{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:06:42Z","timestamp":1760144802896,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"publisher","award":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"],"award-info":[{"award-number":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Research Plan of SHDC","award":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"],"award-info":[{"award-number":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"]}]},{"name":"Shanghai Technology Research Leader Program","award":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"],"award-info":[{"award-number":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"]}]},{"name":"Shanghai three-year plan for biobank construction project","award":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"],"award-info":[{"award-number":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"]}]},{"name":"International Medical Exchange Foundation","award":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"],"award-info":[{"award-number":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"]}]},{"name":"Grant for the construction of Innovative Flagship Hospital for Integrated Traditional Chinese and Western Medicine","award":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"],"award-info":[{"award-number":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"]}]},{"name":"The Health Youth Talent Project of Shanghai Municipal Health Commission","award":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"],"award-info":[{"award-number":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"]}]},{"name":"Shanghai Municipal Health Commission Clinical Research Project","award":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"],"award-info":[{"award-number":["82170388","SHDC2020CR1040B","21XD1434700","SHDC2020CR5009","SHDC2020CR5015-002","Z-2019-42-1908-3","ZY(2021-2023)-0205-05","2022YQ023","20214Y0152"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>This study aimed to investigate the impact of various vasculopathies alongside left ventricular hypertrophy (LVH) on cardiovascular risk in the elderly. This prospective cohort study included 3339 older adults from the Northern Shanghai Study, classified into four mutually exclusive left ventricular (LV) geometry groups based on echocardiographic data: normal geometry, concentric remodeling, eccentric hypertrophy, and concentric hypertrophy. Vasculopathy was categorized into three primary types: arteriosclerosis, atherosclerosis, and renal senescence. Major adverse cardiovascular events (MACEs) were defined as non-fatal acute myocardial infarction, non-fatal stroke, and cardiovascular deaths according to ICD-10 codes. Over a median follow-up period of 5.7 years, 221 incident cases of MACEs were identified. Concentric hypertrophy exhibited the highest prevalence of hypertension, the most significant increase in vascular stiffness, and the highest rate of MACEs. The adjusted Cox regression analysis showed that eccentric hypertrophy is associated with an increased risk of MACEs (HR: 1.638 [95% CI: 1.151\u20132.331], p = 0.006), while concentric hypertrophy shows an even higher risk (HR: 1.751 [95% CI: 1.127\u20132.721], p = 0.013). Conversely, concentric remodeling was not significantly associated with an increased risk of MACEs. Renal senescence presents a moderate but significant risk for MACEs, with an HR of 1.361 (95% CI: 1.019\u20131.819; p = 0.037) when adjusted for LVH. The Kaplan\u2013Meier analysis showed that patients with LVH and multiple vasculopathies experience the most significant decrease in survival probability (log-rank p &lt; 0.001). The subgroup analysis revealed that LVH significantly raises the risk of MACEs, especially in older males with hypertension, diabetes, or vasculopathy. This study reinforces the importance of LVH as a predictor of adverse cardiovascular outcomes and underscores the compounded risk associated with the presence of multiple vasculopathies. Additionally, it highlights renal senescence as a distinct and independent risk factor for MACEs, separate from LVH.<\/jats:p>","DOI":"10.3390\/jpm14060558","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T11:37:13Z","timestamp":1716464233000},"page":"558","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vasculopathy Augments Cardiovascular Risk in Community-Dwelling Elderly with Left Ventricular Hypertrophy"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8524-4961","authenticated-orcid":false,"given":"Rusitanmujiang","family":"Maimaitiaili","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiadela","family":"Teliewubai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shikai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weilun","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5028-9151","authenticated-orcid":false,"given":"Yifan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8693-3554","authenticated-orcid":false,"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/eurjpc\/zwad254","article-title":"Echocardiographic heart ageing patterns predict cardiovascular and non-cardiovascular events and reflect biological age: The SardiNIA study","volume":"31","author":"Ganau","year":"2024","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.jcmg.2016.01.038","article-title":"Natural History of Myocardial Function in an Adult Human Population: Serial Longitudinal Observations From MESA","volume":"9","author":"Yoneyama","year":"2016","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1093\/eurheartj\/ehu389","article-title":"Midlife blood pressure change and left ventricular mass and remodelling in older age in the 1946 British Birth Cohort Study","volume":"35","author":"Ghosh","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1161\/ATVBAHA.120.313128","article-title":"Central Versus Peripheral Artery Stiffening and Cardiovascular Risk","volume":"40","author":"Yu","year":"2020","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/CIRCRESAHA.121.318061","article-title":"Arterial Stiffness and Cardiovascular Risk in Hypertension","volume":"128","author":"Boutouyrie","year":"2021","journal-title":"Circ. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/j.jacc.2015.08.888","article-title":"Carotid stiffness is associated with incident stroke: A systematic review and individual participant data meta-analysis","volume":"66","author":"Sedaghat","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S1474-4422(23)00067-4","article-title":"Effect of atherosclerosis on 5-year risk of major vascular events in patients with transient ischaemic attack or minor ischaemic stroke: An international prospective cohort study","volume":"22","author":"Lavallee","year":"2023","journal-title":"Lancet Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1177\/2047487319893046","article-title":"Myocardial infarction and peripheral arterial disease: Treatment patterns and long-term outcome in men and women results from a Swedish nationwide study","volume":"28","author":"Sigvant","year":"2021","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/ki.2010.123","article-title":"Cardio-Kidney-Damage: A unifying concept","volume":"78","year":"2010","journal-title":"Kidney Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/ejhf.778","article-title":"The association of chronic kidney disease and microalbuminuria with heart failure with preserved vs. reduced ejection fraction","volume":"19","author":"Nayor","year":"2017","journal-title":"Eur. J. Heart Fail."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41371-021-00565-w","article-title":"Association of carotid wall layers with atherosclerotic plaques and cardiac hypertrophy in hypertensive subjects","volume":"36","author":"Bonafe","year":"2022","journal-title":"J. Hum. Hypertens."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e003039","DOI":"10.1161\/CIRCIMAGING.114.003039","article-title":"Relations between aortic stiffness and left ventricular structure and function in older participants in the Age, Gene\/Environment Susceptibility--Reykjavik Study","volume":"8","author":"Bell","year":"2015","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e004426","DOI":"10.1161\/CIRCIMAGING.115.004426","article-title":"Association of Aortic Stiffness with Left Ventricular Remodeling and Reduced Left Ventricular Function Measured by Magnetic Resonance Imaging: The Multi-Ethnic Study of Atherosclerosis","volume":"9","author":"Ohyama","year":"2016","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1161\/HYPERTENSIONAHA.119.14258","article-title":"Left Ventricular Mass and Incident Chronic Kidney Disease","volume":"75","author":"Agarwal","year":"2020","journal-title":"Hypertension"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41598-023-51085-1","article-title":"Association of baseline electrocardiographic left ventricular hypertrophy with future renal function decline in the general population","volume":"14","author":"Ikeda","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10741-010-9197-z","article-title":"Hypertension, left ventricular hypertrophy and chronic kidney disease","volume":"16","author":"Taddei","year":"2011","journal-title":"Heart Fail. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1053\/j.ajkd.2015.06.024","article-title":"Estimated GFR and Subsequent Higher Left Ventricular Mass in Young and Middle-Aged Adults with Normal Kidney Function: The Coronary Artery Risk Development in Young Adults (CARDIA) Study","volume":"67","author":"Bansal","year":"2016","journal-title":"Am. J. Kidney Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/ki.2010.8","article-title":"Urinary albumin excretion, even within the normal range, predicts an increase in left ventricular mass over the following 5 years","volume":"77","author":"Reffelmann","year":"2010","journal-title":"Kidney Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e013880","DOI":"10.1136\/bmjopen-2016-013880","article-title":"Northern Shanghai Study: Cardiovascular risk and its associated factors in the Chinese elderly-a study protocol of a prospective study design","volume":"7","author":"Ji","year":"2017","journal-title":"BMJ Open"},{"key":"ref_20","first-page":"1","article-title":"The guidelines for prevention and control of overweight and obesity in Chinese adults","volume":"17","author":"Chen","year":"2004","journal-title":"Biomed. Environ. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","article-title":"2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA)","volume":"41","author":"Mancia","year":"2023","journal-title":"J. Hypertens."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0002-9149(76)90491-4","article-title":"Problems in echocardiographic volume determinations: Echocardiographic-angiographic correlations in the presence of absence of asynergy","volume":"37","author":"Teichholz","year":"1976","journal-title":"Am. J. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/HJH.0b013e32834fa8b0","article-title":"Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity","volume":"30","author":"Laurent","year":"2012","journal-title":"J. Hypertens."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/eurheartj\/ehx095","article-title":"2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteriesEndorsed by: The European Stroke Organization (ESO)The Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS)","volume":"39","author":"Aboyans","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000343145","article-title":"Mannheim carotid intima-media thickness and plaque consensus (2004\u20132006\u20132011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011","volume":"34","author":"Touboul","year":"2012","journal-title":"Cerebrovasc. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/aje\/kwp382","article-title":"The relevance of different methods of calculating the ankle-brachial index: The multi-ethnic study of atherosclerosis","volume":"171","author":"Allison","year":"2010","journal-title":"Am. J. Epidemiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1097\/00004872-199816090-00020","article-title":"Atherosclerosis and left ventricular hypertrophy: Persisting problems in treated hypertensive patients","volume":"16","author":"Gamble","year":"1998","journal-title":"J. Hypertens."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"ITC1-16","DOI":"10.7326\/AITC201506020","article-title":"Chronic kidney disease","volume":"162","author":"Drawz","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Qiao, S., Hao, H., Li, Q., Bao, X., Wang, K., Gu, R., Li, G., Kang, L., and Wu, H. (2023). The predictive value of relative wall thickness on the prognosis of the patients with ST-segment elevation myocardial infarction. BMC Cardiovasc. Disord., 23.","DOI":"10.1186\/s12872-023-03379-5"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1038\/s41598-024-57058-2","article-title":"Early menopause is associated with abnormal diastolic function and poor clinical outcomes in women with suspected angina","volume":"14","author":"Bae","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/ehjci\/jeu217","article-title":"Relationship of left ventricular mass to coronary atherosclerosis and myocardial ischaemia: The CORE320 multicenter study","volume":"16","author":"Kishi","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.14336\/AD.2023.0222","article-title":"TGF-beta as A Master Regulator of Aging-Associated Tissue Fibrosis","volume":"14","author":"Ren","year":"2023","journal-title":"Aging Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/ckj\/sfad076","article-title":"Early aging and premature vascular aging in chronic kidney disease","volume":"16","author":"Tanriover","year":"2023","journal-title":"Clin. Kidney J."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Fularski, P., Krzeminska, J., Lewandowska, N., Mlynarska, E., Saar, M., Wronka, M., Rysz, J., and Franczyk, B. (2023). Statins in Chronic Kidney Disease-Effects on Atherosclerosis and Cellular Senescence. Cells, 12.","DOI":"10.3390\/cells12131679"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1681\/ASN.2019020117","article-title":"Arterial Stiffness in the Heart Disease of CKD","volume":"30","author":"Zanoli","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.phrs.2018.06.026","article-title":"Changes in left ventricular geometry during antihypertensive treatment","volume":"134","author":"Salvetti","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pcad.2019.11.009","article-title":"Left ventricular hypertrophy and hypertension","volume":"63","author":"Yildiz","year":"2020","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.jacc.2011.07.022","article-title":"Left ventricular structural remodeling in health and disease: With special emphasis on volume, mass, and geometry","volume":"58","author":"Gaasch","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.jacc.2016.07.729","article-title":"52 Genetic Loci Influencing Myocardial Mass","volume":"68","author":"Verweij","year":"2016","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/6\/558\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:47:30Z","timestamp":1760107650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/6\/558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,23]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["jpm14060558"],"URL":"https:\/\/doi.org\/10.3390\/jpm14060558","relation":{},"ISSN":["2075-4426"],"issn-type":[{"type":"electronic","value":"2075-4426"}],"subject":[],"published":{"date-parts":[[2024,5,23]]}}}