{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:44:05Z","timestamp":1793047445231,"version":"4.5.0"},"reference-count":42,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"Basic Science Research Program through the National Research Foundation of Korea, which is funded by the Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2023-00209591"],"award-info":[{"award-number":["RS-2023-00209591"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"Basic Science Research Program through the National Research Foundation of Korea, which is funded by the Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2023-00243616"],"award-info":[{"award-number":["RS-2023-00243616"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"Basic Science Research Program through the National Research Foundation of Korea, which is funded by the Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2023-00229822"],"award-info":[{"award-number":["RS-2023-00229822"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education","award":["RS-2023-00209591"],"award-info":[{"award-number":["RS-2023-00209591"]}]},{"name":"Ministry of Education","award":["RS-2023-00243616"],"award-info":[{"award-number":["RS-2023-00243616"]}]},{"name":"Ministry of Education","award":["RS-2023-00229822"],"award-info":[{"award-number":["RS-2023-00229822"]}]},{"name":"National Research Foundation (NRF) funded by the Korean government (MSIT)","award":["RS-2023-00209591"],"award-info":[{"award-number":["RS-2023-00209591"]}]},{"name":"National Research Foundation (NRF) funded by the Korean government (MSIT)","award":["RS-2023-00243616"],"award-info":[{"award-number":["RS-2023-00243616"]}]},{"name":"National Research Foundation (NRF) funded by the Korean government (MSIT)","award":["RS-2023-00229822"],"award-info":[{"award-number":["RS-2023-00229822"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Objectives: The aim of this nationwide longitudinal cohort study is to determine the risk of congestive heart failure (CHF) associated with a seropositive rheumatoid arthritis (RA) population in Korea. Methods: In this study, National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) data from 2002 to 2003 were used. The cohort was followed up with for 12 years until December of 2015. Seropositive RA was defined as a patient prescribed with a disease-modifying anti-rheumatic drug (DMARD) among patients with the International Classification of Diseases code M05 (seropositive RA). Patients who were diagnosed before 2004 were excluded. The seropositive RA group consisted of 2765 patients, and a total of 13,825 patients were in the control group. The Kaplan\u2013Meier method was used to calculate the 12-year CHF incidence rate for each group. A Cox proportional hazards regression analysis was used to estimate the hazard ratio of CHF. Results: The hazard ratio of CHF in the seropositive RA group was 2.41 (95% confidence interval (CI): 1.40\u20134.14) after adjusting for age and sex. The adjusted hazard ratio of CHF in the seropositive RA group was 2.50 (95% CI: 1.45\u20134.30) after adjusting for age, sex, income, and comorbidities. In females aged \u226565 and aged &lt;65, the incidence rates in the non-hypertension, non-diabetes mellitus, and non-dyslipidemia subgroups were significantly higher in the seropositive RA group than in the control group. Conclusions: This nationwide longitudinal cohort study shows an increased risk of CHF in patients with seropositive RA.<\/jats:p>","DOI":"10.3390\/jpm14060615","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T10:08:43Z","timestamp":1718014123000},"page":"615","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Relationship between Seropositive Rheumatoid Arthritis and Congestive Heart Failure: A Nationwide Longitudinal Cohort Study in Korea"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2056-3719","authenticated-orcid":false,"given":"Yeo Song","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Incheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je Beom","family":"Hong","sequence":"additional","affiliation":[{"name":"Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul 03181, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Genome & Health Big Data Branch, Department of Public Health, Graduate School of Public Health, Seoul National University, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0454-8810","authenticated-orcid":false,"given":"Seung Hun","family":"Sheen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-9325","authenticated-orcid":false,"given":"In-bo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9252-882X","authenticated-orcid":false,"given":"Jeong Gyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Cheongju St. Mary\u2019s Hospital, Cheongju-si 17319, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin Soo","family":"Jeun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5724-8099","authenticated-orcid":false,"given":"Seil","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00296-016-3638-5","article-title":"Mortality in patients with rheumatoid arthritis: A 15-year prospective cohort study","volume":"37","author":"Boshuizen","year":"2017","journal-title":"Rheumatol. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1038\/s41598-020-60621-2","article-title":"Mortality is increased in patients with rheumatoid arthritis or diabetes compared to the general population\u2014The Nord-Tr\u00f8ndelag Health Study","volume":"10","author":"Houge","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1093\/rheumatology\/kead106","article-title":"Mortality estimates and excess mortality in rheumatoid arthritis","volume":"62","author":"Black","year":"2023","journal-title":"Rheumatology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4078\/jrd.2021.28.2.60","article-title":"Epidemiology of Rheumatoid Arthritis in Korea","volume":"28","author":"Kim","year":"2021","journal-title":"J. Rheum. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/art.20855","article-title":"Cardiovascular death in rheumatoid arthritis: A population-based study","volume":"52","author":"Nicola","year":"2005","journal-title":"Arthritis Rheum."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1161\/01.CIR.0000054612.26458.B2","article-title":"Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis","volume":"107","author":"Solomon","year":"2003","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/art.24092","article-title":"Risk of cardiovascular mortality in patients with rheumatoid arthritis: A meta-analysis of observational studies","volume":"59","author":"Choi","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s11883-008-0019-x","article-title":"Rheumatoid arthritis and cardiovascular disease","volume":"10","author":"Dhawan","year":"2008","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1002\/ehf2.12947","article-title":"Incidence of congestive heart failure in rheumatoid arthritis: A review of literature and meta-regression analysis","volume":"7","author":"Khalid","year":"2020","journal-title":"ESC Heart Fail."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ehf2.12005","article-title":"Heart failure: Preventing disease and death worldwide","volume":"1","author":"Ponikowski","year":"2014","journal-title":"ESC Heart Fail."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/art.21560","article-title":"Contribution of congestive heart failure and ischemic heart disease to excess mortality in rheumatoid arthritis","volume":"54","author":"Nicola","year":"2006","journal-title":"Arthritis Rheum."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s10067-024-06878-8","article-title":"Association of congestive heart failure with mortality in individuals with rheumatoid arthritis: A cohort study","volume":"43","author":"Wang","year":"2024","journal-title":"Clin. Rheumatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/art.20855","article-title":"The risk of congestive heart failure in rheumatoid arthritis: A population-based study over 46 years","volume":"52","author":"Nicola","year":"2005","journal-title":"Arthritis Rheum."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e007227","DOI":"10.1161\/JAHA.117.007227","article-title":"Incident Heart Failure in Patients with Rheumatoid Arthritis: A Nationwide Cohort Study","volume":"7","author":"Khalid","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"100455","DOI":"10.1016\/j.cpcardiol.2019.100455","article-title":"Trends of Cardiac Complications in Patients with Rheumatoid Arthritis: Analysis of the United States National Inpatient Sample; 2005\u20132014","volume":"46","author":"Bandyopadhyay","year":"2019","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.jacc.2016.12.033","article-title":"Association Between Rheumatoid Arthritis and Risk of Ischemic and Nonischemic Heart Failure","volume":"69","author":"Mantel","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_17","first-page":"89","article-title":"Changes in the medical burden of pyogenic and tuberculous spondylitis between 2007 and 2016: A nationwide cohort study","volume":"73","author":"Kim","year":"2020","journal-title":"J. Clin. Neurosci. Off. J. Neurosurg. Soc. Australas."},{"key":"ref_18","first-page":"34","article-title":"Association of Acute Myocardial Infarction with ankylosing Spondylitis: A nationwide longitudinal cohort study","volume":"56","author":"Park","year":"2018","journal-title":"J. Clin. Neurosci. Off. J. Neurosurg. Soc. Australas."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3340\/jkns.2018.0110","article-title":"Association of Congestive Heart Failure and Death with Ankylosing Spondylitis: A Nationwide Longitudinal Cohort Study in Korea","volume":"62","author":"Bae","year":"2019","journal-title":"J. Korean Neurosurg. Soc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e016640","DOI":"10.1136\/bmjopen-2017-016640","article-title":"Cohort profile: The National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) in Korea","volume":"7","author":"Seong","year":"2017","journal-title":"BMJ Open"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1007\/s00296-013-2833-x","article-title":"Development of an algorithm for identifying rheumatoid arthritis in the Korean National Health Insurance claims database","volume":"33","author":"Cho","year":"2013","journal-title":"Rheumatol. Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/pan\/mpl013","article-title":"Matching as Nonparametric Preprocessing for Reducing Model Dependence in Parametric Causal Inference","volume":"15","author":"Ho","year":"2007","journal-title":"Political Anal."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v042.i08","article-title":"Matchit: Nonparametric Preprocessing for Parametric Causal Inference","volume":"42","author":"Ho","year":"2011","journal-title":"J. Stat. Softw."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00701-018-3499-7","article-title":"Association of ischemic stroke with ankylosing spondylitis: A nationwide longitudinal cohort study","volume":"160","author":"Lee","year":"2018","journal-title":"Acta Neurochir."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/ije\/dyx175","article-title":"Association between adult height, myocardial infarction, heart failure, stroke and death: A Korean nationwide population-based study","volume":"47","author":"Park","year":"2018","journal-title":"Int. J. Epidemiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9973","DOI":"10.1038\/s41598-017-10556-y","article-title":"Increased Risk of Atrial Fibrillation and Thromboembolism in Patients with Severe Psoriasis: A Nationwide Population-based Study","volume":"7","author":"Rhee","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijcard.2017.02.039","article-title":"Trends in the incidence and prevalence of atrial fibrillation and estimated thromboembolic risk using the CHA2DS2-VASc score in the entire Korean population","volume":"236","author":"Lee","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Lee, S.R., Choi, E.K., Han, K.D., Cha, M.J., Oh, S., and Lip, G.Y.H. (2017). Temporal trends of antithrombotic therapy for stroke prevention in Korean patients with non-valvular atrial fibrillation in the era of non-vitamin K antagonist oral anticoagulants: A nationwide population-based study. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0189495"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/14712598.2018.1462794","article-title":"The effect of biological DMARDs on the risk of congestive heart failure in rheumatoid arthritis: A systematic review","volume":"18","author":"Baniaamam","year":"2018","journal-title":"Expert. Opin. Biol. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-med-060911-090007","article-title":"Mechanisms of premature atherosclerosis in rheumatoid arthritis and lupus","volume":"64","author":"Kahlenberg","year":"2013","journal-title":"Annu. Rev. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.jacc.2007.06.040","article-title":"Unusual CD4+CD28nullT Lymphocytes and Recurrence of Acute Coronary Events","volume":"50","author":"Liuzzo","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/CRD.0000000000000486","article-title":"Cardiovascular Manifestations in Rheumatoid Arthritis","volume":"32","author":"Sanghavi","year":"2024","journal-title":"Cardiol. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000338166","article-title":"Inflammatory cytokines in heart failure: Mediators and markers","volume":"122","author":"Gullestad","year":"2012","journal-title":"Cardiology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1161\/01.CIR.0000097109.90783.FC","article-title":"Inflammatory markers and onset of cardiovascular events: Results from the Health ABC study","volume":"108","author":"Cesari","year":"2003","journal-title":"Circulation"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/art.23149","article-title":"Association of the HLA\u2013DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis","volume":"58","author":"Farragher","year":"2008","journal-title":"Arthritis Rheum. Off. J. Am. Coll. Rheumatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/archinte.160.6.777","article-title":"Consumption of NSAIDs and the development of congestive heart failure in elderly patients: An underrecognized public health problem","volume":"160","author":"Page","year":"2000","journal-title":"Arch. Intern. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/01.EDE.0000034633.74133.C3","article-title":"Nonsteroidal antiinflammatory drugs as a trigger of clinical heart failure","volume":"14","year":"2003","journal-title":"Epidemiology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1136\/annrheumdis-2021-220577","article-title":"Short-term dose and duration-dependent glucocorticoid risk for cardiovascular events in glucocorticoid-naive patients with rheumatoid arthritis","volume":"80","author":"Ocon","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Boers, M., Hartman, L., Opris-Belinski, D., Bos, R., Kok, M., da Silva, J.P., Griep, E., Klaasen, R., Allaart, C.F., and Baudoin, P. (2021). Favorable balance of benefit and harm of long-term, low dose prednisolone added to standard treatment in rheumatoid arthritis patients aged 65+: The pragmatic, multicenter, placebo-controlled GLORIA trial. Arthritis & Rheumatology, Wiley.","DOI":"10.1136\/annrheumdis-2022-eular.698"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1080\/14740338.2021.1956460","article-title":"Safety profile of D-penicillamine: A comprehensive pharmacovigilance analysis by FDA adverse event reporting system","volume":"20","author":"Kumar","year":"2021","journal-title":"Expert. Opin. Drug Saf."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/BOR.0000000000000881","article-title":"Nonsteroidal anti-inflammatory drugs and cardiovascular disease risk in spondyloarthritis-spectrum diseases","volume":"34","author":"So","year":"2022","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1056\/NEJMoa1611593","article-title":"Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis","volume":"375","author":"Nissen","year":"2016","journal-title":"N. Engl. J. Med."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/6\/615\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:55:45Z","timestamp":1760108145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/6\/615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,8]]},"references-count":42,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["jpm14060615"],"URL":"https:\/\/doi.org\/10.3390\/jpm14060615","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,8]]}}}