{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T10:51:00Z","timestamp":1774349460276,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Patients with NSTEMI who are found with a totally occluded culprit vessel on coronary angiography are at higher risk of mortality and major adverse cardiac events. Artificial intelligence (AI) models can help identify this subgroup of NSTEMIs. Objectives: The purpose of this study was to examine the performance of an AI model in identifying patients with total thrombotic coronary artery occlusion myocardial infarctions (OMIs) using a single 12-lead ECG as input. Methods: In this retrospective cohort study, 12-lead ECGs corresponding to patients with suspected OMI were analyzed by an AI model. Confirmation of OMI was based on angiographic evidence of acute culprit coronary artery stenosis. Results: Over a one-year period, emergency physicians at our hospital identified 474 patients with suspected OMI, of whom 88 met STEMI criteria. Out of the 142 angiographically confirmed OMIs, the AI model correctly identified 115 (81%) with high confidence, corresponding to an accuracy of 89.4%, sensitivity of 90.0%, specificity of 93.2%, positive predictive value (PPV) of 84.6%, and negative predictive value (NPV) of 91.4%. Out of the 74 angiographically confirmed OMIs that did not meet STEMI criteria, the AI model correctly identified 49 (66%) with high confidence, corresponding to an accuracy of 87.9%, sensitivity of 66.2%, specificity of 93.4%, PPV of 72.1%, and NPV of 91.5%. Out of the 68 angiographically confirmed OMIs that met STEMI criteria, the AI model correctly identified 66 (97%) with high confidence, corresponding to an accuracy of 95.5%, sensitivity of 97.1%, specificity of 90.0%, PPV of 97.1%, and NPV of 90.0%. Conclusions: The AI model examined in this study outperformed the STEMI criteria for the identification of OMI with respect to accuracy, sensitivity, specificity, PPV, and NPV and accurately identified a significant portion of NSTEMIs found to have total thrombotic coronary artery occlusion.<\/jats:p>","DOI":"10.3390\/jpm16040174","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:02:49Z","timestamp":1774339369000},"page":"174","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detecting Occlusion Myocardial Infarction with an AI-Powered ECG Model: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Mark B.","family":"Hellerman","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northwell Northshore University Hospital, Manhasset, NY 11030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3358-4458","authenticated-orcid":false,"given":"David T.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1284-429X","authenticated-orcid":false,"given":"Andreas P.","family":"Kalogeropoulos","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hal A.","family":"Skopicki","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"ref_1","first-page":"e4","article-title":"2021 ACC\/AHA\/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Lawton","year":"2022","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1093\/eurheartj\/ehx418","article-title":"Impact of total occlusion of culprit artery in acute non-ST elevation myocardial infarction: A systematic review and meta-analysis","volume":"38","author":"Khan","year":"2017","journal-title":"Eur. 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