{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:58:09Z","timestamp":1792515489654,"version":"4.5.0"},"reference-count":70,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Recreational nasal cocaine use (RNCU) presents a significant challenge for rhinologists due to cocaine-induced midline destructive lesions (CIMDLs). This clinical consensus statement (CCS) offers guidelines for diagnosing, assessing, and managing both proven and suspected cases of CIMDL (including those without a prior RNCU history). It aims to support clinicians in addressing these complex cases effectively. Methods: An international, multidisciplinary panel of 18 specialists employed a three-round modified Delphi-method survey to evaluate statements covering CIMDL management issues such as definition, clinical evaluation and diagnosis, initial management approaches, and surgical management of complications and reconstructions. This study primarily targets otorhinolaryngologists. Results: Out of 44 evaluated statements, 20 achieved strong consensus, 20 reached consensus, 3 approached near-consensus, and 1 failed to achieve consensus. Consensus-covered areas included the definition of CIMDL, clinical evaluations, first-line management, and management of complications. However, reconstructive techniques remained a contentious topic. Conclusions: In the absence of extensive data, this CCS establishes a management framework for CIMDL, significantly bridging a knowledge gap. It highlights the need for standardized assessments, multidisciplinary cooperation, and customized follow-up care for patients with CIMDL. Considering the widespread use of cocaine, physicians should consistently consider the possibility of RNCU when encountering chronic inflammatory lesions in the sinonasal tract.<\/jats:p>","DOI":"10.3390\/jpm15060231","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T08:01:07Z","timestamp":1748937667000},"page":"231","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comprehensive Management of Cocaine-Induced Midline Destructive Lesions: A Young-IfOS Consensus"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-6871","authenticated-orcid":false,"given":"Alberto Maria","family":"Saibene","sequence":"first","affiliation":[{"name":"Young Otolaryngologists-International Federation of Otorhinolaryngological Societies (Yo-IFOS), F-75000 Paris, France"},{"name":"Otolaryngology Unit, ASST Santi Paolo E Carlo, Department of Health Sciences, 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Poitiers, F-86000 Poitiers, France"},{"name":"Laboratoire Inflammation Tissus Epith\u00e9liaux et Cytokines (LITEC), Universit\u00e9 de Poitiers, 86000 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5134-7344","authenticated-orcid":false,"given":"Mihaela","family":"Alexandru","sequence":"additional","affiliation":[{"name":"Young Otolaryngologists-International Federation of Otorhinolaryngological Societies (Yo-IFOS), F-75000 Paris, France"},{"name":"Service d\u2019Orl et Chirurgie Cervico-Faciale, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris-Saclay, H\u00f4pital Bic\u00eatre, F-94270 le Kremlin-Bic\u00eatre, France"},{"name":"Sorbonne Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, H\u00f4pital Armand-Trousseau, F-75012 Paris, 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