{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T22:22:46Z","timestamp":1786832566646,"version":"build-2736575974"},"reference-count":69,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background\/Objectives: Olfactory neuroblastoma (ONB), also known as esthesioneuroblastoma, is a rare neuroectodermal malignancy of the nasal cavity characterized by aggressive local invasion and variable metastatic potential, with diverse clinical behavior, often presenting at advanced stages. ONB poses challenges for targeted therapeutic strategies, despite advances in surgical and multimodal treatment strategies, because of the rarity of this disease and the limited understanding of its molecular pathophysiology. Methods: A comprehensive review of genomic, multi-omic, and molecular studies was performed to integrate known targeted sites in ONB with the current understanding of its pathophysiology. Results: Recent genetic and molecular studies have identified significant epigenetic and signaling pathway alterations that are critical in pathogenesis and treatment resistance and may serve as potential therapeutic targets. Additionally, novel discovered immunohistochemical and transcriptomic markers, such as IDH2, NEUROD1, and OTX2, offer improved diagnostic specificity and prognostication. Multi-genomic platforms (i.e., multi-omics), involving the combined integration of transcriptomics, epigenetics, and proteomics findings, have led to several recent insights, including the subclassification of neural and basal genomic subtypes, the identification of key driver mutations, and new insights into disease development. This review synthesizes current knowledge on the molecular landscape of ONB, including its tumor origin, immune microenvironment, genetic alterations, and key molecular pathways involved in its pathogenesis. Conclusions: Future research may benefit from integrating these findings into precision medicine approaches, enabling earlier diagnosis and more accurate prognosis.<\/jats:p>","DOI":"10.3390\/jpm15070309","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T09:56:54Z","timestamp":1752487014000},"page":"309","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Updated Insights into the Molecular Pathophysiology of Olfactory Neuroblastoma Using Multi-Omics Analysis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0950-7740","authenticated-orcid":false,"given":"Enes","family":"Demir","sequence":"first","affiliation":[{"name":"School of Medicine, Eskisehir Osmangazi University, Eski\u015fehir 26040, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deondra","family":"Montgomery","sequence":"additional","affiliation":[{"name":"College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Naravetla","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0422-7937","authenticated-orcid":false,"given":"Michael","family":"Karsy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,13]]},"reference":[{"key":"ref_1","first-page":"410","article-title":"L\u2019esthesioneuroepitheliome olfactif","volume":"13","year":"1924","journal-title":"Bull. Assoc. Fr. Etude Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/PAP.0b013e3181b544cf","article-title":"Olfactory neuroblastoma: A review and update","volume":"16","author":"Faragalla","year":"2009","journal-title":"Adv. Anat. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1158\/1541-7786.MCR-17-0135","article-title":"Comprehensive Molecular Profiling of Olfactory Neuroblastoma Identifies Potentially Targetable FGFR3 Amplifications","volume":"15","author":"McHugh","year":"2017","journal-title":"Mol. Cancer Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s10006-024-01240-3","article-title":"Neuroendocrine and undifferentiated sinonasal and skull base tumors: An up-to-date narrative review","volume":"28","author":"Sideris","year":"2024","journal-title":"Oral Maxillofac. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.ccell.2024.05.003","article-title":"Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer","volume":"42","author":"Finlay","year":"2024","journal-title":"Cancer Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.neures.2010.12.006","article-title":"Immunohistochemical detection of olfactory-specific sensory transduction proteins in olfactory neuroblastoma","volume":"69","author":"Matayoshi","year":"2011","journal-title":"Neurosci. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100122","DOI":"10.1016\/j.modpat.2023.100122","article-title":"Molecular Evidence for Olfactory Neuroblastoma as a Tumor of Malignant Globose Basal Cells","volume":"36","author":"Zunitch","year":"2023","journal-title":"Mod. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/MOO.0000000000001027","article-title":"Recent developments in olfactory neuroblastoma research","volume":"33","author":"Ghanem","year":"2025","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Patel, A., Im, E., Kresak, J., Olgaard, E., Blatt, J.E., Lobo, B.C., and Chapurin, N. (2024). Olfactory Neuroblastoma With Divergent Differentiation: Contemporary Management of Unusual Pathology and Literature Review. Ear Nose Throat J., 01455613241299684.","DOI":"10.1177\/01455613241299684"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Lerner, D.K., and Palmer, J.N. (2024). Personalized Approach to Olfactory Neuroblastoma Care. J. Pers. Med., 14.","DOI":"10.3390\/jpm14040423"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1007\/s12070-021-02726-2","article-title":"A Review on Esthesioneuroblastoma","volume":"74","author":"Rao","year":"2022","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11912-022-01348-3","article-title":"Olfactory Neuroblastoma: Morphological Reappraisal and Molecular Insights with Quantum Leap in Clinical Perspectives","volume":"25","author":"Bell","year":"2023","journal-title":"Curr. Oncol. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1055\/s-0041-1739181","article-title":"Experiences and Outcomes in Olfactory Neuroblastoma Over A Decade at a Tertiary Cancer Center","volume":"11","author":"Korra","year":"2022","journal-title":"South Asian J. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/lio2.597","article-title":"The genomics and epigenetics of olfactory neuroblastoma: A systematic review","volume":"6","author":"Kaur","year":"2021","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Tosoni, A., Di Nunno, V., Gatto, L., Corradi, G., Bartolini, S., Ranieri, L., and Franceschi, E. (2023). Olfactory neuroblastoma: Diagnosis, management, and current treatment options. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1242453"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00428-024-03758-z","article-title":"Update on olfactory neuroblastoma","volume":"484","author":"Lopez","year":"2024","journal-title":"Virchows Arch."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF01054767","article-title":"Expression of the humanAchaete-Scute 1 gene in olfactory neuroblastoma (esthesioneuroblastoma)","volume":"26","author":"Carney","year":"1995","journal-title":"J. Neuro-Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1186\/s12967-024-05339-9","article-title":"Augmentation of tumor expression of HLA-DR, CXCL9, and CXCL10 may improve olfactory neuroblastoma immunotherapeutic responses","volume":"22","author":"Larkin","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1126\/science.aaa6204","article-title":"T cell exclusion, immune privilege, and the tumor microenvironment","volume":"348","author":"Joyce","year":"2015","journal-title":"Science"},{"key":"ref_20","first-page":"e126853","article-title":"Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy","volume":"4","author":"Sun","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12943-020-01238-x","article-title":"Natural killer cells in cancer biology and therapy","volume":"19","author":"Wu","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1084\/jem.20052494","article-title":"Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy","volume":"203","author":"Reits","year":"2006","journal-title":"J. Exp. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1111\/cas.15363","article-title":"Mutational spectrum of ATRX aberrations in neuroblastoma and associated patient and tumor characteristics","volume":"113","author":"Bozsaky","year":"2022","journal-title":"Cancer Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.otohns.2008.03.011","article-title":"Expression of Bcl-2 in Olfactory Neuroblastoma and its Association with Chemotherapy and Survival","volume":"139","author":"Kim","year":"2008","journal-title":"Otolaryngol.\u2013Head Neck Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1038\/s43018-024-00855-5","article-title":"Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity","volume":"5","author":"Yang","year":"2024","journal-title":"Nat. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Topcagic, J., Feldman, R., Ghazalpour, A., Swensen, J., Gatalica, Z., Vranic, S., and Kumar-Sinha, C. (2018). Comprehensive molecular profiling of advanced\/metastatic olfactory neuroblastomas. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0191244"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.celrep.2018.09.047","article-title":"Integrated Multi-omic Analysis of Esthesioneuroblastomas Identifies Two Subgroups Linked to Cell Ontogeny","volume":"25","author":"Classe","year":"2018","journal-title":"Cell Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e3536","DOI":"10.1097\/MD.0000000000003536","article-title":"Recurrent Olfactory Neuroblastoma Treated with Cetuximab and Sunitinib: A Case Report","volume":"95","author":"Wang","year":"2016","journal-title":"Medicine"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11060-008-9602-9","article-title":"Expression of bcl-2 is associated with microvessel density in olfactory neuroblastoma","volume":"89","author":"Diensthuber","year":"2008","journal-title":"J. Neuro-Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.prp.2018.06.002","article-title":"Clinical features and the molecular biomarkers of olfactory neuroblastoma","volume":"214","author":"Peng","year":"2018","journal-title":"Pathol.-Res. Pract."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1158\/2767-9764.CRC-23-0013","article-title":"Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma","volume":"3","author":"Finlay","year":"2023","journal-title":"Cancer Res. Commun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.humpath.2009.02.001","article-title":"Expression patterns of Trk-A, Trk-B, GRP78, and p75NRT in olfactory neuroblastoma","volume":"40","author":"Weinreb","year":"2009","journal-title":"Hum. Pathol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5410","DOI":"10.1038\/s41467-018-07578-z","article-title":"Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma","volume":"9","author":"Gallia","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.anl.2022.08.004","article-title":"Expressions of NeuroD and GAP43 as diagnostic markers for olfactory neuroblastoma","volume":"50","author":"Furukawa","year":"2023","journal-title":"Auris Nasus Larynx"},{"key":"ref_35","first-page":"2730","article-title":"OTX1 and OTX2 as possible molecular markers of sinonasal carcinomas and olfactory neuroblastomas","volume":"61","author":"Pirrone","year":"2017","journal-title":"Eur. J. Histochem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Yang, Y., Wan, Z., Zhang, E., and Piao, Y. (2023). Genomic profiling and immune landscape of olfactory neuroblastoma in China. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1226494"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1097\/PAS.0000000000000285","article-title":"SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract","volume":"38","author":"Bishop","year":"2014","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/PAS.0000000000000797","article-title":"SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity","volume":"41","author":"Agaimy","year":"2017","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1055\/s-0039-1693659","article-title":"Loss of SMARCB1 Expression Confers Poor Prognosis to Sinonasal Undifferentiated Carcinoma","volume":"81","author":"Chitguppi","year":"2020","journal-title":"J. Neurol. Surg. Part B Skull Base"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1097\/PAS.0000000000000236","article-title":"SMARCB1(INI1)-deficient sinonasal basaloid carcinoma: A novel member of the expanding family of SMARCB1-deficient neoplasms","volume":"38","author":"Agaimy","year":"2014","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/PAS.0000000000001428","article-title":"SMARCA4-deficient Sinonasal Carcinoma: A Series of 10 Cases Expanding the Genetic Spectrum of SWI\/SNF-driven Sinonasal Malignancies","volume":"44","author":"Agaimy","year":"2020","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s12105-017-0783-4","article-title":"SMARCA4-deficient Sinonasal Carcinoma","volume":"11","author":"Agaimy","year":"2017","journal-title":"Head Neck Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/00000478-199606000-00009","article-title":"Relationship of p53 gene alterations with tumor progression and recurrence in olfactory neuroblastoma","volume":"20","author":"Papadaki","year":"1996","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1128\/MCB.22.9.3129-3139.2002","article-title":"Notch Signaling Induces Rapid Degradation of Achaete-Scute Homolog 1","volume":"22","author":"Sriuranpong","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"10680","DOI":"10.1158\/0008-5472.CAN-05-1404","article-title":"ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features","volume":"65","author":"Osada","year":"2005","journal-title":"Cancer Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1750-3639.2006.00037.x","article-title":"The dark side of the NGF family: Neurotrophins in neoplasias","volume":"16","author":"Schneider","year":"2006","journal-title":"Brain Pathol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1074\/jbc.M114.599373","article-title":"Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells","volume":"290","author":"Lawn","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/1096-911X(20001201)35:6<569::AID-MPO16>3.0.CO;2-A","article-title":"Expression of neurotrophin receptor TrkA inhibits angiogenesis in neuroblastoma","volume":"35","author":"Eggert","year":"2000","journal-title":"Med. Pediatr. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000236047","article-title":"Activation of sonic hedgehog signaling pathway in olfactory neuroblastoma","volume":"77","author":"Mao","year":"2009","journal-title":"Oncology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/bbrc.2000.3899","article-title":"bFGF induces differentiation and death of olfactory neuroblastoma cells","volume":"279","author":"Nibu","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/labinvest.3700552","article-title":"Achaete-scute homolog-1 linked to remodeling and preneoplasia of pulmonary epithelium","volume":"87","author":"Wang","year":"2007","journal-title":"Mod. Pathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11060-009-0010-6","article-title":"Bortezomib sensitizes primary human esthesioneuroblastoma cells to TRAIL-induced apoptosis","volume":"97","author":"Koschny","year":"2010","journal-title":"J. Neuro-Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Weiss, G.J., Liang, W.S., Izatt, T., Arora, S., Cherni, I., Raju, R.N., Hostetter, G., Kurdoglu, A., Christoforides, A., and Sinari, S. (2012). Paired Tumor and Normal Whole Genome Sequencing of Metastatic Olfactory Neuroblastoma. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0037029"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Cha, S., Lee, J., Shin, J.-Y., Kim, J.-Y., Sim, S.H., Keam, B., Kim, T.M., Kim, D.-W., Heo, D.S., and Lee, S.-H. (2016). Clinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis. BMC Cancer, 16.","DOI":"10.1186\/s12885-016-2209-1"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/humu.22524","article-title":"The Mdm network and its regulation of p53 activities: A rheostat of cancer risk","volume":"35","author":"Eischen","year":"2014","journal-title":"Hum. Mutat."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"254","DOI":"10.7555\/JBR.27.20130030","article-title":"The MDM2-p53 pathway revisited","volume":"27","author":"Subhasree","year":"2013","journal-title":"J. Biomed. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.gendis.2018.07.002","article-title":"Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine","volume":"5","author":"Qin","year":"2018","journal-title":"Genes Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1038\/sj.onc.1208615","article-title":"The p53 pathway: Positive and negative feedback loops","volume":"24","author":"Harris","year":"2005","journal-title":"Oncogene"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1634\/theoncologist.2016-0287","article-title":"Comprehensive Genomic Profiling of Esthesioneuroblastoma Reveals Additional Treatment Options","volume":"22","author":"Gay","year":"2017","journal-title":"Oncologist"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s12105-021-01329-1","article-title":"SSTR2 Expression in Olfactory Neuroblastoma: Clinical and Therapeutic Implications","volume":"15","author":"Cracolici","year":"2021","journal-title":"Head Neck Pathol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/modpathol.2008.57","article-title":"Array comparative genomic hybridization analysis of olfactory neuroblastoma","volume":"21","author":"Guled","year":"2008","journal-title":"Mod. Pathol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"52584","DOI":"10.18632\/oncotarget.9683","article-title":"Genetic and molecular alterations in olfactory neuroblastoma: Implications for pathogenesis, prognosis and treatment","volume":"7","author":"Czapiewski","year":"2016","journal-title":"Oncotarget"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/gcc.22288","article-title":"Comparative genomic hybridization on microarray (a-CGH) in olfactory neuroblastoma: Analysis of ten cases and review of the literature","volume":"54","author":"Valli","year":"2015","journal-title":"Genes Chromosom. Cancer"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00401-018-1854-7","article-title":"DNA methylation-based reclassification of olfactory neuroblastoma","volume":"136","author":"Capper","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e928","DOI":"10.1016\/j.wneu.2024.01.063","article-title":"Characterizing Immune Infiltration in Esthesioneuroblastoma Subtypes Through Gene Expression Deconvolution","volume":"183","author":"Batchu","year":"2024","journal-title":"World Neurosurg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.wneu.2019.03.014","article-title":"Esthesioneuroblastoma: A Comprehensive Review of Diagnosis, Management, and Current Treatment Options","volume":"126","author":"Fiani","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11060-009-0027-x","article-title":"Disease stabilization of progressive olfactory neuroblastoma (esthesioneuroblastoma) under treatment with sunitinib mesylate","volume":"97","author":"Preusser","year":"2010","journal-title":"J. Neuro-Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nrd2012","article-title":"Sunitinib maleate","volume":"5","author":"Atkins","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e12513","DOI":"10.1200\/jco.2011.29.15_suppl.e12513","article-title":"Imatinib mesylate as second-line treatment in a c-kit-positive Esthesioneuroblastoma","volume":"29","author":"Kim","year":"2011","journal-title":"J. Clin. Oncol."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/15\/7\/309\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:09:12Z","timestamp":1760033352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/15\/7\/309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,13]]},"references-count":69,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["jpm15070309"],"URL":"https:\/\/doi.org\/10.3390\/jpm15070309","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,13]]}}}