{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:04:21Z","timestamp":1792109061615,"version":"4.4.0"},"reference-count":75,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union-NextGenerationEU, through the National Recovery and Resilience Plan of the Republic of Bulgaria","award":["BG-RRP-2.004-0004-C01"],"award-info":[{"award-number":["BG-RRP-2.004-0004-C01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Colchicine has a number of effects that suggest it may be useful in the treatment of COVID-19. Myeloid cells are a major source of dysregulated inflammation in COVID-19. The hyperactivation of the NLRP3 inflammasome and the subsequent cytokine storm take place precisely inside them and can lead to multiorgan damage and death. NLRP3 inflammasome inhibition has been assessed at micromolar colchicine concentrations which cannot be achieved in serum. However, colchicine has remarkable ability to accumulate intensively in leukocytes, where the cytokine storm is generated. Over 50 observational studies and randomized clinical trials, small randomized non-controlled trials, and retrospective cohort studies were initiated to test its healing effect in vivo, leading to conflicting, rather disappointing results. The WHO gives a \u201cStrong recommendation against\u201d the use of colchicine for COVID-19 treatment. This is because low doses of colchicine are always used, where the concentrations required to inhibit the NLRP3 inflammasome in leukocytes cannot be reached. Considering this, from March 2020, we started the administration of higher doses of colchicine. Our assumption was that a safe increase in colchicine doses to reach micromolar concentrations in leukocytes will result in NLRP3 inflammasome\/cytokine storm inhibition. We demonstrated that in 785 inpatients treated with increasing doses of colchicine, mortality fell between two and seven times. Our data, including a large number of COVID-19 outpatients, showed that nearly 100% of the patients treated with this therapeutic regimen escaped hospitalization. In addition, post-COVID-19 symptoms in those treated with colchicine were significantly rarer. As a large number of viruses can overactivate the NLRP3 inflammasome (like seasonal influenza), we are convinced that higher colchicine doses would be useful in these cases as well.<\/jats:p>","DOI":"10.3390\/jpm14070756","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T11:31:57Z","timestamp":1721129517000},"page":"756","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Colchicine\u2014The Divine Medicine against COVID-19"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7528-590X","authenticated-orcid":false,"given":"Vanyo","family":"Mitev","sequence":"first","affiliation":[{"name":"Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University\u2014Sofia, 1431 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.amjmed.2014.12.010","article-title":"Colchicine: Old and new","volume":"128","author":"Slobodnick","year":"2015","journal-title":"Am. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/bjd.15896","article-title":"Colchicine: An ancient drug with novel applications","volume":"178","author":"Dasgeb","year":"2018","journal-title":"BJD"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Wall, W.J. (2015). The Search for Human Chromosomes: A History of Discovery, Springer.","DOI":"10.1007\/978-3-319-26336-6_9"},{"key":"ref_4","first-page":"687","article-title":"Colchicine\u2014A short history of an ancient drug","volume":"201","author":"Nerlekar","year":"2014","journal-title":"MJA"},{"key":"ref_5","first-page":"190","article-title":"History of the use of colchicum and related medicaments in gout; with suggestions for further research","volume":"13","author":"Hartung","year":"1954","journal-title":"ARD"},{"key":"ref_6","first-page":"69","article-title":"Examen chimique des plusieurs v\u00e9g\u00e9taux de la famille des colchic\u00e9es, et du principe actif qu\u2019ils renferment. (C\u00e9vadille (veratrum sabadilla); hell\u00e9bore blanc (veratrum album); colchique commun (colchicum autumnale)","volume":"14","author":"Pelletier","year":"1820","journal-title":"Ann. Chim. Phys."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jlac.18330070312","article-title":"Ueber einige neue giftige organische Alkalien","volume":"7","author":"Geiger","year":"1833","journal-title":"Ann. Pharm."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"f5648","DOI":"10.1136\/bmj.f5648","article-title":"Gout","volume":"347","author":"Roddy","year":"2013","journal-title":"BMJ"},{"key":"ref_9","first-page":"2378","article-title":"Revolutions in Chemistry: Assessment of Six 20th Century Candidates (The Instrumental Revolution; H\u00fcckel Molecular Orbital Theory; H\u00fcckel\u2019s 4n + 2 Rule; the Woodward-Hoffmann Rules; Quantum Chemistry; and Retrosynthetic Analysis)","volume":"3","author":"Seeman","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2174\/1871523011312010004","article-title":"Colchicine: An old wine in a new bottle?","volume":"12","author":"Roubille","year":"2013","journal-title":"Antiinflamm. Antiallergy Agents Med. Chem."},{"key":"ref_11","first-page":"e3840","article-title":"Updated Treatment for Calcium Pyrophosphate Deposition Disease","volume":"11","author":"Iqbal","year":"2019","journal-title":"Cureus"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.5603\/CJ.a2021.0123","article-title":"Colchicine\u2014From rheumatology to the new kid on the block: Coronary syndromes and COVID-19","volume":"30","author":"Surma","year":"2023","journal-title":"Cardiol. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4103\/0378-6323.60552","article-title":"Colchicine in dermatology","volume":"76","author":"Konda","year":"2010","journal-title":"IJDVL"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.4103\/idoj.IDOJ_475_20","article-title":"Colchicine in Dermatology: Rediscovering an Old Drug with Novel Uses","volume":"11","author":"Sardana","year":"2020","journal-title":"Indian Dermatol. Online J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"106822","DOI":"10.1016\/j.vph.2020.106822","article-title":"Colchicine inhibits the prothrombotic effects of oxLDL in human endothelial cells","volume":"137","author":"Cimmino","year":"2021","journal-title":"Vasc. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s10753-015-0237-7","article-title":"Effect of Colchicine on Platelet-Platelet and Platelet-Leukocyte Interactions: A Pilot Study in Healthy Subjects","volume":"39","author":"Shah","year":"2016","journal-title":"Inflammation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"106288","DOI":"10.1016\/j.ejps.2022.106288","article-title":"Effect of different doses of colchicine on high sensitivity C-reactive protein in patients with acute minor stroke or transient ischemic attack: A pilot randomized controlled trial","volume":"178","author":"Yuan","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"668","DOI":"10.2174\/1381612824666180116100310","article-title":"The Role of Colchicine in the Prevention of Cerebrovascular Ischemia","volume":"24","author":"Tsivgoulis","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.jacc.2023.05.055","article-title":"Low-Dose Colchicine for Secondary Prevention of Coronary Artery Disease: JACC Review Topic of the Week","volume":"82","author":"Nelson","year":"2023","journal-title":"JACC"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e1570","DOI":"10.1097\/MD.0000000000001570","article-title":"Colchicine significantly reduces incident cancer in gout male patients: A 12-year cohort study","volume":"94","author":"Kuo","year":"2015","journal-title":"Medicine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.kjms.2015.12.006","article-title":"Anticancer effects of clinically acceptable colchicine concentrations on human gastric cancer cell lines","volume":"32","author":"Lin","year":"2016","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Oh, J., An, H.-J., Yeo, H.J., Choi, S., Oh, J., Kim, S., Kim, J.M., Choi, J., and Lee, S. (2022). Colchicine as a novel drug for the treatment of osteosarcoma through drug repositioning based on an FDA drug library. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.893951"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Suryono, S., Rohman, M.S., Widjajanto, E., Prayitnaningsih, S., Wihastuti, T.A., and Oktaviono, Y.H. (2023). Effect of Colchicine in reducing MMP-9, NOX2, and TGF- \u03b21 after myocardial infarction. BMC Cardiovasc. Disord., 23.","DOI":"10.1186\/s12872-023-03464-9"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.3897\/pharmacia.70.e112550","article-title":"Comparison of treatment of COVID-19 with inhaled bromhexine, higher doses of colchicine and hymecromone with WHO-recommended paxlovide, mornupiravir, remdesivir, anti-IL-6 receptor antibodies and baricitinib","volume":"70","author":"Mitev","year":"2023","journal-title":"Pharmacia"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1097\/01.mjt.0000433937.07244.e1","article-title":"Colchicine: New Insights to an Old Drug","volume":"22","author":"Stack","year":"2015","journal-title":"Am. J. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.toxrep.2021.02.012","article-title":"Theophrastus Bombastus Von Hohenheim (Paracelsus) (1493\u20131541): The eminent physician and pioneer of toxicology","volume":"8","author":"Michaleas","year":"2021","journal-title":"Toxicol. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/toxsci\/53.1.2","article-title":"Paracelsus: Herald of Modern Toxicology","volume":"53","author":"Borzelleca","year":"2000","journal-title":"Toxicol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.toxrep.2018.10.001","article-title":"The dose response principle from philosophy to modern toxicology: The impact of ancient philosophy and medicine in modern toxicology science","volume":"5","author":"Tsatsakis","year":"2018","journal-title":"Toxicol. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF00297107","article-title":"What is there that is not poison? A study of the Third Defense by Paracelsus","volume":"58","author":"Deichmann","year":"1986","journal-title":"Arch. Toxicol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"104756","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104756","article-title":"Role of Colchicine in Stroke Prevention: An Updated Meta-Analysis","volume":"29","author":"Masson","year":"2020","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1080\/00498254.2021.1909782","article-title":"Colchicine for the treatment of COVID-19 patients: Efficacy, safety, and model informed dosage regimens","volume":"51","author":"Karatza","year":"2021","journal-title":"Xenobiotica"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/art.27327","article-title":"High versus low dosing of oral colchicine for early acute gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study","volume":"62","author":"Terkeltaub","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1136\/annrheumdis-2015-208690","article-title":"Eular recommendations for the management of familial Mediterranean fever","volume":"75","author":"Ozen","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf","volume":"430","author":"Mariathasan","year":"2004","journal-title":"Nature"},{"key":"ref_35","first-page":"19","article-title":"Practical reports on rheumatic & musculoskeletal diseases: Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis","volume":"19","author":"Cronstein","year":"2013","journal-title":"JCR"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.semarthrit.2015.06.013","article-title":"Colchicine\u2014Update on mechanisms of action and therapeutic uses","volume":"45","author":"Leung","year":"2015","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1016\/j.clinthera.2011.01.008","article-title":"Effect of prophylaxis on gout flares after the initiation of urate-lowering therapy: Analysis of data from three phase III trials","volume":"32","author":"Wortmann","year":"2010","journal-title":"Clin. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Dupuis, J., Sirois, M.G., Rh\u00e9aume, E., Nguyen, Q.T., Clavet-Lanthier, M.-\u00c9., Brand, G., Mihalache-Avram, T., Th\u00e9berge-Julien, G., Charpentier, D., and Rhainds, D. (2020). Colchicine reduces lung injury in experimental acute respiratory distress syndrome. PLoS ONE, 15.","DOI":"10.21203\/rs.3.rs-43204\/v1"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2125.1994.tb04328.x","article-title":"Colchicine concentration in leukocytes of patients with familial Mediterranean fever","volume":"38","author":"Chappey","year":"1994","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0306-9877(98)90031-7","article-title":"Does the lack of the P-glycoprotein efflux pump in neutrophils explain the efficacy of colchicine in familial Mediterranean fever and other inflammatory diseases?","volume":"51","author":"Levy","year":"1998","journal-title":"Med. Hypotheses"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3109\/15563650.2010.495348","article-title":"Colchicine poisoning: The dark side of an ancient drug","volume":"48","author":"Finkelstein","year":"2010","journal-title":"Clin. Toxicol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Mitev, V. (2023). What is the lowest lethal dose of colchicine?. Biotechnol. Biotechnol. Equip., 37.","DOI":"10.1080\/13102818.2023.2288240"},{"key":"ref_43","first-page":"2069","article-title":"Progress in the management of acute colchicine poisoning in adults","volume":"17","author":"Wu","year":"2022","journal-title":"IEM"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e16580","DOI":"10.1097\/MD.0000000000016580","article-title":"Clinical outcomes after colchicine overdose: A case report","volume":"98","author":"Fu","year":"2019","journal-title":"Medicine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3109\/15563650.2010.509101","article-title":"Multiple organ failure after an overdose of less than 0.4 mg\/kg of colchicine: Role of coingestants and drugs during intensive care management","volume":"48","author":"Montiel","year":"2010","journal-title":"Clin. Toxicol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.2147\/DDDT.S140574","article-title":"Severe hypertriglyceridemia and colchicine intoxication following suicide attempt","volume":"11","author":"Lev","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/08860220601166644","article-title":"Colchicine Overdose-Induced Acute Renal Failure and Electrolyte Imbalance","volume":"29","author":"Huang","year":"2007","journal-title":"Ren. Fail."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00134-013-2911-2","article-title":"A new approach for early onset cardiogenic shock in acute colchicine overdose: Place of early extracorporeal life support (ECLS)?","volume":"39","author":"Jouffroy","year":"2013","journal-title":"Intensive Care Med."},{"key":"ref_49","first-page":"528","article-title":"Acute toxicity after excessive ingestion of colchicine","volume":"58","author":"Murray","year":"1983","journal-title":"Mayo Clin. Proc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00540-012-1531-2","article-title":"Severe colchicine intoxication after self-administration of colchicine concomitantly with loxoprofen","volume":"27","author":"Yamazaki","year":"2013","journal-title":"J. Anesth."},{"key":"ref_51","first-page":"e53","article-title":"Clinical Manifestations and Outcomes of Colchicine Poisoning Cases; a Cross Sectional Study","volume":"8","author":"Rahimi","year":"2020","journal-title":"Arch. Acad. Emerg. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/rheumatology\/kead625","article-title":"Colchicine: The good, the bad, the ugly and how to minimize the risks","volume":"63","author":"Stamp","year":"2023","journal-title":"Rheumatology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"252","DOI":"10.2310\/8000.2013.130957","article-title":"Colchicine overdose with coingestion of nonsteroidal antiinflammatory drugs","volume":"16","author":"Little","year":"2014","journal-title":"CJEM"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13075-020-2120-7","article-title":"Adverse events during oral colchicine use: A systematic review and meta-analysis of randomised controlled trials","volume":"22","author":"Stewart","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"ref_55","first-page":"3","article-title":"Treatment of COVID-19 with colchicine and inhaled bromhexine","volume":"1\u20132","author":"Mitev","year":"2022","journal-title":"Med. Sport"},{"key":"ref_56","first-page":"106","article-title":"Colchicine, bromhexine, and hymecromone as part of COVID19 treatment\u2014Cold, warm, hot","volume":"Volume 10","author":"Khan","year":"2023","journal-title":"Current Overview on Disease and Health Research"},{"key":"ref_57","first-page":"e1273","article-title":"Effect of increasing doses of colchicine on the treatment of 333 COVID-19 inpatients","volume":"12","author":"Tiholov","year":"2024","journal-title":"IMID"},{"key":"ref_58","first-page":"e63201","article-title":"Successful Treatment with High-Dose Colchicine of a 101-Year-Old Patient Diagnosed with COVID-19 after an Emergency Cholecystectomy","volume":"16","author":"Bulanov","year":"2024","journal-title":"Cureus"},{"key":"ref_59","first-page":"e30269","article-title":"Complete, rapid resolution of severe bilateral pneumonia and acute respiratory distress syndrome in a COVID-19 patient: Role for a unique therapeutic combination of inhalations with bromhexine, higher doses of colchicine, and hymecromone","volume":"14","author":"Mondeshki","year":"2022","journal-title":"Cureus"},{"key":"ref_60","first-page":"e54441","article-title":"High Doses of Colchicine Act As \u201cSilver Bullets\u201d against Severe COVID-19","volume":"16","author":"Lilov","year":"2024","journal-title":"Cureus"},{"key":"ref_61","first-page":"e58164","article-title":"High-Dose Colchicine: Key Factor in the Treatment of Morbidly Obese COVID-19 Patients","volume":"16","author":"Mondeshki","year":"2024","journal-title":"Cureus"},{"key":"ref_62","first-page":"e35909","article-title":"Effect of an Accidental Colchicine Overdose in a COVID-19 Inpatient with Bilateral Pneumonia and Pericardial Effusion","volume":"15","author":"Mondeshki","year":"2023","journal-title":"Cureus"},{"key":"ref_63","first-page":"e34221","article-title":"Remdesivir-associated acute liver failure in a COVID-19 patient: A case report and literature review","volume":"15","author":"Matar","year":"2023","journal-title":"Cureus"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1056\/NEJMoa2309003","article-title":"Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with COVID-19","volume":"390","author":"Hammond","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Morgenstern, J. (2024). Paxlovid evidence: Still very little reason to prescribe. First10EM.","DOI":"10.51684\/FIRS.133775"},{"key":"ref_66","unstructured":"Sax, P. (2024, June 03). The Rise and Fall of Paxlovid\u2014HIV and ID Observations. NEJM Journal Watch. Available online: https:\/\/blogs.jwatch.org."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa2118542","article-title":"EPIC-HR Investigators. Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with COVID-19","volume":"386","author":"Hammond","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3390\/arm92010009","article-title":"Clinical Effectiveness of Ritonavir-Boosted Nirmatrelvir\u2014A Literature Review","volume":"92","author":"Paltra","year":"2024","journal-title":"Adv. Respir. Med."},{"key":"ref_69","first-page":"100694","article-title":"Efficacy and safety of Paxlovid in severe adult patients with SARS-CoV-2 infection: A multicenter randomized controlled study","volume":"33","author":"Liu","year":"2023","journal-title":"Lancet Reg. Health West. Pac."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e29333","DOI":"10.1002\/jmv.29333","article-title":"Association of nirmatrelvir for acute SARS-CoV-2 infection with subsequent Long COVID symptoms in an observational cohort study","volume":"96","author":"Durstenfeld","year":"2024","journal-title":"J. Med. Virol."},{"key":"ref_71","first-page":"CD015045","article-title":"Colchicine for the treatment of COVID-19","volume":"10","author":"Mikolajewska","year":"2021","journal-title":"CDSR"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e074373","DOI":"10.1136\/bmjopen-2023-074373","article-title":"Colchicine for the treatment of patients with COVID-19: An updated systematic review and meta-analysis of randomised controlled trials","volume":"14","author":"Cheema","year":"2024","journal-title":"BMJ Open"},{"key":"ref_73","unstructured":"RECOVERY (2024, June 03). Trial Closes Recruitment to Colchicine Treatment for Patients Hospitalised with COVID-19. Available online: https:\/\/www.recoverytrial.net."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"RECOVERY Collaborative Group (2021). Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): A randomised, controlled, open-label, platform trial. Lancet Respir. Med., 9, 1419\u20131426.","DOI":"10.1016\/S2213-2600(21)00435-5"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Shi, W., Jin, M., Chen, H., Wu, Z., Yuan, L., Liang, S., Wang, X., Memon, F.U., Eldemery, F., and Si, H. (2023). Inflammasome activation by viral infection: Mechanisms of activation and regulation. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1247377"}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/7\/756\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:17:34Z","timestamp":1760109454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/14\/7\/756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":75,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["jpm14070756"],"URL":"https:\/\/doi.org\/10.3390\/jpm14070756","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,16]]}}}