{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:16:55Z","timestamp":1782825415607,"version":"3.54.5"},"reference-count":39,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Collaborative Research Fund","award":["C4032-21GF"],"award-info":[{"award-number":["C4032-21GF"]}]},{"name":"Collaborative Research Fund","award":["HMRF 20210331"],"award-info":[{"award-number":["HMRF 20210331"]}]},{"name":"Collaborative Research Fund","award":["AoE\/M-402\/20"],"award-info":[{"award-number":["AoE\/M-402\/20"]}]},{"name":"University Grants Committee","award":["C4032-21GF"],"award-info":[{"award-number":["C4032-21GF"]}]},{"name":"University Grants Committee","award":["HMRF 20210331"],"award-info":[{"award-number":["HMRF 20210331"]}]},{"name":"University Grants Committee","award":["AoE\/M-402\/20"],"award-info":[{"award-number":["AoE\/M-402\/20"]}]},{"name":"Health and Medical Research Fund","award":["C4032-21GF"],"award-info":[{"award-number":["C4032-21GF"]}]},{"name":"Health and Medical Research Fund","award":["HMRF 20210331"],"award-info":[{"award-number":["HMRF 20210331"]}]},{"name":"Health and Medical Research Fund","award":["AoE\/M-402\/20"],"award-info":[{"award-number":["AoE\/M-402\/20"]}]},{"name":"Food and Health Bureau","award":["C4032-21GF"],"award-info":[{"award-number":["C4032-21GF"]}]},{"name":"Food and Health Bureau","award":["HMRF 20210331"],"award-info":[{"award-number":["HMRF 20210331"]}]},{"name":"Food and Health Bureau","award":["AoE\/M-402\/20"],"award-info":[{"award-number":["AoE\/M-402\/20"]}]},{"name":"Area of Excellence","award":["C4032-21GF"],"award-info":[{"award-number":["C4032-21GF"]}]},{"name":"Area of Excellence","award":["HMRF 20210331"],"award-info":[{"award-number":["HMRF 20210331"]}]},{"name":"Area of Excellence","award":["AoE\/M-402\/20"],"award-info":[{"award-number":["AoE\/M-402\/20"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Osteosarcopenia is a prevalent geriatric disease with a significantly increased risk of adverse outcomes than osteoporosis or sarcopenia alone. Identification of older adults with osteosarcopenia using High-Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) could allow better clinical decision making. This study aimed to explore the feasibility of HR-pQCT to differentiate osteoporosis, sarcopenia, and osteosarcopenia in older adults, with a primary outcome to derive a model to distinguish older adults with osteosarcopenia from those with low bone mineral density only, and to examine important HR-pQCT parameters associated with osteosarcopenia. This was a cross-sectional study involving 628 community-dwelling Chinese adults aged \u2265 40. Subjects were assessed by dual energy X-ray absorptiometry (DXA) for osteopenia\/osteoporosis and sarcopenia using the Asian Working Group for Sarcopenia definition; then grouped into healthy, osteopenia\/osteoporosis, sarcopenia, and osteosarcopenia groups. A series of regression analyses and other statistical tests were performed to derive the model. HR-pQCT showed the ability to discriminate older adults with osteosarcopenia from those with osteopenia\/osteoporosis only. Cross-validation of our derived model correctly classified 77.0% of the cases with good diagnostic power and showed a sensitivity of 76.0% and specificity of 77.6% (Youden index = 0.54; AUC = 0.79, p &lt; 0.001). Analysis showed trabecular volumetric bone density and cortical periosteal perimeter were important and sensitive parameters in discriminating osteosarcopenia from osteopenia\/osteoporosis subjects. These findings demonstrated that HR-pQCT is a viable and effective screening method for differentiating osteosarcopenia from low bone mineral density alone without the need to carry out multiple assessments for osteosarcopenia, especially for case-finding purposes. This could facilitate the decision of a follow-up and the management of these frail older adults to ensure they receive timely therapeutic interventions to minimise the associated risks.<\/jats:p>","DOI":"10.3390\/jpm14090935","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T09:56:42Z","timestamp":1725357402000},"page":"935","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of Osteosarcopenia by High-Resolution Peripheral Quantitative Computed Tomography"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9891-5529","authenticated-orcid":false,"given":"Keith Yu-Kin","family":"Cheng","sequence":"first","affiliation":[{"name":"Bone Quality and Health Centre, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1742-980X","authenticated-orcid":false,"given":"Simon Kwoon-Ho","family":"Chow","sequence":"additional","affiliation":[{"name":"Bone Quality and Health Centre, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian Wing-Yin","family":"Hung","sequence":"additional","affiliation":[{"name":"Bone Quality and Health Centre, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoey Tsz-Lok","family":"Tsang","sequence":"additional","affiliation":[{"name":"Bone Quality and Health Centre, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin Hon-Kei","family":"Yip","sequence":"additional","affiliation":[{"name":"JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-6627","authenticated-orcid":false,"given":"Ronald Man Yeung","family":"Wong","sequence":"additional","affiliation":[{"name":"Bone Quality and Health Centre, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Bone Quality and Health Centre, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-6167","authenticated-orcid":false,"given":"Ling","family":"Qin","sequence":"additional","affiliation":[{"name":"Bone Quality and Health Centre, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheung-Wai","family":"Law","sequence":"additional","affiliation":[{"name":"Bone Quality and Health Centre, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3247-8255","authenticated-orcid":false,"given":"Wing-Hoi","family":"Cheung","sequence":"additional","affiliation":[{"name":"Bone Quality and Health Centre, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/jcsm.12147","article-title":"Welcome to the ICD-10 code for sarcopenia","volume":"7","author":"Anker","year":"2016","journal-title":"J. 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