{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:44:27Z","timestamp":1781649867131,"version":"3.54.5"},"reference-count":26,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022-R1G1A1008857"],"award-info":[{"award-number":["NRF-2022-R1G1A1008857"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Tonsillectomy has been suggested as a potential intervention to resolve psoriasis; however, its preventive effects on the development of psoriasis remain unclear. This study aimed to investigate the risk of developing late-onset psoriasis among a Korean adult population who had undergone tonsillectomy. Data from the Korean National Health Insurance Service-Health Screening Cohort between 2002 and 2019 were utilized. Out of a total of 514,866 participants, 1082 participants aged 40 years or older who had undergone tonsillectomy were matched with 4328 control participants using overlap weighting adjustment based on the propensity score. The incidence and hazard ratio (HR) of psoriasis were calculated for both tonsillectomy and control groups. The incidence rates of psoriasis were 1.30% in the tonsillectomy group and 1.20% in the control group. The incidence of psoriasis (overlap-weighted HR = 1.08, 95% confidence of interval = 0.69\u20131.69, and p = 0.732) did not differ significantly between the patients who underwent tonsillectomy and those in the control group. The cumulative probability of developing psoriasis was not different between the two groups (Log-rank test: p = 0.440). These findings were consistent across subgroups divided by age, sex, income, and region of residence. We found that tonsillectomy did not confer a preventive effect on the development of late-onset psoriasis in the Korean adult population.<\/jats:p>","DOI":"10.3390\/jpm14060605","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T12:04:28Z","timestamp":1717675468000},"page":"605","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence of Late-Onset Psoriasis Following Tonsillectomy: A Longitudinal Follow-Up Study Using a National Health Screening Cohort"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6370-5997","authenticated-orcid":false,"given":"Sung Joon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Seoul 14353, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hahn Jin","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Kangdong Sacred Heart Hospital, Seoul 05355, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-9549","authenticated-orcid":false,"given":"Hyo Geun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Mdanalytics, Suseoseoulent Clinic, Seoul 06349, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heejin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-7011","authenticated-orcid":false,"given":"Jee Hye","family":"Wee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"743180","DOI":"10.3389\/fmed.2021.743180","article-title":"The Global, Regional, and National Burden of Psoriasis: Results and Insights From the Global Burden of Disease 2019 Study","volume":"8","author":"Damiani","year":"2021","journal-title":"Front. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00403-024-02846-z","article-title":"Global burden and future trends in psoriasis epidemiology: Insights from the global burden of disease study 2019 and predictions to 2030","volume":"316","author":"Wang","year":"2024","journal-title":"Arch. Dermatol. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"761","DOI":"10.5021\/ad.2017.29.6.761","article-title":"Prevalence of Psoriasis in Korea: A Population-Based Epidemiological Study Using the Korean National Health Insurance Database","volume":"29","author":"Lee","year":"2017","journal-title":"Ann. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"460","DOI":"10.5114\/ada.2021.108445","article-title":"Treatments in psoriasis: From standard pharmacotherapy to nanotechnology therapy","volume":"39","author":"Zhu","year":"2022","journal-title":"Postep. Dermatol. Alergol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/08820139.2024.2302823","article-title":"Etiopathogenesis of Psoriasis: Integration of Proposed Theories","volume":"53","year":"2024","journal-title":"Immunol. Investug."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Olejnik-Wojciechowska, J., Boboryko, D., Bratborska, A.W., Rusi\u0144ska, K., Ostrowski, P., Baranowska, M., and Pawlik, A. (2024). The Role of Epigenetic Factors in the Pathogenesis of Psoriasis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073831"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.jid.2019.12.022","article-title":"Specific IgA and CLA(+) T-Cell IL-17 Response to Streptococcus pyogenes in Psoriasis","volume":"140","author":"Ferran","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3109\/09546634.2013.848258","article-title":"Tonsillectomy as a treatment for psoriasis: A review","volume":"25","author":"Wu","year":"2014","journal-title":"J. Dermatol. Treat."},{"key":"ref_9","first-page":"788","article-title":"Throat Infections are Associated with Exacerbation in a Substantial Proportion of Patients with Chronic Plaque Psoriasis","volume":"96","author":"Thorleifsdottir","year":"2016","journal-title":"Acta Derm. Venereol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jaad.2014.10.013","article-title":"Effect of tonsillectomy on psoriasis: A systematic review","volume":"72","author":"Rachakonda","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_11","first-page":"Cd011571","article-title":"Antistreptococcal interventions for guttate and chronic plaque psoriasis","volume":"3","author":"Dupire","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e554","DOI":"10.1111\/ajd.13710","article-title":"Demographic and epidemiological drivers of global burden of psoriasis","volume":"62","author":"Xu","year":"2021","journal-title":"Australas. J. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/bjd.19169","article-title":"Systematic review examining changes over time and variation in the incidence and prevalence of psoriasis by age and gender","volume":"184","author":"Iskandar","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0190-9622(85)70188-0","article-title":"Psoriasis of early and late onset: Characterization of two types of psoriasis vulgaris","volume":"13","author":"Henseler","year":"1985","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"412","DOI":"10.21053\/ceo.2018.01774","article-title":"Tobacco Smoking and Alcohol Consumption Are Related to Benign Parotid Tumor: A Nested Case-Control Study Using a National Health Screening Cohort","volume":"12","author":"Kim","year":"2019","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e016640","DOI":"10.1136\/bmjopen-2017-016640","article-title":"Cohort profile: The National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) in Korea","volume":"7","author":"Seong","year":"2017","journal-title":"BMJ Open"},{"key":"ref_17","first-page":"15","article-title":"The Asia-Pacific perspective: Redefining obesity and its treatment","volume":"2","author":"Region","year":"2000","journal-title":"Int. Obes. Task Force"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/aje\/kwq433","article-title":"Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries","volume":"173","author":"Quan","year":"2011","journal-title":"Am. J. Epidemiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","article-title":"Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data","volume":"43","author":"Quan","year":"2005","journal-title":"Med. Care"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.jaad.2021.01.094","article-title":"Tonsillectomy and the subsequent risk of psoriasis: A nationwide population-based cohort study","volume":"85","author":"Chen","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.4049\/jimmunol.1102834","article-title":"Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants","volume":"188","author":"Thorleifsdottir","year":"2012","journal-title":"J. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.clindermatol.2019.01.011","article-title":"Mechanisms of microbial pathogenesis and the role of the skin microbiome in psoriasis: A review","volume":"37","author":"Lewis","year":"2019","journal-title":"Clin. Dermatol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Kim, S.Y., Min, C., Lee, W.H., and Choi, H.G. (2018). Tonsillectomy increases the risk of retropharyngeal and parapharyngeal abscesses in adults, but not in children: A national cohort study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193913"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/pch\/pxw004","article-title":"Tonsillectomy or adenotonsillectomy versus non-surgical treatment for chronic\/recurrent acute tonsillitis","volume":"22","year":"2017","journal-title":"Paediatr. Child Health"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.jaad.2017.04.1109","article-title":"A cross-sectional study of psoriasis triggers among different ethno-racial groups","volume":"77","author":"Yan","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Chen, J.W., Liao, P.W., Hsieh, C.J., Chen, C.C., and Chiou, S.J. (2018). Factors associated with changing indications for adenotonsillectomy: A population-based longitudinal study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193317"}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/6\/605\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:54:56Z","timestamp":1760108096000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/6\/605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,6]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["jpm14060605"],"URL":"https:\/\/doi.org\/10.3390\/jpm14060605","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,6]]}}}