{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:20:24Z","timestamp":1780492824659,"version":"3.54.1"},"reference-count":51,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Sim\u00f3n Bol\u00edvar, Vicerrector\u00eda de Investigaci\u00f3n, Extensi\u00f3n e Innovaci\u00f3n"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Primary pleural lymphoma is a rare disease posing diagnostic and therapeutic challenges. Case presentation: We present a 65-year-old woman with dyspnoea, cough, and asthenia, with no significant past medical history. Chest X-ray and computed tomography showed extensive right pleural effusion. Video-assisted thoracoscopy demonstrated multiple pleural nodules, while pleural fluid analysis revealed a lymphocytic exudate, and finally, a primary pleural lymphoma diagnosis was confirmed by immunohistochemistry analysis in pleural nodules biopsy. Discussion: In this regard, eight cycles of chemotherapy with cyclophosphamide, doxorubicin, vincristine, dexamethasone, and rituximab were indicated, and after one year of follow-up, complete clinical and radiological remission was observed. Conlusions: We conclude that video-assisted thoracoscopy with an appropriate histopathological examination remains the gold standard for diagnosis, while R-CHOP chemotherapy plus rituximab may represent a highly effective therapeutic choice.<\/jats:p>","DOI":"10.3390\/jpm15050162","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T03:43:37Z","timestamp":1745379817000},"page":"162","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Primary Pleural Lymphoma in an Immune-Competent Patient: A Diagnostic and Therapeutic Challenge"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8483-0276","authenticated-orcid":false,"given":"Carlos Silva","family":"Paredes","sequence":"first","affiliation":[{"name":"Universidad del Zulia, Facultad de Medicina, Departamento de Ciencias Fisiol\u00f3gicas, Maracaibo 4001, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lauretta","sequence":"additional","affiliation":[{"name":"Universidad del Zulia, Facultad de Medicina, Postgrado de Cirug\u00eda de T\u00f3rax, Maracaibo 4001, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2807-2118","authenticated-orcid":false,"given":"Marien","family":"Semprun","sequence":"additional","affiliation":[{"name":"Universidad del Zulia, Facultad de Medicina, Maracaibo 4001, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2169-3208","authenticated-orcid":false,"given":"Diego","family":"Rivera-Porras","sequence":"additional","affiliation":[{"name":"Universidad de la Costa, Departamento de Productividad e Innovaci\u00f3n, Barranquilla 080001, Atl\u00e1ntico, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Elena","family":"Viloria","sequence":"additional","affiliation":[{"name":"Universidad del Zulia, Facultad de Medicina, Instituto de Investigaciones Biol\u00f3gicas, Maracaibo 4001, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-8887","authenticated-orcid":false,"given":"Valmore","family":"Berm\u00fadez","sequence":"additional","affiliation":[{"name":"Universidad Sim\u00f3n Bol\u00edvar, Facultad de Ciencias de la Salud, Centro de Investigaciones en Ciencias de la Vida, Barranquilla 080001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pereira, L.J., Mohrbacher, S., Neves, P.D.M.d.M., Zacchi, F.F.S., Medeiros, I.U.D., Sato, V.A.H., Oliveira, \u00c9.S., Pereira, L.V.B., Cuvello-Neto, A.L., and Baiocchi, O. 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