{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:48:20Z","timestamp":1782456500683,"version":"3.54.5"},"reference-count":31,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Objectives: Tandem spinal stenosis (TSS) is often underdiagnosed and traditionally managed with multi-stage surgery (MSS). Single-stage surgery (SSS) is an alternative, but prior studies largely emphasize younger, healthier patients. This study evaluated perioperative and functional outcomes after SSS for TSS in a surgically diverse cohort. Methods: A retrospective chart review included 20 patients who underwent SSS for TSS at a single academic institution. Mean age was 63.75 years, and median modified frailty index was 2. Etiologies included degenerative, traumatic, and neoplastic disease across cervical, thoracic, and lumbar regions. Outcomes included operative characteristics, complications, readmissions, and functional recovery measured by Visual Analog Scale (VAS) pain and modified Japanese Orthopaedic Association (mJOA) scores. Results: The mean number of operated levels was 5.2, mean operative time was 232.4 min, total OR time was 355.1 min, and length of stay was 6.9 days. Surgical complications occurred in 15% of patients, medical complications in 25%, and 90-day readmission in 15%, with no 30-day mortality. Mean mJOA improved from 12.86 at baseline to 16.08 at first follow-up and 16.46 at 3 months; REML mixed-effects modeling showed a significant timepoint effect (F (4, 34.55) = 9.15, p &lt; 0.001), with significant Sidak-adjusted improvement at both timepoints. VAS pain showed no significant longitudinal effect. Conclusions: SSS for TSS appears feasible in a real-world, surgically diverse cohort including older and moderately frail patients. These findings support individualized SSS candidacy assessment.<\/jats:p>","DOI":"10.3390\/jpm16070347","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:52:11Z","timestamp":1782453131000},"page":"347","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Outcomes Following Single-Stage Surgery for Tandem Spinal Stenosis\u2014A Single-Center Retrospective Cohort"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3249-9657","authenticated-orcid":false,"given":"Adham M.","family":"Khalafallah","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4206-6262","authenticated-orcid":false,"given":"Manav","family":"Daftari","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanuj","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4800-6685","authenticated-orcid":false,"given":"Sebastian","family":"Vargas-George","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Aka","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1147-9435","authenticated-orcid":false,"given":"Christian K.","family":"Ramsoomair","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Bashti","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA"},{"name":"Department of Neurological Surgery, University of Washington School of Medicine, Seattle, WA 98104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth S.","family":"Tigchelaar","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timur","family":"Urakov","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.5435\/JAAOS-D-18-00726","article-title":"Evaluation and Treatment of Tandem Spinal Stenosis","volume":"28","author":"Baker","year":"2020","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.2106\/JBJS.RVW.17.00007","article-title":"Tandem Spinal Stenosis: A Systematic Review","volume":"5","author":"Overley","year":"2017","journal-title":"JBJS Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.spinee.2007.12.005","article-title":"Tandem stenosis: A cadaveric study in osseous morphology","volume":"8","author":"Lee","year":"2008","journal-title":"Spine J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.spinee.2022.07.088","article-title":"Outcomes in surgical treatment for tandem spinal stenosis: Systematic literature review","volume":"22","author":"Ahorukomeye","year":"2022","journal-title":"Spine J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s10143-019-01154-9","article-title":"Symptomatic tandem spinal stenosis: A clinical, diagnostic, and surgical challenge","volume":"43","author":"Jannelli","year":"2020","journal-title":"Neurosurg. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00586-018-5795-6","article-title":"Staged surgery for tandem cervical and lumbar spinal stenosis: Which should be treated first?","volume":"28","author":"Luo","year":"2019","journal-title":"Eur. Spine J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00586-021-07078-7","article-title":"Simultaneous decompression of all stenotic regions versus decompression of only the most symptomatic region in patients with tandem spinal stenosis: A systematic review and meta-analysis","volume":"31","author":"Mittal","year":"2022","journal-title":"Eur. Spine J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.1016\/j.wneu.2022.11.028","article-title":"Meta-Analysis of Simultaneous versus Staged Decompression of Stenotic Regions in Patients with Tandem Spinal Stenosis","volume":"170","author":"Lu","year":"2023","journal-title":"World Neurosurg."},{"key":"ref_9","first-page":"e088","article-title":"Validation of Digital Visual Analog Scale Pain Scoring With a Traditional Paper-based Visual Analog Scale in Adults","volume":"2","author":"Delgado","year":"2018","journal-title":"J. Am. Acad. Orthop. Surg. Glob. Res. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13018-018-0765-6","article-title":"Surgical outcomes for lumbar spinal canal stenosis with coexisting cervical stenosis (tandem spinal stenosis): A retrospective analysis of 565 cases","volume":"13","author":"Yamada","year":"2018","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3171\/jns.1987.66.6.0842","article-title":"Tandem lumbar and cervical spinal stenosis. Natural history, prognostic indices, and results after surgical decompression","volume":"66","author":"Dagi","year":"1987","journal-title":"J. Neurosurg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00586-016-4660-8","article-title":"The modified Japanese Orthopaedic Association scale: Establishing criteria for mild, moderate and severe impairment in patients with degenerative cervical myelopathy","volume":"26","author":"Tetreault","year":"2017","journal-title":"Eur. Spine J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e626","DOI":"10.1016\/j.wneu.2018.12.168","article-title":"The Modified 5-Item Frailty Index: A Concise and Useful Tool for Assessing the Impact of Frailty on Postoperative Morbidity Following Elective Posterior Lumbar Fusions","volume":"124","author":"Weaver","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3171\/2023.7.JNS231214","article-title":"The 5-factor modified frailty index as a prognostic factor of stereotactic radiosurgery for metastatic disease to the brain","volume":"140","author":"Lucido","year":"2024","journal-title":"J. Neurosurg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3171\/2024.8.SPINE24365","article-title":"When is staging complex adult spinal deformity advantageous? Identifying subsets of patients who benefit from staged interventions","volume":"42","author":"Passias","year":"2025","journal-title":"J. Neurosurg. Spine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1177\/15563316241253604","article-title":"A Nationwide Comparison of Outcomes and Resource Use in Staged vs Simultaneous Cervical and Lumbar Fusions: A Retrospective Database Study","volume":"20","author":"Illescas","year":"2024","journal-title":"HSS J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"843","DOI":"10.14444\/8548","article-title":"Comparison of Staged vs Same-Day Circumferential Spinal Fusions for Adult Spinal Deformity","volume":"17","author":"Albayar","year":"2023","journal-title":"Int. J. Spine Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/os.12906","article-title":"Simultaneous or Staged Decompressions for Patients with Tandem Spinal Stenosis","volume":"13","author":"Sun","year":"2021","journal-title":"Orthop. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13018-021-02357-x","article-title":"Simultaneous or staged operation for tandem spinal stenosis: Surgical strategy and efficacy comparison","volume":"16","author":"Cao","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jspd.2017.08.012","article-title":"Deep Vein Thrombosis After Complex Posterior Spine Surgery: Does Staged Surgery Make a Difference?","volume":"6","author":"Edwards","year":"2018","journal-title":"Spine Deform"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"14350","DOI":"10.1038\/s41598-022-18417-z","article-title":"Analysis of risk factors for perioperative complications in spine surgery","volume":"12","author":"Lange","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"100858","DOI":"10.1016\/j.bas.2021.100858","article-title":"Perioperative adverse events in adult and pediatric spine surgery: A prospective cohort analysis of 364 consecutive patients","volume":"2","author":"Lovi","year":"2022","journal-title":"Brain Spine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3171\/2016.1.SPINE14808","article-title":"Spine Trauma Study Group; Degenerative Spine Study Group. Spinal Adverse Events Severity System, version 2 (SAVES-V2): Inter- and intraobserver reliability assessment","volume":"25","author":"Rampersaud","year":"2016","journal-title":"J. Neurosurg. Spine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1177\/21925682221149390","article-title":"Identification of an Operative Time Threshold for Substantially Increased Postoperative Complications Among Elderly Spine Surgery Patients","volume":"14","author":"Findlay","year":"2024","journal-title":"Glob. Spine J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1186\/s13018-024-05066-3","article-title":"Prolonged operative time significantly impacts on the incidence of complications in spinal surgery","volume":"19","author":"Monetta","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"E347","DOI":"10.1097\/BSD.0000000000000659","article-title":"Comparison of Decompression, Decompression Plus Fusion, and Decompression Plus Stabilization for Degenerative Spondylolisthesis: A Prospective, Randomized Study","volume":"31","author":"Inose","year":"2018","journal-title":"Clin. Spine Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/s00586-004-0753-x","article-title":"Blood loss in adult spinal surgery","volume":"13","author":"Hu","year":"2004","journal-title":"Eur. Spine J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.14444\/8423","article-title":"How Much Blood Loss Is Appropriate for a 2- to 3-Level Posterior Lumbar Fusion?","volume":"17","author":"Chen","year":"2023","journal-title":"Int. J. Spine Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.repc.2016.11.007","article-title":"The postoperative venous thromboembolism (TREVO) study\u2014Risk and case mortality by surgical specialty (Estudo TRomboEmbolismo Venoso pos-Operatorio (TREVO)\u2014Risco e mortalidade por especialidade cirurgica)","volume":"36","author":"Amaral","year":"2017","journal-title":"Rev. Port. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.clineuro.2018.01.024","article-title":"Cervical spine surgery for tandem spinal stenosis: The impact on low back pain","volume":"166","author":"Alvin","year":"2018","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s00586-020-06693-0","article-title":"Primary cervical decompression surgery may improve lumbar symptoms in patients with tandem spinal stenosis","volume":"30","author":"Inoue","year":"2021","journal-title":"Eur. Spine J."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/16\/7\/347\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:24:17Z","timestamp":1782455057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/16\/7\/347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":31,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["jpm16070347"],"URL":"https:\/\/doi.org\/10.3390\/jpm16070347","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]}}}