{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:44:06Z","timestamp":1759970646955,"version":"build-2065373602"},"reference-count":64,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of P\u00e9cs, Medical School","award":["FK142942","EK\u00d6P-24-4-I-PTE-209"],"award-info":[{"award-number":["FK142942","EK\u00d6P-24-4-I-PTE-209"]}]},{"name":"National Research, Development, and Innovation Office","award":["FK142942","EK\u00d6P-24-4-I-PTE-209"],"award-info":[{"award-number":["FK142942","EK\u00d6P-24-4-I-PTE-209"]}]},{"name":"the \u00daNKP-23-3 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund","award":["FK142942","EK\u00d6P-24-4-I-PTE-209"],"award-info":[{"award-number":["FK142942","EK\u00d6P-24-4-I-PTE-209"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: The clinical presentation of coeliac disease (CD) is various and may influence disease course. We aimed to investigate the associations of clinical presentation with comorbidities and disease complications in a cohort of Hungarian coeliac patients. Methods: In this retrospective study, data of consecutive CD patients were analysed. Clinical presentation (classical vs. non-classical), extraintestinal manifestations and comorbidities (anaemia, metabolic bone disease, dermatitis herpetiformis, IgA deficiency, chromosomal abnormalities, autoimmune diseases and malignancy) were assessed. Student\u2019s t-test (for age at diagnosis) and the Chi-squared test or Fisher\u2019s exact test (for categorical variables) were applied as analyses. Results: A total of 738 patients were included. In classical vs. non-classical comparisons, classical presentation was significantly associated with metabolic bone disease (59 vs. 36%, respectively, p &lt; 0.001), anaemia (47 vs. 38%, respectively, p = 0.027) and malignancy (6 vs. 2%, respectively, p = 0.006); however, autoimmune diseases and dermatitis herpetiformis were more common with non-classical presentation (23 vs. 31%, p = 0.02, and 5 vs. 16%, p = 0.014, respectively). Conclusions: Our findings confirm that clinical presentation is associated with certain comorbidities and complications in CD. More personalised follow-up may be recommended based on clinical presentation.<\/jats:p>","DOI":"10.3390\/jpm15020055","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T07:45:12Z","timestamp":1738136712000},"page":"55","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Clinical Presentation of Coeliac Disease with Comorbidities and Complications: A Retrospective Single-Centre Analysis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-4871","authenticated-orcid":false,"given":"Judit","family":"Bajor","sequence":"first","affiliation":[{"name":"First Department of Medicine, Medical School, University of P\u00e9cs, Ifj\u00fas\u00e1g Str. 13, H-7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zs\u00f3fia","family":"Vereczkei","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Medical School, University of P\u00e9cs, Szigeti Str. 12, H-7624 P\u00e9cs, Hungary"},{"name":"Department of Sport Nutrition and Hydration, Institute of Nutritional Science and Dietetics, Faculty of Health Sciences, University of P\u00e9cs, V\u00f6r\u00f6smarty Mih\u00e1ly Str. 4, H-7621 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9ka","family":"Bencs","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine and Nephrological Centre, Medical School, University of P\u00e9cs, Pacsirta Str. 1, H-7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enik\u0151","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Medical School, University of P\u00e9cs, Ifj\u00fas\u00e1g Str. 13, H-7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00edra Zs\u00f3fia","family":"Peresztegi","sequence":"additional","affiliation":[{"name":"Medical School, University of P\u00e9cs, Szigeti Str. 12, H-7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivett","family":"Heged\u0171s","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical School, University of P\u00e9cs, Szigeti Str. 12, H-7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5349-6527","authenticated-orcid":false,"given":"Nelli","family":"Farkas","sequence":"additional","affiliation":[{"name":"Institute of Bioanalysis, Medical School, University of P\u00e9cs, Szigeti Str. 12, H-7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"T\u00e1rnok","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Medical School, University of P\u00e9cs, J\u00f3zsef Attila Str. 7, H-7623 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00f3ra","family":"Szigeti","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine and Nephrological Centre, Medical School, University of P\u00e9cs, Pacsirta Str. 1, H-7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7035-941X","authenticated-orcid":false,"given":"Zsolt","family":"Szak\u00e1cs","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Medical School, University of P\u00e9cs, Ifj\u00fas\u00e1g Str. 13, H-7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41575-021-00552-z","article-title":"The global burden of coeliac disease: Opportunities and challenges","volume":"19","author":"Makharia","year":"2022","journal-title":"Nat. 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