{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:20:48Z","timestamp":1780633248187,"version":"3.54.1"},"reference-count":30,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["JPM"],"abstract":"<jats:p>Background\/Objectives: The aim of this study was to evaluate fluid administration and intraoperative bleeding of patients who had major hepatic resection. We used artery pulse contour analysis monitor (ProAQT\u2122) and personalized hemodynamic target-guided therapy, in which the administration of fluid, inotropes and vasopressors is guided by stroke volume, pulse pressure variation (SVV, PPV) and continuous cardiac index (CI). Methods: This trial was a prospective, randomized, parallel-group in adults scheduled for major hepatic resection. Participants were randomly assigned in equal numbers to one of two groups: (1) a control group receiving conventional perioperative care, and (2) an intervention group managed with goal-directed hemodynamic therapy guided by radial artery pulse contour analysis. Results: 45 patients were randomized to the GDHT (n = 16) and control group (n = 19). Blood loss was significantly higher in the control group than in GDHT group (728.13 \u00b1 618.59 versus 292.63 \u00b1 274.06, p = 0.009). The number of patients receiving intraoperative transfusion was significantly higher in the first group (6 \u00b1 16 versus 0 \u00b1 19, p = 0.005). Total volume infused was significantly higher in control group (CG) than in GDHT group (GG) (2853.13 \u00b1 1432.18 versus 1125.79 \u00b1 751.2, p = 0.001). Conclusions: Personalized goal-directed therapy optimizes intraoperative fluid administration during major liver resection and reduces blood transfusion.<\/jats:p>","DOI":"10.3390\/jpm15100457","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T08:21:51Z","timestamp":1759220511000},"page":"457","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Personalizezed Hemodynamic Optimization Using Stroke Volume, Pulse Pressure Variation, and Continuous Cardiac Index in Major Liver Surgery: A Randomized Controlled Trial"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7044-0154","authenticated-orcid":false,"given":"Francisco Javier","family":"Redondo Calvo","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, University General Hospital, 13004 Ciudad Real, Spain"},{"name":"Faculty of Medicine, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain"},{"name":"Translational Research Group, GAI of Ciudad Real, Spain, Research Institute of Castilla-La Mancha (IDISCAM), 13004 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1587-6163","authenticated-orcid":false,"given":"V\u00edctor","family":"Baladr\u00f3n Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, University General Hospital, 13004 Ciudad Real, Spain"},{"name":"Faculty of Medicine, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Padilla Valverde","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain"},{"name":"Department of Surgery, Universitary General Hospital, 13004 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Redondo S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, University General Hospital, 13004 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1165-5593","authenticated-orcid":false,"given":"Pedro Juan","family":"Villarejo Campos","sequence":"additional","affiliation":[{"name":"Department of Surgery, Universitary Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Montenegro Herrera","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, University General Hospital, 13004 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Faba Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, University General Hospital, 13004 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1714-613X","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Villazala Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, University General Hospital, 13004 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3827-5582","authenticated-orcid":false,"given":"Raquel","family":"Bodoque Villar","sequence":"additional","affiliation":[{"name":"Translational Research Group, GAI of Ciudad Real, Spain, Research Institute of Castilla-La Mancha (IDISCAM), 13004 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4585-9401","authenticated-orcid":false,"given":"Juan Fernando","family":"Padin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6045-2039","authenticated-orcid":false,"given":"Jos\u00e9 Ram\u00f3n","family":"Mu\u00f1oz-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain"},{"name":"Translational Research Group, GAI of Ciudad Real, Spain, Research Institute of Castilla-La Mancha (IDISCAM), 13004 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8605-033X","authenticated-orcid":false,"given":"Natalia","family":"Bejarano Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Translational Research Group, GAI of Ciudad Real, Spain, Research Institute of Castilla-La Mancha (IDISCAM), 13004 Ciudad Real, Spain"},{"name":"Department of Pediatrics, University General Hospital, 13004 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Abdelmalak, J., Strasser, S.I., Ngu, N., Dennis, C., Sinclair, M., Majumdar, A., Collins, K., Bateman, K., Dev, A., and Abasszade, J.H. 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