{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:26:57Z","timestamp":1770910017892,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Digital pulp reconstruction with toe-based flaps reliably restores sensibility and contour, yet the healing behavior of viable subcutaneous fat remains underexplored. Because adipose tissue exhibits patient-specific regenerative and volumetric responses, its preservation represents a key element of personalized fingertip reconstruction. This study evaluates the outcomes of toe pulp flaps with targeted fat preservation to assess how individual tissue biology influences contour and functional recovery. Methods: We retrospectively reviewed consecutive digital reconstructions performed with free toe flaps and several variations (pulp toe flap, chimeric pulp toe flap, trimmed great toe flap and chimeric pulp+ trimmed great toe). Particular attention was given to healthy subcutaneous fat that was deliberately maintained or exposed to help shape the final contour. All patients were followed clinically and photographically until complete healing occurred. Results: A total of 126 patients underwent a finger reconstruction with free toe flaps and several variations. The preserved fat layer was intentionally left exposed to promote healthy granulation and spontaneous epithelialization, contributing favorably to the final contour of the distal pulp as the nail advanced. All wounds healed without the need for skin grafts. All patients achieved good to excellent functional and esthetic outcomes with minimal donor-site morbidity. Conclusions: This large retrospective series confirms the reliability of a healthy flap to help shape the digital reconstruction, highlighting the regenerative potential of viable digital fat. Incorporating this concept into the flap design may reduce the need for grafting, minimize donor-site morbidity, and enhance reconstructive outcomes in hand surgery.<\/jats:p>","DOI":"10.3390\/jpm16020110","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:06:16Z","timestamp":1770905176000},"page":"110","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Forgotten Healer: The Role of Adipose Tissue in Spontaneous Healing After Free Flap Finger Reconstruction"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6935-5278","authenticated-orcid":false,"given":"Macarena","family":"Vizcay","sequence":"first","affiliation":[{"name":"IRCCS Multimedica Group, University Department of Hand Surgery & Rehabilitation, San Giuseppe Hospital, 20123 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio E.","family":"Pajardi","sequence":"additional","affiliation":[{"name":"IRCCS Multimedica Group, University Department of Hand Surgery & Rehabilitation, San Giuseppe Hospital, 20123 Milan, Italy"},{"name":"School of Specialization in Plastic, Reconstructive and Aesthetic Surgery, Milan University, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0899-8383","authenticated-orcid":false,"given":"Alessandro","family":"Mastroiacovo","sequence":"additional","affiliation":[{"name":"School of Specialization in Plastic, Reconstructive and Aesthetic Surgery, Milan University, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4754-3075","authenticated-orcid":false,"given":"Luigi","family":"Troisi","sequence":"additional","affiliation":[{"name":"IRCCS Multimedica Group, University Department of Hand Surgery & Rehabilitation, San Giuseppe Hospital, 20123 Milan, Italy"},{"name":"School of Specialization in Plastic, Reconstructive and Aesthetic Surgery, Milan University, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Yuan, B., Hu, D., Gu, S., Xiao, S., and Song, F. 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