{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:14:52Z","timestamp":1785838492395,"version":"3.56.0"},"reference-count":126,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III (ISCIII)","award":["PI18\/00419"],"award-info":[{"award-number":["PI18\/00419"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["PI22\/01467"],"award-info":[{"award-number":["PI22\/01467"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["FORT23\/00002"],"award-info":[{"award-number":["FORT23\/00002"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["II040138"],"award-info":[{"award-number":["II040138"]}]},{"name":"European Union","award":["PI18\/00419"],"award-info":[{"award-number":["PI18\/00419"]}]},{"name":"European Union","award":["PI22\/01467"],"award-info":[{"award-number":["PI22\/01467"]}]},{"name":"European Union","award":["FORT23\/00002"],"award-info":[{"award-number":["FORT23\/00002"]}]},{"name":"European Union","award":["II040138"],"award-info":[{"award-number":["II040138"]}]},{"name":"\u201cla Caixa\u201d Banking Foundation","award":["PI18\/00419"],"award-info":[{"award-number":["PI18\/00419"]}]},{"name":"\u201cla Caixa\u201d Banking Foundation","award":["PI22\/01467"],"award-info":[{"award-number":["PI22\/01467"]}]},{"name":"\u201cla Caixa\u201d Banking Foundation","award":["FORT23\/00002"],"award-info":[{"award-number":["FORT23\/00002"]}]},{"name":"\u201cla Caixa\u201d Banking Foundation","award":["II040138"],"award-info":[{"award-number":["II040138"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background\/Objectives: Sinonasal mucosal melanomas (SNMMs) are rare and aggressive malignancies with poor survival outcomes. Our systematic review and meta-analysis aim to evaluate overall survival (OS) rates in patients with SNMM; Methods: We conducted a systematic search, following PRISMA guidelines across PubMed, Web of Science (WOS), and citation searching for studies reporting survival and prognosis outcomes for SNMMs. Inclusion criteria included studies with 5-year OS rates. Studies were excluded if they included tumor sites other than the paranasal sinuses or nasal cavity, were published in languages other than English and Spanish, or had a sample size of fewer than 15 patients. Two reviewers independently screened studies, extracted data, and assessed study quality using the Joanna Briggs Institute (JBI) critical appraisal checklist. Analyses of survival probabilities were conducted. Meta-analyses were performed using a random-effects model. PROSPERO ID CRD42024565137; Results: A total of 515 articles were identified after removing duplicates, and 99 reports were assessed for eligibility. Of these, 35 studies were included in the meta-analysis, encompassing a total of 2383 SNMM patients, of whom 1192 (50%) were female, with a weighted mean age of 65.4 years (SD = 5.4). Fifteen studies were from Europe (42.9%), six (17.1%) were from America, eleven (31.4%) were from Asia, two (5.7%) were from Australia, and one (2.9%) combined European, United Kingdom, and American populations. The 5-year OS was 34.8 [95% CI = 30.6\u201339.5], with the highest OS in America at 40.5 [95% CI = 34.1\u201348.1], followed by Europe at 36.6 [95% CI = 30.6\u201343.7], Australia at 32.3 [95% CI = 12.5\u201383.8], and Asia at 28.1 [95% CI = 19.5\u201340.7]. The age-standardized incidence rate (ASIR) for SNMM ranges was between 0.07 and 0.14 per 100,000 persons\/year, with a slightly higher incidence in women than in men; Conclusions: This meta-analysis, one of the largest to date on SNMM, confirms the aggressive nature of this melanoma subtype with poor survival outcomes. Despite geographic differences in survival rates, the overall 5-year survival remains low, highlighting the urgent need for improved treatment strategies and more research to improve patient outcomes.<\/jats:p>","DOI":"10.3390\/jpm14121120","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:20:12Z","timestamp":1732681212000},"page":"1120","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Survival Outcomes in Sinonasal Mucosal Melanoma: Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1402-5167","authenticated-orcid":false,"given":"Mar\u00eda Jes\u00fas","family":"Rojas-Lechuga","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Department, Hospital Clinic of Barcelona, Universitat de Barcelona (UB), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Jub\u00e9s","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Hospital Clinic of Barcelona, Universitat de Barcelona (UB), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4218-9756","authenticated-orcid":false,"given":"Manuel","family":"Molina-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Dermatology Department, Hospital Clinic Barcelona, Universitat de Barcelona (UB), 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), CIBERES, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui Milton Patricio","family":"da Silva-J\u00fanior","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Dermatology Department, Hospital Clinic Barcelona, Universitat de Barcelona (UB), 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), CIBERES, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Sampieri","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Hospital Clinic of Barcelona, Universitat de Barcelona (UB), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crist\u00f3bal","family":"Langdon","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Hospital Sant Joan de D\u00e9u, 08950 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Ram\u00f3n","family":"Gras-Cabrerizo","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Head-Neck Surgery Department, Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Bernal-Sprekelsen","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Hospital Clinic of Barcelona, Universitat de Barcelona (UB), 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), CIBERES, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1337-9745","authenticated-orcid":false,"given":"Susana","family":"Puig","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Dermatology Department, Hospital Clinic Barcelona, Universitat de Barcelona (UB), 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), CIBERES, 08036 Barcelona, Spain"},{"name":"Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 08034 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7204-5599","authenticated-orcid":false,"given":"Isam","family":"Alobid","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Hospital Clinic of Barcelona, Universitat de Barcelona (UB), 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), CIBERES, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"ref_1","unstructured":"Itha, F., and Billroth, T. 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