{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:25:38Z","timestamp":1789676738749,"version":"4.0.1"},"reference-count":44,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Roche Medical Department, Spain","award":["ML45454"],"award-info":[{"award-number":["ML45454"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Serum neurofilament light chain (sNfL) is an established biomarker of neuroaxonal damage in multiple sclerosis (MS). Despite its prognostic utility, patient awareness of its clinical application remains poorly characterized. The objective of this study was to assess the acceptance of sNfL monitoring among patients with early-stage relapsing\u2013remitting MS (RRMS) and identify factors predicting their willingness to adopt this tool. Methods: This non-interventional, cross-sectional study was conducted across 16 neuroimmunology clinics. We included RRMS patients with a disease duration of \u22643 years receiving disease-modifying therapy. Acceptance was assessed following a standardized educational tutorial. Multivariable logistic regression was employed to identify predictors of patient acceptance. Results: The study included 144 patients (mean age 37.6 [SD 10.3] years, 69.4% female). Only 19.4% (n = 28) had prior awareness of sNfL. However, after the tutorial, 84.0% (n = 121) expressed willingness to adopt sNfL testing. Furthermore, 62.5% (n = 90) indicated that normal sNfL levels would provide emotional reassurance between clinical visits. Patients willing to undergo testing showed higher disease knowledge, less treatment regret, and better physical quality of life and cognitive performance. In the multivariable analysis, higher disease knowledge (OR = 1.52, 95%CI 1.16\u20131.99; p = 0.002) and lower symptom burden (OR = 0.96, 95%CI 0.93\u20130.99; p = 0.038) were associated with greater acceptance. Conclusions: Patients demonstrate high receptivity to sNfL monitoring when provided with adequate clinical context. Because disease knowledge is a primary driver of acceptance, personalized educational initiatives may be a complementary strategy to facilitate the integration of precision biomarkers into MS management.<\/jats:p>","DOI":"10.3390\/jpm16040185","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:22:36Z","timestamp":1774858956000},"page":"185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Personalizing Relapsing\u2013Remitting Multiple Sclerosis Monitoring: Patient Acceptance of Serum Neurofilament Light Chain and the Role of Disease Knowledge"],"prefix":"10.3390","volume":"16","author":[{"given":"\u00c1ngel","family":"P\u00e9rez-Sempere","sequence":"first","affiliation":[{"name":"Department of Neurology, Hospital Universitario General de Alicante, Universidad Miguel Hern\u00e1ndez, 03010 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2964-2045","authenticated-orcid":false,"given":"Elena","family":"Garc\u00eda-Arcelay","sequence":"additional","affiliation":[{"name":"Medical Department, Roche Farma, 28042 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobo Caruncho","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"AVEMPO (Asociaci\u00f3n Viguesa de Esclerosis M\u00faltiple de Pontevedra), 36208 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9978-0198","authenticated-orcid":false,"given":"Antonio","family":"Candeliere-Merlicco","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Rafael M\u00e9ndez, 30813 Lorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Orviz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0326-3941","authenticated-orcid":false,"given":"Jes\u00fas","family":"Mart\u00edn-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3490-4932","authenticated-orcid":false,"given":"Raquel","family":"Pi\u00f1ar-Morales","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario Cl\u00ednico San Cecilio, 18007 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"\u00c1lvarez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario \u00c1lvaro Cunqueiro, 36312 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M.","family":"Pacheco-Cortegana","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario Juan Ram\u00f3n Jim\u00e9nez, 21005 Huelva, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1425-1789","authenticated-orcid":false,"given":"Laura","family":"Borrega","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, 28922 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5904-9904","authenticated-orcid":false,"given":"Ignacio","family":"Casanova","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario de Torrej\u00f3n, 28850 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7121-4112","authenticated-orcid":false,"given":"Ana Bel\u00e9n","family":"Caminero","sequence":"additional","affiliation":[{"name":"Department of Neurology, Complejo Asistencial de \u00c1vila, 05071 \u00c1vila, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2634-8294","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"S\u00e1nchez-Menoyo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Galdakao-Usansolo University Hospital, Osakidetza (Basque Health Service), 48960 Usansolo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"G\u00f3mez-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital San Pedro de Alc\u00e1ntara, 10003 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5957-0046","authenticated-orcid":false,"given":"Olga","family":"Carmona","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fundaci\u00f3 Salut Empord\u00e0, 17600 Figueres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Calles","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitari Son Espases, 07120 Palma, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Nuestra Se\u00f1ora de la Candelaria, 38010 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"L\u00f3pez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Ll\u00edria Arnau, 46160 Ll\u00edria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0432-3942","authenticated-orcid":false,"given":"Fabien","family":"Bakdache","sequence":"additional","affiliation":[{"name":"Medical Department, Hoffmann-La Roche Limited, Mississauga, ON, ON L5N 5M8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enric","family":"Monreal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario Ram\u00f3n y Cajal, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9897-0771","authenticated-orcid":false,"given":"In\u00e9s","family":"Gonz\u00e1lez-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario \u00c1lvaro Cunqueiro, 36312 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9858-3555","authenticated-orcid":false,"given":"Jorge","family":"Maurino","sequence":"additional","affiliation":[{"name":"Medical Department, Roche Farma, 28042 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105861","DOI":"10.1016\/j.msard.2024.105861","article-title":"Perceived illness-related uncertainty among patients with mid-stage relapsing-remitting multiple sclerosis","volume":"91","author":"Sabin","year":"2024","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00415-025-13293-9","article-title":"The use of high-efficacy disease-modifying therapies in multiple sclerosis: Recommendations from an expert Delphi consensus","volume":"272","author":"Filippi","year":"2025","journal-title":"J. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000487329","article-title":"Facing the Unknown: Fear of Progression Could Be a Relevant Psychological Risk Factor for Depressive Mood States among Patients with Multiple Sclerosis","volume":"87","author":"Nielsen","year":"2018","journal-title":"Psychother. Psychosom."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6669","DOI":"10.1007\/s10072-025-08507-x","article-title":"Fear of relapse in multiple sclerosis: Examining the roles of perfectionism and intolerance of uncertainty","volume":"46","author":"Demirci","year":"2025","journal-title":"Neurol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(23)01473-3","article-title":"Multiple sclerosis","volume":"403","author":"Jakimovski","year":"2024","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.tins.2022.12.004","article-title":"The foundation and architecture of precision medicine in neurology and psychiatry","volume":"46","author":"Hampel","year":"2023","journal-title":"Trends Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41582-024-00955-x","article-title":"Neurofilaments as biomarkers in neurological disorders\u2014Towards clinical application","volume":"20","author":"Khalil","year":"2024","journal-title":"Nat. Rev. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Daponte, A., Koros, C., Skarlis, C., Siozios, D., Rentzos, M., Papageorgiou, S.G., and Anagnostouli, M. (2025). Neurofilament Biomarkers in Neurology: From Neuroinflammation to Neurodegeneration, Bridging Established and Novel Analytical Advances with Clinical Practice. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26199739"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e200427","DOI":"10.1212\/NXI.0000000000200427","article-title":"Exploring the Clinical Utility of Neurofilament Light Chain Assays in Multiple Sclerosis Management","volume":"12","author":"Nicholas","year":"2025","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s00415-025-13093-1","article-title":"The role of serum neurofilament light (sNfL) as a biomarker in multiple sclerosis: Insights from a systematic review","volume":"272","author":"Freedman","year":"2025","journal-title":"J. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"106637","DOI":"10.1016\/j.msard.2025.106637","article-title":"Serum neurofilament light chain as a biomarker in multiple sclerosis: A cross-sectional observation in real-world clinical practice","volume":"103","author":"Sahoo","year":"2025","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e12946","DOI":"10.1002\/advs.202512946","article-title":"Assessing the Relative Importance of Imaging and Serum Biomarkers in Capturing Disability, Cognitive Impairment, and Clinical Progression in Multiple Sclerosis","volume":"13","author":"Cagol","year":"2026","journal-title":"Adv. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Monreal, E., Ruiz, P.D., Rom\u00e1n, I.L.S., Rodr\u00edguez-Antig\u00fcedad, A., Moya-Molina, M.\u00c1., \u00c1lvarez, A., Garc\u00eda-Arcelay, E., Maurino, J., Shepherd, J., and Cabrera, \u00c1.P. (2024). Value contribution of blood-based neurofilament light chain as a biomarker in multiple sclerosis using multi-criteria decision analysis. Front. Public Health, 12.","DOI":"10.3389\/fpubh.2024.1397845"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1177\/13524585251335466","article-title":"Personalized treatment decision algorithms for the clinical application of serum neurofilament light chain in multiple sclerosis: A modified Delphi Study","volume":"31","author":"Yaldizli","year":"2025","journal-title":"Mult. Scler."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1177\/13524585241246536","article-title":"Neurofilament in clinical practice: Is the multiple sclerosis community ready?","volume":"30","author":"Moccia","year":"2024","journal-title":"Mult. Scler."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"105838","DOI":"10.1016\/j.msard.2024.105838","article-title":"Does serum neurofilament light chain measurement influence therapeutic decisions in multiple sclerosis?","volume":"90","author":"Saposnik","year":"2024","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"106550","DOI":"10.1016\/j.msard.2025.106550","article-title":"The practical uses of serum neurofilament light chain as a biomarker in multiple sclerosis","volume":"100","author":"Coker","year":"2025","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Stefanicka-Wojtas, D., and Kurpas, D. (2023). Barriers and Facilitators to the Implementation of Personalised Medicine across Europe. J. Pers. Med., 13.","DOI":"10.3390\/jpm13020203"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.2147\/NDT.S524459","article-title":"Neurologists\u2019 Openness to Evidence-Based Innovation in Multiple Sclerosis Care: Individual and Structural Determinants","volume":"21","author":"Monreal","year":"2025","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"102950","DOI":"10.1016\/j.msard.2021.102950","article-title":"The Symbol Digit Modalities Test (SDMT) is sensitive but non-specific in MS: Lexical access speed, memory, and information processing speed independently contribute to SDMT performance","volume":"51","author":"Sandry","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1177\/1352458520929626","article-title":"Development and psychometric properties of the Multiple Sclerosis Knowledge Assessment Scale: Rasch analysis of a novel tool for evaluating MS knowledge","volume":"27","author":"Bessing","year":"2021","journal-title":"Mult. Scler."},{"key":"ref_22","first-page":"20552173241247680","article-title":"Assessing illness-related uncertainty in relapsing-remitting multiple sclerosis: A psychometric analysis of the Mishel Uncertainty of Illness Scale","volume":"10","author":"Sabin","year":"2024","journal-title":"Mult. Scler. J. Exp. Transl. Clin."},{"key":"ref_23","first-page":"e308","article-title":"Are you SURE?: Assessing patient decisional conflict with a 4-item screening test","volume":"56","author":"Kearing","year":"2010","journal-title":"Can. Fam. Physician"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1177\/0272989X03256005","article-title":"Validation of a decision regret scale","volume":"23","author":"Brehaut","year":"2003","journal-title":"Med. Decis. Mak."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s40120-020-00176-6","article-title":"Psychometric Properties of the SymptoMScreen Questionnaire in a Mild Disability Population of Patients with Relapsing-Remitting Multiple Sclerosis: Quantifying the Patient\u2019s Perspective","volume":"9","author":"Maurino","year":"2020","journal-title":"Neurol. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/brain\/124.5.962","article-title":"The Multiple Sclerosis Impact Scale (MSIS-29): A new patient-based outcome measure","volume":"124","author":"Hobart","year":"2001","journal-title":"Brain"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-3999(00)00204-X","article-title":"Illness perceptions and mood in chronic fatigue syndrome","volume":"50","author":"Edwards","year":"2001","journal-title":"J. Psychosom. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.2044-8260.1992.tb00997.x","article-title":"The development of a six-item short-form of the state scale of the Spielberger State-Trait Anxiety Inventory (STAI)","volume":"31","author":"Marteau","year":"1992","journal-title":"Br. J. Clin. Psychol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1037\/h0037562","article-title":"The measurement of pessimism: The hopelessness scale","volume":"42","author":"Beck","year":"1974","journal-title":"J. Consult. Clin. Psychol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S1474-4422(25)00249-2","article-title":"Blood and CSF biomarkers for multiple sclerosis: Emerging clinical applications","volume":"24","author":"Chitnis","year":"2025","journal-title":"Lancet Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Ubbink, D.T., Damman, O.C., and de Jong, B.A. (2022). Shared decision-making in patients with multiple sclerosis. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.1063904"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.msard.2018.11.016","article-title":"Understanding treatment decisions from the perspective of people with relapsing remitting multiple Sclerosis: A critical interpretive synthesis","volume":"27","author":"Eskyte","year":"2019","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00415-024-12725-2","article-title":"Unveiling preferences in multiple sclerosis care: Insights from an Italian discrete-choice experiment with patients and healthcare professionals","volume":"272","author":"Gasperini","year":"2024","journal-title":"J. Neurol."},{"key":"ref_34","first-page":"e70022","article-title":"Presymptomatic blood tests to detect neurodegeneration: Perceptions of potential consumers across the life course","volume":"1","author":"Fair","year":"2025","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_35","first-page":"e12549","article-title":"Caregivers\u2019 attitudes toward blood-based biomarker testing for Alzheimer\u2019s disease","volume":"16","author":"Bolsewig","year":"2024","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"103969","DOI":"10.1016\/j.msard.2022.103969","article-title":"Long-term prognosis communication preferences in early-stage relapsing-remitting multiple sclerosis","volume":"64","author":"Borges","year":"2022","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Ballesteros, R., de la Maza, S.S., Borges, M., Mart\u00edn-Mart\u00ednez, J., Sotoca, J., Alonso, A., Caminero, A.B., Borrega, L., S\u00e1nchez-Menoyo, J.L., and Barrero-Hern\u00e1ndez, F.J. (2025). Threatening illness perception and associated factors in early-stage relapsing-remitting multiple sclerosis. Front. Psychiatry, 16.","DOI":"10.3389\/fpsyt.2025.1565150"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1007\/s10072-024-07541-5","article-title":"A systematic review to explore patients\u2019 MS knowledge and MS risk knowledge","volume":"45","author":"Smith","year":"2024","journal-title":"Neurol. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Giordano, A., Liethmann, K., K\u00f6pke, S., Poettgen, J., Rahn, A.C., Drulovic, J., Beckmann, Y., Sastre-Garriga, J., Galea, I., and Heerings, M. (2018). Risk knowledge of people with relapsing-remitting multiple sclerosis\u2014Results of an international survey. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0208004"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s40271-020-00454-3","article-title":"High-Efficacy Disease-Modifying Therapies in People with Relapsing-Remitting Multiple Sclerosis: The Role of Risk Attitude in Treatment Decisions","volume":"14","author":"Maurino","year":"2021","journal-title":"Patient"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"102354","DOI":"10.1016\/j.msard.2020.102354","article-title":"Therapeutic status quo in patients with relapsing-remitting multiple sclerosis: A sign of poor self-perception of their clinical status?","volume":"45","author":"Saposnik","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"104970","DOI":"10.1016\/j.ebiom.2024.104970","article-title":"Guidance for use of neurofilament light chain as a cerebrospinal fluid and blood biomarker in multiple sclerosis management","volume":"101","author":"Freedman","year":"2024","journal-title":"EBioMedicine"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Centonze, D., Di Sapio, A., Morra, V.B., Colombo, E., Inglese, M., Paolicelli, D., Salvetti, M., and Furlan, R. (2025). Steps toward the implementation of neurofilaments in multiple sclerosis: Patient profiles to be prioritized in clinical practice. Front. Neurol., 16.","DOI":"10.3389\/fneur.2025.1571605"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1177\/13524585241291452","article-title":"Using serum neurofilament-light in clinical practice: Growing enthusiasm that may need bridling","volume":"30","author":"Lycke","year":"2024","journal-title":"Mult. Scler."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/16\/4\/185\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:32:34Z","timestamp":1776155554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/16\/4\/185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,29]]},"references-count":44,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["jpm16040185"],"URL":"https:\/\/doi.org\/10.3390\/jpm16040185","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,29]]}}}