{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:03:27Z","timestamp":1788537807980,"version":"build-2803163510"},"reference-count":199,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AIRC","award":["30924"],"award-info":[{"award-number":["30924"]}]},{"name":"AIRC","award":["M4C2I1.3"],"award-info":[{"award-number":["M4C2I1.3"]}]},{"name":"AIRC","award":["DR 3392"],"award-info":[{"award-number":["DR 3392"]}]},{"name":"MUR-PNRR","award":["30924"],"award-info":[{"award-number":["30924"]}]},{"name":"MUR-PNRR","award":["M4C2I1.3"],"award-info":[{"award-number":["M4C2I1.3"]}]},{"name":"MUR-PNRR","award":["DR 3392"],"award-info":[{"award-number":["DR 3392"]}]},{"name":"University Scientific Research Call RSA 2024, UTV","award":["30924"],"award-info":[{"award-number":["30924"]}]},{"name":"University Scientific Research Call RSA 2024, UTV","award":["M4C2I1.3"],"award-info":[{"award-number":["M4C2I1.3"]}]},{"name":"University Scientific Research Call RSA 2024, UTV","award":["DR 3392"],"award-info":[{"award-number":["DR 3392"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Acute Myeloid Leukemia (AML) is a genetically and clinically heterogeneous malignancy marked by poor prognosis and limited therapeutic options, especially in older patients. While conventional treatments such as the \u201c7 + 3\u201d chemotherapy regimen and allogeneic stem cell transplantation remain standard care options, the advent of next-generation sequencing (NGS) has transformed our understanding of AML\u2019s molecular complexity. Among the emerging hallmarks of AML, metabolic reprogramming has gained increasing attention for its role in supporting leukemic cell proliferation, survival, and therapy resistance. Distinct AML subtypes\u2014shaped by specific genetic alterations, including FLT3, NPM1, and IDH mutations\u2014exhibit unique metabolic phenotypes that reflect their underlying molecular landscapes. Notably, FLT3-ITD mutations are associated with enhanced reactive oxygen species (ROS) production and altered energy metabolism, contributing to disease aggressiveness and poor clinical outcomes. This review highlights the interplay between metabolic plasticity and genetic heterogeneity in AML, with a particular focus on FLT3-driven metabolic rewiring. We discuss recent insights into how these metabolic dependencies may be exploited therapeutically, offering a rationale for the development of metabolism-targeted strategies in the treatment of FLT3-mutated AML.<\/jats:p>","DOI":"10.3390\/jpm15090431","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T11:51:12Z","timestamp":1757332272000},"page":"431","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Metabolic Signature of FLT3-Mutated AML: Clinical and Therapeutic Implications"],"prefix":"10.3390","volume":"15","author":[{"given":"Cristina","family":"Banella","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology-Oncology, Meyer Children\u2019s Hospital IRCCS, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Catalano","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy"},{"name":"Santa Lucia Foundation, I.R.C.C.S., Neuro-Oncohematology, 00143 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0750-4706","authenticated-orcid":false,"given":"Maura","family":"Calvani","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology-Oncology, Meyer Children\u2019s Hospital IRCCS, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Candi","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7682-862X","authenticated-orcid":false,"given":"Nelida Ines","family":"Noguera","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy"},{"name":"Santa Lucia Foundation, I.R.C.C.S., Neuro-Oncohematology, 00143 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5411-1502","authenticated-orcid":false,"given":"Serena","family":"Travaglini","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1406184","article-title":"Acute Myeloid Leukemia","volume":"373","author":"Weisdorf","year":"2015","journal-title":"N. 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