{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:44:11Z","timestamp":1790628251909,"version":"4.1.0"},"reference-count":96,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Thyroid Eye Disease (TED) is a debilitating autoimmune condition often associated with thyroid dysfunction, leading to significant ocular and orbital morbidity. This review explores recent advancements in the management of TED, focusing on both medical and surgical innovations. The introduction of Teprotumumab, the first FDA-approved drug specifically for TED, marks a pivotal development in medical therapy. Teprotumumab targets the insulin-like growth factor-1 receptor (IGF-1R), effectively reducing inflammation and tissue remodeling. Clinical trials demonstrate its efficacy in reducing proptosis and improving quality of life, making it a cornerstone in the treatment of active, moderate-to-severe TED. Surgical management remains critical for patients with chronic TED or those unresponsive to medical therapy. Advancements in orbital decompression surgery, including image-guided and minimally invasive techniques, offer improved outcomes and reduced complications. Innovations in eyelid and strabismus surgery enhance functional and cosmetic results, further improving patient satisfaction. The management of TED necessitates a multidisciplinary approach involving endocrinologists, ophthalmologists, oculoplastic surgeons, radiologists, and other specialists. This collaborative strategy ensures comprehensive care, addressing the diverse aspects of TED from thyroid dysfunction to ocular health and psychological well-being. Future directions in TED treatment include emerging pharmacological therapies targeting different aspects of the disease\u2019s pathophysiology and advanced surgical techniques aimed at enhancing precision and safety. This review underscores the importance of a personalized, multidisciplinary approach in managing TED, highlighting current advancements, and exploring potential future innovations to improve patient outcomes and quality of life.<\/jats:p>","DOI":"10.3390\/jpm14070776","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T07:57:23Z","timestamp":1721721443000},"page":"776","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Thyroid Eye Disease: Advancements in Orbital and Ocular Pathology Management"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2993-8580","authenticated-orcid":false,"given":"Anna","family":"Scarabosio","sequence":"first","affiliation":[{"name":"Clinic of Plastic and Reconstructive Surgery, Ospedale Santa Maria della Misericordia, 33100 Udine, Italy"},{"name":"Department of Plastic and Reconstructive Surgery, Mass General Hospital, Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7721-4694","authenticated-orcid":false,"given":"Pier Luigi","family":"Surico","sequence":"additional","affiliation":[{"name":"Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, USA"},{"name":"Department of Ophthalmology, Campus Bio-Medico University, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2426-3900","authenticated-orcid":false,"given":"Rohan Bir","family":"Singh","sequence":"additional","affiliation":[{"name":"Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7761-5191","authenticated-orcid":false,"given":"Vlad","family":"Tereshenko","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Mass General Hospital, Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7486-8361","authenticated-orcid":false,"given":"Mutali","family":"Musa","sequence":"additional","affiliation":[{"name":"Department of Optometry, University of Benin, Benin 300238, Nigeria"},{"name":"Africa Eye Laser Centre, Km 7, Benin 300105, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7938-876X","authenticated-orcid":false,"given":"Fabiana","family":"D\u2019Esposito","sequence":"additional","affiliation":[{"name":"Imperial College Ophthalmic Research Group (ICORG) Unit, Imperial College, 153-173 Marylebone Rd., London NW1 5QH, UK"},{"name":"Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Via Pansini 5, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-0068","authenticated-orcid":false,"given":"Caterina","family":"Gagliano","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Enna \u201cKore\u201d, Piazza dell\u2019Universit\u00e0, 94100 Enna, Italy"},{"name":"Eye Clinic, Catania University 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Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/cxo.12472","article-title":"Thyroid Eye Disease: A Review","volume":"100","author":"Weiler","year":"2017","journal-title":"Clin. Exp. Optom."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/01676830.2021.1905669","article-title":"Lower Eyelid Entropion in Thyroid Eye Disease","volume":"41","author":"Vasanthapuram","year":"2022","journal-title":"Orbit"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/IIO.0000000000000352","article-title":"Treatment Options for Lower Eyelid Retraction in Thyroid Eye Disease","volume":"61","author":"Cypen","year":"2021","journal-title":"Int. Ophthalmol. Clin."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S92","DOI":"10.1097\/IOP.0000000000002543","article-title":"Eyelid Surgery in Thyroid Eye Disease","volume":"39","author":"Naik","year":"2023","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_6","first-page":"e4287","article-title":"Change in Upper Eyelid Position after Teprotumumab Treatment for Thyroid Eye Disease","volume":"10","author":"Rosenblatt","year":"2024","journal-title":"Orbit"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/01676830.2021.1933081","article-title":"Teprotumumab for Chronic Thyroid Eye Disease","volume":"41","author":"Ozzello","year":"2022","journal-title":"Orbit"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"G43","DOI":"10.1530\/EJE-21-0479","article-title":"The 2021 European Group on Graves\u2019 Orbitopathy (EUGOGO) Clinical Practice Guidelines for the Medical Management of Graves\u2019 Orbitopathy","volume":"185","author":"Bartalena","year":"2021","journal-title":"Eur. J. Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ecl.2021.12.004","article-title":"2022 Update on Clinical Management of Graves Disease and Thyroid Eye Disease","volume":"51","author":"Hoang","year":"2022","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s10792-019-01258-7","article-title":"Thyroid Eye Disease: Current and Potential Medical Management","volume":"40","author":"Gonzalez","year":"2020","journal-title":"Int. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S2213-8587(21)00056-5","article-title":"Teprotumumab for Patients with Active Thyroid Eye Disease: A Pooled Data Analysis, Subgroup Analyses, and off-Treatment Follow-up Results from Two Randomised, Double-Masked, Placebo-Controlled, Multicentre Trials","volume":"9","author":"Kahaly","year":"2021","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jfo.2022.05.026","article-title":"Torsional Strabismus and Vertical Rectus Muscle Surgery in Thyroid Eye Disease","volume":"46","author":"Tran","year":"2023","journal-title":"J. Fr. Ophtalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/asj\/sjy014","article-title":"Simultaneous Aesthetic Eyelid Surgery and Orbital Decompression for Rehabilitation of Thyroid Eye Disease: The One-Stage Approach","volume":"38","author":"Bernardini","year":"2018","journal-title":"Aesthet. Surg. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/IIO.0000000000000462","article-title":"Surgery in Thyroid Eye Disease","volume":"63","author":"Araya","year":"2023","journal-title":"Int. Ophthalmol. Clin."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1210\/clinem\/dgac252","article-title":"Future Projections in Thyroid Eye Disease","volume":"107","author":"Barbesino","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/s41433-024-02967-9","article-title":"The Changing Landscape of Thyroid Eye Disease: Current Clinical Advances and Future Outlook","volume":"38","author":"Moledina","year":"2024","journal-title":"Eye"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e230043","DOI":"10.1530\/ETJ-23-0043","article-title":"Teprotumumab in Thyroid Eye Disease: Wonder Drug or Great Divider?","volume":"12","author":"Perros","year":"2023","journal-title":"Eur. Thyroid. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/IIO.0000000000000464","article-title":"Pathogenesis of Thyroid Eye Disease","volume":"63","author":"Spadaro","year":"2023","journal-title":"Int. Ophthalmol. Clin."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1210\/clinem\/dgac328","article-title":"Understanding Pathogenesis Intersects With Effective Treatment for Thyroid Eye Disease","volume":"107","author":"Smith","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/bjophthalmol-2015-307399","article-title":"Pathogenesis of Thyroid Eye Disease: Review and Update on Molecular Mechanisms","volume":"100","author":"Khong","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"ref_21","first-page":"222","article-title":"Pathogenesis of Thyroid Eye Disease\u2014Does Autoimmunity against the TSH Receptor Explain All Cases?","volume":"61","author":"Wall","year":"2010","journal-title":"Endokrynol. Pol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Shu, X., Shao, Y., Chen, Y., Zeng, C., Huang, X., and Wei, R. (2024). Immune Checkpoints: New Insights into the Pathogenesis of Thyroid Eye Disease. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1392956"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Smith, T.J., Heged\u00fcs, L., Lesser, I., Perros, P., Dorris, K., Kinrade, M., Troy-Ott, P., Wuerth, L., and Nori, M. (2023). How Patients Experience Thyroid Eye Disease. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1283374"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Qian, L., and Wei, W. (2022). Identified Risk Factors for Dry Eye Syndrome: A Systematic Review and Meta-Analysis. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0271267"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e800","DOI":"10.1111\/aos.14000","article-title":"Dry Eye Syndrome in Thyroid Eye Disease Patients: The Role of Increased Incomplete Blinking and Meibomian Gland Loss","volume":"97","author":"Park","year":"2019","journal-title":"Acta Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/01676830.2020.1814352","article-title":"Natural History of Inflammatory and Non-Inflammatory Dry Eye in Thyroid Eye Disease","volume":"40","author":"Lo","year":"2021","journal-title":"Orbit"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.ajo.2008.12.007","article-title":"Occult Thyroid Eye Disease in Patients Presenting with Dry Eye Symptoms","volume":"147","author":"Gupta","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.ophtha.2021.03.030","article-title":"Systemic Conditions Associated with Severity of Dry Eye Signs and Symptoms in the Dry Eye Assessment and Management Study","volume":"128","author":"Yu","year":"2021","journal-title":"Ophthalmology"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Liao, X., Lai, K.K.H., Aljufairi, F.M.A.A., Chen, W., Hu, Z., Wong, H.Y.M., Jia, R., Wei, Y., Tham, C.C.Y., and Pang, C.P. (2023). Ocular Surface Changes in Treatment-Naive Thyroid Eye Disease. J. Clin. Med., 12.","DOI":"10.3390\/jcm12093066"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jtos.2022.02.001","article-title":"Ocular Surface Disease in Thyroid Eye Disease: A Narrative Review","volume":"24","author":"Rana","year":"2022","journal-title":"Ocul. Surf."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","article-title":"TFOS DEWS II Management and Therapy Report","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.survophthal.2021.05.009","article-title":"Superior Limbic Keratoconjunctivitis: A Comprehensive Review","volume":"67","author":"Lahoti","year":"2022","journal-title":"Surv. Ophthalmol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II Pathophysiology Report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Takahashi, Y., Vaidya, A., and Kakizaki, H. (2021). Changes in Eyelid Pressure and Dry Eye Status after Orbital Decompression in Thyroid Eye Disease. J. Clin. Med., 10.","DOI":"10.3390\/jcm10163687"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.ajo.2013.12.027","article-title":"Topical Rebamipide Treatment for Superior Limbic Keratoconjunctivitis in Patients with Thyroid Eye Disease","volume":"157","author":"Takahashi","year":"2014","journal-title":"Am. J. Ophthalmol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/S0161-6420(84)34207-5","article-title":"Conjunctival Resection for Superior Limbic Keratoconjunctivitis","volume":"91","author":"Passons","year":"1984","journal-title":"Ophthalmology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jtos.2023.03.004","article-title":"Superior Limbic Keratoconjunctivitis: Update on Pathophysiology and Management","volume":"28","author":"Lee","year":"2023","journal-title":"Ocul. Surf."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1365-2265.1997.2331047.x","article-title":"Clinical Activity Score as a Guide in the Management of Patients with Graves\u2019 Ophthalmopathy","volume":"47","author":"Mourits","year":"1997","journal-title":"Clin. Endocrinol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/IOP.0000000000001087","article-title":"Noninflammatory Thyroid Eye Disease","volume":"35","author":"Ugradar","year":"2019","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1097\/IOP.0000000000001150","article-title":"Grading Severity and Activity in Thyroid Eye Disease","volume":"34","author":"Dolman","year":"2018","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/IOP.0000000000001122","article-title":"Anatomic Considerations in Thyroid Eye Disease","volume":"34","author":"Dutton","year":"2018","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/WCO.0000000000000894","article-title":"Optic Neuropathy and Diplopia from Thyroid Eye Disease: Update on Pathophysiology and Treatment","volume":"34","author":"Johnson","year":"2021","journal-title":"Curr. Opin. Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1136\/bjophthalmol-2018-313578","article-title":"Course of Upper Eyelid Retraction in Thyroid Eye Disease","volume":"104","author":"Lee","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/bjophthalmol-2017-310695","article-title":"Non-Surgical Treatment for Eyelid Retraction in Thyroid Eye Disease (TED)","volume":"102","author":"Grisolia","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/ceo.13899","article-title":"Thyroid Eye Disease: Redefining Its Management\u2014A Review","volume":"49","author":"Jain","year":"2021","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.survophthal.2017.03.007","article-title":"Orbital Decompression for Thyroid Eye Disease","volume":"63","author":"Rootman","year":"2018","journal-title":"Surv. Ophthalmol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/eye.2017.260","article-title":"Orbital Decompression for Thyroid Eye Disease: Methods, Outcomes, and Complications","volume":"32","author":"Jefferis","year":"2018","journal-title":"Eye"},{"key":"ref_48","first-page":"103196","article-title":"Revision Orbital Decompression for Thyroid Eye Disease","volume":"43","author":"Pham","year":"2022","journal-title":"Am. J. Otolaryngol.\u2014Head. Neck Med. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"103451","DOI":"10.1016\/j.amjoto.2022.103451","article-title":"Functional Outcomes and Complications in Refractory Dysthyroid Optic Neuropathy Management: Experience with 3 Different Surgical Protocols","volume":"43","author":"Dallan","year":"2022","journal-title":"Am. J. Otolaryngol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/IOP.0000000000001406","article-title":"Endoscopic Orbital Decompression by Oculoplastic Surgeons for Proptosis in Thyroid Eye Disease","volume":"35","author":"Juniat","year":"2019","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ophtha.2007.06.039","article-title":"Treatment of Lower Eyelid Malposition with Dermis Fat Grafting","volume":"115","author":"Korn","year":"2008","journal-title":"Ophthalmology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/tjo.tjo_57_21","article-title":"Management of Eyelid Retraction Related to Thyroid Eye Disease","volume":"12","author":"Osaki","year":"2022","journal-title":"Taiwan. J. Ophthalmol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1001\/jamaophthalmol.2022.1002","article-title":"Nationwide Incidence of Thyroid Eye Disease and Cumulative Incidence of Strabismus and Surgical Interventions in Denmark","volume":"140","author":"Boulakh","year":"2022","journal-title":"JAMA Ophthalmol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/eye.2014.282","article-title":"Management of Strabismus in Thyroid Eye Disease","volume":"29","author":"Harrad","year":"2015","journal-title":"Eye"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joco.2019.10.002","article-title":"Management of Thyroid Eye Disease-Related Strabismus","volume":"32","author":"Akbari","year":"2020","journal-title":"J. Curr. Ophthalmol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ajo.2021.11.022","article-title":"Risk Factors for Reoperation after Strabismus Surgery among Patients with Thyroid Eye Disease","volume":"238","author":"Hwang","year":"2022","journal-title":"Am. J. Ophthalmol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/PRS.0000000000000453","article-title":"Aesthetic Refinements in the Treatment of Graves Ophthalmopathy","volume":"134","author":"Doumit","year":"2014","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/IOP.0000000000001511","article-title":"Temporal Fat Pad Volume in Patients With Thyroid Eye Disease","volume":"36","author":"Choudhary","year":"2020","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1097\/SCS.0b013e31816adca2","article-title":"Correction of Exophthalmos and Eyelid Deformities in Patients with Severe Thyroid Ophthalmopathy","volume":"19","author":"Roncevic","year":"2008","journal-title":"J. Craniofacial Surg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/IOP.0000000000001597","article-title":"Thickness of Retro- and Sub-Orbicularis Oculi Fat in Thyroid Eye Disease: Comparison With Controls and Its Influential Factors","volume":"36","author":"Valencia","year":"2020","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1010-5182(05)80130-1","article-title":"Surgical Treatment of Severe Dysthyroid Ophthalmopathy\u2014Long-Term Results","volume":"23","year":"1995","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1056\/NEJMoa1614949","article-title":"Teprotumumab for Thyroid-Associated Ophthalmopathy","volume":"376","author":"Smith","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1210\/clinem\/dgad637","article-title":"Efficacy and Safety of Teprotumumab in Patients With Thyroid Eye Disease of Long Duration and Low Disease Activity","volume":"109","author":"Douglas","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1055\/a-1386-4512","article-title":"Teprotumumab: The Dawn of Therapies in Moderate-to-Severe Thyroid-Associated Ophthalmopathy","volume":"53","author":"Ding","year":"2021","journal-title":"Horm. Metab. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.yaoo.2022.03.008","article-title":"Teprotumumab","volume":"7","author":"Yu","year":"2022","journal-title":"Adv. Ophthalmol. Optom."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1056\/NEJMoa1910434","article-title":"Teprotumumab for the Treatment of Active Thyroid Eye Disease","volume":"382","author":"Douglas","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ophtha.2021.10.017","article-title":"Teprotumumab Efficacy, Safety, and Durability in Longer-Duration Thyroid Eye Disease and Re-Treatment: OPTIC-X Study","volume":"129","author":"Douglas","year":"2022","journal-title":"Ophthalmology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1089\/thy.2023.0167","article-title":"Medical Therapy in Patients with Moderate to Severe, Steroid-Resistant, Thyroid Eye Disease","volume":"33","author":"Rachmasari","year":"2023","journal-title":"Thyroid."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"E654","DOI":"10.1210\/clinem\/dgad213","article-title":"The Adverse Effects Profile of Teprotumumab","volume":"108","author":"Stan","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/IOP.0000000000002563","article-title":"Teprotumumab and Orbital Decompression for the Management of Proptosis in Patients With Thyroid Eye Disease","volume":"40","author":"Hubschman","year":"2024","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1080\/13543784.2020.1772752","article-title":"Teprotumumab: A Novel Therapeutic Monoclonal Antibody for Thyroid-Associated Ophthalmopathy","volume":"29","author":"Slentz","year":"2020","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajo.2022.02.015","article-title":"Hearing Dysfunction After Treatment With Teprotumumab for Thyroid Eye Disease","volume":"240","author":"Sears","year":"2022","journal-title":"Am. J. Ophthalmol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ophtha.2023.08.001","article-title":"Frequency and Patterns of Hearing Dysfunction in Patients Treated with Teprotumumab","volume":"131","author":"Keen","year":"2024","journal-title":"Ophthalmology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"E208","DOI":"10.1097\/IOP.0000000000002482","article-title":"Teprotumumab-Related Cutaneous Hypersensitivity Reactions","volume":"39","author":"Dallalzadeh","year":"2023","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/WNO.0000000000001515","article-title":"A Paradigm Shift in the Management of Thyroid Eye Disease How Teprotumumab Has Changed the Therapeutic Interface","volume":"42","author":"Ugradar","year":"2022","journal-title":"J. Neuro-Ophthalmol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.ophtha.2021.03.006","article-title":"A Perspective on the Current Role of Teprotumumab in Treatment of Thyroid Eye Disease","volume":"128","author":"Allen","year":"2021","journal-title":"Ophthalmology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/IOP.0000000000002315","article-title":"Monoclonal Antibodies for the Treatment of Graves Orbitopathy: Precision Medicine?","volume":"39","author":"Xavier","year":"2023","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1080\/02713683.2020.1776331","article-title":"Clinical Management and Therapeutic Strategies for the Thyroid-Associated Ophthalmopathy: Current and Future Perspectives","volume":"45","author":"Mishra","year":"2020","journal-title":"Curr. Eye Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.survophthal.2021.08.010","article-title":"Thinking inside the Box: Current Insights into Targeting Orbital Tissue Remodeling and Inflammation in Thyroid Eye Disease","volume":"67","author":"Gupta","year":"2022","journal-title":"Surv. Ophthalmol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.medcli.2022.05.007","article-title":"Outcome of Tocilizumab Treatment in Corticosteroid-Resistant Thyroid Eye Disease","volume":"160","year":"2023","journal-title":"Med. Clin."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1097\/IOP.0000000000001131","article-title":"Efficacy and Safety of Immunosuppressive Agents for Thyroid Eye Disease","volume":"34","author":"Strianese","year":"2018","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/cen.13970","article-title":"Early Low-Dose Rituximab for Active Thyroid Eye Disease: An Effective and Well-Tolerated Treatment","volume":"91","author":"Insull","year":"2019","journal-title":"Clin. Endocrinol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s12020-014-0283-1","article-title":"Intraorbital Injection of Rituximab versus High Dose of Systemic Glucocorticoids in the Treatment of Thyroid-Associated Orbitopathy","volume":"48","author":"Savino","year":"2015","journal-title":"Endocrine"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1007\/s40618-022-01862-y","article-title":"Sirolimus as a Second-Line Treatment for Graves\u2019 Orbitopathy","volume":"45","author":"Lanzolla","year":"2022","journal-title":"J. Endocrinol. Investig."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S2213-8587(18)30020-2","article-title":"Mycophenolate plus Methylprednisolone versus Methylprednisolone Alone in Active, Moderate-to-Severe Graves\u2019 Orbitopathy (MINGO): A Randomised, Observer-Masked, Multicentre Trial","volume":"6","author":"Kahaly","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S2213-8587(21)00238-2","article-title":"Statins for Graves\u2019 Orbitopathy (STAGO): A Phase 2, Open-Label, Adaptive, Single Centre, Randomised Clinical Trial","volume":"9","author":"Lanzolla","year":"2021","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s10278-019-00195-2","article-title":"Assessment of Orbital Computed Tomography (CT) Imaging Biomarkers in Patients with Thyroid Eye Disease","volume":"32","author":"Chaganti","year":"2019","journal-title":"J. Digit. Imaging"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1007\/s00417-022-05727-1","article-title":"Extraocular Muscle Enlargement","volume":"260","author":"Rana","year":"2022","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/IOP.0000000000002072","article-title":"Echographic Assessment of Extraocular Muscle Response to Teprotumumab","volume":"38","author":"Tran","year":"2022","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S1808-8694(15)30069-0","article-title":"Orbital Endoscopic Decompression in Graves Ophthalmopathy","volume":"72","author":"Lima","year":"2006","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ajo.2021.08.013","article-title":"Endoscopic Transconjunctival Deep Lateral Wall Decompression for Thyroid-Associated Orbitopathy: A Minimally Invasive Alternative: Transconjunctival Endoscopic with Wall Decompression for TAO","volume":"235","author":"Tu","year":"2022","journal-title":"Am. J. Ophthalmol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/asj\/sjx003","article-title":"Comparison of Efficacy and Complications Among Various Spacer Grafts in the Treatment of Lower Eyelid Retraction: A Systematic Review","volume":"37","author":"Park","year":"2017","journal-title":"Aesthet. Surg. J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ajo.2013.03.017","article-title":"Correction of Lower Lid Retraction Using TarSys Bioengineered Grafts for Graves Ophthalmopathy","volume":"156","author":"Liao","year":"2013","journal-title":"Am. J. Ophthalmol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/IOP.0000000000000683","article-title":"Correction of Lower Eyelid Retraction Using Acellular Human Dermis During Orbital Decompression","volume":"33","author":"Kim","year":"2017","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.ophtha.2019.11.011","article-title":"Bioengineered Acellular Dermal Matrix Spacer Grafts for Lower Eyelid Retraction Repair: A Report by the American Academy of Ophthalmology","volume":"127","author":"Tao","year":"2020","journal-title":"Ophthalmology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/IOP.0000000000000211","article-title":"Adalimumab as Steroid-Sparing Treatment of Inflammatory-Stage Thyroid Eye Disease","volume":"30","author":"Ayabe","year":"2014","journal-title":"Ophthalmic Plast. Reconstr. 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