions as moderators of human metabolism","volume":"535","author":"Sonnenburg","year":"2016","journal-title":"Nature"},{"doi-asserted-by":"crossref","unstructured":"Stadlbauer, V. (2023). Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease. J. Pers. Med., 13.","key":"ref_31","DOI":"10.3390\/jpm13020220"},{"doi-asserted-by":"crossref","unstructured":"Lederer, T., Hipler, N.M., Thon, C., Kupcinskas, J., and Link, A. (2024). Comparison of Fecal MicroRNA Isolation Using Various Total RNA Isolation Kits. Genes, 15.","key":"ref_32","DOI":"10.3390\/genes15040498"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11882-022-01026-1","article-title":"Telemedicine Lessons Learned During the COVID-19 Pandemic","volume":"22","author":"Greiwe","year":"2022","journal-title":"Curr. Allergy Asthma Rep."},{"doi-asserted-by":"crossref","unstructured":"Akbar, F.N., Choirida, S.R., Muttaqin, A.Z., Ekayanti, F., Nisa, H., and Hendarto, H. (2024). Telemedicine as an Option for Monitoring Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Patients Facing the COVID-19 Pandemic: A Systematic Review and Meta-Analysis. J. Pers. Med., 14.","key":"ref_34","DOI":"10.20944\/preprints202401.2153.v1"},{"key":"ref_35","first-page":"A402","article-title":"Digitale L\u00f6sungen: Telemedizin Wird Ausgebaut","volume":"121","author":"Kurz","year":"2024","journal-title":"Dtsch. Arztebl."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jhep.2018.10.033","article-title":"Non-alcoholic fatty liver disease\u2014A global public health perspective","volume":"70","author":"Younossi","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1136\/gutjnl-2014-307024","article-title":"Vitamin D counteracts fibrogenic TGF-\u03b2 signalling in human hepatic stellate cells both receptor-dependently and independently","volume":"64","author":"Beilfuss","year":"2015","journal-title":"Gut"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1080\/10408398.2017.1389693","article-title":"Vitamin D supplementation and non-alcoholic fatty liver disease: A critical and systematic review of clinical trials","volume":"59","author":"Sharifi","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"doi-asserted-by":"crossref","unstructured":"Kodama, T., and Takehara, T. (2024). Molecular genealogy of metabolic-associated hepatocellular carcinoma. Semin. Liver. Dis.","key":"ref_39","DOI":"10.1055\/a-2289-2298"},{"doi-asserted-by":"crossref","unstructured":"Geier, A., Trost, J., Wang, K., Schmid, C., Krawczyk, M., and Schiffels, S. (2024). PNPLA3 fatty liver allele was fixed in Neanderthals and segregates neutrally in humans. Gut.","key":"ref_40","DOI":"10.1055\/s-0043-1777467"},{"unstructured":"European Commission (2024, March 15). A Biomarker-Based Platform for Early Diagnosis of Chronic Liver Disease to Enable Personalized Therapy (LIVERAIM). Project ID: 101132901; Call: HORIZON-JU-IHI-2022-03-single-stage; Programme: HORIZON; DG\/Agency: IHI. EU Funding & Tenders Portal. Available online: https:\/\/ec.europa.eu\/info\/funding-tenders\/opportunities\/portal\/screen\/how-to-participate\/org-details\/895467917\/project\/101132901\/program\/43108390\/details.","key":"ref_41"},{"doi-asserted-by":"crossref","unstructured":"Canbay, A., G\u00f6tze, O., Kucukoglu, O., Weinert, S., Croner, R.S., Baars, T., \u00d6z\u00e7\u00fcr\u00fcmez, M.K., and Gieseler, R.K. (2024). L-Ornithine-L-Aspartate (LOLA) Normalizes Metabolic Parameters in Models of Steatosis, Insulin Resistance and Metabolic Syndrome. Pharmaceutics, 16.","key":"ref_42","DOI":"10.3390\/pharmaceutics16040506"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000491429","article-title":"Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease","volume":"37","author":"Butterworth","year":"2019","journal-title":"Dig. Dis."},{"key":"ref_44","first-page":"697","article-title":"Changes in the circadian rhythm of ornithine decarboxylase in rat liver during chemical hepatocarcinogenesis","volume":"66","author":"Scalabrino","year":"1981","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"100417","DOI":"10.1016\/j.jlr.2023.100417","article-title":"The circadian clock is required for rhythmic lipid transport in Drosophila in interaction with diet and photic condition","volume":"64","author":"Amatobi","year":"2023","journal-title":"J. Lipid Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0968-0004(78)91764-4","article-title":"Heterogeneity of liver parenchymal cells","volume":"3","author":"Jungermann","year":"1978","journal-title":"Trends Biochem. Sci."},{"doi-asserted-by":"crossref","unstructured":"H\u00e4ussinger, D. (2004). Kurt Jungermann: A pioneer in liver research. Anat. Rec. A Discov. Mol. Cell. Evol. Biol., 280.","key":"ref_47","DOI":"10.1002\/ar.a.20085"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.csbj.2019.07.021","article-title":"Hallmarks of Aging in the Liver","volume":"17","author":"Hunt","year":"2019","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1034\/j.1600-0560.2002.56.x","article-title":"The 2030 problem: Caring for aging baby boomers","volume":"37","author":"Knickman","year":"2002","journal-title":"Health Serv. Res."},{"unstructured":"World Health Organization (2024, April 04). Ageing and Health. 1 October 2022. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ageing-and-health.","key":"ref_50"},{"doi-asserted-by":"crossref","unstructured":"Schreiter, T., Gieseler, R.K., V\u00edlchez-Vargas, R., Jauregui, R., Sowa, J.P., Klein-Scory, S., Broering, R., Croner, R.S., Treckmann, J.W., and Link, A. (2021). Transcriptome-Wide Analysis of Human Liver Reveals Age-Related Differences in the Expression of Select Functional Gene Clusters and Evidence for a PPP1R10-Governed \u2018Aging Cascade\u2019. Pharmaceutics, 13.","key":"ref_51","DOI":"10.3390\/pharmaceutics13122009"},{"doi-asserted-by":"crossref","unstructured":"Agodi, A., Maugeri, A., Kunzova, S., Sochor, O., Bauerova, H., Kiacova, N., Barchitta, M., and Vinciguerra, M. (2018). Association of Dietary Patterns with Metabolic Syndrome: Results from the Kardiovize Brno 2030 Study. Nutrients, 10.","key":"ref_52","DOI":"10.3390\/nu10070898"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.jhep.2022.12.028","article-title":"Gut microbiota promote liver regeneration through hepatic membrane phospholipid biosynthesis","volume":"78","author":"Yin","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"933","DOI":"10.21037\/hbsn-23-508","article-title":"New insights in the metabolic function related to gut microbiota in the process of liver regeneration","volume":"12","author":"Jiang","year":"2023","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"ref_55","first-page":"86","article-title":"An empirical science research on bioinformatics in machine learning","volume":"2","author":"Sindhu","year":"2020","journal-title":"J. Mech. Continua Math. Sci."},{"unstructured":"Russell, S.J., and Norvig, P. (2021). Artificial Intelligence: A Modern Approach, Pearson. [4th ed.].","key":"ref_56"},{"doi-asserted-by":"crossref","unstructured":"Sowa, J.P., Heider, D., Bechmann, L.P., Gerken, G., Hoffmann, D., and Canbay, A. (2013). Novel algorithm for non-invasive assessment of fibrosis in NAFLD. PLoS ONE, 8.","key":"ref_57","DOI":"10.1371\/journal.pone.0062439"},{"doi-asserted-by":"crossref","unstructured":"Sowa, J.P., Atmaca, \u00d6., Kahraman, A., Schlattjan, M., Lindner, M., Sydor, S., Scherbaum, N., Lackner, K., Gerken, G., and Heider, D. (2014). Noninvasive separation of alcoholic and non-alcoholic liver disease with predictive modeling. PLoS ONE, 9.","key":"ref_58","DOI":"10.1371\/journal.pone.0101444"},{"doi-asserted-by":"crossref","unstructured":"Canbay, A., K\u00e4lsch, J., Neumann, U., Rau, M., Hohenester, S., Baba, H.A., Rust, C., Geier, A., Heider, D., and Sowa, J.P. (2019). Noninvasive assessment of NAFLD as systemic disease\u2014A machine learning perspective. PLoS ONE, 14.","key":"ref_59","DOI":"10.1371\/journal.pone.0214436"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"101706","DOI":"10.1016\/j.artmed.2019.101706","article-title":"The virtual doctor: An interactive clinical-decision-support system based on deep learning for non-invasive prediction of diabetes","volume":"100","author":"Sowa","year":"2019","journal-title":"Artif. Intell. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nature14541","article-title":"Probabilistic machine learning and artificial intelligence","volume":"521","author":"Ghahramani","year":"2015","journal-title":"Nature"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/hep.31103","article-title":"Applying Machine Learning in Liver Disease and Transplantation: A Comprehensive Review","volume":"71","author":"Spann","year":"2020","journal-title":"Hepatology"},{"unstructured":"de la Barrera, E. (2024, March 29). Ferrol Ciudad: Val\u00f3n Tiene un H\u00edgado Monumental. La Voz de Galicia: Arteixo A Coru\u00f1a, Spain. 14 April 2023. Available online: https:\/\/www.lavozdegalicia.es\/noticia\/ferrol\/ferrol\/2023\/04\/13\/ferrol-higado-monumental\/00031681378177497559543.htm.","key":"ref_63"}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/5\/492\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:39:26Z","timestamp":1760107166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/5\/492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,4]]},"references-count":63,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["jpm14050492"],"URL":"https:\/\/doi.org\/10.3390\/jpm14050492","relation":{},"ISSN":["2075-4426"],"issn-type":[{"type":"electronic","value":"2075-4426"}],"subject":[],"published":{"date-parts":[[2024,5,4]]}}}