{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:39:28Z","timestamp":1790638768566,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Pers. Med.","JPM"],"abstract":"<jats:p>Background: Critically ill patients undergo rapid and clinically significant skeletal muscle loss during the first week of ICU admission, driven by a complex interplay of systemic inflammation, neuroendocrine dysregulation, and accelerated protein catabolism. While CRP is an established marker of the inflammatory response, its temporal relationship with early muscle wasting\u2014specifically whether the initial inflammatory peak or its subsequent persistence most strongly determines muscle loss\u2014remains poorly characterised. This study investigated the serial dynamics of inflammatory biomarkers and their correlation with skeletal muscle changes during the first seven ICU days. Methods: This is a post hoc analysis of the NUTRITI prospective observational cohort, conducted at a single academic ICU in Udine, Italy (Ethics Committee approval: CEUR-2019-Os-17). Sixty-six adult critically ill patients with an anticipated ICU stay exceeding 72 h and requiring artificial nutritional support were included; patients on renal replacement therapy or with contraindications to bioelectrical impedance analysis (BIA) were excluded. Body composition\u2014skeletal muscle mass (MM, kg) and phase angle (PA\u00b0)\u2014was assessed by single-frequency BIA (50 kHz) on Day 1 and Day 7. The primary outcome was \u0394MM%, the percentage change in muscle mass between admission and Day 7, calculated as \u0394MM% = [(MMd \u2212 MMa)\/MMa] \u00d7 100. Daily inflammatory biomarkers\u2014CRP (mg\/L), total WBC (\u00d7103\/mm3), and lymphocyte count (\u00d7103\/mm3)\u2014were collected throughout. Spearman rank correlations between \u0394MM% and serial biomarkers were computed for each day. Given the large number of tests (42 total), Bonferroni false discovery rate corrections were applied. Results: The cohort had a median age of 68.5 years (IQR 61\u201377.8), was predominantly male (71.2%), with median APACHE II 21.5 and SOFA 7. Median muscle mass declined significantly from 34.3 kg (IQR 29.9\u201339.5) at Day 1 to 30.6 kg (IQR 26.5\u201334.9) at Day 7 (p &lt; 0.001), corresponding to a median MM% of \u22128.45% (IQR \u221214.2% to \u22121.52%). Phase angle also declined significantly (4.9\u00b0 to 4.5\u00b0; p &lt; 0.01). CRP showed no significant correlation with \u0394MM% at Days 1 or 2, but a negative correlation emerged at Day 3 (\u03c1 = \u22120.297; p = 0.020) and peaked at Day 4 (\u03c1 = \u22120.355; p = 0.006), attenuating thereafter. CRP at Days 5 and 6 correlated with phase angle changes (p = 0.017 and p = 0.022, respectively). WBC showed no significant correlations at any time point. Day-7 lymphocyte count was nominally correlated with \u0394MM% (\u03c1 = \u22120.314; p = 0.040). Neither APACHE II nor SOFA at admission correlated with \u0394MM%. No test survived correction for multiple comparisons. Conclusions: The kinetics of CRP\u2014rather than its initial intensity\u2014seem to be associated with early skeletal muscle catabolism in critically ill patients, with a temporally specific signal emerging at Days 3\u20134 of ICU admission. Although these findings are exploratory and did not survive multiple testing correction, their biological plausibility\u2014grounded in the known kinetics of ubiquitin-proteasome activation and NF-\u03baB signalling\u2014and their alignment with the emerging concept of inflammation-guided nutritional timing both support their value as a hypothesis-generating observation. Serial CRP monitoring may represent a pragmatic candidate biomarker to identify the optimal window for nutritional escalation, pending prospective validation in adequately powered trials.<\/jats:p>","DOI":"10.3390\/jpm16080409","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:09:42Z","timestamp":1785398982000},"page":"409","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inflammation Course and Skeletal Muscle Wasting Correlation During the First Week in ICU: A New Approach for Personalised Feeding of Critically Ill Patients?"],"prefix":"10.3390","volume":"16","author":[{"given":"Gilberto","family":"Gremese","sequence":"first","affiliation":[{"name":"Anaesthesia and Intensive Care Unit 1, Department of Anaesthesia and Intensive Care, Academic Hospital of Udine, Health Integrated Agency of Friuli Centrale, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Comuzzi","sequence":"additional","affiliation":[{"name":"Anaesthesia and Intensive Care Unit 1, Department of Anaesthesia and Intensive Care, Academic Hospital of Udine, Health Integrated Agency of Friuli Centrale, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7417-3452","authenticated-orcid":false,"given":"Matteo","family":"Danielis","sequence":"additional","affiliation":[{"name":"Laboratory of Studies and Evidence Based Nursing, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Piani","sequence":"additional","affiliation":[{"name":"Health Professions Staff, Health Integrated Agency of Friuli Centrale, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6839-2416","authenticated-orcid":false,"given":"Daniele Guerino","family":"Biasucci","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Translational Medicine, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5271-1810","authenticated-orcid":false,"given":"Giuseppe","family":"Cuttone","sequence":"additional","affiliation":[{"name":"Anaesthesia and Intensive Care Unit, \u201cAbele Ajello\u201d Hospital, ASP Trapani, 91026 Mazara del Vallo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Fittipaldi","sequence":"additional","affiliation":[{"name":"Anaesthesia and Intensive Care Unit, ASL Napoli 1 Centro\u2014Ospedale del Mare, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Lucchese","sequence":"additional","affiliation":[{"name":"Anaesthesia and Intensive Care Unit 1, Department of Anaesthesia and Intensive Care, Academic Hospital of Udine, Health Integrated Agency of Friuli Centrale, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3745-8368","authenticated-orcid":false,"given":"Luigi","family":"Vetrugno","sequence":"additional","affiliation":[{"name":"Anaesthesia and Intensive Care Unit, Department of Emergency, Tolmezzo Hospital, Health Integrated Agency of Friuli Centrale, 33028 Tolmezzo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1626-3177","authenticated-orcid":false,"given":"Cristian","family":"Deana","sequence":"additional","affiliation":[{"name":"Anaesthesia and Intensive Care Unit 1, Department of Anaesthesia and Intensive Care, Academic Hospital of Udine, Health Integrated Agency of Friuli Centrale, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/bja\/aeu187","article-title":"Metabolic response to the stress of critical illness","volume":"113","author":"Preiser","year":"2014","journal-title":"Br. 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