{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T12:08:32Z","timestamp":1772021312180,"version":"3.50.1"},"reference-count":20,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Wind instrument performance requires sustained and repetitive increases in intrathoracic and pharyngeal pressures, which may lead to rare but clinically relevant anatomical alterations of the upper aerodigestive tract. We report the case of a 46-year-old male semi-professional wind instrument player who developed massive hypopharyngeal dilatation and cervical lung herniation as a consequence of long-term, high-pressure musical activity. Dynamic imaging performed during instrument playing demonstrated marked hypopharyngeal expansion and herniation of the lung apices into the cervical region, highlighting the importance of individualized diagnostic strategies that replicate patient-specific triggers. Multidisciplinary evaluation integrating otorhinolaryngology, thoracic surgery, radiology, and pulmonology led to a personalized risk assessment and the recommendation to cease wind instrument performance in order to prevent potentially life-threatening complications, such as pneumothorax. This case illustrates how personalized diagnostic approaches and tailored clinical decision-making are essential in managing rare occupational conditions. A comprehensive review of the literature is provided, with a focus on individualized risk factors, diagnostic strategies, and personalized treatment concepts relevant to precision medicine.<\/jats:p>","DOI":"10.3390\/jpm16030127","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T10:59:16Z","timestamp":1772017156000},"page":"127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Massive Hypopharyngeal Dilatation and Cervical Lung Herniation in a Semi-Professional Wind Instrument Player: Highlighting the Necessity of Personalized Diagnostic and Management Strategies"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-044X","authenticated-orcid":false,"given":"Michail","family":"Galanis","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Inselspital, University Hospital of Bern, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1251-3536","authenticated-orcid":false,"given":"Florian","family":"Dammann","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital and University of Bern, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Gioutsos","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Inselspital, University Hospital of Bern, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7203-3122","authenticated-orcid":false,"given":"Patrick","family":"Dorn","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Inselspital, University Hospital of Bern, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard","family":"Seifert","sequence":"additional","affiliation":[{"name":"Division of Phoniatrics, ENT Clinic, Head and Neck Surgery, University of Bern, Inselspital, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s12070-008-0108-8","article-title":"Laryngoceles-Presentations and management","volume":"60","author":"Prasad","year":"2008","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1001\/archotol.1966.00760020272018","article-title":"Asymptomatic laryngoceles in wind-instrument bandsmen","volume":"83","author":"Macfie","year":"1966","journal-title":"Arch. Otolaryngol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1055\/s-2007-996164","article-title":"Pneumologische Aspekte des Musizierens auf einem Blasinstrument-Physiologische, pathophysiologische und therapeutische Gesichtspunkte","volume":"62","author":"Kreuter","year":"2008","journal-title":"Pneumologie"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1002\/lary.23971","article-title":"Pharyngoceles: A photo-anatomic study and novel management","volume":"123","author":"Naunheim","year":"2013","journal-title":"Laryngoscope"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1067\/mhn.2003.56","article-title":"Bilateral external laryngoceles in a bagpiper: A case report","volume":"128","author":"Orabi","year":"2003","journal-title":"Otolaryngol.\u2014Head Neck Surg."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ethiraj, D., Kumar, S.D., Indiran, V., and Maduraimuthu, P. (2020). Imaging of pharyngocele: An occupational overuse syndrome. Oman Med. J., 35.","DOI":"10.5001\/omj.2020.122"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.otoeng.2013.10.006","article-title":"Pharyngocele","volume":"64","author":"Konari","year":"2013","journal-title":"Acta Otorrinolaringol. (Engl. Ed.)"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0892-1997(02)00095-4","article-title":"Bilateral mixed laryngoceles: Simultaneous strobovideolaryngoscopy and external video examination","volume":"16","author":"Gallivan","year":"2002","journal-title":"J. Voice"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Azimuddin, A., Jeganathan, C., Hee, G., and Friedland, P. (2023). Neck swelling with Valsalva. Cureus, 15.","DOI":"10.7759\/cureus.42762"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.14309\/ajg.0000000000002757","article-title":"Pharyngeal anomaly: As rare as we thought?","volume":"119","author":"Gregor","year":"2024","journal-title":"Am. J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.amsu.2020.11.024","article-title":"Left mixed laryngocele in absence of risk factors: A case report and review of literature","volume":"60","author":"Bisogno","year":"2020","journal-title":"Ann. Med. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Touihmi, S., Errabhi, C., and Rkain, I. (2023). Pyolaryngocele: Case report. Int. J. Surg. Case Rep., 111.","DOI":"10.1016\/j.ijscr.2023.108820"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.otot.2019.09.007","article-title":"Endoscopic surgical approach to laryngoceles and saccular cysts","volume":"30","author":"Slonimsky","year":"2019","journal-title":"Oper. Tech. Otolaryngol.-Head Neck Surg."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"James, D.L., Garry, S., Corbett, M., and Lang, J. (2021). Mixed infected laryngocoele presenting as airway obstruction: A case report. J. Surg. Case Rep., 2021.","DOI":"10.1093\/jscr\/rjaa615"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Singh, R., Karantanis, W., Fadhil, M., Kumar, S.A., Crawford, J., and Jacobson, I. (2020). Systematic review of laryngocele and pyolaryngocele management in the age of robotic surgery. J. Int. Med. Res., 48.","DOI":"10.1177\/0300060520940441"},{"key":"ref_16","first-page":"E78","article-title":"Novel endoscopic treatment of pharyngocele: Endoscopic suture pharyngoplasty","volume":"36","author":"Cabbarzade","year":"2014","journal-title":"Head Neck"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/014556131209100208","article-title":"Percutaneous injection pharyngoplasty for the treatment of a pharyngocele","volume":"91","author":"Hu","year":"2012","journal-title":"Ear Nose Throat J."},{"key":"ref_18","first-page":"215","article-title":"Treatment of combined laryngocele using an endoscopic approach-A case report","volume":"72","year":"2023","journal-title":"Otorhinolaryngol. Phoniatr."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zhang, J., Ma, X., Li, X., Song, P., and Wu, Y. (2023). Laryngocele: Report of two rare cases and review of the literature. Exp. Ther. Med., 26.","DOI":"10.3892\/etm.2023.12123"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tamilchelvan, S.K., Rozhan, A., Kuppusamy, S., and Hamid, Z. (2024). External laryngocele in an adult: A case report. Cureus, 16.","DOI":"10.7759\/cureus.73234"}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/16\/3\/127\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T11:19:01Z","timestamp":1772018341000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/16\/3\/127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["jpm16030127"],"URL":"https:\/\/doi.org\/10.3390\/jpm16030127","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]}}}