{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:19:54Z","timestamp":1779344394410,"version":"3.51.4"},"reference-count":60,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018841","name":"Associazione Italiana Ricerca Alzheimer Onlus","doi-asserted-by":"publisher","award":["AirAlzh-AGYR-2022"],"award-info":[{"award-number":["AirAlzh-AGYR-2022"]}],"id":[{"id":"10.13039\/501100018841","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondazione Cariplo\u2014SENIOR project","award":["AirAlzh-AGYR-2022"],"award-info":[{"award-number":["AirAlzh-AGYR-2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Spatial navigation deficits are reported as early symptoms of Alzheimer\u2019s disease (AD) alongside episodic memory ones. The aim of the present study was to ascertain whether neuropsychological deficits of visuospatial long-term memory can predict behavioral alterations during the navigation of older adults in novel urban environments along the normal aging\u2013dementia continuum of the Alzheimer\u2019s type. Methods: A total of 24 community-dwelling patients with Mild Cognitive Impairment (MCI) due to AD, 27 individuals with subjective cognitive decline (SCD), and 21 healthy controls were assessed in terms of their sequential egocentric and allocentric navigation abilities by using a modified version of the Detour Navigation Test, and neuropsychologically tested by the Corsi learning suvra-span (CLSS) test. Generalized linear models were adopted to verify whether the scores obtained by the three groups in the CLSS test predicted wrong turns and moments of hesitation during the navigation task, with the results presented as topographical disorientation scores. Results: Higher scores in the CLSS test predicted fewer wrong turns (b = \u22120.05; z = \u22122.91; p = 0.004; net of between-groups differences) and moments of hesitation for patients with MCI due to AD (b = \u22120.14; z = \u22122.43; p = 0.015), and individuals with SCD (b = \u22120.17; z = \u22123.85; p &lt; 0.001). Conclusions: Since the CLSS test has been reported to be a reliable measure of ecological navigational abilities in the progression towards AD dementia, we recommend its use in clinical practice and highlight implications for future research.<\/jats:p>","DOI":"10.3390\/jpm14050539","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T06:53:49Z","timestamp":1715928829000},"page":"539","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Behavioral Disorders of Spatial Cognition in Patients with Mild Cognitive Impairment Due to Alzheimer\u2019s Disease (The BDSC-MCI Project): Ecological Validity of the Corsi Learning Suvra-Span Test"],"prefix":"10.3390","volume":"14","author":[{"given":"Davide Maria","family":"Cammisuli","sequence":"first","affiliation":[{"name":"Department of Psychology, Catholic University, 20123 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4502-3705","authenticated-orcid":false,"given":"Gloria","family":"Marchesi","sequence":"additional","affiliation":[{"name":"Department of Psychology, Catholic University, 20123 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1998-6645","authenticated-orcid":false,"given":"Virginia","family":"Bellocchio","sequence":"additional","affiliation":[{"name":"Catholic University, 20123 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo Nicol\u00f2","family":"Aiello","sequence":"additional","affiliation":[{"name":"Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, 20149 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Poletti","sequence":"additional","affiliation":[{"name":"Department of Neurology and Laboratory 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