{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:19:07Z","timestamp":1784945947957,"version":"3.55.0"},"reference-count":31,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES)\/Ministry of Education of Brazil"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Asymmetrical brain oscillations may be characteristic of Parkinson\u2019s disease (PD). We investigated differences in oscillation asymmetry between individuals with PD and healthy controls and explored associations between the asymmetry and clinical features. Methods: Clinical and resting-state EEG data from 37 patients and 24 controls were cross-sectionally analyzed. EEG asymmetry indices were calculated for the delta, theta, alpha, and beta frequencies in the frontal, central, and parietal regions. Independent t-tests and linear regression models were employed. Results: Patients exhibited lower alpha asymmetry than controls in the parietal region (t(59) = 2.12, p = 0.03). In the frontal alpha asymmetry models, there were associations with time since diagnosis (\u03b2 = \u22120.042) and attention\/orientation (\u03b2 = 0.061), and with Movement Disorder Society-Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRSIII)-posture (\u03b2 = 0.136) and MDS-UPDRSIII-rest-tremor persistence (\u03b2 = \u22120.111). In the central alpha model, higher asymmetry was associated with the physical activity levels (International Physical Activity Questionnaire) IPAQ-active (\u03b2 = 0.646) and IPAQ-very active (\u03b2 = 0.689), (Timed Up and Go) TUG dual-task cost (\u03b2 = 0.023), MDS-UPDRSII-freezing (\u03b2 = 0.238), and being male (\u03b2 = 0.535). In the parietal alpha asymmetry model, MDS-UPDRSII-gait\/balance was inversely associated with alpha asymmetry (\u03b2 = \u22120.156), while IPAQ-active (\u03b2 = \u22120.247) and being male (\u03b2 = \u22120.191) were associated with lower asymmetry. Conclusions: Our findings highlight the potential role of alpha asymmetry as a neurophysiological marker of PD\u2019s motor symptoms, mainly rest tremor, gait\/balance, freezing, and specific cognitive domains such as attention\/orientation. The models stressed the relationship between disease progression and reduced alpha asymmetry. Brazilian Registry of Clinical Trials (RBR-7zjgnrx, 9 June 2022).<\/jats:p>","DOI":"10.3390\/jpm15070291","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T11:20:11Z","timestamp":1751628011000},"page":"291","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Resting-State EEG Alpha Asymmetry as a Potential Marker of Clinical Features in Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9109-0029","authenticated-orcid":false,"given":"Thalita Frigo","family":"da Rocha","sequence":"first","affiliation":[{"name":"Neurosciences and Neurological Rehabilitation Laboratory, Physical Therapy Department, Federal University of Sao Carlos, Rodovia Washington Luis, km 235, Sao Carlos 13565-905, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-7523","authenticated-orcid":false,"given":"Valton","family":"Costa","sequence":"additional","affiliation":[{"name":"Neurosciences and Neurological Rehabilitation Laboratory, Physical Therapy Department, Federal University of Sao Carlos, Rodovia Washington Luis, km 235, Sao Carlos 13565-905, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4112-6473","authenticated-orcid":false,"given":"Lucas","family":"Camargo","sequence":"additional","affiliation":[{"name":"Spaulding Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4086-0606","authenticated-orcid":false,"given":"Elayne Borges","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Neurosciences and Neurological Rehabilitation Laboratory, Physical Therapy Department, Federal University of Sao Carlos, Rodovia Washington Luis, km 235, Sao Carlos 13565-905, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7334-3835","authenticated-orcid":false,"given":"Anna Carolyna","family":"Gianloren\u00e7o","sequence":"additional","affiliation":[{"name":"Neurosciences and Neurological Rehabilitation Laboratory, Physical Therapy Department, Federal University of Sao Carlos, Rodovia Washington Luis, km 235, Sao Carlos 13565-905, Brazil"},{"name":"Spaulding Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chen, H., Wang, K., Scheperjans, F., and Killinger, B. 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