{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T22:19:35Z","timestamp":1770243575755,"version":"3.49.0"},"reference-count":65,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disorder most commonly caused by pathogenic variants in sarcomeric genes, yet many patients remain genotype-negative and the mechanisms linking genetic alterations to disease pathology are not fully understood. Traditional bulk analyses have provided limited insight into the cellular and molecular changes that drive disease progression. Recent advances in single-cell and spatial multi-omics technologies now allow detailed characterization of cell type-specific transcriptional programs, signaling pathways, and tissue remodeling within the human myocardium. These approaches have begun to redefine HCM as a complex, multicellular disease rather than a purely sarcomeric disorder. This review summarizes current single-cell and spatial transcriptomic studies of human septal myectomy tissue, outlines their major findings and limitations, and discusses how these data may inform the development of precision medicine strategies in obstructive HCM.<\/jats:p>","DOI":"10.3390\/jpm16020088","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T09:02:01Z","timestamp":1770195721000},"page":"88","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single-Cell Multi-Omics Profiling of Human Septal Myectomy Tissue: Toward Precision Medicine in Obstructive Hypertrophic Cardiomyopathy"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-9026","authenticated-orcid":false,"given":"Quynh","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada"},{"name":"School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada"},{"name":"Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada"},{"name":"Providence Research, Providence Health Care, Vancouver, BC V6Z 1Y6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Parker","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada"},{"name":"Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada"},{"name":"Providence Research, Providence Health Care, Vancouver, BC V6Z 1Y6, Canada"},{"name":"Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7475-1646","authenticated-orcid":false,"given":"Amrit","family":"Singh","sequence":"additional","affiliation":[{"name":"Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada"},{"name":"Providence Research, Providence Health Care, Vancouver, BC V6Z 1Y6, Canada"},{"name":"Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1444-5778","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada"},{"name":"Providence Research, Providence Health Care, Vancouver, BC V6Z 1Y6, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamil","family":"Bashir","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada"},{"name":"Providence Research, Providence Health Care, Vancouver, BC V6Z 1Y6, Canada"},{"name":"St. Paul\u2019s Hospital, Vancouver, BC V6Z 1Y6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Laksman","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada"},{"name":"Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada"},{"name":"Providence Research, Providence Health Care, Vancouver, BC V6Z 1Y6, Canada"},{"name":"Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada"},{"name":"St. Paul\u2019s Hospital, Vancouver, BC V6Z 1Y6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jacc.2021.12.002","article-title":"Diagnosis and Evaluation of Hypertrophic Cardiomyopathy: JACC State-of-the-Art Review","volume":"79","author":"Maron","year":"2022","journal-title":"J. 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