{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:38:57Z","timestamp":1790912337439,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background\/Objectives: Polycystic ovarian syndrome (PCOS) is a complex endocrine disorder affecting up to 15% of reproductive-age women, characterized by hyperandrogenism, chronic oligo-ovulation, and metabolic dysfunction. This study aims to evaluate serum sortilin levels in women with PCOS for the first time and investigate their potential associations with metabolic and hormonal alterations. Material and Methods: Eighty PCOS patients and 80 healthy controls were included; serum sortilin levels were measured using ELISA kits, with documented intra-assay and inter-assay variations below 6% and 8%, respectively, ensuring high specificity and sensitivity. Results: Serum sortilin levels were significantly elevated in PCOS patients (69.51 \u00b1 27.75 pg\/mL) versus controls (48.60 \u00b1 21.20 pg\/mL) (p &lt; 0.001). PCOS patients exhibited higher mean HOMA-IR, free androgen index values, serum glucose, insulin, triglycerides, high-sensitivity C-reactive protein, luteinizing hormone, total testosterone, and DHEA-S levels, alongside reduced high-density lipoprotein cholesterol and sex hormone-binding globulin levels (all, p &lt; 0.05). Notably, inverse correlations were observed between sortilin and low-density lipoprotein cholesterol levels in both groups (p = 0.028 and 0.033). Conclusions: This pioneering study indicates that serum sortilin may be implicated in PCOS pathogenesis and serves as a potential biomarker for metabolic dysfunction in PCOS. Larger, diverse studies with longitudinal designs are needed for further validation.<\/jats:p>","DOI":"10.3390\/jpm15020070","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T11:31:17Z","timestamp":1739791877000},"page":"70","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum Sortilin Levels as a Biomarker for Metabolic and Hormonal Dysregulation in Polycystic Ovary Syndrome"],"prefix":"10.3390","volume":"15","author":[{"given":"Pinar","family":"Alarslan","sequence":"first","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Istanbul Aydin University, Medical Park Florya Hospital, Besyol, Florya, Akasya Sk., 34295 Kucukcekmece\/Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Doruk","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, \u0130zmir Bozkaya Research and Education Hospital, Bahar, Saim \u00c7\u0131kr\u0131k\u00e7\u0131 Cd., 35170 Karaba\u011flar\/\u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Shele, G., Genkil, J., and Speelman, D. (2020). A systematic review of the effects of exercise on hormones in women with polycystic ovary syndrome. J. Funct. Morphol. Kinesiol., 5.","DOI":"10.3390\/jfmk5020035"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00404-012-2568-z","article-title":"Clinical characteristics, metabolic features, and phenotype of Chinese women with polycystic ovary syndrome: A large-scale case\u2013control study","volume":"287","author":"Zhang","year":"2012","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/humupd\/dmaa029","article-title":"Long-term cardiometabolic disease risk in women with PCOS: A systematic review and meta-analysis","volume":"26","author":"Wekker","year":"2020","journal-title":"Hum. Reprod. Updat."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1093\/emboj\/20.9.2180","article-title":"The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein","volume":"20","author":"Nielsen","year":"2001","journal-title":"EMBO J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1089\/dna.2017.3853","article-title":"Implications of sortilin in lipid metabolism and lipid disorder diseases","volume":"36","author":"Gao","year":"2017","journal-title":"DNA Cell Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12933-019-0805-5","article-title":"Sortilin levels are associated with peripheral arterial disease in type 2 diabetic subjects","volume":"18","author":"Biscetti","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/ATVBAHA.117.310292","article-title":"Sortilin and its multiple roles in cardiovascular and metabolic diseases","volume":"38","author":"Goettsch","year":"2018","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"The Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group (2004). Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil. Steril., 81, 19\u201325.","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"ref_9","first-page":"B5232","article-title":"Endocrine and metabolic characteristics in polycystic ovary syndrome","volume":"63","author":"Glintborg","year":"2016","journal-title":"Dan. Med. J."},{"key":"ref_10","unstructured":"Ong, M.L.T. (2018). The Effects and Mechanisms of Paeoniflorin on Murine Ovarian Cells for the Treatment of Polycystic Ovarian Syndrome. [Ph.D. Thesis, Open Publications of UTS Scholars]."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.cca.2019.11.003","article-title":"Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity","volume":"502","author":"Zeng","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e230342","DOI":"10.1530\/JOE-23-0342","article-title":"Hormonal changes in PCOS","volume":"261","author":"Yang","year":"2024","journal-title":"J. Endocrinol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.tins.2012.01.003","article-title":"Sortilin: A receptor to regulate neuronal viability and function","volume":"35","author":"Nykjaer","year":"2012","journal-title":"Trends Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1089\/mab.2015.0042","article-title":"Production and characterization of a novel monoclonal antibody against human sortilin","volume":"34","author":"Ghaemimanesh","year":"2015","journal-title":"Monoclon. Antibodies Immunodiagn. Immunother."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1007\/s43032-024-01615-7","article-title":"Unveiling the role of artificial intelligence (AI) in polycystic ovary syndrome (PCOS) diagnosis: A comprehensive review","volume":"31","author":"Verma","year":"2024","journal-title":"Reprod. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1074\/jbc.M710604200","article-title":"Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocytes","volume":"283","author":"Ariga","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nm1097-1096","article-title":"GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes","volume":"3","author":"Stenbit","year":"1997","journal-title":"Nat. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"11526","DOI":"10.1074\/jbc.M115.641225","article-title":"Insulin resistance induces posttranslational hepatic sortilin 1 degradation in mice","volume":"290","author":"Li","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Blondeau, N., B\u00e9raud-Dufour, S., Lebrun, P., Hivelin, C., and Coppola, T. (2019). Sortilin in Glucose Homeostasis: From Accessory Protein to Key Player?. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.01561"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.amjms.2019.10.003","article-title":"Relation of decreased circulating sortilin levels with unfavorable metabolic profiles in subjects with newly diagnosed type 2 diabetes mellitus","volume":"359","author":"Demir","year":"2020","journal-title":"Am. J. Med. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12933-017-0568-9","article-title":"Circulating sortilin level as a potential biomarker for coronary atherosclerosis and diabetes mellitus","volume":"16","author":"Oh","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6276187","DOI":"10.1155\/2020\/6276187","article-title":"From prediabetes to type 2 diabetes mellitus in women with polycystic ovary syndrome: Lifestyle and pharmacological management","volume":"2020","author":"Pani","year":"2020","journal-title":"Int. J. Endocrinol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3109\/09513590.2015.1126818","article-title":"SORCS1 polymorphism and insulin secretion in obese women with polycystic ovary syndrome","volume":"32","author":"Hrovat","year":"2016","journal-title":"Gynecol. Endocrinol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nature09266","article-title":"From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus","volume":"466","author":"Musunuru","year":"2010","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12933-020-01123-3","article-title":"Sortilin levels correlate with major cardiovascular events of diabetic patients with peripheral artery disease following revascularization: A prospective study","volume":"19","author":"Biscetti","year":"2020","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11883-012-0248-x","article-title":"Sortilin as a regulator of lipoprotein metabolism","volume":"14","author":"Strong","year":"2012","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1210\/endrev\/bnac001","article-title":"Deconstructing a syndrome: Genomic insights into PCOS causal mechanisms and classification","volume":"43","author":"Dapas","year":"2022","journal-title":"Endocr. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cmet.2010.08.006","article-title":"Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export","volume":"12","author":"Kjolby","year":"2010","journal-title":"Cell Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1007\/s10815-022-02625-7","article-title":"A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS)","volume":"39","author":"Siddiqui","year":"2022","journal-title":"J. Assist. Reprod. Genet."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/15\/2\/70\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:34:57Z","timestamp":1760027697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/15\/2\/70"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,15]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["jpm15020070"],"URL":"https:\/\/doi.org\/10.3390\/jpm15020070","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,15]]}}}