{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:02:32Z","timestamp":1775674952687,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["NEURORECA-0007-2022"],"award-info":[{"award-number":["NEURORECA-0007-2022"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Amyloid positron emission tomography (PET) has been proposed as a tool to monitor myelination in multiple sclerosis (MS). We present baseline results from an ongoing prospective study, which is the first to include both early and standard phases of amyloid PET in patients with newly diagnosed MS. Methods: The prospective study includes patients with newly diagnosed MS (January 2023\u2013February 2024). Clinical evaluation includes neurological disability (EDSS) and neuropsychological assessment. Brain MRI, early [18F]florbetaben (FBB) PET (eFBB; 0\u20135, 0\u201310 min post-injection), and standard FBB PET (sFBB; 90 min post-injection) were acquired. Normal-appearing white matter (NAWM) and damaged white matter (DWM) in MRI were segmented and co-registered with PET images. Results are presented as standardized uptake values (SUV), with the ratio using cerebellum as the reference region (SUVR) and the percentage of change between the DWM and NAWM. Results: Twenty patients were included (35.05 \u00b1 10.72 years; 75% women). Both eFBB and sFBB acquisitions showed significantly lower SUVRmax and SUVRmean, and higher SUVRmin in the DWM compared to NAWM (p &lt; 0.001) in all patients. SUV parameters in both DWM and NAWM from eFBB and sFBB PET correlated with the number of relapses and EDSS (r = \u22120.454 and r = \u22120.446, respectively; p &lt; 0.05). Additionally, SUVR values in the DWM during eFBB correlated with cognitive impairment (SDMT; r = \u22120.516, p &lt; 0.01), fatigue (MFIS-5; r = \u22120.450, p &lt; 0.05), and quality of life (EQ-5D; r = \u22120.490, p &lt; 0.05). Conclusions: Quantitative analysis of dual-phase FBB PET demonstrates differential uptake between DWM and NAWM, which is probably associated with demyelination and neurodegeneration. These preliminary findings suggest that amyloid PET may have predictive value for disease activity and progression, supporting its potential as a biomarker in MS. Follow-up data from this study are needed to support the baseline results.<\/jats:p>","DOI":"10.3390\/jpm15110520","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:32:01Z","timestamp":1762191121000},"page":"520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Baseline Findings from Dual-Phase Amyloid PET Study in Newly Diagnosed Multiple Sclerosis: Exploring Its Potential as a Biomarker of Myelination and Neurodegeneration"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7277-7607","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Barrios-L\u00f3pez","sequence":"first","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital Universitario Virgen de las Nieves, 18013 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6604-6608","authenticated-orcid":false,"given":"Eva Mar\u00eda","family":"Trivi\u00f1o-Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs. GRANADA, 18012 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0376-7381","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Pi\u00f1eiro-Donis","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1940-8834","authenticated-orcid":false,"given":"Ferm\u00edn","family":"Segovia-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Signal Theory, Networking and Communications, University of Granada, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3408-7688","authenticated-orcid":false,"given":"Mar\u00eda del Carmen","family":"P\u00e9rez Garc\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Radiolog\u00eda, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartolom\u00e9","family":"Mar\u00edn-Romero","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital Universitario Virgen de las Nieves, 18013 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Romero Villarrubia","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital Universitario Virgen de las Nieves, 18013 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Guill\u00e9n Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital Universitario Virgen de las Nieves, 18013 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4217-0633","authenticated-orcid":false,"given":"Jos\u00e9 Pablo","family":"Mart\u00ednez-Barbero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs. GRANADA, 18012 Granada, Spain"},{"name":"Servicio de Radiolog\u00eda, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Pi\u00f1ar Morales","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs. GRANADA, 18012 Granada, Spain"},{"name":"Servicio de Neurolog\u00eda, Hospital Universitario Cl\u00ednico San Cecilio, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1843-9002","authenticated-orcid":false,"given":"Francisco J.","family":"Barrero Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs. GRANADA, 18012 Granada, Spain"},{"name":"Servicio de Neurolog\u00eda, Hospital Universitario Cl\u00ednico San Cecilio, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7086-1867","authenticated-orcid":false,"given":"Adolfo","family":"M\u00ednguez-Castellanos","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital Universitario Virgen de las Nieves, 18013 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs. GRANADA, 18012 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"G\u00f3mez-R\u00edo","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs. GRANADA, 18012 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/jama.2020.26858","article-title":"Diagnosis and Treatment of Multiple Sclerosis: A Review","volume":"325","author":"McGinley","year":"2021","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kavaliunas, A., Danylait\u0117 Karrenbauer, V., Binzer, S., and Hillert, J. (2022). Systematic Review of the Socioeconomic Consequences in Patients with Multiple Sclerosis with Different Levels of Disability and Cognitive Function. Front. 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