{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:39:57Z","timestamp":1791038397976,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background\/Objectives: Benralizumab is a monoclonal antibody that targets the interleukin-5 receptor (IL-5R\u03b1), leading to the rapid depletion of blood eosinophils. RCTs have demonstrated efficacy in patients with severe eosinophilic asthma (SEA). The aim of this study was to assess the efficacy of benralizumab on sinonasal outcomes in a real-life setting in patients with SEA and concomitant chronic rhinosinusitis with nasal polyps (CRSwNP). Methods: We included 25 patients (mean age: 57.47 years, range: 35\u201377, F\/M = 12:13) who were prescribed 30 mg benralizumab every month for the first three administrations and then every 2 months. The primary endpoint was to evaluate changes in the SinoNasal Outcome Test-22 (SNOT-22) and nasal polyp score (NPS) over a 24-month treatment period. Secondary endpoints included measuring the effects on nasal obstruction and impaired sense of smell. Results: The mean NPS score decreased significantly from 5.11 \u00b1 1.84 at baseline to 2.37 \u00b1 1.96 at 24 months. The mean SNOT-22 decreased from 57 \u00b1 15.30 at baseline to 26 \u00b1 16.73 at 24 months. The SSIT-16 mean score improved with an increase in olfactory performance from 5.23 \u00b1 2.58 at baseline to 7 \u00b1 3.65 at 24 months. Moreover, 8\/25 patients (32%) required rescue treatment with systemic steroids and 2 patients required endoscopic sinus surgery. Conclusions: While the improvement may not seem optimal at 12 months, a progressive enhancement was noted during the second year of treatment. Despite our data showing an improvement in quality of life and a reduction in the size of nasal polyps, no significant improvement in olfactory sensitivity was observed. In addition, in several patients, rescue treatments were required to maintain control of nasal and sinus symptoms. A careful risk\u2013benefit assessment is therefore needed when deciding to continue treatment, weighing the potential for further improvement against the risks of complications. Such decisions should always be made in the context of a multidisciplinary team.<\/jats:p>","DOI":"10.3390\/jpm14091014","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T03:49:46Z","timestamp":1727149786000},"page":"1014","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sinonasal Outcomes Obtained after 2 Years of Treatment with Benralizumab in Patients with Severe Eosinophilic Asthma and CRSwNP: A \u201cReal-Life\u201d Observational Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5761-7018","authenticated-orcid":false,"given":"Eugenio","family":"De Corso","sequence":"first","affiliation":[{"name":"UOC Otorinolaringoiatria, Fondazione Policlinico Universitario Agostino Gemelli\u2014IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0765-9233","authenticated-orcid":false,"given":"Dario Antonio","family":"Mele","sequence":"additional","affiliation":[{"name":"UOC Otorinolaringoiatria, Fondazione Policlinico Universitario Agostino Gemelli\u2014IRCCS, 00168 Roma, Italy"},{"name":"Department of Head-Neck and Sensory Organs, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6795-746X","authenticated-orcid":false,"given":"Angela","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Unit of Allergology e Clinical Immunology, Fondazione Policlinico Universitario Agostino Gemelli\u2014IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Spanu","sequence":"additional","affiliation":[{"name":"Department of Head-Neck and Sensory Organs, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7394-8630","authenticated-orcid":false,"given":"Marco","family":"Corb\u00f2","sequence":"additional","affiliation":[{"name":"Department of Head-Neck and Sensory Organs, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2487-1219","authenticated-orcid":false,"given":"Serena","family":"Pisciottano","sequence":"additional","affiliation":[{"name":"Department of Head-Neck and Sensory Organs, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-8081","authenticated-orcid":false,"given":"Rodolfo Francesco","family":"Mastrapasqua","sequence":"additional","affiliation":[{"name":"ENT Department, Rivoli Hospital, ASL TO3, 10098 Rivoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8528-7533","authenticated-orcid":false,"given":"Silvia","family":"Baroni","sequence":"additional","affiliation":[{"name":"Unit of Chemistry, Biochemistry and Clinical Molecular Biology, Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide Paolo","family":"Porru","sequence":"additional","affiliation":[{"name":"Department of Head-Neck and Sensory Organs, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"De Maio","sequence":"additional","affiliation":[{"name":"Department of Head-Neck and Sensory Organs, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta","family":"Rizzuti","sequence":"additional","affiliation":[{"name":"Department of Head-Neck and Sensory Organs, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe Alberto","family":"Di Bella","sequence":"additional","affiliation":[{"name":"Department of Head-Neck and Sensory Organs, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3131-0939","authenticated-orcid":false,"given":"Augusta","family":"Ortolan","sequence":"additional","affiliation":[{"name":"UOC Reumatologia, Universit\u00e0 Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli\u2014IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bonini","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario Agostino Gemelli\u2014IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6929-0912","authenticated-orcid":false,"given":"Francesca","family":"Cefaloni","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario Agostino Gemelli\u2014IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Boccabella","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario Agostino Gemelli\u2014IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario Agostino Gemelli\u2014IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Chini","sequence":"additional","affiliation":[{"name":"Unit of Allergology e Clinical Immunology, Fondazione Policlinico Universitario Agostino Gemelli\u2014IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7631-029X","authenticated-orcid":false,"given":"Cristiano","family":"Caruso","sequence":"additional","affiliation":[{"name":"Unit of Allergology e Clinical Immunology, Fondazione Policlinico Universitario Agostino Gemelli\u2014IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-8854","authenticated-orcid":false,"given":"Marco","family":"Panfili","sequence":"additional","affiliation":[{"name":"Neuroradiology, Fondazione Policlinico Universitario Agostino Gemelli\u2014IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Galli","sequence":"additional","affiliation":[{"name":"UOC Otorinolaringoiatria, Fondazione Policlinico Universitario Agostino Gemelli\u2014IRCCS, 00168 Roma, Italy"},{"name":"Department of Head-Neck and Sensory Organs, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/S0140-6736(16)31322-8","article-title":"Benralizumab, an anti-interleukin-5 receptor \u03b1 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