{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:59:52Z","timestamp":1785243592117,"version":"3.55.0"},"reference-count":30,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Pers. Med.","JPM"],"abstract":"<jats:p>Introduction: Desmoid fibromatosis (DF) is a rare, locally invasive, and typically non-metastatic neoplasm. Its pathophysiology is poorly understood, and the subtle clinical presentation makes diagnosis challenging. A multidisciplinary approach is necessary to achieve a definitive diagnosis and identify the most effective therapeutic strategy. Because of its heterogeneous presentation and unpredictable behavior, DF cannot be managed through a standardized protocol, and diagnostic and therapeutic decisions must instead be tailored to the individual patient, consistent with a personalized-medicine approach. We present an unusual case in which we aim to evaluate the diagnostic procedures and treatments used and determine whether they align with the recent literature. Materials and Methods: A case report. A 27-year-old man presented with fever and worsening abdominal pain, without clinical signs of intestinal obstruction. He had undergone a sleeve gastrectomy five years earlier. A computed tomography (CT) scan revealed an intra-abdominal mass in the mesohypogastric region, likely originating from the mesentery of the small intestine. The patient underwent a right hemicolectomy extended to the terminal ileum. Histopathological examination and immunohistochemistry confirmed the diagnosis of DF. The patient was discharged on the 5th postoperative day (POD) in good general clinical condition. To date, there are no signs of recurrence. Conclusions: The multidisciplinary approach is essential for managing DF and R0 surgical resection remains the gold standard. The diagnostic and therapeutic pathway followed in our patient appears consistent with the recent literature. This case illustrates how individualized clinical reasoning can be applied even to a rare, heterogeneous neoplasm for which no standardized protocol exists. Furthermore, an established post-surgical management protocol for DF has not yet been developed. Additionally, we observed a possible, hypothesis-generating association between bariatric surgery and the subsequent onset of an intra-abdominal desmoid tumor; given the rarity of desmoid fibromatosis relative to the high volume of bariatric procedures performed worldwide, this observation should not be interpreted as a confirmed correlation, and we conducted a literature review to explore it as a hypothesis. Numerous studies are needed on this matter, but we hope that this case can provide a small starting point for subsequent studies.<\/jats:p>","DOI":"10.3390\/jpm16080402","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:08:14Z","timestamp":1785161294000},"page":"402","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Giant Desmoid Fibromatosis of the Small Bowel After Sleeve Gastrectomy: Case Report and Review of the Literature"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1684-1849","authenticated-orcid":false,"given":"Teresa","family":"Sinicropi","sequence":"first","affiliation":[{"name":"Department of Human Pathology of the Adult and Evolutive Age \u201cGaetano Barresi\u201d, Section of General Surgery, University of Messina, Via Consolare Valeria, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9893-7480","authenticated-orcid":false,"given":"Carmelo","family":"Mazzeo","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of the Adult and Evolutive Age \u201cGaetano Barresi\u201d, Section of General Surgery, University of Messina, Via Consolare Valeria, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5806-2307","authenticated-orcid":false,"given":"Mariausilia","family":"Franchina","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of the Adult and Evolutive Age \u201cGaetano Barresi\u201d, Section of Pathology, University of Messina, Via Consolare Valeria, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6951-2459","authenticated-orcid":false,"given":"Maria","family":"Iannello","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of the Adult and Evolutive Age \u201cGaetano Barresi\u201d, Section of General Surgery, University of Messina, Via Consolare Valeria, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-8975","authenticated-orcid":false,"given":"Francesco","family":"Fleres","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of the Adult and Evolutive Age \u201cGaetano Barresi\u201d, Section of General Surgery, University of Messina, Via Consolare Valeria, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/RCT.0000000000000790","article-title":"Current Update on Desmoid Fibromatosis","volume":"43","author":"Ganeshan","year":"2019","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/ajcp\/77.6.665","article-title":"The desmoid tumor. I. Incidence, sex-, age- and anatomical distribution in the Finnish population","volume":"77","author":"Reitamo","year":"1982","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.32074\/1591-951X-213","article-title":"The 2020 WHO Classification of Soft Tissue Tumours: News and perspectives","volume":"113","author":"Sbaraglia","year":"2021","journal-title":"Pathologica"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e263030","DOI":"10.1136\/bcr-2024-263030","article-title":"Desmoid fibromatosis arising from caecum: An overview of the challenges in diagnosis and treatment","volume":"18","author":"Luca","year":"2025","journal-title":"BMJ Case Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.radcr.2024.10.101","article-title":"Mesenteric desmoid tumor in its cystic form: Case report of a very rare variant","volume":"20","author":"Bahlouli","year":"2024","journal-title":"Radiol. Case Rep."},{"key":"ref_6","first-page":"283","article-title":"Primary mesenteric fibromatosis: A single Center experience","volume":"91","author":"Yalav","year":"2020","journal-title":"Ann. Ital. Chir."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1245\/s10434-012-2638-2","article-title":"Desmoid tumor: Analysis of prognostic factors and outcomes in a surgical series","volume":"19","author":"Mullen","year":"2012","journal-title":"Ann. Surg. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/bjs.9411","article-title":"Risk of desmoid tumours after open and laparoscopic colectomy in patients with familial adenomatous polyposis","volume":"101","author":"Vitellaro","year":"2014","journal-title":"Br. J. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"815","DOI":"10.6004\/jnccn.2022.0035","article-title":"Soft Tissue Sarcoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology","volume":"20","author":"Kane","year":"2022","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"880","DOI":"10.4103\/jcrt.JCRT_582_20","article-title":"Desmoid tumor of Meckel\u2019s diverticulum presenting as intestinal obstruction: A rare case report with literature review","volume":"18","author":"Mundada","year":"2022","journal-title":"J. Cancer Res. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"rjz411","DOI":"10.1093\/jscr\/rjz411","article-title":"Desmoid tumor at the gastrointestinal anastomosis after a one-anastomosis gastric bypass (mini-gastric bypass): A case report","volume":"2020","author":"Mahnashi","year":"2020","journal-title":"J. Surg. Case Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"rjz379","DOI":"10.1093\/jscr\/rjz379","article-title":"Desmoid tumor presenting 2 years after elective Roux-en-Y gastric bypass: A case report and review of the literature","volume":"2020","author":"Anderson","year":"2020","journal-title":"J. Surg. Case Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000533959","article-title":"Desmoid Tumor after Sleeve Gastrectomy: Case Report and Literature Review","volume":"31","author":"Medas","year":"2023","journal-title":"GE Port. J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.21037\/pcm-22-2","article-title":"Sporadic mesenteric desmoid-type fibromatosis with \u201cdouble-hit\u201d T41A and S45P beta-catenin mutation profile: A case report of an extremely rare event\u2014Clinically relevant or much ado about nothing?","volume":"5","author":"Shafi","year":"2022","journal-title":"Precis. Cancer Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.1016\/j.soard.2015.08.228","article-title":"A Hidden Danger: Case Report of Massive Desmoid Tumor in a Post-Bariatric Surgery Patient","volume":"11","author":"Sedeyn","year":"2015","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_16","first-page":"114","article-title":"Desmoid tumor originating from sleeve gastrectomy stapler line (V060)","volume":"Volume 39","author":"Aljomah","year":"2025","journal-title":"2025 SAGES Annual Meeting, Long Beach, California, USA, 12\u201315 March 2025: Podium Video"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.12998\/wjcc.v12.i25.5791","article-title":"Solitary fibrous tumor: A case report of this multifaceted tumor","volume":"12","author":"Maalouf","year":"2024","journal-title":"World J. Clin. Cases"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Freire, A.P.E., and Skubitz, K.M. (2025). Clinical Benefit of Pegylated Liposomal Doxorubicin and High Prevalence of Pre-Existing Psychiatric Conditions in Patients with Desmoid-Type Fibromatosis. Cancers, 17.","DOI":"10.3390\/cancers17020293"},{"key":"ref_19","first-page":"103741","article-title":"Huge mesenteric desmoid-type fibromatosis with unusual presentation: A case report","volume":"78","author":"Hajri","year":"2022","journal-title":"Ann. Med. Surg. (Lond.)"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5114\/pg.2019.83429","article-title":"Fibromatosis\u2014Immunohistochemical evaluation, differential diagnosis from gastrointestinal tumors, and other mesenchymal tumours","volume":"14","author":"Lacka","year":"2019","journal-title":"Gastroenterol. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.3892\/ol.2016.4082","article-title":"Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement with bland cytological features mimicking desmoid-type fibromatosis: A case report and review of the literature","volume":"11","author":"Huang","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/pin.13096","article-title":"A comparison of the usefulness of nuclear beta-catenin in the diagnosis of desmoid-type fibromatosis among commonly used anti-beta-catenin antibodies","volume":"71","author":"Yamada","year":"2021","journal-title":"Pathol. Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/ajcp\/aqv094","article-title":"Morphologic Spectrum of Desmoid-Type Fibromatosis","volume":"145","author":"Zreik","year":"2016","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2058460121992455","DOI":"10.1177\/2058460121992455","article-title":"An intra-abdominal desmoid tumor","volume":"10","author":"Silye","year":"2021","journal-title":"Acta Radiol. Open"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"102675","DOI":"10.1016\/j.ctrv.2023.102675","article-title":"Desmoid-type fibromatosis: Current therapeutic strategies and future perspectives","volume":"123","author":"Ibrahim","year":"2024","journal-title":"Cancer Treat. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s40487-016-0017-z","article-title":"Intra-Abdominal and Abdominal Wall Desmoid Fibromatosis","volume":"4","author":"Howard","year":"2016","journal-title":"Oncol. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"W1008","DOI":"10.2214\/AJR.11.6657","article-title":"A to Z of desmoid tumors","volume":"197","author":"Shinagare","year":"2011","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/(SICI)1097-0142(20000401)88:7<1517::AID-CNCR3>3.0.CO;2-9","article-title":"Surgery versus radiation therapy for patients with aggressive fibromatosis or desmoid tumors: A comparative review of 22 articles","volume":"88","author":"Nuyttens","year":"2000","journal-title":"Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1748-717X-2-12","article-title":"The impact of radiotherapy in the treatment of desmoid tumours. An international survey of 110 patients. A study of the Rare Cancer Network","volume":"2","author":"Baumert","year":"2007","journal-title":"Radiat. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/SLA.0b013e31828c8a30","article-title":"A prognostic nomogram for prediction of recurrence in desmoid fibromatosis","volume":"258","author":"Crago","year":"2013","journal-title":"Ann. Surg."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/16\/8\/402\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:04:46Z","timestamp":1785240286000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/16\/8\/402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":30,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["jpm16080402"],"URL":"https:\/\/doi.org\/10.3390\/jpm16080402","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]}}}