{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:15:31Z","timestamp":1791944131271,"version":"4.3.4"},"reference-count":25,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PolyMedics Innovations GmbH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background\/Objectives: Enzymatic debridement with NexoBrid\u00ae is an effective alternative to surgical debridement in burn care, but its potential systemic effects remain unclear. In the context of personalized burn care, understanding individual patient responses to topical agents is essential to optimize outcomes and minimize risks. This study aimed to characterize laboratory and clinical parameter changes following NexoBrid\u00ae application in patients with small burn injuries (\u226410% TBSA). Methods: We retrospectively analyzed 75 burn patients treated with NexoBrid\u00ae to evaluate changes in systemic inflammatory markers, coagulation parameters, and clinical parameters before and after enzymatic debridement. Results: Statistically significant increases in body temperature (p = 0.018), decreases in hemoglobin (p &lt; 0.001), and increases in C-reactive protein (CRP) levels (p &lt; 0.001) were observed, suggesting mild systemic inflammatory changes. However, leukocyte counts did not change significantly (p = 0.927), and body temperature remained within the normothermic range, indicating that these changes were not clinically significant. A significant decrease in the prothrombin time ratio (% of normal; p = 0.002) was also observed, suggesting potential impacts on coagulation. Importantly, while body temperature was slightly higher in patients with a higher degree of BSA exposure within the \u226410% TBSA cohort (p = 0.036), the extent of NexoBrid\u00ae application did not correlate with other inflammatory markers. Conclusions: These findings suggest that measurable systemic changes can occur following NexoBrid\u00ae application in small burns, particularly affecting inflammatory and coagulation parameters. These observations contribute to the understanding of treatment-related responses and may help inform clinical decision-making.<\/jats:p>","DOI":"10.3390\/jpm15080330","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T11:38:41Z","timestamp":1753443521000},"page":"330","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Systemic Effects of Enzymatic Necrosectomy in Minor Burn Wounds Using NexoBrid\u00ae"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-2863","authenticated-orcid":false,"given":"David","family":"Breidung","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Burn Unit, Paracelsus Medical University, Klinikum N\u00fcrnberg,  Breslauer Str. 201, 90471 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3614-9600","authenticated-orcid":false,"given":"Moritz","family":"Billner","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Burn Unit, Paracelsus Medical University, Klinikum N\u00fcrnberg,  Breslauer Str. 201, 90471 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Ortner","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Burn Unit, Paracelsus Medical University, Klinikum N\u00fcrnberg,  Breslauer Str. 201, 90471 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"von Imhoff","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Burn Unit, Paracelsus Medical University, Klinikum N\u00fcrnberg,  Breslauer Str. 201, 90471 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonas","family":"Lapinskas","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Burn Unit, Paracelsus Medical University, Klinikum N\u00fcrnberg,  Breslauer Str. 201, 90471 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Karcz","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Burn Unit, Paracelsus Medical University, Klinikum N\u00fcrnberg,  Breslauer Str. 201, 90471 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarina","family":"Delavari","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Burn Unit, Paracelsus Medical University, Klinikum N\u00fcrnberg,  Breslauer Str. 201, 90471 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9394-8412","authenticated-orcid":false,"given":"Denis","family":"Ehrl","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Burn Unit, Paracelsus Medical University, Klinikum N\u00fcrnberg,  Breslauer Str. 201, 90471 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e469","DOI":"10.1097\/BCR.0000000000000355","article-title":"Burns: Pathophysiology of Systemic Complications and Current Management","volume":"38","author":"Nielson","year":"2017","journal-title":"J. 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