{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:46:59Z","timestamp":1792820819160,"version":"4.5.0"},"reference-count":32,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Soonchunhyang University Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Aseptic meningitis comprises meningeal inflammation and cerebrospinal fluid (CSF) pleocytosis without positive Gram stain and culture. Regional differences exist in the prevalence of viral etiologies of aseptic meningitis. We aimed to assess the etiologies of aseptic meningitis in immunocompetent adults, focusing on herpes simplex virus type 2 (HSV-2). Methods: This study retrospectively analyzed immunocompetent adults diagnosed with meningitis at a Korean tertiary care hospital from 2016 to 2018. Aseptic meningitis was defined through clinical and CSF analysis. We compared clinical and laboratory characteristics across viral etiologies and investigated predictors of HSV-2 meningitis. Results: A total of 98 patients (46.9% female) with aseptic meningitis were finally enrolled. The etiologies of aseptic meningitis were identified in 62 patients (63.3%), including enterovirus (28.5%), HSV-2 (16.3%), and varicella zoster virus (VZV, 15.3%). HSV-2 showed female predominance, with shorter admission times with longer hospital stays and a recurrent meningitis history. Compared to other viral etiologies, HSV-2 showed higher CSF white blood cell (WBC) counts and protein levels but lower C-reactive protein (CRP) levels. A random forest model identified previous meningitis history and serum CRP level as key predictors of HSV-2 meningitis. Conclusions: This study provides insights into the etiologies of aseptic meningitis in a specific Korean region, identifying HSV-2 as a notable cause. The prediction model suggested that the clinical history of previous meningitis and serum CRP level may guide clinical assessment of meningitis.<\/jats:p>","DOI":"10.3390\/jpm14090998","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T04:31:23Z","timestamp":1726806683000},"page":"998","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Viral Etiology of Aseptic Meningitis and Clinical Prediction of Herpes Simplex Virus Type 2 Meningitis"],"prefix":"10.3390","volume":"14","author":[{"given":"Pamela","family":"Song","sequence":"first","affiliation":[{"name":"Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang 10380, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Myoung","family":"Seok","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Hospital Cheonan, Soonchunhyang University College of Medicine, 31 Soonchunhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Hospital Cheonan, Soonchunhyang University College of Medicine, 31 Soonchunhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaehyeok","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Hospital Cheonan, Soonchunhyang University College of Medicine, 31 Soonchunhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Yeong","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Hospital Cheonan, Soonchunhyang University College of Medicine, 31 Soonchunhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Nae","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Hospital Cheonan, Soonchunhyang University College of Medicine, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongkyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Hospital Cheonan, Soonchunhyang University College of Medicine, 31 Soonchunhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9730-3363","authenticated-orcid":false,"given":"Kyomin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Hospital Cheonan, Soonchunhyang University College of Medicine, 31 Soonchunhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngsoon","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Hospital Cheonan, Soonchunhyang University College of Medicine, 31 Soonchunhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dushin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Hospital Cheonan, Soonchunhyang University College of Medicine, 31 Soonchunhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6343-6520","authenticated-orcid":false,"given":"Kwang Ik","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Hospital Cheonan, Soonchunhyang University College of Medicine, 31 Soonchunhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungkook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Hospital Cheonan, Soonchunhyang University College of Medicine, 31 Soonchunhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.1016\/j.vaccine.2007.04.058","article-title":"Aseptic meningitis: Case definition and guidelines for collection, analysis and presentation of immunization safety 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