{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:03:11Z","timestamp":1767834191778,"version":"3.49.0"},"reference-count":97,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Multiple sclerosis (MS) is a neurodegenerative immunological disease causing significant impairment in all life areas. Therefore, personality changes are observed and associated with higher prevalence of depression and anxiety disorders. Considering this relationship, we hypothesized that clinical symptoms and personality disorders are more prevalent in MS and that dysfunctional psychological mechanisms mediate the path from personality disorders to clinical symptoms. Methods: The study sample consisted of 43 patients with MS (age M = 41.9, SD = 11.5) and 31 controls (age M = 39.8, SD = 10.3). Measures of personality, anxiety, depression, fatigue, health status, and dysfunctional psychological mechanisms were conducted. Results: The prevalence of clinical symptoms was increased in MS patients as compared to controls. Also, dependent and schizoid personality traits (PTs) were observed in the patient sample. Negative automatic thoughts (NATs) were found to mediate the association between dependent PT and clinical symptoms. Along with schizoid PT, all dysfunctional psychological mechanisms impacted clinical symptoms. Discussion: The results of our research are in line with previous studies showing that anxiety, depression, and dysfunctional personality traits are more prevalent in MS as compared to controls. Conclusions: PTs and dysfunctional psychological mechanisms predicted depression, anxiety, fatigue, and health status in MS patients. Cognition acts as a strong mediator between PTs and psychopathology in MS. Hence, integrative personalized psychological treatment is recommended to improve the quality of care in MS.<\/jats:p>","DOI":"10.3390\/jpm14070682","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T04:19:26Z","timestamp":1719461966000},"page":"682","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Path from Personality to Anxiety and Depression Is Mediated by Cognition in Multiple Sclerosis"],"prefix":"10.3390","volume":"14","author":[{"given":"Alina","family":"Schenk","sequence":"first","affiliation":[{"name":"The Doctoral School of George Emil Palade, University of Medicine, Pharmacy, Science and Technology, 540142 Targu-Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3155-9291","authenticated-orcid":false,"given":"Cosmin Octavian","family":"Popa","sequence":"additional","affiliation":[{"name":"Department of Ethics and Social Science, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540142 Targu-Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7344-5882","authenticated-orcid":false,"given":"Cristiana Manuela","family":"Cojocaru","sequence":"additional","affiliation":[{"name":"The Doctoral School of George Emil Palade, University of Medicine, Pharmacy, Science and Technology, 540142 Targu-Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-8384","authenticated-orcid":false,"given":"\u0218tefan","family":"Marian","sequence":"additional","affiliation":[{"name":"Department of Psychology, West University of Timi\u015foara, 4 Vasile P\u00e2van Boulevard, 300223 Timi\u015foara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smaranda","family":"Maier","sequence":"additional","affiliation":[{"name":"Neurology Clinic I, Emergency Clinical County Hospital, 40136 Targu Mures, Romania"},{"name":"Department of Neurology, University of Medicine, Pharmacy, Science and Technology, 540142 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodica","family":"B\u0103la\u0219a","sequence":"additional","affiliation":[{"name":"Neurology Clinic I, Emergency Clinical County Hospital, 40136 Targu Mures, Romania"},{"name":"Department of Neurology, University of Medicine, Pharmacy, Science and Technology, 540142 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"a028944","DOI":"10.1101\/cshperspect.a028944","article-title":"Lifestyle and Environmental Factors in Multiple Sclerosis","volume":"9","author":"Alfredsson","year":"2019","journal-title":"Cold Spring Harb. 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