{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:24:54Z","timestamp":1785799494165,"version":"3.56.0"},"reference-count":91,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Fibromyalgia and osteoarthritis are among the most prevalent rheumatic conditions worldwide. Nonpharmacological interventions have gained scientific endorsements as the preferred initial treatments before resorting to pharmacological modalities. Repetitive transcranial magnetic stimulation (rTMS) is among the most widely researched neuromodulation techniques, though it has not yet been officially recommended for fibromyalgia. This review aims to summarize the current evidence supporting rTMS for treating various fibromyalgia symptoms. Recent findings: High-frequency rTMS directed at the primary motor cortex (M1) has the strongest support in the literature for reducing pain intensity, with new research examining its long-term effectiveness. Nonetheless, some individuals may not respond to M1-targeted rTMS, and symptoms beyond pain can be prominent. Ongoing research aims to improve the efficacy of rTMS by exploring new brain targets, using innovative stimulation parameters, incorporating neuronavigation, and better identifying patients likely to benefit from this treatment. Summary: Noninvasive brain stimulation with rTMS over M1 is a well-tolerated treatment that can improve chronic pain and overall quality of life in fibromyalgia patients. However, the data are highly heterogeneous, with a limited level of evidence, posing a significant challenge to the inclusion of rTMS in official treatment guidelines. Research is ongoing to enhance its effectiveness, with future perspectives exploring its impact by targeting additional areas of the brain such as the medial prefrontal cortex, anterior cingulate cortex, and inferior parietal lobe, as well as selecting the right patients who could benefit from this treatment.<\/jats:p>","DOI":"10.3390\/jpm14060662","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T03:44:49Z","timestamp":1718941489000},"page":"662","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Repetitive Transcranial Magnetic Stimulation in Fibromyalgia: Exploring the Necessity of Neuronavigation for Targeting New Brain Regions"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0590-8590","authenticated-orcid":false,"given":"Zoran","family":"Velickovic","sequence":"first","affiliation":[{"name":"Institute of Rheumatology, Resavska 69, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Radunovic","sequence":"additional","affiliation":[{"name":"Institute of Rheumatology, Resavska 69, 11000 Belgrade, Serbia"},{"name":"School of Medicine, University of Belgrade, Dr Suboti\u0107a 1, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"ref_1","first-page":"1205","article-title":"Fibromyalgia: One Year in Review 2023","volume":"41","author":"Giorgi","year":"2023","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Favretti, M., Iannuccelli, C., and Di Franco, M. (2023). Pain Biomarkers in Fibromyalgia Syndrome: Current Understanding and Future Directions. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310443"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Al Sharie, S., Varga, S.J., Al-Husinat, L., Sarzi-Puttini, P., Araydah, M., Bal\u2019awi, B.R., and Varrassi, G. (2024). Unraveling the Complex Web of Fibromyalgia: A Narrative Review. Med. Kaunas Lith., 60.","DOI":"10.20944\/preprints202401.0959.v1"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/S0140-6736(21)00392-5","article-title":"Nociplastic Pain: Towards an Understanding of Prevalent Pain Conditions","volume":"397","author":"Fitzcharles","year":"2021","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3233\/NRE-208007","article-title":"Functional Pain Disorders\u2014More than Nociplastic Pain","volume":"47","author":"Popkirov","year":"2020","journal-title":"NeuroRehabilitation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/j.pain.0000000000001390","article-title":"The IASP Classification of Chronic Pain for ICD-11: Chronic Primary Pain","volume":"160","author":"Nicholas","year":"2019","journal-title":"Pain"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1002\/acr.25104","article-title":"Identifying and Managing Nociplastic Pain in Individuals with Rheumatic Diseases: A Narrative Review","volume":"75","author":"Murphy","year":"2023","journal-title":"Arthritis Care Res."},{"key":"ref_8","first-page":"90","article-title":"Fibromyalgia Syndrome: Under-, over- and Misdiagnosis","volume":"37","author":"Fitzcharles","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1515\/sjpain-2019-0054","article-title":"Revised Chronic Widespread Pain Criteria: Development from and Integration with Fibromyalgia Criteria","volume":"20","author":"Wolfe","year":"2019","journal-title":"Scand. J. Pain"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.semarthrit.2016.08.012","article-title":"2016 Revisions to the 2010\/2011 Fi Bromyalgia Diagnostic Criteria","volume":"46","author":"Wolfe","year":"2016","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jpain.2018.10.008","article-title":"AAPT Diagnostic Criteria for Fibromyalgia","volume":"20","author":"Arnold","year":"2019","journal-title":"J. Pain"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"570","DOI":"10.7861\/clinmed.2022-0402","article-title":"The Diagnosis of Fibromyalgia Syndrome","volume":"22","author":"Berwick","year":"2022","journal-title":"Clin. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e11179","DOI":"10.32872\/cpe.11179","article-title":"Aetiological Understanding of Fibromyalgia, Irritable Bowel Syndrome, Chronic Fatigue Syndrome and Classificatory Analogues: A Systematic Umbrella Review","volume":"5","author":"Daehler","year":"2023","journal-title":"Clin. Psychol. Eur."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/j.pain.0000000000001360","article-title":"The IASP Classification of Chronic Pain for ICD-11: Applicability in Primary Care","volume":"160","author":"Smith","year":"2019","journal-title":"Pain"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Gyorfi, M., Rupp, A., and Abd-Elsayed, A. (2022). Fibromyalgia Pathophysiology. Biomedicines, 10.","DOI":"10.3390\/biomedicines10123070"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Bu\u0142dy\u015b, K., G\u00f3rnicki, T., Ka\u0142ka, D., Szuster, E., Biernikiewicz, M., Markuszewski, L., and Sobieszcza\u0144ska, M. (2023). What Do We Know about Nociplastic Pain?. Healthcare, 11.","DOI":"10.3390\/healthcare11121794"},{"key":"ref_17","first-page":"13","article-title":"Alterations of Brain Activity in Fibromyalgia Patients","volume":"38","author":"Sawaddiruk","year":"2017","journal-title":"J. Clin. Neurosci. Off. J. Neurosurg. Soc. Australas."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ricci, M., Cimini, A., Grivet Fojaja, M.R., Ullo, M., Carabellese, B., Frantellizzi, V., and Lubrano, E. (2022). Novel Approaches in Molecular Imaging and Neuroimaging of Fibromyalgia. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415519"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2147\/JPR.S290795","article-title":"How fMRI Analysis Using Structural Equation Modeling Techniques Can Improve Our Understanding of Pain Processing in Fibromyalgia","volume":"14","author":"Warren","year":"2021","journal-title":"J. Pain Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3344\/kjp.22225","article-title":"Primary Somatosensory Cortex and Periaqueductal Gray Functional Connectivity as a Marker of the Dysfunction of the Descending Pain Modulatory System in Fibromyalgia","volume":"36","author":"Soldatelli","year":"2023","journal-title":"Korean J. Pain"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Feraco, P., Nigro, S., Passamonti, L., Grecucci, A., Caligiuri, M.E., Gagliardo, C., and Bacci, A. (2020). Neurochemical Correlates of Brain Atrophy in Fibromyalgia Syndrome: A Magnetic Resonance Spectroscopy and Cortical Thickness Study. Brain Sci., 10.","DOI":"10.3390\/brainsci10060395"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103355","DOI":"10.1016\/j.nicl.2023.103355","article-title":"Neural Correlates of Control over Pain in Fibromyalgia Patients","volume":"37","author":"Mosch","year":"2023","journal-title":"NeuroImage Clin."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/2773-2398.348254","article-title":"Motor Cortex Inhibition as a Fibromyalgia Biomarker: A Meta-Analysis of Transcranial Magnetic Stimulation Studies","volume":"1","author":"Lima","year":"2022","journal-title":"Brain Netw. Modul."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"17135","DOI":"10.1038\/s41598-022-21557-x","article-title":"Resting-State Functional Connectivity Predicts Motor Cortex Stimulation-Dependent Pain Relief in Fibromyalgia Syndrome Patients","volume":"12","author":"Argaman","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1097\/j.pain.0000000000002927","article-title":"Evidence of Neuroinflammation in Fibromyalgia Syndrome: A [18F]DPA-714 Positron Emission Tomography Study","volume":"164","author":"Mueller","year":"2023","journal-title":"Pain"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e33305","DOI":"10.1097\/MD.0000000000033305","article-title":"Central Metabolites and Peripheral Parameters Associated Neuroinflammation in Fibromyalgia Patients: A Preliminary Study","volume":"102","author":"Jung","year":"2023","journal-title":"Medicine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1097\/j.pain.0000000000002973","article-title":"Large-Scale Momentary Brain Co-Activation Patterns Are Associated with Hyperalgesia and Mediate Focal Neurochemistry and Cross-Network Functional Connectivity in Fibromyalgia","volume":"164","author":"Mawla","year":"2023","journal-title":"Pain"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ioachim, G., Warren, H.J.M., Powers, J.M., Staud, R., Pukall, C.F., and Stroman, P.W. (2022). Altered Pain in the Brainstem and Spinal Cord of Fibromyalgia Patients During the Anticipation and Experience of Experimental Pain. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.862976"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Seo, S., Jung, Y.-H., Lee, D., Lee, W.J., Jang, J.H., Lee, J.-Y., Choi, S.-H., Moon, J.Y., Lee, J.S., and Cheon, G.J. (2021). Abnormal Neuroinflammation in Fibromyalgia and CRPS Using [11C]-(R)-PK11195 PET. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0246152"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"117504","DOI":"10.1016\/j.neuroimage.2020.117504","article-title":"Altered Network Architecture of Functional Brain Communities in Chronic Nociplastic Pain","volume":"226","author":"Larkin","year":"2021","journal-title":"NeuroImage"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/ALN.0000000000002130","article-title":"Neuroinflammation and Central Sensitization in Chronic and Widespread Pain","volume":"129","author":"Ji","year":"2018","journal-title":"Anesthesiology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2147\/JPR.S128508","article-title":"Evidence of Both Systemic Inflammation and Neuroinflammation in Fibromyalgia Patients, as Assessed by a Multiplex Protein Panel Applied to the Cerebrospinal Fluid and to Plasma","volume":"10","author":"Tanum","year":"2017","journal-title":"J. Pain Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"103424","DOI":"10.1016\/j.autrev.2023.103424","article-title":"Is Fibromyalgia an Autoimmune Disorder?","volume":"23","author":"Clauw","year":"2024","journal-title":"Autoimmun. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Li, C., Sun, M., and Tian, S. (2022). Research Hotspots and Effectiveness of Transcranial Magnetic Stimulation in Pain: A Bibliometric Analysis. Front. Hum. Neurosci., 16.","DOI":"10.3389\/fnhum.2022.887246"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Cardinal, T.M., Antunes, L.C., Brietzke, A.P., Parizotti, C.S., Carvalho, F., De Souza, A., da Silva Torres, I.L., Fregni, F., and Caumo, W. (2019). Differential Neuroplastic Changes in Fibromyalgia and Depression Indexed by Up-Regulation of Motor Cortex Inhibition and Disinhibition of the Descending Pain System: An Exploratory Study. Front. Hum. Neurosci., 13.","DOI":"10.3389\/fnhum.2019.00138"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.clinph.2014.05.021","article-title":"Evidence-Based Guidelines on the Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS)","volume":"125","author":"Lefaucheur","year":"2014","journal-title":"Clin. Neurophysiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1152\/jn.00670.2020","article-title":"Operculo-Insular and Anterior Cingulate Plasticity Induced by Transcranial Magnetic Stimulation in the Human Motor Cortex: A Dynamic Casual Modeling Study","volume":"125","author":"Hodkinson","year":"2021","journal-title":"J. Neurophysiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4103\/indianjpsychiatry.indianjpsychiatry_492_22","article-title":"Clinical Practice Guidelines for the Therapeutic Use of Repetitive Transcranial Magnetic Stimulation in Neuropsychiatric Disorders","volume":"65","author":"Tikka","year":"2023","journal-title":"Indian J. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Jung, J., Bungert, A., Bowtell, R., and Jackson, S.R. (2020). Modulating Brain Networks with Transcranial Magnetic Stimulation Over the Primary Motor Cortex: A Concurrent TMS\/fMRI Study. Front. Hum. Neurosci., 14.","DOI":"10.3389\/fnhum.2020.00031"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.apmr.2022.05.006","article-title":"Efficacy of High-Frequency Repetitive Transcranial Magnetic Stimulation at 10 Hz in Fibromyalgia: A Systematic Review and Meta-Analysis","volume":"104","author":"Zhu","year":"2023","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Cuenca-Mart\u00ednez, F., Sempere-Rubio, N., Moll\u00e0-Casanova, S., Mu\u00f1oz-G\u00f3mez, E., Fern\u00e1ndez-Carnero, J., S\u00e1nchez-Sabater, A., and Suso-Mart\u00ed, L. (2023). Effects of Repetitive-Transcranial Magnetic Stimulation (rTMS) in Fibromyalgia Syndrome: An Umbrella and Mapping Review. Brain Sci., 13.","DOI":"10.3390\/brainsci13071059"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Kim, H., Jung, J., Park, S., Joo, Y., Lee, S., and Lee, S. (2022). Effects of Repetitive Transcranial Magnetic Stimulation on the Primary Motor Cortex of Individuals with Fibromyalgia: A Systematic Review and Meta-Analysis. Brain Sci., 12.","DOI":"10.3390\/brainsci12050570"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jpain.2021.11.001","article-title":"Clinical Effects of Repetitive Transcranial Magnetic Stimulation of the Motor Cortex Are Associated with Changes in Resting-State Functional Connectivity in Patients With Fibromyalgia Syndrome","volume":"23","author":"Argaman","year":"2022","journal-title":"J. Pain"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1744-8069-9-33","article-title":"Shaped Magnetic Field Pulses by Multi-Coil Repetitive Transcranial Magnetic Stimulation (rTMS) Differentially Modulate Anterior Cingulate Cortex Responses and Pain in Volunteers and Fibromyalgia Patients","volume":"9","author":"Tzabazis","year":"2013","journal-title":"Mol. Pain"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jpsychires.2023.12.016","article-title":"TMS in Combination with a Pain Directed Intervention for the Treatment of Fibromyalgia\u2014A Randomized, Double-Blind, Sham-Controlled Trial","volume":"170","author":"Tilbor","year":"2024","journal-title":"J. Psychiatr. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1155\/2013\/270183","article-title":"Reduction of Pain Thresholds in Fibromyalgia after Very Low-Intensity Magnetic Stimulation: A Double-Blinded, Randomized Placebo-Controlled Clinical Trial","volume":"18","author":"Blanco","year":"2013","journal-title":"Pain Res. Manag."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1533-2500.2012.00562.x","article-title":"Efficacy of Transcranial Direct Current Stimulation and Repetitive Transcranial Magnetic Stimulation for Treating Fibromyalgia Syndrome: A Systematic Review","volume":"13","author":"Marlow","year":"2013","journal-title":"Pain Pract."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.pain.2011.05.033","article-title":"Ten Sessions of Adjunctive Left Prefrontal rTMS Significantly Reduces Fibromyalgia Pain: A Randomized, Controlled Pilot Study","volume":"152","author":"Short","year":"2011","journal-title":"Pain"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/j.1526-4637.2009.00625.x","article-title":"Low-Frequency Transcranial Magnetic Stimulation in Patients with Fibromyalgia and Major Depression","volume":"10","author":"Carretero","year":"2009","journal-title":"Pain Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.pain.2011.01.034","article-title":"Long-Term Maintenance of the Analgesic Effects of Transcranial Magnetic Stimulation in Fibromyalgia","volume":"152","author":"Mhalla","year":"2011","journal-title":"Pain"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1093\/brain\/awm189","article-title":"Effects of Unilateral Repetitive Transcranial Magnetic Stimulation of the Motor Cortex on Chronic Widespread Pain in Fibromyalgia","volume":"130","author":"Passard","year":"2007","journal-title":"Brain J. Neurol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/papr.12276","article-title":"Repetitive Transcranial Magnetic Stimulation for Fibromyalgia: Systematic Review and Meta-Analysis","volume":"16","author":"Knijnik","year":"2016","journal-title":"Pain Pract."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1212\/WNL.0000000000000280","article-title":"rTMS in Fibromyalgia: A Randomized Trial Evaluating QoL and Its Brain Metabolic Substrate","volume":"82","author":"Boyer","year":"2014","journal-title":"Neurology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/PHM.0b013e3182745a04","article-title":"The Effect of Repetitive Transcranial Magnetic Stimulation on Fibromyalgia: A Randomized Sham-Controlled Trial with 1-Mo Follow-Up","volume":"91","author":"Lee","year":"2012","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3109\/10582452.2014.883042","article-title":"Efficacy of High Frequency [10 Hz] Repetitive Transcranial Magnetic Stimulation of the Primary Motor Cortex in Patients with Fibromyalgia Syndrome: A Randomized, Double Blind, Sham-Controlled Trial","volume":"22","author":"Tekin","year":"2014","journal-title":"J. Musculoskelet. Pain"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/YCT.0000000000000125","article-title":"Transcranial Magnetic Stimulation in the Treatment of Chronic Widespread Pain: A Randomized Controlled Study","volume":"31","author":"Avery","year":"2015","journal-title":"J. ECT"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/MRR.0000000000000207","article-title":"Effectiveness of Repetitive Transcranial Magnetic Stimulation in Patients with Fibromyalgia: A Meta-Analysis","volume":"40","author":"Saltychev","year":"2017","journal-title":"Int. J. Rehabil. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1093\/rheumatology\/kew205","article-title":"The Effects of Add-on Non-Invasive Brain Stimulation in Fibromyalgia: A Meta-Analysis and Meta-Regression of Randomized Controlled Trials","volume":"55","author":"Hou","year":"2016","journal-title":"Rheumatology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"206","DOI":"10.5152\/tftrd.2014.37074","article-title":"Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?","volume":"60","author":"Yagci","year":"2014","journal-title":"Turk. J. Phys. Med. Rehabil."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jpsychires.2012.09.003","article-title":"Unilateral Repetitive Transcranial Magnetic Stimulation of the Motor Cortex Does Not Affect Cognition in Patients with Fibromyalgia","volume":"47","author":"Baudic","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.nrl.2020.07.024","article-title":"Effects of Transcranial Direct Current Stimulation and Transcranial Magnetic Stimulation in Patients with Fibromyalgia. A Systematic Review","volume":"38","year":"2023","journal-title":"Neurologia"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/ejp.1213","article-title":"Evidence for the Improvement of Fatigue in Fibromyalgia: A 4-Week Left Dorsolateral Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation Randomized-Controlled Trial","volume":"22","author":"Fitzgibbon","year":"2018","journal-title":"Eur. J. Pain"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/08990220.2019.1587400","article-title":"Is High-Frequency Repetitive Transcranial Magnetic Stimulation of the Left Primary Motor Cortex Superior to the Stimulation of the Left Dorsolateral Prefrontal Cortex in Fibromyalgia Syndrome?","volume":"36","author":"Altas","year":"2019","journal-title":"Somatosens. Mot. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/pcn.12812","article-title":"Analgesic Effects of Repetitive Transcranial Magnetic Stimulation on Modified 2010 Criteria-Diagnosed Fibromyalgia: Pilot Study","volume":"73","author":"Cheng","year":"2019","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/PHM.0000000000001536","article-title":"Effects of High-Frequency Neuronavigated Repetitive Transcranial Magnetic Stimulation in Fibromyalgia Syndrome: A Double-Blinded, Randomized Controlled Study","volume":"100","author":"Bilir","year":"2021","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/acr.24118","article-title":"Effects of Repetitive Transcranial Magnetic Stimulation and Multicomponent Therapy in Patients with Fibromyalgia: A Randomized Controlled Trial","volume":"73","author":"Guinot","year":"2021","journal-title":"Arthritis Care Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s42358-020-00135-7","article-title":"Repetitive Transcranial Magnetic Stimulation of the Prefrontal Cortex for Fibromyalgia Syndrome: A Randomised Controlled Trial with 6-Months Follow Up","volume":"60","author":"Tanwar","year":"2020","journal-title":"Adv. Rheumatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"pzab159","DOI":"10.1093\/ptj\/pzab159","article-title":"Effectiveness of High-Frequency Transcranial Magnetic Stimulation and Physical Exercise in Women with Fibromyalgia: A Randomized Controlled Trial","volume":"101","year":"2021","journal-title":"Phys. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Su, Y.C., Guo, Y.H., Hsieh, P.C., and Lin, Y.C. (2021). Efficacy of Repetitive Transcranial Magnetic Stimulation in Fibromyalgia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J. Clin. Med., 10.","DOI":"10.3390\/jcm10204669"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/pm\/pnab354","article-title":"Effectiveness of Repetitive Transcranial Magnetic Stimulation on Managing Fibromyalgia: A Systematic Meta-Analysis","volume":"23","author":"Choo","year":"2022","journal-title":"Pain Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/PSY.0000000000001062","article-title":"Repetitive Transcranial Magnetic Stimulation for Fibromyalgia: An Updated Systematic Review and Meta-Analysis","volume":"84","author":"Toh","year":"2022","journal-title":"Psychosom. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/pm\/pnab276","article-title":"Repetitive Transcranial Magnetic Stimulation for Patients with Fibromyalgia: A Systematic Review with Meta-Analysis","volume":"23","author":"Sun","year":"2022","journal-title":"Pain Med."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Molero-Chamizo, A., Nitsche, M.A., Barroso, R.T.A., Bail\u00e9n, J.R.A., Palomeque, J.C.G., and Rivera-Urbina, G.N. (2023). Non-Invasive Electric and Magnetic Brain Stimulation for the Treatment of Fibromyalgia. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030954"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.genhosppsych.2024.01.007","article-title":"Efficacy of Neuromodulation on the Treatment of Fibromyalgia: A Network Meta-Analysis","volume":"87","author":"Cheng","year":"2024","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.neucli.2021.03.002","article-title":"Repetitive Transcranial Magnetic Stimulation (rTMS) versus Transcranial Direct Current Stimulation (tDCS) in the Management of Patients with Fibromyalgia: A Randomized Controlled Trial","volume":"51","author":"Forogh","year":"2021","journal-title":"Neurophysiol. Clin."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3233\/BMR-181127","article-title":"Regenerative Injection Therapy and Repetitive Transcranial Magnetic Stimulation in Primary Fibromyalgia Treatment: A Comparative Study","volume":"32","author":"Elghany","year":"2019","journal-title":"J. Back Musculoskelet. Rehabil."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.neurom.2021.12.015","article-title":"Effectiveness of Repetitive Transcranial Magnetic Stimulation on Fibromyalgia Patients Responding to a First Repetitive Transcranial Magnetic Stimulation Induction Course After Six Months of Maintenance Treatment: A Randomized Pilot-Controlled Study","volume":"25","author":"Lacroix","year":"2022","journal-title":"Neuromodul. J. Int. Neuromodul. Soc."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Badr, M.Y., Ahmed, G.K., Amer, R.A., Aref, H.M., Salem, R.M., Elmokadem, H.A., and Khedr, E.M. (2024). Impact of Repetitive Transcranial Magnetic Stimulation on Cognitive and Psychiatric Dysfunction in Patients with Fibromyalgia: A Double-Blinded, Randomized Clinical Trial. Brain Sci., 14.","DOI":"10.3390\/brainsci14050416"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1007\/s10072-024-07317-x","article-title":"Effect of Neuronavigated Repetitive Transcranial Magnetic Stimulation on Pain, Cognition and Cortical Excitability in Fibromyalgia Syndrome","volume":"45","author":"Tiwari","year":"2024","journal-title":"Neurol. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4103\/aian.aian_1041_23","article-title":"Role of Repetitive Transcranial Magnetic Stimulation in Treatment of Fibromyalgia: A Randomized Controlled Trial","volume":"27","author":"Kankane","year":"2024","journal-title":"Ann. Indian Acad. Neurol."},{"key":"ref_81","first-page":"742","article-title":"Guidelines for the diagnosis and treatment of the fibromyalgia syndrome","volume":"152","author":"Ablin","year":"2013","journal-title":"Harefuah"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1155\/2013\/918216","article-title":"2012 Canadian Guidelines for the Diagnosis and Management of Fibromyalgia Syndrome: Executive Summary","volume":"18","author":"Fitzcharles","year":"2013","journal-title":"Pain Res. Manag."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00482-012-1172-2","article-title":"Drug therapy of fibromyalgia syndrome. Systematic review, meta-analysis and guideline","volume":"26","author":"Sommer","year":"2012","journal-title":"Schmerz"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1136\/annrheumdis-2017-211587","article-title":"EULAR Recommendations for Management of Fibromyalgia","volume":"76","author":"Macfarlane","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Kia, S., and Choy, E. (2017). Update on Treatment Guideline in Fibromyalgia Syndrome with Focus on Pharmacology. Biomedicines, 5.","DOI":"10.3390\/biomedicines5020020"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4081\/reumatismo.2021.1362","article-title":"The Italian Society for Rheumatology Clinical Practice Guidelines for the Diagnosis and Management of Fibromyalgia Best Practices Based on Current Scientific Evidence","volume":"73","author":"Ariani","year":"2021","journal-title":"Reumatismo"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"152101","DOI":"10.1016\/j.semarthrit.2022.152101","article-title":"International, Multidisciplinary Delphi Consensus Recommendations on Non-Pharmacological Interventions for Fibromyalgia","volume":"57","author":"Kundakci","year":"2022","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/j.pain.0000000000002387","article-title":"Distinct Aberrations in Cerebral Pain Processing Differentiating Patients with Fibromyalgia from Patients with Rheumatoid Arthritis","volume":"163","author":"Ellerbrock","year":"2022","journal-title":"Pain"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/art.41069","article-title":"Association of Inflammation with Pronociceptive Brain Connections in Rheumatoid Arthritis Patients with Concomitant Fibromyalgia","volume":"72","author":"Kaplan","year":"2020","journal-title":"Arthritis Rheumatol."},{"key":"ref_90","first-page":"1159","article-title":"Modification in Pittsburgh Sleep Quality Index after low intensity transcranial magnetic stimulation in patients with fibromyalgia","volume":"40","author":"Travesi","year":"2022","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_91","first-page":"1112","article-title":"Treatment with low-intensity transcranial magnetic stimulation in women with fibromyalgia improves diagnostic variables up to 6 months after treatment completion","volume":"40","author":"Pareja","year":"2022","journal-title":"Clin. Exp. Rheumatol."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/6\/662\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:02:03Z","timestamp":1760108523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/6\/662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,20]]},"references-count":91,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["jpm14060662"],"URL":"https:\/\/doi.org\/10.3390\/jpm14060662","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,20]]}}}