{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:42:55Z","timestamp":1780663375994,"version":"3.54.1"},"reference-count":49,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background\/Objectives: Deep endometriosis is a chronic inflammatory disease that significantly affects fertility. The objective was to evaluate the magnitude of the effect of minimally invasive nerve-sparing complete excision of endometriosis on natural conception rate in women with documented infertility. Methods: This pre-planned interdisciplinary retrospective observational study included 45 patients who wished to conceive naturally (spontaneous pregnancy) and were followed for 12 months after surgery. Results: The spontaneous conception rate was 33.3% (95% CI: 20.0\u201346.7) and the mean time to conception was 6.7 months. Age, body mass index, and history of infertility showed no significant differences between the success and failure spontaneous pregnancy groups, but annual income was positively associated with reproductive success (p = 0.022). None of the procedures needed to be converted to open surgery, required colostomy\/ileostomy, blood transfusion or abdominal drains. No cases of urinary retention were observed across different levels of nerve preservation. In addition, the absence of serious surgical complications (Clavien\u2013Dindo III\/IV) supports the safety of this intervention for infertile patients. Conclusions: The absence of serious surgical complications in this cohort supports the concept that minimally invasive nerve-sparing complete excision of endometriosis is a safe intervention when performed by an experienced team. The results underscore the importance of exploring socioeconomic-related factors through an individualized assessment of patients who wish to conceive naturally after minimally invasive nerve-sparing surgery. Future studies focusing on personalized management of endometriosis should attempt to identify socioeconomic-related covariates that influence natural conception.<\/jats:p>","DOI":"10.3390\/jpm16030166","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T10:21:41Z","timestamp":1773742901000},"page":"166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and Reproductive Outcomes of Minimally Invasive Nerve-Sparing Surgery for Deep Endometriosis in Infertile Women: A One-Year Follow-Up Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3000-7070","authenticated-orcid":false,"given":"Bruna Rafaela","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Women\u2019s Health, Fernandes Figueira National Institute for Women, Children and Youth Health, Oswaldo Cruz Foundation, Rio de Janeiro 22250-020, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4371-4754","authenticated-orcid":false,"given":"Claudio Peixoto","family":"Crispi Jr.","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Fernandes Figueira National Institute for Women, Children and Youth Health, Oswaldo Cruz Foundation, Rio de Janeiro 22250-020, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7510-0485","authenticated-orcid":false,"given":"Fabio Bastos","family":"Russomano","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Fernandes Figueira National Institute for Women, Children and Youth Health, Oswaldo Cruz Foundation, Rio de Janeiro 22250-020, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Maia","family":"Peixoto Filho","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Rio de Janeiro State University, Rio de Janeiro 20550-013, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-6578","authenticated-orcid":false,"given":"Nilton","family":"de Nadai Filho","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Fernandes Figueira National Institute for Women, Children and Youth Health, Oswaldo Cruz Foundation, Rio de Janeiro 22250-020, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8568-324X","authenticated-orcid":false,"given":"Marlon de Freitas","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Fernandes Figueira National Institute for Women, Children and Youth Health, Oswaldo Cruz Foundation, Rio de Janeiro 22250-020, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N. 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