{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:21:29Z","timestamp":1792092089601,"version":"4.4.0"},"reference-count":20,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>The global incidence of cutaneous melanoma (CM) is rising, necessitating early detection and identification of risk factors across different populations. A case\u2013control study with 180 patients with primary diagnosed CM and 182 healthy controls was conducted. Participants underwent ophthalmic and skin examinations, where the identification and counting of common melanocytic nevi (CMN) and atypical melanocytic nevi (AMN) was performed. During ophthalmic examination, high-resolution slit lamp iris images were taken. Images were categorized according to iris periphery, collaret, and freckles. There was no difference in iris periphery and collaret color between groups. However, blue\/grey iris periphery and blue collaret with or without freckles were the most common patterns. The presence of pigmented iris lesions and 2\u20135 mm and \u22655 mm in diameter CMNs was strongly associated with CM risk. The evidence from this study indicates that blue or grey periphery and blue collaret iris pattern with iris freckles are 2.74 times higher in the CM group than controls. Further research is needed to explore iris patterns\u2019 association with CM risk in diverse populations.<\/jats:p>","DOI":"10.3390\/jpm14050530","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T11:31:52Z","timestamp":1715772712000},"page":"530","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Iris Pigmented Lesions and Risk of Cutaneous Melanoma: Case\u2013Control Study in Lithuania"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7001-1782","authenticated-orcid":false,"given":"Lukas","family":"\u0160emeklis","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"},{"name":"Department of Ophthalmology, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, LT-50161 Kaunas, Lithuania"},{"name":"Department of Skin and Venereal Diseases, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6426-7616","authenticated-orcid":false,"given":"Laura","family":"Kapitanovait\u0117","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"},{"name":"Department of Ophthalmology, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, LT-50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grinvydas","family":"Butrimas","sequence":"additional","affiliation":[{"name":"Department of Skin and Venereal Diseases, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"},{"name":"Department of Skin and Venereal Diseases, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, LT-50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0562-6403","authenticated-orcid":false,"given":"Kamilija","family":"Bried\u0117","sequence":"additional","affiliation":[{"name":"Department of Skin and Venereal Diseases, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"},{"name":"Department of Skin and Venereal Diseases, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, LT-50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"August\u0117","family":"Dubinskait\u0117","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reda","family":"\u017demaitien\u0117","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"},{"name":"Department of Ophthalmology, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, LT-50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1219-5928","authenticated-orcid":false,"given":"Skaidra","family":"Valiukevi\u010dien\u0117","sequence":"additional","affiliation":[{"name":"Department of Skin and Venereal Diseases, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"},{"name":"Department of Skin and Venereal Diseases, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, LT-50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.14740\/wjon1349","article-title":"Cutaneous Malignant Melanoma: A Review of Early Diagnosis and Management","volume":"12","author":"Naik","year":"2021","journal-title":"World J. 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